cyc 202 has been researched along with B-Cell Chronic Lymphocytic Leukemia in 11 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (63.64) | 29.6817 |
| 2010's | 3 (27.27) | 24.3611 |
| 2020's | 1 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Blake, D; Chen, R; Chen, Y; Keating, MJ; Plunkett, W; Wierda, WG; Xiong, P; Zheleva, D | 1 |
| Berthou, C; Carter-Brzezinski, LJ; Cosimo, E; Durieu, E; Galons, H; Le Ster, K; Leach, MT; McCaig, AM; Meijer, L; Michie, AM; Oumata, N; Wheadon, H | 1 |
| Chen, R; Chubb, S; Fox, JA; Gandhi, V; Hawtin, RE; Keating, MJ; Plunkett, W; Wierda, WG | 1 |
| Błoński, JZ; Kiliańska, ZM; Robak, T; Wesierska-Gadek, J; Zolnierczyk, JD | 1 |
| Błoński, JZ; Góralski, P; Kiliańska, ZM; Komina, O; Piekarski, H; Robak, T; Rogalińska, M; Wesierska-Gadek, J; Zołnierczyk, JD | 1 |
| Borowiak, A; Błoński, JZ; Cebula-Obrzut, B; Kiliańska, ZM; Komina, O; Robak, P; Smolewski, P; Węsierska-Gądek, J; Żołnierczyk, JD | 1 |
| Decker, T; Fend, F; Hahntow, IN; Oelsner, M; Peschel, C; Ringshausen, I; Schneller, F; Weick, K | 1 |
| Decker, T; Hahntow, I; Hipp, S; Peschel, C; Schneller, F | 1 |
| Alvi, AJ; Austen, B; Fegan, C; Gianella-Borradori, A; Hubank, M; Lane, DP; MacCallum, D; Moss, PA; Powell, JE; Stankovic, T; Taylor, AM; Wei, W; Weston, VJ | 1 |
| Alves, NL; de Boer, JP; de Jong, D; Derks, IA; Eldering, E; Green, SR; Hallaert, DY; Jak, M; Spijker, R; van Oers, MH; Wensveen, FM | 1 |
| Liebmann, PM; Linkesch, W; Sill, H; Strunk, D; Weingrill, E; Wölfler, A | 1 |
11 other study(ies) available for cyc 202 and B-Cell Chronic Lymphocytic Leukemia
| Article | Year |
|---|---|
Cyclin-dependent kinase inhibitor fadraciclib (CYC065) depletes anti-apoptotic protein and synergizes with venetoclax in primary chronic lymphocytic leukemia cells.
Topics: Adenosine; Apoptosis; Apoptosis Regulatory Proteins; Bridged Bicyclo Compounds, Heterocyclic; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Myeloid Cell Leukemia Sequence 1 Protein; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-bcl-2; Roscovitine; Sulfonamides; Tumor Microenvironment | 2022 |
Inhibition of NF-κB-mediated signaling by the cyclin-dependent kinase inhibitor CR8 overcomes prosurvival stimuli to induce apoptosis in chronic lymphocytic leukemia cells.
Topics: Adult; Aged; Antineoplastic Agents; Apoptosis; CD40 Ligand; Cell Cycle Checkpoints; Cell Proliferation; Cell Survival; Cyclin-Dependent Kinases; Drug Evaluation, Preclinical; Female; Gene Expression Regulation, Leukemic; Humans; Inhibitory Concentration 50; Interleukin-4; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Myeloid Cell Leukemia Sequence 1 Protein; NF-kappa B; Proto-Oncogene Proteins c-bcl-2; Purines; Pyridines; RNA Polymerase II; Roscovitine; Signal Transduction; Tumor Cells, Cultured; X-Linked Inhibitor of Apoptosis Protein | 2013 |
Mechanism of action of SNS-032, a novel cyclin-dependent kinase inhibitor, in chronic lymphocytic leukemia.
Topics: Adult; Aged; Aged, 80 and over; Apoptosis; Caspases; Cyclin-Dependent Kinases; Female; Flavonoids; Humans; Immunoblotting; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphocytes; Male; Membrane Potential, Mitochondrial; Middle Aged; Myeloid Cell Leukemia Sequence 1 Protein; Oxazoles; Phosphorylation; Piperidines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-bcl-2; Purines; RNA Polymerase II; RNA, Neoplasm; Roscovitine; Thiazoles; Transcription, Genetic; X-Linked Inhibitor of Apoptosis Protein | 2009 |
Roscovitine triggers apoptosis in B-cell chronic lymphocytic leukemia cells with similar efficiency as combinations of conventional purine analogs with cyclophosphamide.
