cyanidin-3-o-beta-glucopyranoside and Cardiovascular-Diseases

Platelet granule release is considered an important target for preventing and treating cardiovascular diseases (CVDs). Cyanidin-3-glucoside (Cy-3-g) is a predominant bioactive anthocyanin compound in many edible plants and has been reported to be protective against CVDs by attenuating platelet dysfunction. However, direct evidence of the action of Cy-3-g on platelet granule secretion in purified platelets from in vivo assays is still poor. In the present study, we demonstrated that dietary supplementation of purified Cy-3-g reduces serum lipid levels and facilitates down-regulation of the platelet granule release of substances such as P-selectin, CD40L, 5-HT, RANTES and TGF-β1 in gel-filtered platelets, in addition to attenuating serum PF4 and β-TG levels in mice fed high-fat diets. These results provide evidence that Cy-3-g protects against thrombosis and CVDs by inhibiting purified platelet granule release in vivo.

Topics: Animals; Anthocyanins; beta-Thromboglobulin; Blood Platelets; Cardiovascular Diseases; Chemokine CCL5; Diet; Diet, High-Fat; Dietary Supplements; Glucosides; Lipids; Male; Mice; Mice, Inbred C57BL; Platelet Activation; Platelet Factor 4; Secretory Vesicles; Serotonin; Transforming Growth Factor beta1