cyclic-gmp and Carcinoma--Bronchogenic

cyclic-gmp has been researched along with Carcinoma--Bronchogenic* in 2 studies

Other Studies

2 other study(ies) available for cyclic-gmp and Carcinoma--Bronchogenic

Article	Year
Nitrite/nitrate and cytokine levels in bronchoalveolar lavage fluid of lung cancer patients. Cancer, 1994, Sep-01, Volume: 74, Issue:5 Cytokines are produced by tumor cells in vitro, but evidence for in vivo increased production of cytokines in cancer patients is controversial. Conversely, nitric oxide (NO) is implicated increasingly in the mediation of cytokine effects. Lung cancer patients may show an increased local production of cytokines and NO, and chronic paracrine exposure of epithelial lung cells to these medicators may influence the production of surfactant phosphatidylcholine.. The presence of the cytokine tumor necrosis factor (TNF alpha), interleukin-1 (IL-1), and interleukin-6 (IL-6), as well as NO, cyclic guanosine 3'5' monophosphate (cGMP) and phosphatidylcholine levels in bronchoalveolar lavage fluid (BLF) of lung cancer patients were investigated. Bronchoalveolar lavage fluid was obtained from 30 male smokers: 22 patients with squamous cell lung cancer and 8 subjects without cancer.. When compared with the control subjects, the cancer patients had elevated BLF levels of TNF alpha (1.58 +/- 0.47 vs. 0.04 +/- 0.02 pg/microgram protein, P < 0.001), IL-6 (1.39 +/- 0.29 vs. 0.04 +/- 0.02 pg/microgram protein, P < 0.001), and NO2-/NO3- (23.3 +/- 5.6 vs 1.1 +/- 0.6 nmol/mg protein, P < 0.001). However, phosphatidylcholine levels were lower in those with cancer than in the control subjects (3.0 +/- 1.2 vs. 24.8 +/- 6.4 micrograms protein, P < 0.001).. The results showed in vivo production of inflammatory cytokines in human lung cancer and increased tumor-associated NO production, as suggested by increased levels of nitrite/nitrate in the BLF. A decreased phosphatidylcholine content in the BLF also was found in patients with lung cancer. Topics: Bronchoalveolar Lavage Fluid; Carcinoma, Bronchogenic; Carcinoma, Squamous Cell; Cyclic GMP; Cytokines; Humans; Interleukin-1; Interleukin-6; Lung Diseases; Lung Neoplasms; Male; Middle Aged; Nitrates; Nitric Oxide; Nitrites; Phosphatidylcholines; Smoking; Tumor Necrosis Factor-alpha	1994
Urinary excretion of adenosine 3',5'-monophosphate and guanosine 3',5'-monophosphate. The New England journal of medicine, 1972, Jun-29, Volume: 286, Issue:26 Topics: Adult; Caffeine; Calcitonin; Calcium; Carcinoma, Bronchogenic; Circadian Rhythm; Cyclic AMP; Cyclic GMP; Diagnosis, Differential; Humans; Hypercalcemia; Hyperparathyroidism; Hypoparathyroidism; Lung Neoplasms; Middle Aged; Osteitis Deformans; Parathyroid Glands; Parathyroid Neoplasms; Physical Exertion; Sarcoidosis	1972

Article

Year

Nitrite/nitrate and cytokine levels in bronchoalveolar lavage fluid of lung cancer patients.

Cancer, 1994, Sep-01, Volume: 74, Issue:5

Cytokines are produced by tumor cells in vitro, but evidence for in vivo increased production of cytokines in cancer patients is controversial. Conversely, nitric oxide (NO) is implicated increasingly in the mediation of cytokine effects. Lung cancer patients may show an increased local production of cytokines and NO, and chronic paracrine exposure of epithelial lung cells to these medicators may influence the production of surfactant phosphatidylcholine.. The presence of the cytokine tumor necrosis factor (TNF alpha), interleukin-1 (IL-1), and interleukin-6 (IL-6), as well as NO, cyclic guanosine 3'5' monophosphate (cGMP) and phosphatidylcholine levels in bronchoalveolar lavage fluid (BLF) of lung cancer patients were investigated. Bronchoalveolar lavage fluid was obtained from 30 male smokers: 22 patients with squamous cell lung cancer and 8 subjects without cancer.. When compared with the control subjects, the cancer patients had elevated BLF levels of TNF alpha (1.58 +/- 0.47 vs. 0.04 +/- 0.02 pg/microgram protein, P < 0.001), IL-6 (1.39 +/- 0.29 vs. 0.04 +/- 0.02 pg/microgram protein, P < 0.001), and NO2-/NO3- (23.3 +/- 5.6 vs 1.1 +/- 0.6 nmol/mg protein, P < 0.001). However, phosphatidylcholine levels were lower in those with cancer than in the control subjects (3.0 +/- 1.2 vs. 24.8 +/- 6.4 micrograms protein, P < 0.001).. The results showed in vivo production of inflammatory cytokines in human lung cancer and increased tumor-associated NO production, as suggested by increased levels of nitrite/nitrate in the BLF. A decreased phosphatidylcholine content in the BLF also was found in patients with lung cancer.

Topics: Bronchoalveolar Lavage Fluid; Carcinoma, Bronchogenic; Carcinoma, Squamous Cell; Cyclic GMP; Cytokines; Humans; Interleukin-1; Interleukin-6; Lung Diseases; Lung Neoplasms; Male; Middle Aged; Nitrates; Nitric Oxide; Nitrites; Phosphatidylcholines; Smoking; Tumor Necrosis Factor-alpha

1994

Urinary excretion of adenosine 3',5'-monophosphate and guanosine 3',5'-monophosphate.

The New England journal of medicine, 1972, Jun-29, Volume: 286, Issue:26

Topics: Adult; Caffeine; Calcitonin; Calcium; Carcinoma, Bronchogenic; Circadian Rhythm; Cyclic AMP; Cyclic GMP; Diagnosis, Differential; Humans; Hypercalcemia; Hyperparathyroidism; Hypoparathyroidism; Lung Neoplasms; Middle Aged; Osteitis Deformans; Parathyroid Glands; Parathyroid Neoplasms; Physical Exertion; Sarcoidosis

1972