Page last updated: 2024-08-26

cyanates and Airway Hyper-Responsiveness

cyanates has been researched along with Airway Hyper-Responsiveness in 77 studies

Research

Studies (77)

Timeframe	Studies, this research(%)	All Research%
pre-1990	42 (54.55)	18.7374
1990's	19 (24.68)	18.2507
2000's	10 (12.99)	29.6817
2010's	5 (6.49)	24.3611
2020's	1 (1.30)	2.80

Authors

Authors	Studies
Colnot, T; Dekant, W	1
Cruz, T; Dinis, TC; Lopes, C; Martins, J; Neves, B; Nunes, C; Silva, A	1
Basketter, DA; Dearman, RJ; Kimber, I	2
Pauluhn, J	2
Egelrud, L; Eriksson, K; Liljelind, I; Norberg, C; Nylander-French, LA; Westberg, H	1
Ahonen, N; Järvelä, M; Järventaus, H; Korpi, A; Lindberg, HK; Norppa, H; Pasanen, AL; Rosenberg, C; Säkkinen, K; Santonen, T; Tornaeus, J	1
Bramé, B; Ferrari, M; Moscato, G; Perfetti, L	1
JACOB, M; MARCHAND, M; MASURE, J; SAVINEL, E; VOISIN, C	1
HARRIS, WC; TRENCHARD, HJ	1
Anderson, PK; Holsapple, MP; Ladics, GS; Loveless, SE; Plitnick, LM; Selgrade, MJ; Smialowicz, RJ; Smith, C; Woolhiser, MR	1
Andrews, DL; Boykin, EH; Doerfler, DL; Farraj, AK; Gavett, SH; Haykal-Coates, N; Selgrade, M; Wiescinski, C; Woolhiser, MR	1
Pauluhn, J; Vohr, HW	1
Baur, X	2
Doekes, G; Heederik, D; Jonkers, IC; Lammers, JW; Preller, L; Pronk, A; Raulf-Heimsoth, M; Wisnewski, AV; Wouters, IM	1
Boykin, E; Doerfler, D; Farraj, AK; Gavett, SH; Haykal-Coates, N; Selgrade, M	1
Alarie, Y; Brady, M; Dixon, C; Karol, MH	1
Butcher, BT; O'Neil, CE; Reed, MA; Salvaggio, JE; Weill, H	1
Hayes, JP; Newman Taylor, AJ	1
Dalene, M; Littorin, M; Skarping, G	1
Ammon, J; Baur, X; Czuppon, AB; Fruhmann, G; Marczynski, B; Marek, W; Raulf-Heimsoth, M; Roemmelt, H	1
Blaikie, L; Botham, PA; Hartop, PJ; Hext, P; Morrow, T; Rattray, NJ; Wilson, AP; Woodcock, D	1
Mohr, U; Pauluhn, J	1
Littorin, M; Mårtensson, U; Sjöholm, AG; Skarping, G; Truedsson, L; Welinder, H	1
Botham, PA; Dearman, RJ; Fielding, I; Hext, PM; Kimber, I; Rattray, NJ; Woodcock, DR	1
Cartier, A; Leroyer, C; Malo, JL; Perfetti, L	1
Aul, DJ; Bhaumik, A; Brown, WE; Kennedy, AL; Lesage, J; Malo, JL	1
Dearman, R; Doe, J; Hext, P; Landry, TD; Pauluhn, J	1
Allmers, H; Barbinova, L; Baur, X; Chen, Z; Kirschmann, V; Marczynski, B	1
Emura, M; Mohr, U; Pauluhn, J; Thiel, A	1
Eidmann, P; Mohr, U; Pauluhn, J	1
Eben, A; Pauluhn, J	1
Banks, DE; Butcher, BT; Salvaggio, JE	1
Eggum, P; Grammer, LC; Liotta, JL; Patterson, R; Shaughnessy, MA; Silverstein, M	1
Grunewalder, E; Karol, MH	1
Alarie, Y; Karol, MH	1
Baur, X; Diller, W; Dorsch, W; Fruhmann, G; Römmelt, H; Roth, P	1
Sepúlveda, R	1
Hauth, BA; Karol, MH; Magreni, CM; Riley, EJ	1
Baschieri, L; Cantalupi, R; Filieri, M; Loi, AM; Paggiaro, PL; Parlanti, A; Roselli, MG; Toma, G	1
Karol, MH	2
McGrath, KG; Patterson, R; Zeiss, CR	1
Baur, X; Dewair, M; Fruhmann, G	1
Reed, CE	1
Butcher, BT; Garg, O; O'Neil, CE; Salvaggio, JE; Weill, H	1
Alarie, Y; Hauth, BA; Karol, MH	1
Adams, WG	1
Higgins, RL; Porter, CV; Scheel, LD	1
Butcher, BT; Salvaggio, JE; Weill, H; Ziskind, MM	1
Bernstein, A; Charles, J; Edwards, JH; Jones, B; Jones, DJ; Seal, RM; Seaton, A	1
Alarie, YC; Karol, MH	1
Cirla, AM; Sala, C; Zedda, S	1
Hopkins, J	1
Lubach, D	1
Fujimura, N	1
Fabbri, LM	1
Belin, L; Wass, U	1
Alegre, J; Cobo, E; Morell, F	1
Baur, X; Behr, J; Fruhmann, G; Römmelt, H	1
Scypinski, L; Sheppard, D	1
Liu, JY	1
Musk, AW; Peters, JM; Wegman, DH	1
Blandin, G; Fargetton, B; Latil, F	1
Chan-Yeung, M; Lam, S	1
Harris, KE; Patterson, R	1
Brune, J; Cordier, G; Mornex, JF; Pages, J; Vergnon, JM; Wiesendanger, T	1
Pepys, J	1
Resnick, H	1
Rye, WA	1
Bouhuys, A; Peters, JM	1
Avery, SB; Bruckner, HC; Dodson, VN; Ronayne, JJ; Stetson, DM	1
Williamson, KS	1
Bellardo, G; De Dominicis, G	1

