cyc 202 has been researched along with Disease Models, Animal in 43 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 16 (37.21) | 29.6817 |
| 2010's | 26 (60.47) | 24.3611 |
| 2020's | 1 (2.33) | 2.80 |
| Authors | Studies |
|---|---|
| Chon, YS; Ha, I; Hwang, MK; Kim, JH; Kim, ND; Lee, JT; Song, WJ; Yoon, J | 1 |
| Braisted, J; Dranchak, P; Earnest, TW; Gu, X; Hoon, MA; Inglese, J; Oliphant, E; Solinski, HJ | 1 |
| Abrams, RPM; Bachani, M; Balasubramanian, A; Brimacombe, K; Dorjsuren, D; Eastman, RT; Hall, MD; Jadhav, A; Lee, MH; Li, W; Malik, N; Nath, A; Padmanabhan, R; Simeonov, A; Steiner, JP; Teramoto, T; Yasgar, A; Zakharov, AV | 1 |
| Adamczyk, A; Czapski, GA; Gąssowska-Dobrowolska, M; Strawski, M; Wilkaniec, A | 1 |
| Billot, K; Boletta, A; Bukanov, N; Coquil, C; Delehouzé, C; Desban, N; Fautrel, A; Fischer, E; Grosch, M; Ibraghimov-Beskrovnaya, O; Josselin-Foll, B; Le Meur, Y; Meijer, L; Mrug, M; Oumata, N; Pontoglio, M; Saunier, S; Tran, PV; Trudel, M; Villiers, B; Wallace, D; Weimbs, T; Witzgall, R | 1 |
| Angele, B; Högen, T; Höhne, C; Klein, M; Koedel, U; Pfister, HW; Tüfekci, H | 1 |
| Babu, PP; Narne, P; Pandey, V; Ranjan, N | 1 |
| Airik, M; Airik, R; Bates, CM; Hildebrandt, F; Schueler, M | 1 |
| Chen, J; Chen, Y; Li, L; Xie, Y; Zhong, Y | 1 |
| Gu, X; Ma, Z; Yang, L; Zhang, J; Zhang, W | 1 |
| Cui, SS; Li, K; Li, LY; Wu, GZ; Zhao, GQ | 1 |
| He, CX; Hu, F; Huang, HZ; Li, K; Liu, D; Liu, FF; Wang, JZ; Xie, AJ; Zhu, LQ | 1 |
| Beier, DR; Billot, K; Bukanov, NO; Carlson, G; Husson, H; Ibraghimov-Beskrovnaya, O; Lane, M; Ledbetter, SR; Meijer, L; Moreno, S; Pitstick, R; Russo, RJ; Sergeev, M; Shah, J; Smith, LA; Smith, MM; Zhang, K | 1 |
| Jiang, ZX; Lin, XF; Lou, BS; Qiu, S; Wang, WC; Yang, Y | 1 |
| Bukanov, NO; Ibraghimov-Beskrovnaya, O; Moreno, S | 1 |
| Beales, PL; Tobin, JL | 1 |
| Di, Q; Xu, L; Zhang, Y | 1 |
| Chen, C; Dong, Q; Lü, J; Luo, X; Pan, D; Wang, W; Xie, M; Yu, Z; Zhang, Q | 1 |
| Camins, A; Canudas, AM; Crespo-Biel, N; Gutiérrez-Cuesta, J; Melchiorri, D; Nicoletti, F; Pallàs, M | 1 |
| Ingham, PW; Loynes, CA; Martin, JS; Renshaw, SA; Robertson, A; Trushell, DM; Whyte, MK | 1 |
| Graña, X; Knudsen, ES; Mayhew, CN; Reed, CA; Rivadeneira, DB; Sotillo, E; Thangavel, C | 1 |
| Crosier, P; Hall, C | 1 |
| Guan, Q; He, Y; Jin, L; Liu, X; Zhao, L | 1 |
| Bach, S; Blevins, TL; Campbell, M; Meijer, L; Menn, B; Timsit, S | 1 |
| Chilvers, ER; Condliffe, AM; Cowburn, AS; Farahi, N; Farrow, SN; Foster, MR; Gibson, A; Juss, JK; Langton, AJ; Marco-Casanova, P; Sobolewski, A; Uller, L | 1 |
| Barnett, A; Bhangal, G; Cook, T; McClue, S; Pusey, CD; Sheryanna, AM; Smith, J; Tam, FW | 1 |
