cyclic-gmp and Eye-Diseases

cyclic-gmp has been researched along with Eye-Diseases* in 1 studies

Other Studies

1 other study(ies) available for cyclic-gmp and Eye-Diseases

Article	Year
Effects of cyclic nucleotide analogs on intraocular pressure and trauma-induced inflammation in the rabbit eye. Current eye research, 1992, Volume: 11, Issue:1 In this study the effects of cell-permeable 8-bromo-cAMP and 8-bromo-cGMP on intraocular pressure (IOP) and puncture-induced inflammatory response were investigated. Both 8-bromo-cAMP and 8-Bromo-cGMP reduced IOP when given subconjunctivally, but not topically. Subconjunctival administration of 8-bromo-cAMP induced a moderate disruption of the blood-aqueous barrier (BAB); in addition, subconjunctival 8-bromo-cAMP, but not topical 8-bromo-cAMP or subconjunctival 8-bromo-cGMP, reduced the disruption of the BAB and elevation of the aqueous PGE2 level after puncture trauma. It is concluded that the effects of 8-bromo-cAMP depend on the mode of administration, since this determines the concentration of 8-bromo-cAMP reached in the aqueous humor. It is suggested that 8-bromo-cAMP can partially suppress a slight inflammatory response by interference with the release of arachidonic acid from the tissues surrounding the aqueous humor. Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Aqueous Humor; Biological Transport, Active; Conjunctiva; Corneal Injuries; Cyclic AMP; Cyclic GMP; Dinoprostone; Eye Diseases; Eye Proteins; Inflammation; Intraocular Pressure; Rabbits	1992

Article

Year

Effects of cyclic nucleotide analogs on intraocular pressure and trauma-induced inflammation in the rabbit eye.

Current eye research, 1992, Volume: 11, Issue:1

In this study the effects of cell-permeable 8-bromo-cAMP and 8-bromo-cGMP on intraocular pressure (IOP) and puncture-induced inflammatory response were investigated. Both 8-bromo-cAMP and 8-Bromo-cGMP reduced IOP when given subconjunctivally, but not topically. Subconjunctival administration of 8-bromo-cAMP induced a moderate disruption of the blood-aqueous barrier (BAB); in addition, subconjunctival 8-bromo-cAMP, but not topical 8-bromo-cAMP or subconjunctival 8-bromo-cGMP, reduced the disruption of the BAB and elevation of the aqueous PGE2 level after puncture trauma. It is concluded that the effects of 8-bromo-cAMP depend on the mode of administration, since this determines the concentration of 8-bromo-cAMP reached in the aqueous humor. It is suggested that 8-bromo-cAMP can partially suppress a slight inflammatory response by interference with the release of arachidonic acid from the tissues surrounding the aqueous humor.

Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Aqueous Humor; Biological Transport, Active; Conjunctiva; Corneal Injuries; Cyclic AMP; Cyclic GMP; Dinoprostone; Eye Diseases; Eye Proteins; Inflammation; Intraocular Pressure; Rabbits

1992