Reviews

10 review(s) available for cyanates and Airway Hyper-Responsiveness

Article	Year
Diisocyanates, occupational asthma and IgE antibody: implications for hazard characterization. Journal of applied toxicology : JAT, 2014, Volume: 34, Issue:10 Topics: Air Pollutants, Occupational; Allergens; Asthma, Occupational; Humans; Immunoglobulin E; Isocyanates; Respiratory Hypersensitivity	2014
In vivo models of occupational asthma due to low molecular weight chemicals. Occupational and environmental medicine, 1995, Volume: 52, Issue:8 Topics: Allergens; Anhydrides; Animals; Asthma; Disease Models, Animal; Dogs; Guinea Pigs; Haplorhini; Humans; Isocyanates; Lignans; Mice; Naphthols; Occupational Diseases; Platinum Compounds; Rabbits; Rats; Respiratory Hypersensitivity	1995
Respiratory and other hazards of isocyanates. International archives of occupational and environmental health, 1994, Volume: 66, Issue:3 Topics: Air Pollutants, Occupational; Animals; Asthma; Bronchial Provocation Tests; Carcinogenicity Tests; Dogs; Guinea Pigs; Humans; Immunoglobulin E; Immunoglobulin G; Isocyanates; Mice; Mutagenicity Tests; Rabbits; Rats; Respiratory Hypersensitivity	1994
Isocyanate-induced respiratory disease. Annals of allergy, 1986, Volume: 57, Issue:6 Topics: Asthma; Cyanates; Drug Hypersensitivity; Humans; Isocyanates; Occupational Diseases; Respiratory Hypersensitivity; Respiratory System; Toluene 2,4-Diisocyanate	1986
Allergic reactions to industrial chemicals. Clinical immunology reviews, 1983, Volume: 2, Issue:1 Topics: Adult; Animals; Asthma; Chemical Industry; Cyanates; Dermatitis, Atopic; Dogs; Ethylenediamines; Guinea Pigs; Humans; Hypersensitivity, Delayed; Hypersensitivity, Immediate; Male; Molecular Weight; Nickel; Occupational Diseases; Phthalic Anhydrides; Platinum; Rabbits; Respiratory Hypersensitivity; Rubber	1983
[The problem of isocyanates in industry. From pathology to control of the risk]. La Medicina del lavoro, 1978, Volume: 69 Suppl 3 Topics: Air Pollutants; Air Pollutants, Occupational; Asthma; Bronchitis; Cough; Cyanates; Humans; Industry; Lung Diseases; Occupational Diseases; Polyurethanes; Respiratory Hypersensitivity; Toluene 2,4-Diisocyanate	1978
Isocyanates and respiratory disease: current status. American journal of industrial medicine, 1988, Volume: 13, Issue:3 Topics: Air Pollutants, Occupational; Animals; Carcinogens, Environmental; Cyanates; Humans; Nervous System Diseases; Occupational Diseases; Respiratory Hypersensitivity; Respiratory Tract Diseases	1988
Occupational asthma. The American review of respiratory disease, 1986, Volume: 133, Issue:4 Topics: Asthma; Biomechanical Phenomena; Bronchial Provocation Tests; Bronchial Spasm; Bronchitis; Byssinosis; Cyanates; Dust; Edible Grain; Forecasting; Humans; Hypersensitivity; Insecticides; Lignans; Naphthols; Occupational Diseases; Organophosphorus Compounds; Prognosis; Reflex; Respiratory Function Tests; Respiratory Hypersensitivity; Serology; Skin Tests; Smoking; Terminology as Topic	1986
Immunopathology of allergic lung disease. Clinical allergy, 1973, Volume: 3, Issue:1 Topics: Adolescent; Adult; Antigen-Antibody Complex; Aspergillosis; Asthma; Autoantibodies; Bronchial Diseases; Child; Cyanates; Dust; Humans; Hypersensitivity, Immediate; Immunoglobulin E; Immunoglobulin G; Lung Diseases; Lung Diseases, Fungal; Piperazines; Platinum; Pulmonary Eosinophilia; Respiratory Hypersensitivity; Skin Tests; Toluene	1973
Control of environmental lung disease. The New England journal of medicine, 1970, Sep-10, Volume: 283, Issue:11 Topics: Aging; Animals; Asbestosis; Beryllium; Cadmium; Coal Mining; Cyanates; Disability Evaluation; Dust; Environmental Exposure; Farmer's Lung; Gas Poisoning; Humans; Lung Diseases; Lung Neoplasms; Occupational Diseases; Pneumoconiosis; Respiratory Function Tests; Respiratory Hypersensitivity; Silicosis; Smoking; Textile Industry; United States	1970