| Byrnes, KR; Faden, AI; Hanscom, M; Kabadi, SV; Loane, DJ; Stoica, BA | 1 |
| Menn, B; Timsit, S | 1 |
| Hoogendijk, AJ; Kuipers, MT; Schultz, MJ; van der Poll, T; Wieland, CW | 1 |
| Benfenati, F; Chami, M; Checler, F; Del Prete, D; Greco, B; Lauritzen, I; Moreno, S; Oulès, B; Paterlini-Bréchot, P; Sevalle, J; Trebak, M; Zhang, X | 1 |
| Duan, H; Hao, J; Liu, Q; Liu, S; Liu, W; Shi, Y; Zhang, Y; Zhao, S | 1 |
| Bukanov, NO; Galons, H; Ibraghimov-Beskrovnaya, O; Ledbetter, SR; Meijer, L; Moreno, SE; Natoli, TA; Oumata, N; Rogers, KA; Smith, LA | 1 |
| Abbasoglu, O; Ayhan, A; Kilinc, K; Sokmensuer, C; Topaloglu, S | 1 |
| Barnett, A; Chu, TH; D'Agati, V; Gelman, IH; Gherardi, D; Gianella-Borradori, A; Nelson, PJ | 1 |
| Bu, B; Chakrabarty, P; Li, J; Vincent, I; Zhang, M | 1 |
| Barnett, A; Eitner, F; Floege, J; Kerjaschki, D; Kunter, U; Milovanceva-Popovska, M; Ostendorf, T; Petermann, A; Rong, S | 1 |
| Nagumo, Y; Narita, M; Shibasaki, M; Suzuki, T; Yajima, Y | 1 |
| Green, KN; Kitazawa, M; LaFerla, FM; Oddo, S; Yamasaki, TR | 1 |
| Brun-Zinkernagel, AM; Koulen, P; Liu, R; Perez, EJ; Simpkins, JW; Wen, Y; Yang, SH | 1 |
| Bukanov, NO; Ibraghimov-Beskrovnaya, O; Klinger, KW; Ledbetter, SR; Smith, LA | 1 |
| Kuehn, EW; Walz, G | 1 |
| Benigni, A; Casiraghi, F; Cavinato, RA; Conti, S; Corna, D; Remuzzi, G; Rottoli, D; Zoja, C | 1 |
| Bukanov, NO; Dackowski, WR; Gareski, TC; Husson, H; Ibraghimov-Beskrovnaya, O; Matthews, D; Natoli, TA; Piepenhagen, P; Russo, RJ; Smith, L | 1 |
1 review(s) available for cyc 202 and Disease Models, Animal
| Article | Year |
|---|---|
Prime time for polycystic kidney disease: does one shot of roscovitine bring the cure?
Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Clinical Trials as Topic; Disease Models, Animal; Genes, Dominant; Humans; Mice; Models, Biological; Polycystic Kidney Diseases; Protein Kinase Inhibitors; Protein Kinases; Purines; Roscovitine; TOR Serine-Threonine Kinases | 2007 |
1 trial(s) available for cyc 202 and Disease Models, Animal
| Article | Year |
|---|---|
Cyclin-dependent kinase inhibition reduces lung damage in a mouse model of ventilator-induced lung injury.
Topics: Animals; Apoptosis; Biomarkers; Cells, Cultured; Cyclin-Dependent Kinases; Disease Models, Animal; Female; Humans; Lung; Male; Mice; Neutrophils; Protein Kinase Inhibitors; Purines; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Roscovitine; Ventilator-Induced Lung Injury; Ventilators, Mechanical | 2012 |
41 other study(ies) available for cyc 202 and Disease Models, Animal
| Article | Year |
|---|---|
Putative therapeutic agents for the learning and memory deficits of people with Down syndrome.
