cyc 202 has been researched along with Neuroblastoma in 19 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (10.53) | 18.2507 |
| 2000's | 9 (47.37) | 29.6817 |
| 2010's | 8 (42.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bhadra, K; Bhadra, U; Haritha, V; Kamal, A; Lavanya, A; Pal-Bhadra, M; Patel, N; Pushpavalli, SN; Ramaiah, MJ; Tamboli, JR | 1 |
| Bruyère, C; Delehouzé, C; Desban, N; Galibert, MD; Galons, H; Garbis, SD; Giannopoulou, EG; Godl, K; Grenet, J; Lahti, J; Loaëc, N; Meijer, L; Mouchet, N; Oumata, N; Roumeliotis, TI; Twitchell, D | 1 |
| Caron, HN; Ebus, ME; Geerts, D; Koster, J; Lamers, F; Molenaar, JJ; Valentijn, LJ; Versteeg, R; Westerhout, EM | 1 |
| Bartek, J; Fechter, A; Hornung, C; Krämer, A; Löffler, H; Marhold, J; Matuszewska, M; Mistrik, M; Saffrich, R; Westermann, F | 1 |
| Auladell, C; Beas-Zarate, C; Camins, A; Folch, J; Junyent, F; Pallàs, M; Pizarro, JG; Verdaguer, E | 1 |
| Boix, J; Cosialls, AM; Garrofé-Ochoa, X; Gil, J; Ribas, J | 1 |
| Huttunen, HJ; Kysenius, K; Nykänen, NP; Sakha, P; Tammela, P | 1 |
| Chen, Y; Tsai, YH; Tseng, SH | 1 |
| Benfenati, F; Chami, M; Checler, F; Del Prete, D; Greco, B; Lauritzen, I; Moreno, S; Oulès, B; Paterlini-Bréchot, P; Sevalle, J; Trebak, M; Zhang, X | 1 |
| Boix, J; Ribas, J | 1 |
| Donnelly, M; Mandelkow, EM; Moran, CM; Ortiz, D; Pant, HC; Shea, TB | 1 |
| Boix, J; Gomez-Arbones, X; Ribas, J | 1 |
| Jope, RS; Song, L | 1 |
| Boix, J; Meijer, L; Ribas, J | 1 |
| DeFuria, J; Shea, TB | 1 |
| Camins, A; Esparza, JL; Folch, J; Pallàs, M; Pizarro, JG; Verdaguer, E; Yeste-Velasco, M | 1 |
| Kuijpers, HJ; Ramaekers, FC; Reutelingsperger, CP; Schutte, B; van Engeland, M | 1 |
| Henfling, ME; Meijer, L; Nieland, L; Ramaekers, FC; Schutte, B; van Engeland, M | 1 |
| Johnson, GV; Krishnamurthy, PK; Zhang, J | 1 |
19 other study(ies) available for cyc 202 and Neuroblastoma
| Article | Year |
|---|---|
Novel anthranilamide-pyrazolo[1,5-a]pyrimidine conjugates modulate the expression of p53-MYCN associated micro RNAs in neuroblastoma cells and cause cell cycle arrest and apoptosis.
Topics: Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p21; G2 Phase Cell Cycle Checkpoints; Gene Expression Regulation, Neoplastic; HeLa Cells; Humans; M Phase Cell Cycle Checkpoints; MicroRNAs; N-Myc Proto-Oncogene Protein; Neuroblastoma; Nuclear Proteins; Oncogene Proteins; ortho-Aminobenzoates; Proto-Oncogene Proteins c-mdm2; Purines; Pyrazoles; Pyrimidines; Roscovitine; Tumor Suppressor Protein p53 | 2013 |
CDK/CK1 inhibitors roscovitine and CR8 downregulate amplified MYCN in neuroblastoma cells.
Topics: Animals; CDC2 Protein Kinase; Cell Line, Tumor; Cyclin-Dependent Kinases; Down-Regulation; Gene Amplification; Gene Expression Regulation, Neoplastic; Humans; Mice; Mice, Inbred NOD; Mice, SCID; Mice, Transgenic; N-Myc Proto-Oncogene Protein; Neuroblastoma; Nuclear Proteins; Oncogene Proteins; Protein Kinase Inhibitors; Purines; Pyridines; Roscovitine; Xenograft Model Antitumor Assays | 2014 |
Inactivation of CDK2 is synthetically lethal to MYCN over-expressing cancer cells.
