curcumin and Skin-Ulcer

curcumin has been researched along with Skin-Ulcer* in 2 studies

Other Studies

2 other study(ies) available for curcumin and Skin-Ulcer

Article	Year
Wound healing effects of a Curcuma zedoaria polysaccharide with platelet-rich plasma exosomes assembled on chitosan/silk hydrogel sponge in a diabetic rat model. International journal of biological macromolecules, 2018, Oct-01, Volume: 117 One homogeneous polysaccharide (ZWP) was successfully isolated and purified from the rhizomes of Curcuma zedoaria and the aim of present study was to determine the potential of chitosan/silk hydrogel sponge loaded with platelet-rich plasma exosomes (PRP-Exos), ZWP or PRP-Exos/ZWP on wound-healing in diabetic rats. An in vivo diabetic wound healing study showed that separate or combined treatments all resulted in a wound contraction in diabetic rats, as evidenced by a decrease of ulcer and an increase of epidermal thickness, but PRP-Exos/ZWP combination therapy was more successful in wound closing than either PRP-Exos or ZWP single administration. This could be due to the upregulation of collagen synthesis and deposition, as well as angiogenesis at the wound site. In addition to this, no side effects was observed in all treated groups during healing process. These findings provide a mechanistic basis for PRP-Exos/ZWP as a potential therapeutic strategy to accelerate skin repair in diabetes. Topics: Animals; Bandages; Blood Glucose; Chitosan; Curcuma; Diabetes Mellitus, Experimental; Exosomes; Female; Hydrogels; Molecular Weight; Monosaccharides; Plant Extracts; Platelet-Rich Plasma; Polysaccharides; Rats; Silk; Skin Ulcer; Wound Healing	2018
Turmeric and curcumin as topical agents in cancer therapy. Tumori, 1987, Feb-28, Volume: 73, Issue:1 An ethanol extract of turmeric ("Curcuma longa") as well as an ointment of curcumin (its active ingredient) were found to produce remarkable symptomatic relief in patients with external cancerous lesions. Reduction in smell were noted in 90% of the cases and reduction in itching in almost all cases. Dry lesions were observed in 70% of the cases, and a small number of patients (10%) had a reduction in lesion size and pain. In many patients the effect continued for several months. An adverse reaction was noticed in only one of the 62 patients evaluated. Topics: Administration, Topical; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Breast Neoplasms; Catechols; Curcuma; Curcumin; Drug Evaluation; Female; Humans; Male; Middle Aged; Mouth Neoplasms; Odorants; Palliative Care; Plant Extracts; Pruritus; Skin Neoplasms; Skin Ulcer; Vulvar Neoplasms	1987

Article

Year

Wound healing effects of a Curcuma zedoaria polysaccharide with platelet-rich plasma exosomes assembled on chitosan/silk hydrogel sponge in a diabetic rat model.

International journal of biological macromolecules, 2018, Oct-01, Volume: 117

One homogeneous polysaccharide (ZWP) was successfully isolated and purified from the rhizomes of Curcuma zedoaria and the aim of present study was to determine the potential of chitosan/silk hydrogel sponge loaded with platelet-rich plasma exosomes (PRP-Exos), ZWP or PRP-Exos/ZWP on wound-healing in diabetic rats. An in vivo diabetic wound healing study showed that separate or combined treatments all resulted in a wound contraction in diabetic rats, as evidenced by a decrease of ulcer and an increase of epidermal thickness, but PRP-Exos/ZWP combination therapy was more successful in wound closing than either PRP-Exos or ZWP single administration. This could be due to the upregulation of collagen synthesis and deposition, as well as angiogenesis at the wound site. In addition to this, no side effects was observed in all treated groups during healing process. These findings provide a mechanistic basis for PRP-Exos/ZWP as a potential therapeutic strategy to accelerate skin repair in diabetes.

Topics: Animals; Bandages; Blood Glucose; Chitosan; Curcuma; Diabetes Mellitus, Experimental; Exosomes; Female; Hydrogels; Molecular Weight; Monosaccharides; Plant Extracts; Platelet-Rich Plasma; Polysaccharides; Rats; Silk; Skin Ulcer; Wound Healing

2018

Turmeric and curcumin as topical agents in cancer therapy.

Tumori, 1987, Feb-28, Volume: 73, Issue:1

An ethanol extract of turmeric ("Curcuma longa") as well as an ointment of curcumin (its active ingredient) were found to produce remarkable symptomatic relief in patients with external cancerous lesions. Reduction in smell were noted in 90% of the cases and reduction in itching in almost all cases. Dry lesions were observed in 70% of the cases, and a small number of patients (10%) had a reduction in lesion size and pain. In many patients the effect continued for several months. An adverse reaction was noticed in only one of the 62 patients evaluated.

Topics: Administration, Topical; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Breast Neoplasms; Catechols; Curcuma; Curcumin; Drug Evaluation; Female; Humans; Male; Middle Aged; Mouth Neoplasms; Odorants; Palliative Care; Plant Extracts; Pruritus; Skin Neoplasms; Skin Ulcer; Vulvar Neoplasms

1987