Compounds > cyc 202
Page last updated: 2024-09-04

cyc 202 and Acute Liver Injury, Drug-Induced

cyc 202 has been researched along with Acute Liver Injury, Drug-Induced in 5 studies

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (20.00)29.6817
2010's3 (60.00)24.3611
2020's1 (20.00)2.80

Authors

AuthorsStudies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Chen, KX; Fan, S; Fu, R; Huang, H; Huang, J; Li, GM; Li, J; Liao, L; Liu, Y; Luo, C; Shi, C; Yu, L; Zhang, YY1
Filipski, E; Guettier, C; Harper, F; Hassan, M; Iacobelli, S; Iurisci, I; Lévi, F; Maire, I; Sallam, H1
Graña, X; Knudsen, ES; Mayhew, CN; Reed, CA; Rivadeneira, DB; Sotillo, E; Thangavel, C1
Armour, S; Chiao, J; Delbaldo, C; Diéras, V; Faivre, S; Frame, S; Gianella-Borradori, A; Girre, V; Green, SR; Laurence, V; Le Tourneau, C; Raymond, E; Vera, K1

Trials

1 trial(s) available for cyc 202 and Acute Liver Injury, Drug-Induced

ArticleYear
Phase I evaluation of seliciclib (R-roscovitine), a novel oral cyclin-dependent kinase inhibitor, in patients with advanced malignancies.
    European journal of cancer (Oxford, England : 1990), 2010, Volume: 46, Issue:18

    Topics: Administration, Oral; Adult; Aged; Antineoplastic Agents; Chemical and Drug Induced Liver Injury; Female; Humans; Male; Maximum Tolerated Dose; Metabolic Diseases; Middle Aged; Nausea; Neoplasms; Purines; Roscovitine; Vomiting

2010

Other Studies

4 other study(ies) available for cyc 202 and Acute Liver Injury, Drug-Induced

ArticleYear
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Cyclin-dependent kinase inhibitor roscovitine attenuates liver inflammation and fibrosis by influencing initiating steps of liver injury.
    Clinical science (London, England : 1979), 2021, 04-16, Volume: 135, Issue:7

    Topics: Animals; Carbon Tetrachloride; Cell Line; Chemical and Drug Induced Liver Injury; Galactosamine; Humans; Inflammation; Lipopolysaccharides; Liver Cirrhosis; Male; Mice; Mice, Inbred C57BL; Protein Kinase Inhibitors; RAW 264.7 Cells; Roscovitine; Sequence Analysis, RNA

2021
Liver circadian clock, a pharmacologic target of cyclin-dependent kinase inhibitor seliciclib.
    Chronobiology international, 2009, Volume: 26, Issue:6

    Topics: Animals; Antineoplastic Agents; Area Under Curve; Biological Clocks; Cell Cycle; Chemical and Drug Induced Liver Injury; Cyclin-Dependent Kinases; Dose-Response Relationship, Drug; Gastrointestinal Diseases; Gene Expression Regulation; Liver; Male; Mice; Purines; Roscovitine

2009
Proliferative suppression by CDK4/6 inhibition: complex function of the retinoblastoma pathway in liver tissue and hepatoma cells.
    Gastroenterology, 2010, Volume: 138, Issue:5

    Topics: Adenovirus E1A Proteins; Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Cycle; Cell Proliferation; Chemical and Drug Induced Liver Injury; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase 6; Cyclin-Dependent Kinase Inhibitor p16; Cyclin-Dependent Kinases; Disease Models, Animal; E2F Transcription Factors; Gene Knockdown Techniques; Hep G2 Cells; Hepatocytes; Humans; Liver Neoplasms; Male; Mice; Mice, Knockout; Mice, Nude; Neoplasm Transplantation; Phosphorylation; Piperazines; Protein Kinase Inhibitors; Purines; Pyridines; Retinoblastoma Protein; Retinoblastoma-Like Protein p107; RNA Interference; Roscovitine; Time Factors; Transfection

2010