cyclic-gmp and Respiratory-Tract-Infections

cyclic-gmp has been researched along with Respiratory-Tract-Infections* in 6 studies

Reviews

2 review(s) available for cyclic-gmp and Respiratory-Tract-Infections

ArticleYear
The pathophysiology of asthma. Extrinsic influences other than immunologic.
    Clinics in chest medicine, 1984, Volume: 5, Issue:4

    Atopy is not the most common factor causing asthma in adults. Recent elucidations of pathophysiologic mechanisms involving the autonomic nervous system, cyclic nucleotide metabolism, and arachnoidonic biochemistry give us a better understanding of the similarities and unique differences among asthma events related to exercise, aspirin, emotions, occupational environments, atmospheric conditions, and respiratory tract infections. The ultimate value of this information is no greater than its potential to aid the physician in decreasing the interference of asthma in the daily lives of patients.

    Topics: Aerosols; Air Pollution; Aspirin; Asthma; Asthma, Exercise-Induced; Autonomic Nervous System; Cyclic AMP; Cyclic GMP; Emotions; Humans; Humidity; Immunoglobulin E; Occupational Diseases; Parasympathetic Nervous System; Receptors, Adrenergic; Respiratory Tract Infections; Tobacco Smoke Pollution

1984
Allergy versus clinical immunology: a critical analysis.
    Annals of allergy, 1974, Volume: 33, Issue:5

    Topics: Adrenergic beta-Antagonists; Allergens; Allergy and Immunology; Asthma; Austria; Autonomic Nervous System; Bronchodilator Agents; Cyclic AMP; Cyclic GMP; Emotions; Expectorants; Histamine Release; History, 20th Century; Humans; Hypersensitivity; Hypersensitivity, Delayed; Lymphokines; Phosphates; Phosphoric Diester Hydrolases; Potassium Iodide; Prostaglandins; Reflex; Respiratory Tract Infections; SRS-A; Temperature; United States

1974

Other Studies

4 other study(ies) available for cyclic-gmp and Respiratory-Tract-Infections

ArticleYear
Biofilm formation and cellulose expression by Bordetella avium 197N, the causative agent of bordetellosis in birds and an opportunistic respiratory pathogen in humans.
    Research in microbiology, 2017, Volume: 168, Issue:5

    Although bacterial cellulose synthase (bcs) operons are widespread within the Proteobacteria phylum, subunits required for the partial-acetylation of the polymer appear to be restricted to a few γ-group soil, plant-associated and phytopathogenic pseudomonads, including Pseudomonas fluorescens SBW25 and several Pseudomonas syringae pathovars. However, a bcs operon with acetylation subunits has also been annotated in the unrelated β-group respiratory pathogen, Bordetella avium 197N. Our comparison of subunit protein sequences and GC content analyses confirms the close similarity between the B. avium 197N and pseudomonad operons and suggests that, in both cases, the cellulose synthase and acetylation subunits were acquired as a single unit. Using static liquid microcosms, we can confirm that B. avium 197N expresses low levels of cellulose in air-liquid interface biofilms and that biofilm strength and attachment levels could be increased by elevating c-di-GMP levels like the pseudomonads, but cellulose was not required for biofilm formation itself. The finding that B. avium 197N is capable of producing cellulose from a highly-conserved, but relatively uncommon bcs operon raises the question of what functional role this modified polymer plays during the infection of the upper respiratory tract or survival between hosts, and what environmental signals control its production.

    Topics: Animals; Bacterial Adhesion; Biofilms; Bird Diseases; Birds; Bordetella avium; Bordetella Infections; Cellulose; Cyclic GMP; Gene Expression Regulation, Bacterial; Glucosyltransferases; Humans; Operon; Opportunistic Infections; Pseudomonas fluorescens; Respiratory Tract Infections

2017
Homologs of the LapD-LapG c-di-GMP Effector System Control Biofilm Formation by Bordetella bronchiseptica.
    PloS one, 2016, Volume: 11, Issue:7

    Biofilm formation is important for infection by many pathogens. Bordetella bronchiseptica causes respiratory tract infections in mammals and forms biofilm structures in nasal epithelium of infected mice. We previously demonstrated that cyclic di-GMP is involved in biofilm formation in B. bronchiseptica. In the present work, based on their previously reported function in Pseudomonas fluorescens, we identified three genes in the B. bronchiseptica genome likely involved in c-di-GMP-dependent biofilm formation: brtA, lapD and lapG. Genetic analysis confirmed a role for BrtA, LapD and LapG in biofilm formation using microtiter plate assays, as well as scanning electron and fluorescent microscopy to analyze the phenotypes of mutants lacking these proteins. In vitro and in vivo studies showed that the protease LapG of B. bronchiseptica cleaves the N-terminal domain of BrtA, as well as the LapA protein of P. fluorescens, indicating functional conservation between these species. Furthermore, while BrtA and LapG appear to have little or no impact on colonization in a mouse model of infection, a B. bronchiseptica strain lacking the LapG protease has a significantly higher rate of inducing a severe disease outcome compared to the wild type. These findings support a role for c-di-GMP acting through BrtA/LapD/LapG to modulate biofilm formation, as well as impact pathogenesis, by B. bronchiseptica.

