cyclic-gmp and Autoimmune-Diseases-of-the-Nervous-System

The cGMP-AMP Synthase (cGAS)-Stimulator of Interferon Genes (STING) pathway plays a critical role in sensing dsDNA localized to the cytosol, resulting in the activation of a robust inflammatory response. While cGAS-STING signaling is essential for antiviral immunity, aberrant STING activation is observed in amyotrophic lateral sclerosis (ALS), lupus, and autoinflammatory diseases such as Aicardi-Goutières syndrome (AGS) and STING associated vasculopathy with onset in infancy (SAVI). Significant efforts have therefore focused on the development of STING inhibitors. In a concurrent submission, we reported that

Topics: Amyotrophic Lateral Sclerosis; Antiviral Agents; Autoimmune Diseases of the Nervous System; Cyclic GMP; Humans; Nucleotidyltransferases; Proteome