cx-614 and Cognition-Disorders

cx-614 has been researched along with Cognition-Disorders* in 1 studies

Reviews

1 review(s) available for cx-614 and Cognition-Disorders

ArticleYear
Glutamate-based therapeutic approaches: ampakines.
    Current opinion in pharmacology, 2006, Volume: 6, Issue:1

    Ampakines are a structurally diverse family of small molecules that positively modulate alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors, and thereby enhance fast, excitatory transmission throughout the brain. Surprisingly, ampakines have discrete effects on brain activity and behavior. Because their excitatory synaptic targets mediate communication between cortical regions, serve as sites of memory encoding, and regulate the production of growth factors, ampakines have a broad range of potential therapeutic applications. Several of these possibilities have been tested with positive results in preclinical models; preliminary clinical work has also been encouraging.

    Topics: Animals; Brain; Cognition Disorders; Dioxoles; Drug Evaluation, Preclinical; Excitatory Amino Acid Agonists; Humans; Memory; Mental Disorders; Nerve Growth Factors; Oxazines; Piperidines; Protein Conformation; Receptors, AMPA

2006