Topics: Apoptosis; Cell Line, Tumor; Cyclin-Dependent Kinase 2; Gene Amplification; Humans; N-Myc Proto-Oncogene Protein; Neuroblastoma; Nuclear Proteins; Oncogene Proteins; Purines; RNA Interference; Roscovitine; Tumor Suppressor Protein p53 | 2009 |
Cep63 recruits Cdk1 to the centrosome: implications for regulation of mitotic entry, centrosome amplification, and genome maintenance.
Topics: CDC2 Protein Kinase; Cell Cycle Proteins; Cell Line, Tumor; Centrosome; Down-Regulation; Genome, Human; Green Fluorescent Proteins; HEK293 Cells; HeLa Cells; Humans; Immunoblotting; Interphase; Microscopy, Fluorescence; Mitosis; N-Myc Proto-Oncogene Protein; Neoplasm Proteins; Neuroblastoma; Nuclear Proteins; Oncogene Proteins; Polyploidy; Protein Kinase Inhibitors; Purines; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Roscovitine | 2011 |
Antiapoptotic effects of roscovitine on camptothecin-induced DNA damage in neuroblastoma cells.
Topics: Amino Acid Chloromethyl Ketones; Antineoplastic Agents; Apoptosis; Ataxia Telangiectasia Mutated Proteins; Calpain; Camptothecin; Cell Cycle Proteins; Cell Line, Tumor; Cyclin-Dependent Kinase 5; Dipeptides; DNA Damage; DNA-Binding Proteins; Humans; Morpholines; Neuroblastoma; Protein Serine-Threonine Kinases; Purines; Pyrones; Roscovitine; Tumor Suppressor Proteins | 2011 |
Transcriptional modulation of apoptosis regulators by roscovitine and related compounds.
Topics: Apoptosis Regulatory Proteins; bcl-X Protein; Cell Line, Tumor; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Myeloid Cell Leukemia Sequence 1 Protein; Neuroblastoma; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Purines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Roscovitine; Time Factors; Transcription, Genetic; Tumor Suppressor Protein p53 | 2011 |
γ-Aminobutyric acid type A (GABAA) receptor activation modulates tau phosphorylation.
Topics: Alzheimer Disease; Animals; Cell Line, Tumor; Cyclin-Dependent Kinase 5; Cytoskeleton; Enzyme Inhibitors; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Marine Toxins; Mice; Naphthoquinones; Nerve Degeneration; Neuroblastoma; NIMA-Interacting Peptidylprolyl Isomerase; Oxazoles; Peptidylprolyl Isomerase; Phosphorylation; Protein Kinase Inhibitors; Protein Phosphatase 2; Purines; Rats; Receptors, GABA-A; Roscovitine; tau Proteins; Tauopathies | 2012 |
Inhibition of cyclin-dependent kinase 1-induced cell death in neuroblastoma cells through the microRNA-34a-MYCN-survivin pathway.
Topics: Antineoplastic Agents; Apoptosis; Biomarkers, Tumor; Blotting, Western; CDC2 Protein Kinase; Cell Line, Tumor; Cell Survival; Chromatin Immunoprecipitation; Dose-Response Relationship, Drug; Down-Regulation; Flow Cytometry; Humans; Inhibitor of Apoptosis Proteins; MicroRNAs; N-Myc Proto-Oncogene Protein; Neuroblastoma; Nuclear Proteins; Oncogene Proteins; Purines; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Roscovitine; Survivin | 2013 |
Ryanodine receptor blockade reduces amyloid-β load and memory impairments in Tg2576 mouse model of Alzheimer disease.
Topics: Alzheimer Disease; Aminophenols; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Analysis of Variance; Animals; Brain; Caffeine; Calcium; Calcium Channel Blockers; Cells, Cultured; Cytosol; Dantrolene; Disease Models, Animal; Embryo, Mammalian; Endoplasmic Reticulum; Enzyme Inhibitors; Exploratory Behavior; Gene Expression Regulation; Humans; Inositol 1,4,5-Trisphosphate Receptors; Maleimides; Maze Learning; Membrane Potentials; Membrane Proteins; Memory Disorders; Mice; Mice, Transgenic; Muscle Relaxants, Central; Mutation; Nerve Tissue Proteins; Neuroblastoma; Neurons; Patch-Clamp Techniques; Peptide Fragments; Phosphorylation; Plaque, Amyloid; Purines; Reaction Time; Recognition, Psychology; RNA, Messenger; Roscovitine; Ryanodine Receptor Calcium Release Channel; Transfection | 2012 |
Cell differentiation, caspase inhibition, and macromolecular synthesis blockage, but not BCL-2 or BCL-XL proteins, protect SH-SY5Y cells from apoptosis triggered by two CDK inhibitory drugs.