Trials

1 trial(s) available for cyanates and Airway Hyper-Responsiveness

Article	Year
Effect of antiasthma drugs on asthmatic reactions induced by toluene diisocyanate in sensitized subjects. Lung, 1990, Volume: 168 Suppl Topics: Adrenergic beta-Agonists; Airway Resistance; Asthma; Bronchial Provocation Tests; Bronchodilator Agents; Cyanates; Humans; Respiratory Hypersensitivity; Toluene 2,4-Diisocyanate	1990

Other Studies

66 other study(ies) available for cyanates and Airway Hyper-Responsiveness

Article	Year
Evaluation of animal toxicity studies with diisocyanates regarding presence of thresholds for induction and elicitation of respiratory allergy by quantitative weight of evidence. Toxicology and industrial health, 2022, Volume: 38, Issue:9 Topics: Allergens; Animals; Humans; Isocyanates; Rats; Respiratory Hypersensitivity	2022
Respiratory sensitizer hexamethylene diisocyanate inhibits SOD 1 and induces ERK-dependent detoxifying and maturation pathways in dendritic-like cells. Free radical biology & medicine, 2014, Volume: 72 Topics: Air Pollutants; Blotting, Western; Cell Line; Dendritic Cells; Gene Expression; Humans; Isocyanates; MAP Kinase Signaling System; Membrane Potential, Mitochondrial; Real-Time Polymerase Chain Reaction; Respiratory Hypersensitivity; Reverse Transcriptase Polymerase Chain Reaction; Superoxide Dismutase; Superoxide Dismutase-1	2014
Analysis of the interrelationship of the pulmonary irritation and elicitation thresholds in rats sensitized with 1,6-hexamethylene diisocyanate (HDI). Inhalation toxicology, 2015, Volume: 27, Issue:4 Topics: Administration, Inhalation; Allergens; Animals; Bronchoalveolar Lavage Fluid; Dose-Response Relationship, Immunologic; Irritants; Isocyanates; Leukocyte Count; Lung; Male; Neutrophils; Nitric Oxide; Rats; Respiratory Function Tests; Respiratory Hypersensitivity	2015
Dermal and inhalation exposure to methylene bisphenyl isocyanate (MDI) in iron foundry workers. The Annals of occupational hygiene, 2010, Volume: 54, Issue:1 Topics: Air Pollutants, Occupational; Allergens; Environmental Monitoring; Humans; Inhalation Exposure; Iron; Isocyanates; Limit of Detection; Metallurgy; Occupational Exposure; Respiratory Hypersensitivity; Skin; Skin Absorption	2010
Micronuclei, hemoglobin adducts and respiratory tract irritation in mice after inhalation of toluene diisocyanate (TDI) and 4,4'-methylenediphenyl diisocyanate (MDI). Mutation research, 2011, Jul-14, Volume: 723, Issue:1 Topics: Administration, Inhalation; Aerosols; Animals; Hemoglobins; Isocyanates; Male; Mice; Mice, Inbred C57BL; Micronucleus Tests; Mutagens; Respiratory Hypersensitivity; Toluene 2,4-Diisocyanate	2011
Occupational asthma (OA) with sensitization to diphenylmethane diisocyanate (MDI) presenting at the onset like a reactive airways dysfunction syndrome (RADS). American journal of industrial medicine, 2003, Volume: 44, Issue:3 Topics: Asthma; Diagnosis, Differential; Drug Hypersensitivity; Female; Humans; Industry; Isocyanates; Middle Aged; Occupational Diseases; Respiratory Hypersensitivity	2003
[Bronchopneumopathy caused by inhalation of isocyanates]. Lille medical : journal de la Faculte de medecine et de pharmacie de l'Universite de Lille, 1963, Volume: 8 Topics: Asthma; Cyanates; Humans; Isocyanates; Respiratory Hypersensitivity; Respiratory Insufficiency	1963
An outbreak of respiratory symptoms caused by toluene di-isocyanate. Lancet (London, England), 1963, Feb-23, Volume: 1, Issue:7278 Topics: Cyanates; Disease Outbreaks; Humans; Isocyanates; Occupational Diseases; Respiratory Hypersensitivity; Toluene	1963
Cytokine mRNA profiles for isocyanates with known and unknown potential to induce respiratory sensitization. Toxicology, 2005, Feb-28, Volume: 207, Issue:3 Topics: Allergens; Animals; Cytokines; Dose-Response Relationship, Drug; Female; Gene Expression Regulation; Humans; Isocyanates; Local Lymph Node Assay; Lymph Nodes; Mice; Mice, Inbred BALB C; Mice, Inbred CBA; Respiratory Hypersensitivity; Ribonucleases; RNA, Messenger; Skin; Th1 Cells; Th2 Cells	2005
Inconsistencies between cytokine profiles, antibody responses, and respiratory hyperresponsiveness following dermal exposure to isocyanates. Toxicological sciences : an official journal of the Society of Toxicology, 2006, Volume: 94, Issue:1 Topics: Administration, Cutaneous; Animals; Antibody Formation; Chemokine CCL2; Cytokines; Dinitrochlorobenzene; Dose-Response Relationship, Drug; Female; Gene Expression Regulation; Immunoglobulin E; Immunoglobulin G; Inhalation Exposure; Isocyanates; Lymph Nodes; Methacholine Chloride; Mice; Mice, Inbred BALB C; Respiratory Hypersensitivity; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Skin; Th2 Cells; Time Factors	2006
