cyclic-gmp has been researched along with Adenofibroma* in 3 studies
3 other study(ies) available for cyclic-gmp and Adenofibroma
| Article | Year |
|---|---|
[Cyclic nucleotides during radiotherapy of breast cancer].
Levels of cAMP and cGMP were higher in breast cancer tissue as compared with benign tumors. Large-fraction irradiation was followed by a decrease in cGMP concentration matched by a rise in cAMP/cGMP ratio in cases of radiosensitive tumors. Small-fraction treatment did not affect cyclic nucleotide levels. Radiotherapy was followed by a decrease in initially raised blood plasma cyclic nucleotide concentration. Topics: Adenofibroma; Breast Neoplasms; Cyclic AMP; Cyclic GMP; Female; Fibrocystic Breast Disease; Humans | 1987 |
Cyclic nucleotide levels in human breast cancer and in rat mammary tissues during tumor development.
The levels of cyclic adenosine 3':5'-monophosphate (cAMP) and cyclic guanosine 3':5'-monophosphate (cGMP) were studied in dimethylbenz(a)anthracene (DMBA)-induced mammary tumors of Sprague-Dawley rats and in human breast cancer. In the rat carcinomas, these levels were significantly lower than in non-malignant tissues when calculated on the basis of DNA content, but higher (cAMP) or equal (cGMP) when calculated on the basis of weight. In human breast cancer the cyclic nucleotide levels were higher than in non-malignant tissues according to both methods of calculation. No correlation was found in human carcinomas between the cyclic nucleotide levels and mitotic index, nuclear grade, tumor size, or lymph node involvement. The rat tumors were subclassified according to state of differentiation, mitotic index, and state of development. Not all the sub-groups had cAMP levels different from normal values. Differences in cAMP levels between the sub-groups could not be correlated with tumor growth rates and/or mitotic index. Thus, cyclic nucleotides may not be useful in prognosis of breast cancer. Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenofibroma; Animals; Breast Neoplasms; Carcinoma, Intraductal, Noninfiltrating; Cyclic AMP; Cyclic GMP; DNA, Neoplasm; Female; Fibrocystic Breast Disease; Humans; Mammary Neoplasms, Experimental; Prognosis; Rats; Rats, Inbred Strains | 1985 |
Altered levels of cyclic nucleotides, cyclic AMP phosphodiesterase and adenylyl cyclase activities in normal, dysplastic and neoplastic human mammary tissue.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenofibroma; Adenylyl Cyclases; Breast; Breast Neoplasms; Carcinoma; Cyclic AMP; Cyclic GMP; Cytosol; Female; Humans; Hyperplasia | 1977 |