Compounds > cyclic(arg-gly-asp-d-phe-val)

cyclic(arg-gly-asp-d-phe-val) and Melanoma

cyclic(arg-gly-asp-d-phe-val) has been researched along with Melanoma* in 1 studies

Other Studies

1 other study(ies) available for cyclic(arg-gly-asp-d-phe-val) and Melanoma

Article	Year
Succinimide-Based Conjugates Improve IsoDGR Cyclopeptide Affinity to α Journal of medicinal chemistry, 2018, 09-13, Volume: 61, Issue:17 The isoDGR sequence is an integrin-binding motif that has been successfully employed as a tumor-vasculature-homing molecule or for the targeted delivery of drugs and diagnostic agents to tumors. In this context, we previously demonstrated that cyclopeptide 2, the product of the conjugation of c(CGisoDGRG) (1) to 4-( N-maleimidomethyl)cyclohexane-1-carboxamide, can be successfully used as a tumor-homing ligand for nanodrug delivery to neoplastic tissues. Here, combining NMR, computational, and biochemical methods, we show that the succinimide ring contained in 2 contributes to stabilizing interactions with α Topics: Allosteric Regulation; Binding, Competitive; Cell Line, Tumor; Cell Membrane; HEK293 Cells; Humans; Integrin alphaVbeta3; Magnetic Resonance Spectroscopy; Melanoma; Molecular Docking Simulation; Peptides, Cyclic; Protein Conformation; Snake Venoms; Structure-Activity Relationship; Succinimides; Tyrosine	2018

Article

Year

Succinimide-Based Conjugates Improve IsoDGR Cyclopeptide Affinity to α

Journal of medicinal chemistry, 2018, 09-13, Volume: 61, Issue:17

The isoDGR sequence is an integrin-binding motif that has been successfully employed as a tumor-vasculature-homing molecule or for the targeted delivery of drugs and diagnostic agents to tumors. In this context, we previously demonstrated that cyclopeptide 2, the product of the conjugation of c(CGisoDGRG) (1) to 4-( N-maleimidomethyl)cyclohexane-1-carboxamide, can be successfully used as a tumor-homing ligand for nanodrug delivery to neoplastic tissues. Here, combining NMR, computational, and biochemical methods, we show that the succinimide ring contained in 2 contributes to stabilizing interactions with α

Topics: Allosteric Regulation; Binding, Competitive; Cell Line, Tumor; Cell Membrane; HEK293 Cells; Humans; Integrin alphaVbeta3; Magnetic Resonance Spectroscopy; Melanoma; Molecular Docking Simulation; Peptides, Cyclic; Protein Conformation; Snake Venoms; Structure-Activity Relationship; Succinimides; Tyrosine

2018