Partial C-fiber ablation modulates diphenylmethane-4,4'-diisocyanate (MDI)-induced respiratory allergy in Brown Norway rats. Toxicology, 2006, Dec-07, Volume: 228, Issue:2-3 Topics: Administration, Inhalation; Aerosols; Animals; Axons; Body Weight; Bronchoalveolar Lavage Fluid; Capsaicin; Chemokines; Cytokines; Diet; Hypersensitivity, Delayed; Isocyanates; L-Lactate Dehydrogenase; Lung; Lymph Nodes; Nerve Fibers, Unmyelinated; Neuropeptides; Organ Size; Rats; Rats, Inbred BN; Rats, Wistar; Reflex; Respiratory Hypersensitivity	2006
Evidence for allergic reactions in isocyanate asthma. The Journal of allergy and clinical immunology, 2007, Volume: 119, Issue:3 Topics: Asthma; Humans; Immunoglobulin E; Interleukin-4; Interleukin-5; Isocyanates; Respiratory Hypersensitivity; RNA, Messenger	2007
Respiratory symptoms, sensitization, and exposure response relationships in spray painters exposed to isocyanates. American journal of respiratory and critical care medicine, 2007, Dec-01, Volume: 176, Issue:11 Topics: Adult; Aerosols; Air Pollutants, Occupational; Asthma; Chest Pain; Cyanates; Female; Humans; Immunoglobulin E; Immunoglobulin G; Inhalation Exposure; Isocyanates; Male; Middle Aged; Occupational Diseases; Paint; Prevalence; Pulmonary Disease, Chronic Obstructive; Respiration Disorders; Respiratory Hypersensitivity	2007
Th2 Cytokines in Skin Draining Lymph Nodes and Serum IgE Do Not Predict Airway Hypersensitivity to Intranasal Isocyanate Exposure in Mice. Toxicological sciences : an official journal of the Society of Toxicology, 2007, Volume: 100, Issue:1 Topics: Administration, Cutaneous; Administration, Intranasal; Allergens; Animals; Biomarkers; Bronchial Provocation Tests; Bronchoconstrictor Agents; Cells, Cultured; Cytokines; Female; Immunoglobulin E; Interferon-gamma; Interleukin-13; Interleukin-4; Interleukin-5; Isocyanates; Lymph Nodes; Methacholine Chloride; Mice; Mice, Inbred BALB C; Respiratory Hypersensitivity; Respiratory Mucosa; Th2 Cells	2007
Immunologic sensitization and pulmonary hypersensitivity by repeated inhalation of aromatic isocyanates. Toxicology and applied pharmacology, 1980, Volume: 53, Issue:2 Topics: Animals; Cyanates; Drug Hypersensitivity; Female; Gases; Guinea Pigs; Immunodiffusion; Immunoelectrophoresis; Isocyanates; Passive Cutaneous Anaphylaxis; Respiration; Respiratory Hypersensitivity; Time Factors; Toluene 2,4-Diisocyanate	1980
Development and loss of toluene diisocyanate reactivity: immunologic, pharmacologic, and provocative challenge studies. The Journal of allergy and clinical immunology, 1982, Volume: 70, Issue:4 Topics: Adult; Bronchial Provocation Tests; Cyanates; Humans; Isocyanates; Lymphocyte Activation; Male; Methacholine Compounds; Plants, Edible; Radioallergosorbent Test; Respiratory Function Tests; Respiratory Hypersensitivity; Serum Albumin; Skin Tests; Toluene 2,4-Diisocyanate	1982
4,4'-Methylenedianiline in hydrolysed serum and urine from a worker exposed to thermal degradation products of methylene diphenyl diisocyanate elastomers. International archives of occupational and environmental health, 1995, Volume: 67, Issue:2 Topics: Aniline Compounds; Body Burden; Chromatography, Gas; Hot Temperature; Humans; Hydrolysis; Immune Complex Diseases; Isocyanates; Male; Mass Spectrometry; Middle Aged; Occupational Diseases; Respiratory Hypersensitivity; Rubber; Time Factors	1995
A two-centre study for the evaluation and validation of an animal model for the assessment of the potential of small molecular weight chemicals to cause respiratory allergy. Toxicology, 1995, Jan-19, Volume: 96, Issue:1 Topics: Administration, Inhalation; Allergens; Animals; Antibody Specificity; Antigen-Antibody Complex; Dinitrochlorobenzene; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Female; Guinea Pigs; Haptens; Injections, Intradermal; Isocyanates; Male; Molecular Weight; Phthalic Anhydrides; Respiration; Respiratory Hypersensitivity; Serum Albumin; Toluene 2,4-Diisocyanate	1995
Assessment of respiratory hypersensitivity in guinea-pigs sensitized to diphenylmethane-4,4'-diisocyanate (MDI) and challenged with MDI, acetylcholine or MDI-albumin conjugate. Toxicology, 1994, Sep-06, Volume: 92, Issue:1-3 Topics: Acetylcholine; Administration, Inhalation; Animals; Atmosphere Exposure Chambers; Eosinophils; Female; Guinea Pigs; Haptens; Injections, Intradermal; Isocyanates; Lung; Lymph Nodes; Male; Respiratory Function Tests; Respiratory Hypersensitivity; Serum Albumin	1994
