cyclic-gmp and Cocarcinogenesis

Topics: Adenylyl Cyclases; Animals; Cocarcinogenesis; Cyclic GMP; Enzyme Activation; Epidermis; Isoproterenol; Mice; Neoplasms, Experimental; Papilloma; Phorbols; Receptors, Adrenergic; Receptors, Adrenergic, beta; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate

Topics: Animals; Calcium; Cell Movement; Cocarcinogenesis; Cyclic AMP; Cyclic GMP; Cytotoxicity, Immunologic; Glutathione; Hydrogen Peroxide; Macrophages; Malondialdehyde; Mice; Phorbols; Superoxides; Tetradecanoylphorbol Acetate

Topics: 1-Methyl-3-isobutylxanthine; Administration, Topical; Animals; Cocarcinogenesis; Cyclic AMP; Cyclic GMP; DNA, Neoplasm; Dose-Response Relationship, Drug; Female; Mice; Neoplasms, Experimental; Ornithine Decarboxylase; Papilloma; Phorbols; Skin Neoplasms; Tetradecanoylphorbol Acetate; Theophylline

The effect of nucleotides on initiation-promotion skin carcinogenesis in Swiss mice was investigated. Cyclic AMP was given before initiation with DMBA, between initiation and promotion, and at the same time as promotion with croton oil. Cyclic AMP was more effective in inhibiting tumor development when injected at the same as promotion with croton oil. 5'-adenosine-monophosphate (5'-AMP) and cyclic GMP were as effective as cyclic AMP in inhibiting tumor development under these conditions. However, adenosine, dibutyryl-cyclic AMP and 5'-guanosine-monophosphate (5'-GMP) were ineffective.

Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenosine Monophosphate; Animals; Benz(a)Anthracenes; Cocarcinogenesis; Croton Oil; Cyclic AMP; Cyclic GMP; Female; Mice; Neoplasms, Experimental; Ribonucleotides; Skin Neoplasms; Time Factors