cyclic-gmp and Pleurisy

Experimental pleurisy induced in rats with an intrapleural injection of 0.2 ml of 2% acetic acid, was used to test the effect of some non-steroidal anti-inflammatory drugs. During the acute phlogistic reaction there is a variation of the cAMP/cGMP ratio, with a sharp increase of the cGMP concentration and a parallel decrease of the cAMP level in the exudate. Indometacin and 1-methyl-5-p-toluoylpyrrole-2-acetic acid (tolmetin, Tolectin), two non-steroidal anti-inflammatory drugs, injected intrapleurally 1 h before the acetic acid injection were able to reduce the inflammatory response, affecting the cAMP and cGMP ratio. That is there is an increase of the cAMP level and a decrease of the cGMP level.

Topics: Acetates; Animals; Cyclic AMP; Cyclic GMP; Indomethacin; Male; Pleurisy; Pyrroles; Rats; Tolmetin

Topics: Acetates; Bradykinin; Cyclic AMP; Cyclic GMP; Histamine; Kininogens; Pleural Effusion; Pleurisy

The changes in leucocyte concentrations of cyclic AMP and cyclic GMP were monitored during pyrophosphate-induced pleurisy in rats. A classical 'Yin Yang' relationship was demonstrated.

Topics: Animals; Cyclic AMP; Cyclic GMP; Diphosphates; Inflammation; Male; Pleurisy; Rats; Time Factors