Acute respiratory disorder, rhinoconjunctivitis and fever associated with the pyrolysis of polyurethane derived from diphenylmethane diisocyanate. Scandinavian journal of work, environment & health, 1994, Volume: 20, Issue:3 Topics: Allergens; Antigen-Antibody Complex; Conjunctivitis, Allergic; Humans; Immunoglobulin E; Immunoglobulin G; Isocyanates; Male; Middle Aged; Occupational Exposure; Polyurethanes; Respiratory Hypersensitivity; Rhinitis, Allergic, Perennial	1994
Induction of respiratory hypersensitivity to diphenylmethane-4,4'-diisocyanate (MDI) in guinea pigs. Influence of route of exposure. Toxicology, 1994, Mar-11, Volume: 88, Issue:1-3 Topics: Administration, Inhalation; Administration, Topical; Animals; Drug Administration Routes; Female; Guinea Pigs; Injections, Intradermal; Isocyanates; Respiratory Function Tests; Respiratory Hypersensitivity	1994
Test methods for respiratory sensitization. Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement, 1994, Volume: 16 Topics: Allergens; Animals; Bronchial Provocation Tests; Female; Guinea Pigs; Immunoglobulin G; Injections, Intradermal; Isocyanates; Male; Ovalbumin; Phthalic Anhydrides; Respiratory Hypersensitivity	1994
Can reactive airways dysfunction syndrome (RADS) transform into occupational asthma due to "sensitisation" to isocyanates? Thorax, 1998, Volume: 53, Issue:2 Topics: Allergens; Asthma; Bronchial Provocation Tests; Humans; Isocyanates; Male; Middle Aged; Occupational Diseases; Occupational Exposure; Respiratory Hypersensitivity	1998
Specific IgG response to monomeric and polymeric diphenylmethane diisocyanate conjugates in subjects with respiratory reactions to isocyanates. The Journal of allergy and clinical immunology, 1999, Volume: 103, Issue:5 Pt 1 Topics: Adult; Allergens; Antibody Specificity; Asthma; Cross Reactions; Female; Forced Expiratory Volume; Humans; Immunoglobulin G; Isocyanates; Male; Middle Aged; Respiratory Hypersensitivity; Toluene 2,4-Diisocyanate	1999
Respiratory hypersensitivity to diphenylmethane-4,4'-diisocyanate in guinea pigs: comparison with trimellitic anhydride. Inhalation toxicology, 1999, Volume: 11, Issue:3 Topics: Administration, Inhalation; Allergens; Animals; Atmosphere Exposure Chambers; Enzyme-Linked Immunosorbent Assay; Female; Guinea Pigs; Hypersensitivity, Delayed; Immunoglobulin E; Inhalation Exposure; Injections, Intradermal; Isocyanates; Metals; Respiratory Function Tests; Respiratory Hypersensitivity; Respiratory Mechanics	1999
Challenge from methacholine, natural rubber latex, or 4,4-diphenylmethane diisocyanate in workers with suspected sensitization affects exhaled nitric oxide [change in exhaled NO levels after allergen challenges]. International archives of occupational and environmental health, 2000, Volume: 73, Issue:3 Topics: Adolescent; Adult; Allergens; Bronchial Provocation Tests; Confounding Factors, Epidemiologic; Female; Humans; Isocyanates; Male; Methacholine Chloride; Middle Aged; Nitric Oxide; Occupational Diseases; Respiratory Hypersensitivity; Rubber; Skin Tests	2000
Respiratory sensitization to diphenyl-methane-4,4'-diisocyanate (MDI) in guinea pigs: impact of particle size on induction and elicitation of response. Toxicological sciences : an official journal of the Society of Toxicology, 2000, Volume: 56, Issue:1 Topics: Administration, Inhalation; Aerosols; Allergens; Animals; Enzyme-Linked Immunosorbent Assay; Eosinophilia; Eosinophils; Female; Guinea Pigs; Immunoglobulin G; Injections, Intradermal; Isocyanates; Particle Size; Respiration; Respiratory Hypersensitivity; Respiratory Mucosa	2000
Respiratory hypersensitivity in guinea pigs sensitized to 1,6-hexamethylene diisocyanate (HDI): comparison of results obtained with the monomer and homopolymers of HDI. Toxicology, 2002, Feb-28, Volume: 171, Issue:2-3 Topics: Air Pollutants; Animals; Antibodies; Cyanates; Guinea Pigs; Isocyanates; Lung; Molecular Structure; No-Observed-Adverse-Effect Level; Polymers; Respiration; Respiratory Hypersensitivity	2002
Validation of a non-invasive technique to assess immediate or delayed onset of airway hypersensitivity in guinea-pigs. Journal of applied toxicology : JAT, 1991, Volume: 11, Issue:6 Topics: Administration, Inhalation; Animals; Cyanates; Female; Guinea Pigs; Hypersensitivity, Delayed; Hypersensitivity, Immediate; Immunoglobulin G; Isocyanates; Lung; Ovalbumin; Phthalic Anhydrides; Respiratory Hypersensitivity	1991
