curcumin has been researched along with Duodenitis* in 1 studies
1 other study(ies) available for curcumin and Duodenitis
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Targeted inhibition of glucuronidation markedly improves drug efficacy in mice - a model.
Finding UDP-glucuronosyltransferases (UGT) require protein kinase C-mediated phosphorylation is important information that allows manipulation of this critical system. UGTs glucuronidate numerous aromatic-like chemicals derived from metabolites, diet, environment and, inadvertently, therapeutics to reduce toxicities. As UGTs are inactivated by downregulating PKCs with reversibly-acting dietary curcumin, we determined the impact of gastro-intestinal glucuronidation on free-drug uptake and efficacy using immunosuppressant, mycophenolic acid (MPA), in mice. Expressed in COS-1 cells, mouse GI-distributed Ugt1a1 glucuronidates curcumin and MPA and undergoes irreversibly and reversibly dephosphorylation by PKC-specific inhibitor calphostin-C and general-kinase inhibitor curcumin, respectively, with parallel effects on activity. Moreover, oral curcumin-administration to mice reversibly inhibited glucuronidation in GI-tissues. Finally, successive oral administration of curcumin and MPA to antigen-treated mice increased serum free MPA and immunosuppression up to 9-fold. Results indicate targeted inhibition of GI glucuronidation in mice markedly improved free-chemical uptake and efficacy using MPA as a model. Topics: Animals; Chlorocebus aethiops; COS Cells; Curcumin; Disease Models, Animal; Drug Delivery Systems; Duodenitis; Glucuronosyltransferase; Immunosuppressive Agents; Mice; Mycophenolic Acid; Protein Kinase C; Treatment Outcome | 2007 |