curcumin has been researched along with Sjogren-s-Syndrome* in 2 studies
2 other study(ies) available for curcumin and Sjogren-s-Syndrome
Article | Year |
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In vitro effects of curcumin on proinflammatory cytokines and expression of their genes in minor salivary gland tissue of patients with Sjogren's syndrome.
Topics: Adult; Animals; Anti-Inflammatory Agents, Non-Steroidal; Curcumin; Female; Gene Expression; Humans; Interleukin-6; Male; Mice; Middle Aged; Receptors, Interleukin-1 Type II; Salivary Glands, Minor; Sjogren's Syndrome | 2022 |
Heat-solubilized curry spice curcumin inhibits antibody-antigen interaction in in vitro studies: a possible therapy to alleviate autoimmune disorders.
Chronic and complex autoimmune diseases, currently treated palliatively with immunosuppressives, require multi-targeted therapy for greater effectiveness. The naturally occurring polyphenol curcumin has emerged as a powerful "nutraceutical" that interacts with multiple targets to regress diseases safely and inexpensively. Up to 8 g/day of curcumin for 18 months was non-toxic to humans. However, curcumin's utility is limited by its aqueous insolubility. We have demonstrated a heat-mediated 12-fold increase in curcumin's aqueous solubility. Here, we show by SDS-PAGE and surface plasmon resonance that heat-solubilized curcumin binds to proteins. Based on this binding we hypothesized that heat-solubilized curcumin or turmeric would prevent autoantibody targeting of cognate autoantigens. Heat-solubilized curcumin/turmeric significantly decreased binding of autoantibodies from Sjögren's syndrome (up to 43/70%, respectively) and systemic lupus erythematosus (up to 52/70%, respectively) patients as well as an animal model of Sjögren's syndrome (up to 50/60%, respectively) to their cognate antigens. However, inhibition was not specific to autoimmunity. Heat-solubilized curcumin/turmeric also inhibited binding of commercial polyclonal anti-spectrin to spectrin (50/56%, respectively). Thus, we suggest that the multifaceted heat-solubilized curcumin can ameliorate autoimmune disorders. In addition, the non-toxic curcumin could serve as a new protein stain in SDS-PAGE even though it is less sensitive than the Coomassie system which involves toxic chemicals. Topics: Animals; Antigen-Antibody Reactions; Autoantibodies; Autoantigens; Autoimmune Diseases; Curcuma; Curcumin; Dietary Supplements; Electrophoresis, Polyacrylamide Gel; Hot Temperature; Humans; Immunologic Factors; Indicators and Reagents; Lupus Erythematosus, Systemic; Mice; Mice, Inbred BALB C; Plant Extracts; Sjogren's Syndrome; Solubility; Spectrin; Surface Plasmon Resonance | 2010 |