Prospective immunologic and clinical study of a population exposed to hexamethylene diisocyanate. The Journal of allergy and clinical immunology, 1988, Volume: 82, Issue:4 Topics: Antibodies; Cyanates; Humans; Immunoglobulin E; Immunoglobulin G; Isocyanates; Occupational Diseases; Prospective Studies; Respiratory Hypersensitivity; Surveys and Questionnaires	1988
Nitrocellulose-based RAST to detect IgE antibodies in workers hypersensitive to diphenylmethane-4,4'-diisocyanate. Allergy, 1986, Volume: 41, Issue:3 Topics: Antibodies; Antibody Specificity; Collodion; Cyanates; Drug Hypersensitivity; Humans; Immunoglobulin E; Isocyanates; Male; Occupational Diseases; Paper; Radioallergosorbent Test; Radioimmunoassay; Respiratory Hypersensitivity	1986
Antigens which detect IgE antibodies in workers sensitive to toluene diisocyanate. Clinical allergy, 1980, Volume: 10, Issue:1 Topics: Antigen-Antibody Reactions; Binding Sites, Antibody; Cyanates; Humans; Immunoglobulin E; Radioallergosorbent Test; Respiratory Hypersensitivity; Serum Albumin; Toluene; Toluene 2,4-Diisocyanate	1980
[Clinical symptoms and results of RAST and inhalation provocation tests]. Zentralblatt fur Arbeitsmedizin, Arbeitsschutz, Prophylaxe und Ergonomie, 1980, Volume: 30, Issue:4 Topics: Adult; Cyanates; Humans; Middle Aged; Occupational Diseases; Radioallergosorbent Test; Radioimmunoassay; Respiratory Hypersensitivity; Toluene 2,4-Diisocyanate	1980
[Occupational asthma (author's transl)]. Revista medica de Chile, 1980, Volume: 108, Issue:2 Topics: Airway Resistance; Asthma; Bronchial Provocation Tests; Cyanates; Humans; Occupational Diseases; Respiratory Hypersensitivity; Toluene 2,4-Diisocyanate	1980
Dermal contact with toluene diisocyanate (TDI) produces respiratory tract hypersensitivity in guinea pigs. Toxicology and applied pharmacology, 1981, Volume: 58, Issue:2 Topics: Administration, Topical; Animals; Antibody Formation; Cyanates; Dermatitis, Contact; Female; Guinea Pigs; Respiratory Hypersensitivity; Toluene 2,4-Diisocyanate	1981
Absence of IgG antibodies to TDI-HSA in a radioimmunological study. Clinical allergy, 1983, Volume: 13, Issue:1 Topics: Animals; Asthma; Cyanates; Humans; Immunoglobulin G; Occupational Diseases; Rabbits; Radioimmunoassay; Respiratory Hypersensitivity; Serum Albumin; Toluene 2,4-Diisocyanate	1983
Concentration-dependent immunologic response to toluene diisocyanate (TDI) following inhalation exposure. Toxicology and applied pharmacology, 1983, Volume: 68, Issue:2 Topics: Animals; Antibody Formation; Atmosphere Exposure Chambers; Bronchial Provocation Tests; Cyanates; Dose-Response Relationship, Drug; Female; Guinea Pigs; Immunization; Intradermal Tests; Lung; Passive Cutaneous Anaphylaxis; Respiratory Hypersensitivity; Toluene 2,4-Diisocyanate	1983
Detection of immunologically sensitized isocyanate workers by RAST and intracutaneous skin tests. The Journal of allergy and clinical immunology, 1984, Volume: 73, Issue:5 Pt 1 Topics: Antibodies, Anti-Idiotypic; Antibody Specificity; Chemical Phenomena; Chemistry; Cyanates; Desensitization, Immunologic; Humans; Hypersensitivity, Delayed; Immunoglobulin E; Occupational Diseases; Radioallergosorbent Test; Respiratory Function Tests; Respiratory Hypersensitivity; Serum Albumin; Skin Tests	1984
[Attacks of dyspnea and frequent asthma episodes in a painter using sprays]. Der Internist, 1982, Volume: 23, Issue:3 Topics: Asthma; Bronchi; Cyanates; Dyspnea; Humans; Male; Middle Aged; Occupational Diseases; Paint; Respiratory Hypersensitivity	1982
Measurement of airborne antigens. The Journal of allergy and clinical immunology, 1982, Volume: 70, Issue:1 Topics: Air Pollutants; Air Pollutants, Occupational; Animals; Antigens; Cyanates; Humans; Lung Diseases; Methods; Mice; Occupational Diseases; Respiratory Hypersensitivity	1982
Toluene diisocyanate pulmonary disease: immunopharmacologic and mecholyl challenge studies. The Journal of allergy and clinical immunology, 1977, Volume: 59, Issue:3 Topics: Administration, Intranasal; Aerosols; Cyanates; Cyclic AMP; Histamine Release; Isoproterenol; Lymphocytes; Methacholine Compounds; Occupational Diseases; Receptors, Adrenergic, beta; Respiratory Hypersensitivity; Toluene 2,4-Diisocyanate	1977