Topics: Apoptosis; bcl-X Protein; Caspase Inhibitors; Cell Differentiation; Cell Line, Tumor; Cell Survival; Cyclin-Dependent Kinases; Enzyme Inhibitors; Humans; Kinetics; Kinetin; Neuroblastoma; Proto-Oncogene Proteins c-bcl-2; Purines; Roscovitine | 2004 |
Cdk5 inhibits anterograde axonal transport of neurofilaments but not that of tau by inhibition of mitogen-activated protein kinase activity.
Topics: Animals; Axonal Transport; Cell Line, Tumor; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinases; Drug Interactions; Enzyme Inhibitors; Flavonoids; Green Fluorescent Proteins; Mice; Mitogen-Activated Protein Kinases; Neuroblastoma; Neurofilament Proteins; Purines; Roscovitine; tau Proteins; Transfection | 2005 |
Caspase 8/10 are not mediating apoptosis in neuroblastoma cells treated with CDK inhibitory drugs.
Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Caspase 10; Caspase 8; Caspase 9; Caspase Inhibitors; Caspases; Cell Line, Tumor; Cyclin-Dependent Kinases; Enzyme Inhibitors; Humans; Jurkat Cells; Kinetin; Neuroblastoma; Purines; Roscovitine; Time Factors | 2005 |
Cellular stress increases RGS2 mRNA and decreases RGS4 mRNA levels in SH-SY5Y cells.
Topics: Camptothecin; Cell Cycle; Cell Line, Tumor; Cyclin-Dependent Kinase 2; Humans; Neuroblastoma; Purines; RGS Proteins; RNA, Messenger; Roscovitine; Topoisomerase I Inhibitors | 2006 |
(R)-roscovitine (CYC202, Seliciclib) sensitizes SH-SY5Y neuroblastoma cells to nutlin-3-induced apoptosis.
Topics: Antineoplastic Agents; Apoptosis; bcl-X Protein; Caspases; Cell Line, Tumor; Cell Survival; Cyclin-Dependent Kinase Inhibitor p21; Drug Synergism; Enzyme Inhibitors; Humans; Imidazoles; L-Lactate Dehydrogenase; Neuroblastoma; Peptide Hydrolases; Piperazines; Proto-Oncogene Proteins c-mdm2; Purines; Roscovitine; Time Factors; Transfection; Tumor Suppressor Protein p53 | 2006 |
Arsenic inhibits neurofilament transport and induces perikaryal accumulation of phosphorylated neurofilaments: roles of JNK and GSK-3beta.
Topics: Animals; Arsenic; Axons; Cells, Cultured; Chick Embryo; Environmental Pollutants; Enzyme Inhibitors; Epitopes; Ganglia, Spinal; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; JNK Mitogen-Activated Protein Kinases; Mice; Neurites; Neuroblastoma; Neurofilament Proteins; Neurons; Neurotoxins; Phosphorylation; Purines; Roscovitine; Tumor Cells, Cultured | 2007 |
The antiproliferative activity of melatonin in B65 rat dopaminergic neuroblastoma cells is related to the downregulation of cell cycle-related genes.
Topics: Animals; Antineoplastic Agents; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Dopamine; Down-Regulation; Melatonin; Neuroblastoma; Purines; Rats; Roscovitine; Signal Transduction | 2008 |
Plasma membrane alterations and cytoskeletal changes in apoptosis.
Topics: Actins; Annexin A5; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Membrane; Chromatin; Cytoskeleton; Ethylmaleimide; Humans; Keratins; Kinetin; Lung Neoplasms; Neuroblastoma; Phosphatidylserines; Purines; Roscovitine; Tetradecanoylphorbol Acetate; Tubulin; Tumor Cells, Cultured; Vimentin | 1997 |
The effect of the cyclin-dependent kinase inhibitor olomoucine on cell cycle kinetics.
Topics: Antimetabolites; Apoptosis; Bromodeoxyuridine; Carcinoma, Non-Small-Cell Lung; CDC2 Protein Kinase; Cell Cycle; Cyclin-Dependent Kinases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flow Cytometry; G2 Phase; Humans; Kinetin; Lung Neoplasms; Mitosis; Neuroblastoma; Purines; Roscovitine; S Phase; Tumor Cells, Cultured | 1997 |
Cdk5 phosphorylates p53 and regulates its activity.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Cell Line; CHO Cells; Cricetinae; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinases; Cyclins; Enzyme Inhibitors; Genes, Dominant; Humans; Nerve Growth Factor; Nerve Tissue Proteins; Neuroblastoma; PC12 Cells; Phosphorylation; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Purines; Rats; Roscovitine; Substrate Specificity; Transcription, Genetic; Transfection; Tumor Suppressor Protein p53 | 2002 |