Topics: Amino Acids; Animals; Binding Sites; Disease Models, Animal; Down Syndrome; Dyrk Kinases; Enzyme Inhibitors; Humans; Hydrogen Bonding; Learning Disabilities; Memory Disorders; Mice; Molecular Structure; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases | 2006 |
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, Spinal; Humans; Mice, Inbred C57BL; Mice, Knockout; Neurons; Pruritus; Receptors, Atrial Natriuretic Factor; Reproducibility of Results; Signal Transduction; Small Molecule Libraries | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Immunocompetence; Inhibitory Concentration 50; Methacycline; Mice, Inbred C57BL; Protease Inhibitors; Quantitative Structure-Activity Relationship; Small Molecule Libraries; Vero Cells; Zika Virus; Zika Virus Infection | 2020 |
Inhibition of cyclin-dependent kinase 5 affects early neuroinflammatory signalling in murine model of amyloid beta toxicity.
Topics: Amyloid beta-Peptides; Animals; Cell Line, Tumor; Cyclin-Dependent Kinase 5; Disease Models, Animal; Hippocampus; Humans; Inflammation Mediators; Male; Mice; Mice, Inbred C57BL; Peptide Fragments; Protein Kinase Inhibitors; Roscovitine | 2018 |
Casein kinase 1ε and 1α as novel players in polycystic kidney disease and mechanistic targets for (R)-roscovitine and (S)-CR8.
Topics: Animals; Casein Kinase 1 epsilon; Casein Kinase Ialpha; Catalysis; Chromatography, Affinity; Disease Models, Animal; Humans; Kidney; Mice, Transgenic; Polycystic Kidney Diseases; Protein Binding; Protein Kinase Inhibitors; Purines; Pyridines; Roscovitine; Signal Transduction | 2018 |
Adjuvant non-bacteriolytic and anti-inflammatory combination therapy in pneumococcal meningitis: an investigation in a mouse model.
Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Antibodies; Brain; Chemotherapy, Adjuvant; Combined Modality Therapy; Daptomycin; Dexamethasone; Disease Models, Animal; Drug Therapy, Combination; Interleukin-1beta; Male; Meningitis, Pneumococcal; Mice; Mice, Inbred C57BL; Roscovitine; Streptococcus pneumoniae | 2019 |
Roscovitine effectively enhances antitumor activity of temozolomide in vitro and in vivo mediated by increased autophagy and Caspase-3 dependent apoptosis.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Autophagy; Caspase 3; Cell Line, Tumor; Cell Survival; Disease Models, Animal; Drug Resistance, Neoplasm; Drug Synergism; Gene Expression Regulation, Neoplastic; Glioma; Humans; Platelet Endothelial Cell Adhesion Molecule-1; Rats; Rats, Wistar; Roscovitine; Temozolomide; Vascular Endothelial Growth Factor A; Xenograft Model Antitumor Assays | 2019 |
Roscovitine blocks collecting duct cyst growth in Cep164-deficient kidneys.
Topics: Animals; Animals, Newborn; Cell Cycle; Cilia; Ciliopathies; Cyclin-Dependent Kinases; Disease Models, Animal; Drug Evaluation, Preclinical; Embryo, Mammalian; Epithelium; Female; Humans; Kidney Diseases, Cystic; Kidney Tubules, Collecting; Male; Mice; Mice, Knockout; Microtubule Proteins; Organoselenium Compounds; Proof of Concept Study; Protein Kinase Inhibitors; Roscovitine | 2019 |
Crosstalk between Cdk5/p35 and ERK1/2 signalling mediates spinal astrocyte activity via the PPARγ pathway in a rat model of chronic constriction injury.
Topics: Animals; Astrocytes; Butadienes; Constriction, Pathologic; Cyclin-Dependent Kinase 5; Disease Models, Animal; Enzyme Inhibitors; Male; MAP Kinase Signaling System; Nitriles; Phosphotransferases; PPAR gamma; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Roscovitine; Sciatic Neuropathy; Spinal Cord | 2019 |
Cdk5 inhibitor roscovitine alleviates neuropathic pain in the dorsal root ganglia by downregulating N-methyl-D-aspartate receptor subunit 2A.
