curcumin and Sjogren-s-Syndrome

curcumin has been researched along with Sjogren-s-Syndrome* in 2 studies

Other Studies

2 other study(ies) available for curcumin and Sjogren-s-Syndrome

Article	Year
In vitro effects of curcumin on proinflammatory cytokines and expression of their genes in minor salivary gland tissue of patients with Sjogren's syndrome. Rheumatology international, 2022, Volume: 42, Issue:3 Topics: Adult; Animals; Anti-Inflammatory Agents, Non-Steroidal; Curcumin; Female; Gene Expression; Humans; Interleukin-6; Male; Mice; Middle Aged; Receptors, Interleukin-1 Type II; Salivary Glands, Minor; Sjogren's Syndrome	2022
Heat-solubilized curry spice curcumin inhibits antibody-antigen interaction in in vitro studies: a possible therapy to alleviate autoimmune disorders. Molecular nutrition & food research, 2010, Volume: 54, Issue:8 Chronic and complex autoimmune diseases, currently treated palliatively with immunosuppressives, require multi-targeted therapy for greater effectiveness. The naturally occurring polyphenol curcumin has emerged as a powerful "nutraceutical" that interacts with multiple targets to regress diseases safely and inexpensively. Up to 8 g/day of curcumin for 18 months was non-toxic to humans. However, curcumin's utility is limited by its aqueous insolubility. We have demonstrated a heat-mediated 12-fold increase in curcumin's aqueous solubility. Here, we show by SDS-PAGE and surface plasmon resonance that heat-solubilized curcumin binds to proteins. Based on this binding we hypothesized that heat-solubilized curcumin or turmeric would prevent autoantibody targeting of cognate autoantigens. Heat-solubilized curcumin/turmeric significantly decreased binding of autoantibodies from Sjögren's syndrome (up to 43/70%, respectively) and systemic lupus erythematosus (up to 52/70%, respectively) patients as well as an animal model of Sjögren's syndrome (up to 50/60%, respectively) to their cognate antigens. However, inhibition was not specific to autoimmunity. Heat-solubilized curcumin/turmeric also inhibited binding of commercial polyclonal anti-spectrin to spectrin (50/56%, respectively). Thus, we suggest that the multifaceted heat-solubilized curcumin can ameliorate autoimmune disorders. In addition, the non-toxic curcumin could serve as a new protein stain in SDS-PAGE even though it is less sensitive than the Coomassie system which involves toxic chemicals. Topics: Animals; Antigen-Antibody Reactions; Autoantibodies; Autoantigens; Autoimmune Diseases; Curcuma; Curcumin; Dietary Supplements; Electrophoresis, Polyacrylamide Gel; Hot Temperature; Humans; Immunologic Factors; Indicators and Reagents; Lupus Erythematosus, Systemic; Mice; Mice, Inbred BALB C; Plant Extracts; Sjogren's Syndrome; Solubility; Spectrin; Surface Plasmon Resonance	2010

Article

Year

In vitro effects of curcumin on proinflammatory cytokines and expression of their genes in minor salivary gland tissue of patients with Sjogren's syndrome.

Rheumatology international, 2022, Volume: 42, Issue:3

Topics: Adult; Animals; Anti-Inflammatory Agents, Non-Steroidal; Curcumin; Female; Gene Expression; Humans; Interleukin-6; Male; Mice; Middle Aged; Receptors, Interleukin-1 Type II; Salivary Glands, Minor; Sjogren's Syndrome

2022

Heat-solubilized curry spice curcumin inhibits antibody-antigen interaction in in vitro studies: a possible therapy to alleviate autoimmune disorders.

Molecular nutrition & food research, 2010, Volume: 54, Issue:8

Chronic and complex autoimmune diseases, currently treated palliatively with immunosuppressives, require multi-targeted therapy for greater effectiveness. The naturally occurring polyphenol curcumin has emerged as a powerful "nutraceutical" that interacts with multiple targets to regress diseases safely and inexpensively. Up to 8 g/day of curcumin for 18 months was non-toxic to humans. However, curcumin's utility is limited by its aqueous insolubility. We have demonstrated a heat-mediated 12-fold increase in curcumin's aqueous solubility. Here, we show by SDS-PAGE and surface plasmon resonance that heat-solubilized curcumin binds to proteins. Based on this binding we hypothesized that heat-solubilized curcumin or turmeric would prevent autoantibody targeting of cognate autoantigens. Heat-solubilized curcumin/turmeric significantly decreased binding of autoantibodies from Sjögren's syndrome (up to 43/70%, respectively) and systemic lupus erythematosus (up to 52/70%, respectively) patients as well as an animal model of Sjögren's syndrome (up to 50/60%, respectively) to their cognate antigens. However, inhibition was not specific to autoimmunity. Heat-solubilized curcumin/turmeric also inhibited binding of commercial polyclonal anti-spectrin to spectrin (50/56%, respectively). Thus, we suggest that the multifaceted heat-solubilized curcumin can ameliorate autoimmune disorders. In addition, the non-toxic curcumin could serve as a new protein stain in SDS-PAGE even though it is less sensitive than the Coomassie system which involves toxic chemicals.

Topics: Animals; Antigen-Antibody Reactions; Autoantibodies; Autoantigens; Autoimmune Diseases; Curcuma; Curcumin; Dietary Supplements; Electrophoresis, Polyacrylamide Gel; Hot Temperature; Humans; Immunologic Factors; Indicators and Reagents; Lupus Erythematosus, Systemic; Mice; Mice, Inbred BALB C; Plant Extracts; Sjogren's Syndrome; Solubility; Spectrin; Surface Plasmon Resonance

2010