cyc 202 has been researched along with Kahler Disease in 7 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 4 (57.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Anderson, S; Frame, S; Gianella-Borradori, A; Green, SR; Lane, DP; MacCallum, DE; Melville, J; Watt, K | 1 |
| He, X; Liu, Y; Sui, Y; Xu, G; Yu, R | 1 |
| Komina, O; Maurer, M; Nosske, E; Wesierska-Gadek, J | 1 |
| Gritsch, D; Maurer, M; Wesierska-Gadek, J; Zulehner, N | 1 |
| Beider, K; Josefsberg Ben-Yehoshua, L; Nagler, A; Ostrovsky, O; Peled, A; Samookh, M; Shimoni, A | 1 |
| Anderson, KC; Chauhan, D; Green, SR; Hideshima, T; Ishitsuka, K; Kumar, S; Munshi, NC; Raje, N; Roccaro, A; Shiraishi, N; Yasui, H | 1 |
| Murakami, H | 1 |
1 review(s) available for cyc 202 and Kahler Disease
| Article | Year |
|---|---|
[New strategy for the treatment of multiple myeloma].
Topics: Angiogenesis Inhibitors; Antineoplastic Combined Chemotherapy Protocols; Arsenic Trioxide; Arsenicals; Boronic Acids; Bortezomib; Dexamethasone; Drug Design; Drug Therapy, Combination; Hematopoietic Stem Cell Transplantation; Humans; Lenalidomide; Multiple Myeloma; Oxides; Prognosis; Protease Inhibitors; Purines; Pyrazines; Roscovitine; Thalidomide; Transplantation Conditioning | 2005 |
6 other study(ies) available for cyc 202 and Kahler Disease
| Article | Year |
|---|---|
Seliciclib (CYC202, R-Roscovitine) induces cell death in multiple myeloma cells by inhibition of RNA polymerase II-dependent transcription and down-regulation of Mcl-1.
Topics: Apoptosis; Cell Line, Tumor; Dichlororibofuranosylbenzimidazole; Down-Regulation; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Multiple Myeloma; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Proteins; Proto-Oncogene Proteins c-bcl-2; Purines; RNA Polymerase II; RNA, Messenger; Roscovitine; Transcription, Genetic | 2005 |
Transcription factor IKZF1 is degraded during the apoptosis of multiple myeloma cells induced by kinase inhibition.
Topics: Apoptosis; Cell Line, Tumor; Cell Survival; Dichlororibofuranosylbenzimidazole; HEK293 Cells; Humans; Ikaros Transcription Factor; Immunoblotting; Multiple Myeloma; Protein Kinase Inhibitors; Protein Stability; Proteolysis; Purines; Roscovitine; Time Factors; Ubiquitination | 2015 |
Roscovitine, a small molecule CDK inhibitor induces apoptosis in multidrug-resistant human multiple myeloma cells.
Topics: Antibiotics, Antineoplastic; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cyclin-Dependent Kinases; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Flow Cytometry; Humans; Immunoblotting; Multiple Myeloma; Protein Kinase Inhibitors; Purines; Roscovitine; Tumor Cells, Cultured | 2011 |
Tamoxifen enhances the anti-proliferative effect of roscovitine, a selective cyclin-dependent kinase inhibitor, on human ER-positive human breast cancer cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cyclin-Dependent Kinases; Drug Synergism; Estrogen Receptor alpha; Flow Cytometry; G1 Phase; Humans; Immunoblotting; Multiple Myeloma; Purines; Roscovitine; S Phase; Tamoxifen; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2011 |
Characterization of cyclin E expression in multiple myeloma and its functional role in seliciclib-induced apoptotic cell death.
Topics: Apoptosis; Cell Line, Tumor; Cyclin D1; Cyclin E; Flavonoids; Gene Expression Profiling; Gene Expression Regulation; Gene Silencing; Genomic Instability; Humans; Multiple Myeloma; Oncogene Proteins; Piperidines; Protein Kinase Inhibitors; Purines; RNA, Small Interfering; Roscovitine | 2012 |
Seliciclib (CYC202 or R-roscovitine), a small-molecule cyclin-dependent kinase inhibitor, mediates activity via down-regulation of Mcl-1 in multiple myeloma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Adhesion; Coculture Techniques; Cyclin-Dependent Kinases; DNA-Binding Proteins; Down-Regulation; Drug Synergism; Humans; Interleukin-6; Multiple Myeloma; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Proteins; Proto-Oncogene Proteins c-bcl-2; Purines; Roscovitine; STAT3 Transcription Factor; Stromal Cells; Trans-Activators; Transcription, Genetic; Tumor Cells, Cultured | 2005 |