curcumin and Pulmonary-Arterial-Hypertension

To investigate the role of curcumin in regulating pathogenesis of pulmonary arterial smooth muscle cells (PASMCs) derived from pulmonary arterial hypertension (PAH) model.. Male Sprague Dawley rats were injected with monocrotaline (MCT) to establish the PAH experimental model. The rats were divided into control group, MCT group, and curcumin group. At the end of the study, hemodynamic data were measured to determine pulmonary hypertension. Proliferation ability of PASMCs, a remodeling indicator of pulmonary artery and right ventricle, was detected. In addition, the morphology and function of mitochondria, antiglycolysis and antiproliferation pathways, and genes were also analyzed.. Curcumin may function by reversing MCT-mediated pulmonary vascular remodeling in rats. Curcumin effectively improved pulmonary vascular remodeling, promoted PASMC apoptosis, and protected mitochondrial function. In addition, curcumin treatment suppressed the PI3K/AKT pathway in PASMCs and regulated the expression of antiproliferative genes.. Curcumin can improve energy metabolism and reverse the process of PAHS. However, there were side effects of curcumin in MCT-induced rats, suggesting that the dosage should be treated with caution and its toxicological mechanism should be further studied and evaluated.

Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Cell Proliferation; Cells, Cultured; Curcumin; Disease Models, Animal; Hemodynamics; Male; Mitochondria; Myocytes, Smooth Muscle; Phosphatidylinositol 3-Kinase; Proto-Oncogene Proteins c-akt; Pulmonary Arterial Hypertension; Rats; Signal Transduction

Pulmonary hypertension is one of the most common diseases among older people. This disease is usually associated with complications such as vascular changes, vascular remodeling, vasoconstriction, endothelial dysfunction, right ventricular failure, and reduction in nitric oxide availability. Many chemical drugs have been used to treat pulmonary hypertension, but result in limited efficacy and several side effects, and these medications are not always available worldwide. Various studies in traditional medicine have shown that changes in lifestyle and nutritional habits can be extremely effective in both the prevention and treatment of various diseases. One treatment method related to changing nutritional habits is the use of curcumin as a nutritional supplement. Curcumin plays an important role in treating pulmonary hypertension and positively alters the aforementioned complications.

Topics: Aged; Curcumin; Humans; Hypertension, Pulmonary; Pulmonary Arterial Hypertension; Pulmonary Artery; Vascular Remodeling; Vasoconstriction