curcumin and Rhabdomyolysis

curcumin has been researched along with Rhabdomyolysis* in 2 studies

Other Studies

2 other study(ies) available for curcumin and Rhabdomyolysis

Article	Year
Curcumin reduces renal damage associated with rhabdomyolysis by decreasing ferroptosis-mediated cell death. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019, Volume: 33, Issue:8 Topics: Acute Kidney Injury; Animals; Antioxidants; Cells, Cultured; Curcumin; Disease Models, Animal; Ferroptosis; Heme Oxygenase-1; Humans; Male; MAP Kinase Signaling System; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Myoglobin; NF-kappa B; Oxidative Stress; Receptor-Interacting Protein Serine-Threonine Kinases; Rhabdomyolysis; Toll-Like Receptor 4	2019
Curcumin-Loaded Nanoparticles Protect Against Rhabdomyolysis-Induced Acute Kidney Injury. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2017, Volume: 43, Issue:5 Rhabdomyolysis (RM) is a potentially life-threatening condition that results from the breakdown of muscle and consequent release of toxic compounds into circulation. The most common and severe complication of RM is acute kidney injury (AKI). This study aimed to evaluate the efficacy and mechanisms of action of curcumin-loaded nanoparticles (Cur-NP) for treatment of RM-induced AKI.. Curcumin-NP was synthesized using the nanocarrier distearoylphosphatidylethanolamine-polyethylene glycol (DSPE-PEG) to achieve a prolonged and constant drug release profile compared with the curcumin-free group. The anti-AKI effects of Curcumin-NP were examined both in vitro (myoglobin-treated renal tubular epithelial HK-2 cells) and in vivo (glycerol-induced AKI model).. Our results indicated that Curcumin-NP reversed oxidative stress, growth inhibition and cell apoptosis accompanied with down-regulation of apoptotic markers Caspase-3 and GRP-78 in vitro. In vivo studies revealed enhanced AKI treatment efficacy with Curcumin-NP as characterized by reduced serum creatine phosphokinase (CPK), creatinine (Cr) and urea and less severe histological damage in renal tubules. In addition, kidney tissues from Curcumin-NP-treated AKI rats exhibited reduced oxidative stress, apoptosis, and cleaved Capase-3 and GRP-78 expression.. Our results suggest that nanoparticle-loaded curcumin enhances treatment efficacy for RM-induced AKI both in vitro and in vivo. Topics: Acute Kidney Injury; Animals; Apoptosis; Blotting, Western; Cell Line; Cell Proliferation; Curcumin; Humans; In Situ Nick-End Labeling; Lipid Peroxidation; Male; Microscopy, Electron, Transmission; Nanoparticles; Rats; Rats, Sprague-Dawley; Rhabdomyolysis	2017

Article

Year

Curcumin reduces renal damage associated with rhabdomyolysis by decreasing ferroptosis-mediated cell death.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019, Volume: 33, Issue:8

Topics: Acute Kidney Injury; Animals; Antioxidants; Cells, Cultured; Curcumin; Disease Models, Animal; Ferroptosis; Heme Oxygenase-1; Humans; Male; MAP Kinase Signaling System; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Myoglobin; NF-kappa B; Oxidative Stress; Receptor-Interacting Protein Serine-Threonine Kinases; Rhabdomyolysis; Toll-Like Receptor 4

2019

Curcumin-Loaded Nanoparticles Protect Against Rhabdomyolysis-Induced Acute Kidney Injury.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2017, Volume: 43, Issue:5

Rhabdomyolysis (RM) is a potentially life-threatening condition that results from the breakdown of muscle and consequent release of toxic compounds into circulation. The most common and severe complication of RM is acute kidney injury (AKI). This study aimed to evaluate the efficacy and mechanisms of action of curcumin-loaded nanoparticles (Cur-NP) for treatment of RM-induced AKI.. Curcumin-NP was synthesized using the nanocarrier distearoylphosphatidylethanolamine-polyethylene glycol (DSPE-PEG) to achieve a prolonged and constant drug release profile compared with the curcumin-free group. The anti-AKI effects of Curcumin-NP were examined both in vitro (myoglobin-treated renal tubular epithelial HK-2 cells) and in vivo (glycerol-induced AKI model).. Our results indicated that Curcumin-NP reversed oxidative stress, growth inhibition and cell apoptosis accompanied with down-regulation of apoptotic markers Caspase-3 and GRP-78 in vitro. In vivo studies revealed enhanced AKI treatment efficacy with Curcumin-NP as characterized by reduced serum creatine phosphokinase (CPK), creatinine (Cr) and urea and less severe histological damage in renal tubules. In addition, kidney tissues from Curcumin-NP-treated AKI rats exhibited reduced oxidative stress, apoptosis, and cleaved Capase-3 and GRP-78 expression.. Our results suggest that nanoparticle-loaded curcumin enhances treatment efficacy for RM-induced AKI both in vitro and in vivo.

Topics: Acute Kidney Injury; Animals; Apoptosis; Blotting, Western; Cell Line; Cell Proliferation; Curcumin; Humans; In Situ Nick-End Labeling; Lipid Peroxidation; Male; Microscopy, Electron, Transmission; Nanoparticles; Rats; Rats, Sprague-Dawley; Rhabdomyolysis

2017