Topics: Analysis of Variance; Animals; Cyclin-Dependent Kinase 5; Disease Models, Animal; Down-Regulation; Ganglia, Spinal; Male; Neuralgia; Pain Measurement; Pain Threshold; Physical Stimulation; Protein Kinase Inhibitors; Purines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, N-Methyl-D-Aspartate; Roscovitine; Subarachnoid Space; Time Factors | 2014 |
Epigenetic upregulation of Cdk5 in the dorsal horn contributes to neuropathic pain in rats.
Topics: Acetylation; Animals; Chronic Disease; Constriction, Pathologic; Cyclic AMP Response Element-Binding Protein; Cyclin-Dependent Kinase 5; Disease Models, Animal; Epigenesis, Genetic; Hyperalgesia; Male; Neuralgia; Phosphorylation; Promoter Regions, Genetic; Protein Kinase Inhibitors; Purines; Rats, Sprague-Dawley; Roscovitine; Sciatic Nerve; Spinal Cord Dorsal Horn; Touch; Up-Regulation | 2014 |
Olfactory Deprivation Hastens Alzheimer-Like Pathologies in a Human Tau-Overexpressed Mouse Model via Activation of cdk5.
Topics: Alzheimer Disease; Animals; Calpain; Cholinergic Neurons; Cyclin-Dependent Kinase 5; Dendrites; Disease Models, Animal; Enzyme Activation; Humans; Mice; Olfactory Bulb; Phosphorylation; Purines; Roscovitine; Septal Nuclei; Solubility; tau Proteins; Tauopathies | 2016 |
Reduction of ciliary length through pharmacologic or genetic inhibition of CDK5 attenuates polycystic kidney disease in a model of nephronophthisis.
Topics: Animals; Cell Differentiation; Cilia; Cyclin-Dependent Kinase 5; Disease Models, Animal; Humans; Intercellular Signaling Peptides and Proteins; Kidney; Kidney Failure, Chronic; Mice; Nerve Tissue Proteins; Polycystic Kidney Diseases; Purines; Roscovitine; Tubulin | 2016 |
Roscovitine ameliorates endotoxin-induced uveitis through neutrophil apoptosis.
Topics: Animals; Apoptosis; Caspase 3; Cytokines; Disease Models, Animal; Endotoxins; Female; Inflammation Mediators; Mice; Myeloid Cell Leukemia Sequence 1 Protein; Neutrophil Infiltration; Neutrophils; Protein Kinase Inhibitors; Purines; Roscovitine; Uveitis | 2016 |
Serum and urinary biomarker signatures for rapid preclinical in vivo assessment of CDK inhibition as a therapeutic approach for PKD.
Topics: Animals; Biomarkers; Blood Proteins; Cyclin-Dependent Kinases; Disease Models, Animal; Mice; Mice, Inbred C57BL; Polycystic Kidney Diseases; Protein Kinase Inhibitors; Proteins; Purines; Roscovitine; Treatment Outcome | 2008 |
Restoration of renal function in zebrafish models of ciliopathies.
Topics: Animals; Antineoplastic Agents; Bardet-Biedl Syndrome; Cilia; Disease Models, Animal; Immunosuppressive Agents; Kidney; Polycystic Kidney Diseases; Purines; Recovery of Function; Roscovitine; Sirolimus; Zebrafish | 2008 |
Cell cycle proteins preceded neuronal death after chronic cerebral hypoperfusion in rats.
Topics: Animals; Apoptosis; Blotting, Western; Brain; Brain Damage, Chronic; Brain Ischemia; Carotid Artery, Common; Cell Cycle Proteins; Cyclin B; Cyclin B1; Cyclin-Dependent Kinase 4; Disease Models, Animal; Immunohistochemistry; In Situ Nick-End Labeling; Injections, Intraventricular; Ligation; Male; Maze Learning; Memory; Neurons; Protein Kinase Inhibitors; Purines; Rats; Rats, Sprague-Dawley; Roscovitine; Spatial Behavior; Time Factors | 2008 |
Cell cycle inhibition attenuates microglial proliferation and production of IL-1beta, MIP-1alpha, and NO after focal cerebral ischemia in the rat.