    Topics: Animals; Bacterial Proteins; Biofilms; Blotting, Western; Bordetella bronchiseptica; Bordetella Infections; Cyclic GMP; Female; Gene Expression Regulation, Bacterial; Genetic Complementation Test; Green Fluorescent Proteins; Host-Pathogen Interactions; Mice, Inbred BALB C; Microscopy, Electron, Scanning; Microscopy, Fluorescence; Mutation; Pseudomonas fluorescens; Respiratory Tract Infections; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction

2016
The CRP/FNR family protein Bcam1349 is a c-di-GMP effector that regulates biofilm formation in the respiratory pathogen Burkholderia cenocepacia.
    Molecular microbiology, 2011, Volume: 82, Issue:2

    Burkholderia cenocepacia is an opportunistic respiratory pathogen that can cause severe infections in immune-compromised individuals and is associated with poor prognosis for patients suffering from cystic fibrosis. The second messenger cyclic diguanosine monophosphate (c-di-GMP) has been shown to control a wide range of functions in bacteria, but little is known about these regulatory mechanisms in B. cenocepacia. Here we investigated the role that c-di-GMP plays in the regulation of biofilm formation and virulence in B. cenocepacia. Elevated intracellular levels of c-di-GMP promoted wrinkly colony, pellicle and biofilm formation in B. cenocepacia. A screen for transposon mutants unable to respond to elevated levels of c-di-GMP led to the identification of the mutant bcam1349 that did not display increased biofilm and pellicle formation with excessive c-di-GMP levels, and displayed a biofilm defect with physiological c-di-GMP levels. The bcam1349 gene is predicted to encode a transcriptional regulator of the CRP/FNR superfamily. Analyses of purified Bcam1349 protein and truncations demonstrated that it binds c-di-GMP in vitro. The Bcam1349 protein was shown to regulate the production of a number of components, including cellulose and fimbriae. It was demonstrated that the Bcam1349 protein binds to the promoter region of the cellulose synthase genes, and that this binding is enhanced by the presence of c-di-GMP. The bcam1349 mutant showed reduced virulence in a Galleria mellonella wax moth larvae infection model. Taken together, these findings suggest that the Bcam1349 protein is a transcriptional regulator that binds c-di-GMP and regulates biofilm formation and virulence in B. cenocepacia in response to the level of c-di-GMP.

    Topics: Animals; Bacterial Proteins; Biofilms; Burkholderia cenocepacia; Burkholderia Infections; Cyclic GMP; Gene Expression Regulation, Bacterial; Humans; Moths; Multigene Family; Promoter Regions, Genetic; Protein Binding; Respiratory Tract Infections; Transcription Factors; Virulence

2011
Viral respiratory infection increases alveolar macrophage cytoplasmic motility in rats: role of NO.
    The American journal of physiology, 1995, Volume: 268, Issue:3 Pt 1

    Ingested ferrimagnetic (Fe3O4) particles were used to estimate noninvasively the motion of organelles in alveolar macrophages (AM) in intact rats during viral respiratory infection by parainfluenza type 1 (Sendai) virus. Four days after instillation of Fe3O4 particles (3 mg/kg) into the lung, remnant field strength (RFS) was measured at the body surface immediately after magnetization of Fe3O4 particles by an externally applied magnetic field. RFS decreases with time, due to particle rotation (relaxation) which is related to cytoplasmic motility of AM. Viral infection increased the relaxation rate (lambda o per min), and increases in lambda o reached a maximum 3 days after nasal inoculation (day 3). Viral infection (day 3)-induced increases in lambda o were dose dependently inhibited by either the L-arginine analogue N-nitro-L-arginine or by methylene blue, an inhibitor of guanylate cyclase activity. Bronchoalveolar lavage fluid obtained from infected rats contained significantly higher levels of nitrite than that from control rats (P < 0.01). In in vitro experiments, AM from infected rats showed significantly higher lambda o, nitrite production, and intracellular guanosine 3',5'-cyclic monophosphate levels than those from control rats (P < 0.01). Sodium nitroprusside, known to release nitric oxide concentration dependently, increased lambda o of AM from noninfected rats in vitro. These results suggest that nitric oxide plays an important role in AM cytoplasmic motility during viral respiratory infection.

    Topics: Animals; Cell Movement; Cyclic GMP; Cytoplasm; Ferric Compounds; Lung; Macrophages, Alveolar; Magnetics; Microspheres; Nitric Oxide; Parainfluenza Virus 1, Human; Paramyxoviridae Infections; Rats; Rats, Sprague-Dawley; Respiratory Tract Infections; Specific Pathogen-Free Organisms

1995