Topics: Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Caspase 9; Cell Survival; Cells, Cultured; Cladribine; Cyclin E; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinases; Cyclophosphamide; Drug Synergism; Female; Flow Cytometry; Humans; Intracellular Signaling Peptides and Proteins; Leukemia, Lymphocytic, Chronic, B-Cell; Leukocytes, Mononuclear; Male; Myeloid Cell Leukemia Sequence 1 Protein; Proto-Oncogene Proteins c-bcl-2; Purines; Roscovitine; Vidarabine | 2009 |
R-roscovitine (Seliciclib) affects CLL cells more strongly than combinations of fludarabine or cladribine with cyclophosphamide: Inhibition of CDK7 sensitizes leukemic cells to caspase-dependent apoptosis.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Caspases; Cell Survival; Cells, Cultured; Cladribine; Cyclin-Dependent Kinase-Activating Kinase; Cyclin-Dependent Kinases; Cyclophosphamide; Female; Humans; Immunoblotting; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Neoplasm Staging; Purines; Roscovitine; Vidarabine | 2010 |
Can ex vivo evaluation (testing) predict the sensitivity of CLL cells to therapy with purine analogs in conjunction with an alkylating agent? A comparison of in vivo and ex vivo responses to treatment.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Apoptosis; Cell Line; Cladribine; Cyclophosphamide; Drug Resistance, Neoplasm; Female; Flow Cytometry; Humans; Immunohistochemistry; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Purines; Roscovitine; Vidarabine | 2012 |
Cyclin-dependent kinase inhibitor Roscovitine induces apoptosis in chronic lymphocytic leukemia cells.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents; Apoptosis; B-Lymphocytes; Caspases; Cells, Cultured; Cyclin-Dependent Kinases; Dose-Response Relationship, Drug; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Protein-Tyrosine Kinases; Purines; Roscovitine; Tumor Suppressor Protein p53; ZAP-70 Protein-Tyrosine Kinase | 2004 |
Expression of cyclin E in resting and activated B-chronic lymphocytic leukaemia cells: cyclin E/cdk2 as a potential therapeutic target.
Topics: Aged; Aged, 80 and over; Blotting, Western; CDC2-CDC28 Kinases; Cell Cycle; Cell Cycle Proteins; Cyclin E; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p27; Enzyme Inhibitors; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Purines; Roscovitine; Tumor Suppressor Proteins | 2004 |
A novel CDK inhibitor, CYC202 (R-roscovitine), overcomes the defect in p53-dependent apoptosis in B-CLL by down-regulation of genes involved in transcription regulation and survival.
Topics: Aged; Aged, 80 and over; Apoptosis; Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins; Cell Survival; Cyclin-Dependent Kinases; DNA-Binding Proteins; Down-Regulation; Drug Evaluation; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Middle Aged; Mutation; Protein Serine-Threonine Kinases; Purines; RNA Polymerase II; Roscovitine; Transcription, Genetic; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Tumor Suppressor Proteins | 2005 |
Crosstalk among Bcl-2 family members in B-CLL: seliciclib acts via the Mcl-1/Noxa axis and gradual exhaustion of Bcl-2 protection.
Topics: Aged; Aged, 80 and over; Apoptosis; Apoptosis Regulatory Proteins; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; Bcl-2-Like Protein 11; Cell Line, Tumor; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Membrane Proteins; Middle Aged; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Proteins; Protein Kinase Inhibitors; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Purines; RNA Interference; Roscovitine | 2007 |
Roscovitine in B-chronic lymphocytic leukemia cells: high apoptosis-inducing efficacy and synergism with alemtuzumab independent of the patients' pretreatment status.
Topics: Aged; Aged, 80 and over; Alemtuzumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antibodies, Neoplasm; Antigens, CD; Antigens, Neoplasm; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; CD52 Antigen; Cohort Studies; Drug Synergism; Female; Glycoproteins; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Mitoxantrone; Purines; Roscovitine; Salvage Therapy | 2007 |