curcumin-glucuronide and Osteoporosis

Curcumin prevents bone loss in resorptive bone diseases and inhibits osteoclast formation, a key process driving bone loss. Curcumin circulates as an inactive glucuronide that can be deconjugated in situ by bone's high β-glucuronidase (GUSB) content, forming the active aglycone. Because curcumin is a common remedy for musculoskeletal disease, effects of microenvironmental changes consequent to skeletal development or disease on bone curcumin metabolism are explored.. Across sexual/skeletal development or between sexes in C57BL/6 mice ingesting curcumin (500 mg kg. Dietary polyphenols circulating as glucuronides may require in situ deconjugation for bone-protective effects, a process influenced by bone microenvironmental changes.

Topics: Aging; Animals; Bone and Bones; Bone Neoplasms; Curcumin; Female; Glucuronidase; Glucuronides; Male; Mice, Inbred C57BL; Osteogenesis; Osteolysis; Osteoporosis; Ovariectomy; Polyphenols; Quercetin