Topics: Animals; Aquaporins; Brain Ischemia; Cell Count; Cell Cycle; Cell Line, Transformed; Cell Proliferation; Disease Models, Animal; Eye Proteins; In Situ Nick-End Labeling; Injections, Intraventricular; Interleukin-1beta; Male; Mice; Microglia; Neurologic Examination; Nitric Oxide; Protein Kinase Inhibitors; Purines; Rats; Rats, Sprague-Dawley; Roscovitine; Tetrazolium Salts; Up-Regulation | 2009 |
Regulation of GSK-3beta by calpain in the 3-nitropropionic acid model.
Topics: Amino Acid Chloromethyl Ketones; Aminophenols; Animals; Calpain; Caspases; Cell Survival; Cells, Cultured; Convulsants; Disease Models, Animal; Embryo, Mammalian; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Hippocampus; Male; Maleimides; Mice; Neurodegenerative Diseases; Neurons; Neuroprotective Agents; Nitro Compounds; Propionates; Purines; Rats; Roscovitine; Signal Transduction; Time Factors | 2010 |
Pivotal Advance: Pharmacological manipulation of inflammation resolution during spontaneously resolving tissue neutrophilia in the zebrafish.
Topics: Animals; Animals, Genetically Modified; Antineoplastic Agents; Apoptosis; Disease Models, Animal; Drug Evaluation, Preclinical; Humans; Inflammation; Neutrophils; Purines; Pyocyanine; Roscovitine; Zebrafish | 2010 |
Proliferative suppression by CDK4/6 inhibition: complex function of the retinoblastoma pathway in liver tissue and hepatoma cells.
Topics: Adenovirus E1A Proteins; Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Cycle; Cell Proliferation; Chemical and Drug Induced Liver Injury; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase 6; Cyclin-Dependent Kinase Inhibitor p16; Cyclin-Dependent Kinases; Disease Models, Animal; E2F Transcription Factors; Gene Knockdown Techniques; Hep G2 Cells; Hepatocytes; Humans; Liver Neoplasms; Male; Mice; Mice, Knockout; Mice, Nude; Neoplasm Transplantation; Phosphorylation; Piperazines; Protein Kinase Inhibitors; Purines; Pyridines; Retinoblastoma Protein; Retinoblastoma-Like Protein p107; RNA Interference; Roscovitine; Time Factors; Transfection | 2010 |
Editorial: Maintaining the balance--fishing for drugs to treat persistent neutrophilic inflammation.
Topics: Animals; Animals, Genetically Modified; Antineoplastic Agents; Apoptosis; Disease Models, Animal; Drug Evaluation, Preclinical; Humans; Inflammation; Neutrophils; Purines; Pyocyanine; Roscovitine; Zebrafish | 2010 |
Effect of cdk5 antagonist on L-dopa-induced dyskinesias in a rat model of Parkinson's disease.
Topics: Animals; Antiparasitic Agents; Corpus Striatum; Cyclin-Dependent Kinase 5; Disease Models, Animal; Dopamine and cAMP-Regulated Phosphoprotein 32; Dyskinesia, Drug-Induced; Female; Levodopa; Male; Oxidopamine; Parkinsonian Disorders; Phosphorylation; Protein Kinase Inhibitors; Purines; Random Allocation; Rats; Rats, Sprague-Dawley; Roscovitine; Severity of Illness Index; Treatment Outcome | 2010 |
Delayed treatment with systemic (S)-roscovitine provides neuroprotection and inhibits in vivo CDK5 activity increase in animal stroke models.
Topics: Animals; Brain Ischemia; Cell Death; Chemistry, Pharmaceutical; Cyclin-Dependent Kinase 5; Disease Models, Animal; Drug Administration Routes; Humans; Injections; Male; Mice; Mitosis; Neuroprotective Agents; Purines; Rats; Roscovitine; Stroke; Time Factors | 2010 |
Effects of the cyclin-dependent kinase inhibitor R-roscovitine on eosinophil survival and clearance.
Topics: Animals; Apoptosis; Cell Survival; Cells, Cultured; Cyclin-Dependent Kinases; Disease Models, Animal; Dose-Response Relationship, Drug; Eosinophils; Female; HeLa Cells; Humans; Mice; Mice, Inbred BALB C; Ovalbumin; Protein Kinase Inhibitors; Purines; Roscovitine; Time Factors | 2011 |
Treatment with a cyclin-dependent kinase inhibitor, seliciclib, is effective in reducing glomerular macrophage numbers and the severity of established experimental glomerulonephritis.
