curcumin and Toxoplasmosis

Toxoplasmosis is a zoonotic protozoal disease caused by Toxoplasma gondii, an intracellular opportunistic protozoan parasite that can infect any warm-blooded vertebrate cell. In this study, zirconium, and iron-based metal-organic framework was prepared according to the solvothermal method. New nanocomposite (Curcumin@MOFs) was prepared by reacting curcumin with amino-functionalized metal-organic frameworks (Fe-MOF and UiO-66-NH

Topics: Animals; Biological Products; Brain; Chronic Disease; Curcumin; Female; Immunoglobulin G; Liver; Metal-Organic Frameworks; Microscopy, Electron, Scanning; Nanocomposites; Nanomedicine; Porosity; Powders; Rats; Spiramycin; Spleen; Toxoplasma; Toxoplasmosis; X-Ray Diffraction; Zirconium

The aim of this study was to prepare curcumin nanoemulsion (CR-NE) to solve the problems associated with poor water solubility and low bioavailability of CR and to test its efficiency in the treatment of acute and chronic toxoplasmosis in mouse models.. The mean particle size and zeta potential of CR-NE included 215.66±16.8 nm and -29.46±2.65 mV, respectively, and were stable in particle size after a three freeze-thaw cycle. In acute phase experiment, the survival time of mice infected with RH strain of. Results from the current study showed the potential of CR-S and CR-NE in treatment of acute and chronic toxoplasmosis in mouse models for the first time. However, CR-NE was more efficient than CR-S, and it seems that CR-NE has a potential formula for the treatment of acute and chronic toxoplasmosis, especially in those with latent bradyzoites in brain.

Topics: Acute Disease; Animals; Brain; Chronic Disease; Curcumin; Disease Models, Animal; Emulsions; Female; Gene Expression Regulation; Mice, Inbred BALB C; Nanoparticles; Toxicity Tests; Toxoplasma; Toxoplasmosis