curcumin and Gastroenteritis--Transmissible--of-Swine

Emerging coronaviruses represent serious threats to human and animal health worldwide, and no approved therapeutics are currently available. Here, we used Transmissible gastroenteritis virus (TGEV) as the alpha-coronavirus model, and investigated the antiviral properties of curcumin against TGEV. Our results demonstrated that curcumin strongly inhibited TGEV proliferation and viral protein expression in a dose-dependent manner. We also observed that curcumin exhibited direct virucidal abilities in a dose-, temperature- and time-dependent manner. Furthermore, time-of-addition assays showed that curcumin mainly acted in the early phase of TGEV replication. Notably, in an adsorption assay, curcumin at 40 µM resulted in a reduction in viral titres of 3.55 log TCID

Topics: Animals; Antiviral Agents; Cell Line; Curcumin; Gastroenteritis, Transmissible, of Swine; Gene Expression Regulation, Viral; Swine; Swine Diseases; Transmissible gastroenteritis virus; Virus Attachment; Virus Replication