Pulmonary hypersensitivity to hexyl isocyanate-ovalbumin aerosol in guinea pigs. Toxicology and applied pharmacology, 1979, Volume: 51, Issue:1 Topics: Aerosols; Animals; Cyanates; Female; Guinea Pigs; Haptens; Immunodiffusion; Ovalbumin; Passive Cutaneous Anaphylaxis; Respiratory Hypersensitivity; Time Factors	1979
Long-term effects on the health of men engaged in the manufacture of tolylene di-isocyanate. British journal of industrial medicine, 1975, Volume: 32, Issue:1 Topics: Age Factors; Body Height; Chemical Industry; Cyanates; Humans; Male; Occupational Diseases; Prospective Studies; Respiratory Hypersensitivity; Smoking; Spirometry; Toluene; Toluene 2,4-Diisocyanate; Vital Capacity	1975
A retrospective study of clinical, physiologic and immunologic changes in workers exposed to toluene diisocyanate. American Industrial Hygiene Association journal, 1975, Volume: 36, Issue:3 Topics: Adult; Agglutination Tests; Air Pollution; Chemical Industry; Cyanates; Environmental Exposure; Humans; Hypersensitivity, Delayed; Immunization, Passive; Middle Aged; Occupational Diseases; Pollen; Respiratory Function Tests; Respiratory Hypersensitivity; Retrospective Studies; Time Factors; Toluene 2,4-Diisocyanate	1975
Toluene diisocyanate (TDI) pulmonary disease: immunologic and inhalation challenge studies. The Journal of allergy and clinical immunology, 1976, Volume: 58, Issue:1 PT 1 Topics: Airway Obstruction; Allergens; Antibodies; Cyanates; Eosinophils; Humans; Immunoglobulin E; Immunoglobulin G; Intradermal Tests; Leukocyte Count; Lymphocyte Activation; Passive Cutaneous Anaphylaxis; Radioimmunoassay; Respiratory Hypersensitivity; Serum Albumin; Skin Tests; Toluene 2,4-Diisocyanate	1976
Hypersensitivity pneumonitis after exposure to isocyanates. Thorax, 1976, Volume: 31, Issue:2 Topics: Animals; Cyanates; Dyspnea; Humans; Lung; Male; Middle Aged; Pneumonia; Prednisone; Rabbits; Respiratory Hypersensitivity; Toluene 2,4-Diisocyanate	1976
Serologic test for toluene diisocyanate (TDI) antibodies. Journal of occupational medicine. : official publication of the Industrial Medical Association, 1978, Volume: 20, Issue:6 Topics: Antibodies; Cyanates; Dermatitis, Occupational; Humans; Respiratory Hypersensitivity; Toluene 2,4-Diisocyanate	1978
Evidence of a safe level of TDI. Food and cosmetics toxicology, 1979, Volume: 17, Issue:1 Topics: Cyanates; Forced Expiratory Volume; Humans; Lung Diseases; Occupational Diseases; Respiratory Hypersensitivity; Time Factors; Toluene 2,4-Diisocyanate	1979
[Diseases caused by diisocyanates. 1. Irritation of the respiratory system and skin]. Dermatosen in Beruf und Umwelt. Occupation and environment, 1978, Volume: 26, Issue:6 Topics: Cyanates; Dermatitis, Contact; Dermatitis, Occupational; Environmental Exposure; Fever; Humans; Lung Diseases; Maximum Allowable Concentration; Occupational Diseases; Respiratory Hypersensitivity; Toluene 2,4-Diisocyanate	1978
[Occupational allergy and immunological toxicology--special reference to respiratory diseases]. Sangyo igaku. Japanese journal of industrial health, 1992, Volume: 34, Issue:7 Topics: Asbestos; Beryllium; Cyanates; Humans; Immunoglobulin E; Occupational Diseases; Respiratory Hypersensitivity	1992
Variable effects of chemical allergens on serum IgE concentration in mice. Preliminary evaluation of a novel approach to the identification of respiratory sensitizers. Journal of applied toxicology : JAT, 1992, Volume: 12, Issue:5 Topics: Allergens; Animals; Cyanates; Dermatitis, Contact; Dinitrochlorobenzene; Female; Humans; Immunoglobulin E; Lymph Nodes; Mice; Mice, Inbred BALB C; Oxazolone; Phthalic Anhydrides; Respiratory Hypersensitivity	1992
Comparison of clinical and experimental data from an animal model of pulmonary immunologic sensitivity. Annals of allergy, 1991, Volume: 66, Issue:6 Topics: Allergens; Animals; Antigen-Antibody Reactions; Atmosphere Exposure Chambers; Cyanates; Disease Models, Animal; Equipment Design; Guinea Pigs; Lung Diseases; Respiratory Hypersensitivity; Toluene 2,4-Diisocyanate	1991
An in vitro method for predicting sensitizing properties of inhaled chemicals. Scandinavian journal of work, environment & health, 1990, Volume: 16, Issue:3 Topics: Administration, Inhalation; Cyanates; Environmental Exposure; Haptens; Histamine Antagonists; Humans; In Vitro Techniques; Lysine; Respiratory Hypersensitivity	1990
