curcumin and Uterine-Diseases

To evaluate the impact of systemic cyclophosphamide treatment on the rat uterus and investigate the potential therapeutic effects of natural antioxidant preparations curcumin and capsaicin against cyclophosphamide side effects.. A 40 healthy adult female Wistar albino rats were used in this study. Rats were randomly divided into four groups to determine the effects of curcumin and capsaicin against Cyclophosphamide side effects on the uterus (n=10 in each group); Group 1 was the control group (sham-operated), Group 2 was the cyclophosphamide group, Group 3 was the cyclophosphamide + curcumin (100mg/kg) group, and Group 4 was the cyclophosphamide + capsaicin (0.5 mg/kg) group.. Increased tissue oxidative stress and histological damage in the rat uterus were demonstrated due to the treatment of systemic cyclophosphamide chemotherapy alone. The level of tissue oxidant and antioxidant markers and histopathological changes were improved by the treatment of curcumin and capsaicin.. Cytotoxic effects of natural alkylating chemotherapeutic agents like cyclophosphamide on the uterus can be prevented by curcumin and capsaicin.

Topics: Animals; Antineoplastic Agents, Alkylating; Antioxidants; Capsaicin; Catalase; Curcumin; Cyclophosphamide; Female; Glutathione; Glutathione Peroxidase; Malondialdehyde; Oxidative Stress; Random Allocation; Rats, Wistar; Reproducibility of Results; Superoxide Dismutase; Uterine Diseases; Uterus

To study the effect of TCTS on endometriosis rats.. On the model of surgical induced rat endometriosis, weight and pathological changes of endometrial transplant and serum hormones were observed.. Weight of endometrial transplants was reduced by TCTS 11.2 g.kg-1 and 22.5 g.kg-1 and transplants of TCTS treated rat showed poorly developed epithelium, thinner stroma, fewer stromal cells and glands. At the same time elevated serum E2, FSH and LH were reduced by TCTS.. TCTS can inhibit the growth of endometrial transplants, which is related with serum hormone, especially E2.

Topics: Animals; Cinnamomum zeylanicum; Curcuma; Drug Combinations; Drugs, Chinese Herbal; Endometriosis; Endometrium; Estradiol; Female; Follicle Stimulating Hormone; Luteinizing Hormone; Phytotherapy; Plants, Medicinal; Prunella; Rats; Rats, Sprague-Dawley; Uterine Diseases