cyclic-gmp and Meningeal-Neoplasms

Since the cyclic nucleotides (CN) adenosine 3',5'-monophosphate (cAMP) and guanoside 3',5'-monophosphate (cGMP) are involved in the regulation of cell proliferation and tumor growth in vitro, a study was made of the levels of these compounds in the lumbar cerebrospinal fluid (CSF) of 20 patients with intracranial and spinal tumors. In the presence of benign or malignant intracranial tumors there was a slight and not significant decrease of cAMP as well as cGMP levels in the CSF, as compared to control patients. While there was no significant correlation between the levels of the two CN in controls, there was a positive correlation in tumor patients. Total protein content and cAMP were negatively correlated in malignant intracranial tumors. Possible influences of tumor growth and intracranial pressure increases on CN levels are discussed. In spinal tumor patients normal CN levels were observed. However, in a patient with meningeal sarcoma an extremely marked elevation of cAMP occurred in parallel with the extension of the tumor to the spinal meningeal space, suggesting massive secretion of cAMP from the tumor cells.

Topics: Adolescent; Adult; Aged; Brain Neoplasms; Cyclic AMP; Cyclic GMP; Female; Humans; Male; Meningeal Neoplasms; Middle Aged; Sarcoma; Spinal Neoplasms

Topics: Astrocytoma; Brain Neoplasms; Cyclic AMP; Cyclic GMP; Glioblastoma; Glioma; Humans; Meningeal Neoplasms; Meningioma

Cyclic 3-5-adenosine-monophosphate and 3-5-guanosinemonophosphate concentrations were studied in the bioptate of brain tumors, examined during neurosurgical operation and in normal brain tissues. The correlations between cyclic nucleotides in the tumors appeared to be significantly decreased in comparison to the intact tissue, being a characteristic signs for all types of tumors. There were significant fluctuations in the level of cyclic nucleotides both in the tumours and nontumorous brain tissues. There were no correlations found between the level of cyclic adenosine-monophosphate and cyclic guanosine-monophosphate on the one hand and the duration of the disease, localization of the tumor, degree of the brain oedema and the type of narcosis on the other.

Topics: Adult; Arachnoid; Astrocytoma; Brain Neoplasms; Cerebellar Neoplasms; Cyclic AMP; Cyclic GMP; Female; Frontal Lobe; Humans; Male; Meningeal Neoplasms; Meningioma; Middle Aged; Parietal Lobe