Topics: Administration, Oral; Animals; Cell Proliferation; Creatinine; Cyclin-Dependent Kinases; Disease Models, Animal; Glomerulonephritis; Kidney Glomerulus; Macrophages; Male; Protein Kinase Inhibitors; Proteinuria; Purines; Rats; Rats, Inbred WKY; Roscovitine; Severity of Illness Index; Time Factors | 2011 |
Selective CDK inhibitor limits neuroinflammation and progressive neurodegeneration after brain trauma.
Topics: Animals; Apoptosis; Behavior, Animal; Blotting, Western; Brain Injuries; Carrier Proteins; Cell Cycle; Cyclin A; Cyclin D1; Cyclin-Dependent Kinases; Disease Models, Animal; Immunohistochemistry; Maze Learning; Mice; Mice, Inbred C57BL; Microfilament Proteins; Microglia; Motor Activity; Neurons; Neuroprotective Agents; Purines; Roscovitine; Time Factors | 2012 |
Cyclin-dependent kinase inhibition with roscovitine: neuroprotection in acute ischemic stroke.
Topics: Animals; Brain Ischemia; Clinical Trials as Topic; Cyclin-Dependent Kinases; Disease Models, Animal; Drug Evaluation, Preclinical; Humans; Models, Biological; Neuroprotective Agents; Protein Kinase Inhibitors; Purines; Roscovitine; Stroke | 2012 |
Ryanodine receptor blockade reduces amyloid-β load and memory impairments in Tg2576 mouse model of Alzheimer disease.
Topics: Alzheimer Disease; Aminophenols; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Analysis of Variance; Animals; Brain; Caffeine; Calcium; Calcium Channel Blockers; Cells, Cultured; Cytosol; Dantrolene; Disease Models, Animal; Embryo, Mammalian; Endoplasmic Reticulum; Enzyme Inhibitors; Exploratory Behavior; Gene Expression Regulation; Humans; Inositol 1,4,5-Trisphosphate Receptors; Maleimides; Maze Learning; Membrane Potentials; Membrane Proteins; Memory Disorders; Mice; Mice, Transgenic; Muscle Relaxants, Central; Mutation; Nerve Tissue Proteins; Neuroblastoma; Neurons; Patch-Clamp Techniques; Peptide Fragments; Phosphorylation; Plaque, Amyloid; Purines; Reaction Time; Recognition, Psychology; RNA, Messenger; Roscovitine; Ryanodine Receptor Calcium Release Channel; Transfection | 2012 |
The expression of intermediate filament protein nestin and its association with cyclin-dependent kinase 5 in the glomeruli of rats with diabetic nephropathy.
Topics: Animals; Cyclin-Dependent Kinase 5; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Disease Models, Animal; Intermediate Filament Proteins; Kidney Glomerulus; Male; Nerve Tissue Proteins; Nestin; Protein Kinase Inhibitors; Purines; Rats; Rats, Wistar; Roscovitine; Streptozocin; Vimentin | 2013 |
CDK inhibitors R-roscovitine and S-CR8 effectively block renal and hepatic cystogenesis in an orthologous model of ADPKD.
Topics: Adenine; Animals; Apoptosis; Cyclin-Dependent Kinases; Disease Models, Animal; Humans; Kidney Diseases, Cystic; Liver Diseases; Mice; Mice, Knockout; Polycystic Kidney, Autosomal Dominant; Protein Kinase C; Protein Kinase Inhibitors; Purines; Roscovitine | 2012 |
Antiapoptotic and protective effects of roscovitine on ischemia-reperfusion injury of the rat liver.
Topics: Alanine Transaminase; Animals; Apoptosis; Aspartate Aminotransferases; Disease Models, Animal; Enzyme Inhibitors; Liver; Male; Malondialdehyde; Peroxidase; Purines; Rats; Rats, Wistar; Reperfusion Injury; Roscovitine | 2003 |
Reversal of collapsing glomerulopathy in mice with the cyclin-dependent kinase inhibitor CYC202.
