cyanoginosin-lr and Hepatic-Insufficiency

Microcystins (MCs) are a family of cyclic heptapeptides that are produced by blooming algae Microcystis. MCs have been implicated in the development of liver cancer, necrosis and even intrahepatic bleeding. Effective prophylactic approaches and complete removal of MCs are urgently needed. Accumulating evidence suggests that microcystin-LR (MC-LR)-induced damage is accompanied by oxidative stress. Supplementation of Se can enhance resistance to oxidative stress. Therefore, in the present study, we investigated the protective effects of κ-Selenocarrageenan (Se-Car), a kind of organic Se compound, in Balb/c mice exposed to MC-LR. Our results proved that Se-Car could significantly ameliorate the hepatic damage induced by MC-LR, including serum markers of liver dysfunction, oxidative damages and histological alterations. Furthermore, Se-Car could significantly alleviate the up-regulation of the molecular targets indicating mitochondrial dysfunction and endoplasmic reticulum stress induced by MC-LR. In conclusion, Se-Car showed clear protection against toxicity induced by MC-LR. Thus, Se-Car could be useful as a new category of anti-MC-LR toxicity reagent.

Topics: Adaptor Proteins, Signal Transducing; Animals; Antitoxins; Bacterial Toxins; Biomarkers; Carrageenan; Carrier Proteins; Cell Cycle Proteins; Endoplasmic Reticulum Stress; Eukaryotic Initiation Factors; Hepatic Insufficiency; Lipid Peroxidation; Liver; Male; Marine Toxins; Mice; Mice, Inbred BALB C; Microcystins; Microcystis; Mitochondria, Liver; Organoselenium Compounds; Oxidative Stress; Phosphoproteins; Random Allocation; Signal Transduction; Survival Analysis