cyclic-gmp and Enterobacteriaceae-Infections

cyclic-gmp has been researched along with Enterobacteriaceae-Infections* in 2 studies

Other Studies

2 other study(ies) available for cyclic-gmp and Enterobacteriaceae-Infections

Article	Year
Dysregulation of Cytosolic c-di-GMP in Frontiers in cellular and infection microbiology, 2022, Volume: 12 Programmed cell death plays an important role in modulating host immune defense and pathogen infection. Ferroptosis is a type of inflammatory cell death induced by intracellular iron-dependent accumulation of toxic lipid peroxides. Although ferroptosis has been associated with cancer and other sterile diseases, very little is known about the role of ferroptosis in modulating host-pathogen interactions. We show that accumulation of the secondary messenger bis-(3',5')-cyclic dimeric GMP (c-di-GMP) in the pathogenic bacterium Topics: Bacterial Proteins; Cyclic GMP; Edwardsiella; Enterobacteriaceae Infections; Ferroptosis; HeLa Cells; Humans; Virulence	2022
The DSF type quorum sensing signalling system RpfF/R regulates diverse phenotypes in the opportunistic pathogen Cronobacter. Scientific reports, 2016, Jan-04, Volume: 6 Several bacterial pathogens produce diffusible signal factor (DSF)-type quorum sensing (QS) signals to control biofilm formation and virulence. Previous work showed that in Burkholderia cenocepacia the RpfFBc/RpfR system is involved in sensing and responding to DSF signals and that this signal/sensor gene pair is highly conserved in several bacterial species including Cronobacter spp. Here we show that C. turicensis LMG 23827(T) possesses a functional RpfF/R system that is involved in the regulation of various phenotypes, including colony morphology, biofilm formation and swarming motility. In vivo experiments using the zebrafish embryo model revealed a role of this regulatory system in virulence of this opportunistic pathogen. We provide evidence that the RpfF/R system modulates the intracellular c-di-GMP level of the organism, an effect that may underpin the alteration in phenotype and thus the regulated phenotypes may be a consequence thereof. This first report on an RpfF/R-type QS system of an organism outside the genus Burkholderia revealed that both the underlying molecular mechanisms as well as the regulated functions show a high degree of conservation. Topics: Animals; Bacterial Proteins; Biofilms; Biosensing Techniques; Cronobacter; Cyclic GMP; Enterobacteriaceae Infections; Peptide Hydrolases; Phenotype; Quorum Sensing; Zebrafish	2016

Article

Year

Frontiers in cellular and infection microbiology, 2022, Volume: 12

Programmed cell death plays an important role in modulating host immune defense and pathogen infection. Ferroptosis is a type of inflammatory cell death induced by intracellular iron-dependent accumulation of toxic lipid peroxides. Although ferroptosis has been associated with cancer and other sterile diseases, very little is known about the role of ferroptosis in modulating host-pathogen interactions. We show that accumulation of the secondary messenger bis-(3',5')-cyclic dimeric GMP (c-di-GMP) in the pathogenic bacterium

Topics: Bacterial Proteins; Cyclic GMP; Edwardsiella; Enterobacteriaceae Infections; Ferroptosis; HeLa Cells; Humans; Virulence

2022

The DSF type quorum sensing signalling system RpfF/R regulates diverse phenotypes in the opportunistic pathogen Cronobacter.

Scientific reports, 2016, Jan-04, Volume: 6

Several bacterial pathogens produce diffusible signal factor (DSF)-type quorum sensing (QS) signals to control biofilm formation and virulence. Previous work showed that in Burkholderia cenocepacia the RpfFBc/RpfR system is involved in sensing and responding to DSF signals and that this signal/sensor gene pair is highly conserved in several bacterial species including Cronobacter spp. Here we show that C. turicensis LMG 23827(T) possesses a functional RpfF/R system that is involved in the regulation of various phenotypes, including colony morphology, biofilm formation and swarming motility. In vivo experiments using the zebrafish embryo model revealed a role of this regulatory system in virulence of this opportunistic pathogen. We provide evidence that the RpfF/R system modulates the intracellular c-di-GMP level of the organism, an effect that may underpin the alteration in phenotype and thus the regulated phenotypes may be a consequence thereof. This first report on an RpfF/R-type QS system of an organism outside the genus Burkholderia revealed that both the underlying molecular mechanisms as well as the regulated functions show a high degree of conservation.

Topics: Animals; Bacterial Proteins; Biofilms; Biosensing Techniques; Cronobacter; Cyclic GMP; Enterobacteriaceae Infections; Peptide Hydrolases; Phenotype; Quorum Sensing; Zebrafish

2016