Respiratory symptoms and pulmonary function of workers exposed to cork dust, toluene diisocyanate and conidia. Scandinavian journal of work, environment & health, 1990, Volume: 16, Issue:3 Topics: Adult; Alveolitis, Extrinsic Allergic; Chronic Disease; Confounding Factors, Epidemiologic; Cross-Sectional Studies; Cyanates; Environmental Exposure; Female; Humans; Lung Diseases, Obstructive; Male; Middle Aged; Respiratory Function Tests; Respiratory Hypersensitivity; Risk Factors; Spain; Spores, Fungal; Toluene 2,4-Diisocyanate; Trees	1990
[Diagnosis of irritative-toxic isocyanate asthma with the isocyanate exposure test]. Pneumologie (Stuttgart, Germany), 1990, Volume: 44 Suppl 1 Topics: Airway Resistance; Asthma; Bronchial Provocation Tests; Cyanates; Environmental Exposure; Humans; Occupational Diseases; Respiratory Hypersensitivity	1990
A tachykinin receptor antagonist inhibits and an inhibitor of tachykinin metabolism potentiates toluene diisocyanate-induced airway hyperresponsiveness in guinea pigs. The American review of respiratory disease, 1988, Volume: 138, Issue:3 Topics: Acetylcholine; Animals; Cyanates; Depression, Chemical; Drug Synergism; Glycopeptides; Guinea Pigs; Male; Receptors, Neurotransmitter; Receptors, Tachykinin; Respiratory Hypersensitivity; Substance P; Tachykinins; Toluene 2,4-Diisocyanate	1988
[Toluene diisocyanate induced asthma]. Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine], 1985, Volume: 19, Issue:4 Topics: Adult; Asthma; Cyanates; Female; Humans; Immunoglobulin E; Male; Middle Aged; Respiratory Hypersensitivity; Toluene 2,4-Diisocyanate	1985
Bathtub refinishers' lung. Journal of occupational medicine. : official publication of the Industrial Medical Association, 1987, Volume: 29, Issue:5 Topics: Cyanates; Humans; Occupational Diseases; Respiratory Hypersensitivity; Toluene 2,4-Diisocyanate	1987
[The isocyanates: respiratory pathology]. Allergie et immunologie, 1987, Volume: 19, Issue:4 Topics: Airway Obstruction; Asthma; Chronic Disease; Cyanates; Drug Hypersensitivity; Humans; Occupational Diseases; Paint; Polyurethanes; Respiratory Hypersensitivity	1987
Responses of human airways to inhaled chemicals. New England and regional allergy proceedings, 1985,Summer, Volume: 6, Issue:3 Topics: Antigen-Antibody Complex; Cyanates; Humans; Immunoglobulin E; In Vitro Techniques; Lung; Occupational Diseases; Phthalic Acids; Phthalic Anhydrides; Respiratory Hypersensitivity	1985
[Pneumopathy caused by hypersensitivity to isocyanates. Value and dangers of a realistic provocation test]. Revue des maladies respiratoires, 1985, Volume: 2, Issue:2 Topics: Bronchi; Bronchial Provocation Tests; Cyanates; Drug Hypersensitivity; Female; Humans; Methylprednisolone; Middle Aged; Occupational Diseases; Pneumonia; Respiratory Function Tests; Respiratory Hypersensitivity; Therapeutic Irrigation	1985
Letter: Hypersusceptibility and genetic problems. Journal of occupational medicine. : official publication of the Industrial Medical Association, 1973, Volume: 15, Issue:11 Topics: Anemia, Sickle Cell; Carbon Disulfide; Cyanates; Drug Hypersensitivity; Genetic Diseases, Inborn; Genetic Techniques; Genotype; Glucosephosphate Dehydrogenase Deficiency; Humans; Metabolism, Inborn Errors; Occupational Diseases; Occupational Health Services; Phenotype; Physical Examination; Pulmonary Emphysema; Respiratory Hypersensitivity; Trypsin Inhibitors	1973
Human responses to isocyanate exposure. Journal of occupational medicine. : official publication of the Industrial Medical Association, 1973, Volume: 15, Issue:3 Topics: Aerosols; Animals; Carbon Monoxide; Cyanates; Environmental Exposure; Eye Diseases; Hot Temperature; Humans; Molecular Weight; Occupational Diseases; Polymers; Respiratory Hypersensitivity; Respiratory Tract Diseases; Skin Diseases; Time Factors; Urethane	1973
Clinical and immunologic appraisal of workers exposed to diisocyanates. Archives of environmental health, 1968, Volume: 16, Issue:5 Topics: Air Pollution; Asthma; Cyanates; Environmental Exposure; Humans; Lymphocytes; Male; Mucous Membrane; Occupational Diseases; Respiratory Hypersensitivity; Respiratory Tract Diseases; Time Factors	1968
Studies of diisocyanate workers. (2). The Transactions of the Association of Industrial Medical Officers, 1965, Volume: 15, Issue:1 Topics: Adult; Cyanates; Female; Humans; Male; Middle Aged; Occupational Diseases; Respiratory Hypersensitivity	1965
[Pathology of the respiratory system caused by toluene-di-isocyanate. Contribution to the case reports]. Minerva medica, 1966, Jun-09, Volume: 57, Issue:46 Topics: Adult; Asthma; Cyanates; Dyspnea; Humans; Male; Occupational Medicine; Respiratory Hypersensitivity; Toluene	1966