Topics: Animals; Cyclin-Dependent Kinases; Disease Models, Animal; Dose-Response Relationship, Drug; Glomerulosclerosis, Focal Segmental; Kidney; Mice; Mice, Transgenic; Purines; Roscovitine | 2004 |
Cyclin-dependent kinase inhibitors attenuate protein hyperphosphorylation, cytoskeletal lesion formation, and motor defects in Niemann-Pick Type C mice.
Topics: Animals; Apoptosis; Cyclin-Dependent Kinases; Cytoskeleton; Disease Models, Animal; Enzyme Inhibitors; Female; Humans; Intracellular Signaling Peptides and Proteins; Kinetin; Male; Mice; Mice, Inbred BALB C; Mice, Neurologic Mutants; Motor Activity; Nerve Degeneration; Neurons; Niemann-Pick C1 Protein; Niemann-Pick Diseases; Phosphorylation; Proteins; Purines; Purkinje Cells; Roscovitine; tau Proteins | 2004 |
R-roscovitine (CYC202) alleviates renal cell proliferation in nephritis without aggravating podocyte injury.
Topics: Animals; Cell Division; Cyclin-Dependent Kinases; Disease Models, Animal; Enzyme Inhibitors; Glomerulonephritis; Kidney; Kidney Glomerulus; Male; Purines; Rats; Rats, Sprague-Dawley; Roscovitine; Urothelium | 2005 |
Implication of cyclin-dependent kinase 5 in the development of psychological dependence on and behavioral sensitization to morphine.
Topics: Animals; Behavior, Animal; Brain Chemistry; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinases; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Enzyme Inhibitors; Female; Gyrus Cinguli; Male; Mice; Mice, Knockout; Morphine; Morphine Dependence; Narcotics; Neuronal Plasticity; Phosphorylation; Purines; Reward; Roscovitine; Up-Regulation | 2005 |
Lipopolysaccharide-induced inflammation exacerbates tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer's disease.
Topics: Aging; Alzheimer Disease; Animals; Cyclin-Dependent Kinase 5; Disease Models, Animal; Encephalitis; Enzyme Activation; Female; Hippocampus; Lipopolysaccharides; Male; Mice; Mice, Transgenic; Microglia; Neural Pathways; Phosphorylation; Protein Kinase Inhibitors; Purines; Roscovitine; tau Proteins; Tauopathies | 2005 |
Cdk5 is involved in NFT-like tauopathy induced by transient cerebral ischemia in female rats.
Topics: Animals; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinases; Disease Models, Animal; Female; Functional Laterality; Ischemic Attack, Transient; Neurofibrillary Tangles; Phosphorylation; Protein Kinase Inhibitors; Purines; Rats; Rats, Sprague-Dawley; Roscovitine; Tauopathies | 2007 |
Long-lasting arrest of murine polycystic kidney disease with CDK inhibitor roscovitine.
Topics: Animals; Apoptosis; Cyclin-Dependent Kinases; Disease Models, Animal; Disease Progression; Kidney; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Polycystic Kidney Diseases; Purines; Roscovitine; Time Factors | 2006 |
Cyclin-dependent kinase inhibition limits glomerulonephritis and extends lifespan of mice with systemic lupus.
Topics: Animals; Anti-Inflammatory Agents; Autoimmunity; B-Lymphocytes; Cell Proliferation; Cyclin-Dependent Kinases; Disease Models, Animal; Drug Therapy, Combination; Female; Glomerulonephritis; Longevity; Lupus Erythematosus, Systemic; Methylprednisolone; Mice; Mice, Inbred NZB; Mice, Inbred Strains; Protein Kinase Inhibitors; Proteinuria; Purines; Roscovitine; T-Lymphocytes | 2007 |
Pkd1 and Nek8 mutations affect cell-cell adhesion and cilia in cysts formed in kidney organ cultures.
Topics: Alleles; Animals; Cadherins; Cell Adhesion; Cilia; Cyclin-Dependent Kinases; Cysts; Disease Models, Animal; Female; Male; Mice; Mice, Knockout; Mutation; NIMA-Related Kinases; Organ Culture Techniques; Polycystic Kidney Diseases; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Purines; Roscovitine; TRPP Cation Channels | 2008 |