cyc 202 has been researched along with Colonic Neoplasms in 10 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (30.00) | 29.6817 |
| 2010's | 6 (60.00) | 24.3611 |
| 2020's | 1 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Berdini, V; Boulstridge, JA; Carr, MG; Cross, DM; Davis, DJ; Devine, LA; Early, TR; Feltell, RE; Lewis, EJ; McMenamin, RL; Navarro, EF; O'Brien, MA; O'Reilly, M; Reule, M; Saxty, G; Seavers, LC; Smith, DM; Squires, MS; Trewartha, G; Walker, MT; Woodhead, AJ; Woolford, AJ; Wyatt, PG | 1 |
| Cheng, C; Ullah, S; Yuan, Q; Yun, F | 1 |
| Arisan, ED; Gürkan, AC; Obakan, P; Palavan-Ünsal, N | 1 |
| Arisan, ED; Coker-Gurkan, A; Guvenir, E; Obakan, P; Unsal, NP | 1 |
| Cavino, M; D'Angelo, M; De Leon, G; Krucher, NA | 1 |
| Akyuz, S; Akyuz, T; Arisan, ED; Balci, K; Coker, A; Ozalpan, A; Ozel, AE; Palavan-Unsal, N | 1 |
| Arısan, ED; Coker, A; Palavan-Ünsal, N | 2 |
| Garrett, MD; Walton, MI; Whittaker, SR; Workman, P | 1 |
| Barth, P; Göke, R; Lankat-Buttgereit, B; Samans, B; Schmidt, A | 1 |
10 other study(ies) available for cyc 202 and Colonic Neoplasms
| Article | Year |
|---|---|
Identification of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide (AT7519), a novel cyclin dependent kinase inhibitor using fragment-based X-ray crystallography and structure based drug design.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Colonic Neoplasms; Crystallography, X-Ray; Cyclin-Dependent Kinase 2; Drug Design; Enzyme Inhibitors; Humans; Mice; Piperidines; Pyrazoles; Structure-Activity Relationship | 2008 |
Design, synthesis and biological evaluation of novel histone deacetylase1/2 (HDAC1/2) and cyclin-dependent Kinase2 (CDK2) dual inhibitors against malignant cancer.
Topics: Animals; Antineoplastic Agents; Apoptosis; Benzamides; Cell Cycle; Cell Line, Tumor; Colonic Neoplasms; Cyclin-Dependent Kinase 2; Drug Design; Drug Screening Assays, Antitumor; Female; Histone Deacetylases; Humans; Male; Mice, Inbred BALB C; Mice, Inbred ICR; Mice, Nude; Molecular Docking Simulation; Neoplasms, Experimental; Protein Kinase Inhibitors; Purines; Structure-Activity Relationship | 2020 |
Inhibition of polyamine oxidase prevented cyclin-dependent kinase inhibitor-induced apoptosis in HCT 116 colon carcinoma cells.
Topics: Apoptosis; Colonic Neoplasms; Cyclin-Dependent Kinases; Down-Regulation; HCT116 Cells; Humans; Oxidoreductases Acting on CH-NH Group Donors; Polyamine Oxidase; Polyamines; Protein Kinase Inhibitors; Purines; Roscovitine | 2013 |
Inhibition of autophagy by 3-MA potentiates purvalanol-induced apoptosis in Bax deficient HCT 116 colon cancer cells.
Topics: Antineoplastic Agents; Apoptosis; Autophagy; bcl-2-Associated X Protein; Blotting, Western; CDC2 Protein Kinase; Cell Cycle; Cell Proliferation; Colonic Neoplasms; Cyclin-Dependent Kinases; Drug Synergism; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Humans; Immunoprecipitation; Membrane Potential, Mitochondrial; Methylcholanthrene; Purines; Roscovitine; Tumor Cells, Cultured | 2014 |
PNUTS knockdown potentiates the apoptotic effect of Roscovitine in breast and colon cancer cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; DNA-Binding Proteins; E2F1 Transcription Factor; Gene Expression Regulation, Neoplastic; Humans; Mice; Mice, Transgenic; Nuclear Proteins; Purines; RNA Interference; RNA-Binding Proteins; Roscovitine | 2010 |
Raman micro-spectroscopic analysis of cultured HCT116 colon cancer cells in the presence of roscovitine.
Topics: Colonic Neoplasms; Flow Cytometry; HCT116 Cells; Humans; Propidium; Purines; Roscovitine; Spectrum Analysis, Raman | 2011 |
Polyamine depletion enhances the roscovitine-induced apoptosis through the activation of mitochondria in HCT116 colon carcinoma cells.
Topics: Antineoplastic Agents; Apoptosis; Biogenic Polyamines; Cell Line, Tumor; Colonic Neoplasms; Humans; Mitochondria; Purines; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Roscovitine | 2012 |
Silencing of the polyamine catabolic key enzyme SSAT prevents CDK inhibitor-induced apoptosis in Caco-2 colon cancer cells.
Topics: Acetyltransferases; Apoptosis; Caco-2 Cells; Caspase 3; Caspase 9; Colonic Neoplasms; Cyclin-Dependent Kinases; Humans; Membrane Potential, Mitochondrial; Polyamines; Protein Kinase Inhibitors; Purines; Putrescine; RNA Interference; RNA, Small Interfering; Roscovitine; Spermine | 2012 |
The Cyclin-dependent kinase inhibitor CYC202 (R-roscovitine) inhibits retinoblastoma protein phosphorylation, causes loss of Cyclin D1, and activates the mitogen-activated protein kinase pathway.
Topics: 3T3 Cells; Animals; Antineoplastic Agents; Cell Cycle; Cell Division; Colonic Neoplasms; Cyclin D1; Cyclin-Dependent Kinases; Enzyme Activation; Enzyme Inhibitors; Flow Cytometry; Humans; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphorylation; Purines; Retinoblastoma Protein; Roscovitine; Tumor Cells, Cultured | 2004 |
Programmed cell death protein 4 suppresses CDK1/cdc2 via induction of p21(Waf1/Cip1).
Topics: Apoptosis; Apoptosis Regulatory Proteins; Breast Neoplasms; Carcinoid Tumor; CDC2 Protein Kinase; Cell Cycle Proteins; Cell Division; Cell Line, Tumor; Colonic Neoplasms; Cyclin-Dependent Kinase Inhibitor p21; Endocrine Gland Neoplasms; Female; Humans; Insulinoma; Lung Neoplasms; Male; Pancreatic Neoplasms; Phosphorylation; Prostatic Neoplasms; Protein Kinase Inhibitors; Purines; Retinoblastoma Protein; RNA-Binding Proteins; Roscovitine | 2004 |