curcumin and Microsatellite-Instability

Recent evidences highlight a role of the mitochondria calcium homeostasis in the development of colorectal cancer (CRC). To overcome treatment resistance, we aimed to evaluate the role of the mitochondrial sodium-calcium-lithium exchanger (NCLX) and its targeting in CRC. We also identified curcumin as a new inhibitor of NCLX.. We examined whether curcumin and pharmacological compounds induced the inhibition of NCLX-mediated mitochondrial calcium (mtCa. In vitro, curcumin exerted strong anti-tumoral activity through its action on NCLX with mtCa. Our findings highlight a novel anti-tumoral mechanism of curcumin through its action on NCLX and mitochondria calcium overload that could benefit for therapeutic schedule of patients with MSI CRC.

Topics: Animals; Calcium; Calcium Signaling; Colorectal Neoplasms; Curcumin; Humans; Mice; Microsatellite Instability; Microsatellite Repeats; Mitochondrial Proteins; Sodium-Calcium Exchanger