cyanine-dye-1 and Disease-Models--Animal

cyanine-dye-1 has been researched along with Disease-Models--Animal* in 2 studies

Reviews

1 review(s) available for cyanine-dye-1 and Disease-Models--Animal

ArticleYear
Fluorescent macromolecular sensors of enzymatic activity for in vivo imaging.
    Progress in molecular biology and translational science, 2013, Volume: 113

    Macromolecular imaging probes (or sensors) of enzymatic activity have a unique place in the armamentarium of modern optical imaging techniques. Such probes were initially developed by attaching optically "silent" fluorophores via enzyme-sensitive linkers to large copolymers of biocompatible poly(ethylene glycol) and poly(amino acids). In diseased tissue, where the concentration of enzymes is high, the fluorophores are freed from the macromolecular carrier and regain their initial ability to fluoresce, thus allowing in vivo optical localization of the diseased tissue. This chapter describes the design and application of these probes and their alternatives in various areas of experimental medicine and gives an overview of currently available techniques that allow imaging of animals using visible and near-infrared light.

    Topics: Amino Acids; Animals; Biosensing Techniques; Carbocyanines; Diagnostic Imaging; Disease Models, Animal; Enzymes; Fluorescence; Fluorescent Dyes; Humans; Macromolecular Substances; Mice; Neoplasm Transplantation; Polyethylene Glycols; Polymers; Spectroscopy, Near-Infrared

2013

Other Studies

1 other study(ies) available for cyanine-dye-1 and Disease-Models--Animal

ArticleYear
New stains for anterior capsule surgery.
    Journal of cataract and refractive surgery, 2019, Volume: 45, Issue:2

    To investigate whether new dyes and dye combinations can give equivalent or better staining in anterior capsule surgery than existing dyes with a low degree of toxicity on relevant cells.. University laboratory of Jacobs University Bremen, Germany.. Laboratory experimental study.. Pig eyes were collected post mortem. Cataract was induced by microwave irradiation. Access to the lens capsule was through open-sky surgery. Staining was performed and results were documented by photography. The toxicity of the dyes was evaluated in 3 different cell lines immediately after exposure and with a delay of 24 hours, with exposure in the dark or subsequent strong illumination.. A new cyanine dye, BIP (2-[5-[3,3-dimethyl-1-(4-sulfobutyl)-1,3-dihydro-indol-2-ylidene]-penta-1,3-dienyl]-3,3-dimethyl-1-(4-sulfobutyl)-3H-indolium sodium), was found to lead to green staining, with reduced toxicity on corneal endothelial cells. Staining could be further enhanced by combining it with trypan blue. Methylene blue was very toxic, whereas its combination with trypan blue was much less toxic.. With BIP alone or in combination with trypan blue, safe staining of the capsule can be achieved, resulting in a green color.

    Topics: Animals; Anterior Capsule of the Lens; Capsulorhexis; Carbocyanines; Cataract; Coloring Agents; Disease Models, Animal; Swine; Trypan Blue

2019