cyclic-gmp and Meningioma

Topics: Astrocytoma; Brain Neoplasms; Cyclic AMP; Cyclic GMP; Glioblastoma; Glioma; Humans; Meningeal Neoplasms; Meningioma

Cyclic 3-5-adenosine-monophosphate and 3-5-guanosinemonophosphate concentrations were studied in the bioptate of brain tumors, examined during neurosurgical operation and in normal brain tissues. The correlations between cyclic nucleotides in the tumors appeared to be significantly decreased in comparison to the intact tissue, being a characteristic signs for all types of tumors. There were significant fluctuations in the level of cyclic nucleotides both in the tumours and nontumorous brain tissues. There were no correlations found between the level of cyclic adenosine-monophosphate and cyclic guanosine-monophosphate on the one hand and the duration of the disease, localization of the tumor, degree of the brain oedema and the type of narcosis on the other.

Topics: Adult; Arachnoid; Astrocytoma; Brain Neoplasms; Cerebellar Neoplasms; Cyclic AMP; Cyclic GMP; Female; Frontal Lobe; Humans; Male; Meningeal Neoplasms; Meningioma; Middle Aged; Parietal Lobe

Several reports have suggested that cylcic guanosine 3'-5' monophosphate (cGMP) and cyclic 3'-5' adenosine monophosphate (cAMP) are involved in the regulation of cellular proliferation. Following our previous reports on the cAMP system in human brain tumors, we decided to investigate the cGMP system in the same pathological tissues by studying the activity of guanylate cyclase and cGMP-phosphodiesterase (cGMP-PDE). We found that the activity of both enzymes is lower in neurinomas and glioblastomas than in meningiomas or in normal cerebral cortex. Furthermore, the subcellular distribution of guanylate cyclase in human cerebral cortex differs from that of neurinomas and glioblastomas. On the basis of such observations we have discussed the possibility that the regulatory mechanism of the enzymes related to the cyclic nucleotide metabolism is altered in brain tumors.

Topics: Brain Neoplasms; Cerebral Cortex; Cyclic GMP; Glioma; Guanosine; Guanylate Cyclase; Humans; Meningioma; Neurilemmoma; Phosphoric Diester Hydrolases