cyanidin-3-o-beta-glucopyranoside and Eye-Diseases

Recently, the NLRP3 inflammasome activation in the eyes has been known to be associated with the pathogenesis of age-related macular degeneration. The aim of this study was to investigate the protective effects of cyanidin-3-glucoside (C3G), an important anthocyanin with great potential for preventing eye diseases, against 4-hydroxyhexenal- (HHE-) induced inflammatory damages in human retinal pigment epithelial cells, ARPE-19. We noticed that C3G pretreatment to the ARPE-19 cells rescued HHE-induced antiproliferative effects. Cell apoptosis ratio induced by HHE was also decreased by C3G, measured by flow cytometry. The activation of NLRP3 inflammasome induced by HHE was found with increases of caspase-1 activity, proinflammatory cytokine releases (IL-1

Topics: Aldehydes; Anthocyanins; Anti-Inflammatory Agents; Caspase 1; Cell Line; Cytokines; Eye Diseases; Glucosides; Humans; Inflammasomes; Inflammation Mediators; MAP Kinase Kinase 4; NLR Family, Pyrin Domain-Containing 3 Protein; Oncogene Protein p65(gag-jun); Retinal Pigment Epithelium; Signal Transduction; Transcription Factor AP-1