curcumin and Schistosomiasis

curcumin has been researched along with Schistosomiasis* in 3 studies

Reviews

2 review(s) available for curcumin and Schistosomiasis

ArticleYear
Application of nanotized formulation in the control of snail intermediate hosts of schistosomes.
    Acta tropica, 2021, Volume: 220

    Schistosomiasis continues to pose significant public health problems in many developing countries. Mass drug administration (MDA) is the most adopted control option but there is increasing evidence for the development of praziquantel-resistant Schistosoma strains. This shortcoming has necessitated the search for other effective methods for the control of schistosomiasis. The breaking of Schistosoma transmission cycles through the application of molluscicides into snail infested freshwater bodies has yielded positive outcomes when integrated with MDA in some countries. However, few of such effective molluscicides are currently available, and where available, their application is restricted due to toxicity concerns. Some nanotized particles with molluscicidal activities against the different stages of snail intermediate hosts of schistosomes have been reported. Importantly, the curcumin-nisin nanoparticle synthesized by our group was very effective and it showed no significant toxicity in a mouse model and brine shrimps. This, therefore, offers the possibility of developing a molluscicide that is not only safe for man but also is environmentally friendly. This paper reviews nanoparticles with molluscicidal potential. The methods of their formulation, activities, probable mechanisms of actions, and their toxicity profiles are discussed. More research should be made in this field as it offers great potential for the development of new molluscicides.

    Topics: Animals; Curcumin; Drug Compounding; Humans; Mice; Molluscacides; Nanoparticles; Nisin; Schistosomiasis; Snails

2021
Curcuma as a parasiticidal agent: a review.
    Planta medica, 2011, Volume: 77, Issue:6

    Members of the Curcuma plant species (Zingiberaceae) have been used for centuries in cooking, cosmetics, staining and in traditional medicine as "omnipotent" remedies. Herbal preparations made with, and molecules extracted from, Curcuma have been shown to possess a wide variety of pharmacological properties against malignant proliferation, hormonal disorders, inflammation, and parasitosis among other conditions. This review evaluates Curcuma and its associated bioactive compounds, particularly focusing on studies examining the parasiticidal activity of these components against the tropical parasites Plasmodium, leishmania, Trypanosoma, Schistosoma and more generally against other cosmopolitan parasites (nematodes, Babesia, Candida, Giardia, Coccidia and Sarcoptes).

    Topics: Animals; Antiparasitic Agents; Babesiosis; Coccidiosis; Curcuma; Curcumin; Giardiasis; Helminthiasis; Humans; Leishmaniasis; Malaria; Parasites; Parasitic Diseases; Plant Preparations; Scabies; Schistosomiasis; Trypanosomiasis

2011

Other Studies

1 other study(ies) available for curcumin and Schistosomiasis

ArticleYear
EF24, a schistosomicidal curcumin analog: Insights from its synthesis and phenotypic, biochemical and cytotoxic activities.
    Chemico-biological interactions, 2022, Dec-01, Volume: 368

    Praziquantel (PZQ) is the only drug available for community-based control programs which aim to reduce the prevalence and morbidity associated with schistosomiasis. Here, we synthesized and evaluated the schistosomicidal, biochemical and cytotoxic activities of EF24, a synthetic curcumin analog, against different isolates of Schistosoma mansoni. EF24 elicited marked phenotypic alterations at 10 μM against schistosomula and 42-day-old adult worms of the Naval Medical Research Institute (NMRI) isolate. EF24 had 50% effective concentration (EC

    Topics: Animals; Antioxidants; Curcumin; Female; Glutathione Peroxidase; Glutathione Reductase; Glutathione Transferase; Male; Mammals; Praziquantel; Reactive Oxygen Species; Schistosoma mansoni; Schistosomiasis; Schistosomicides

2022