curcumin and Dermatitis--Allergic-Contact

Topics: Allergens; Curcuma; Dermatitis, Allergic Contact; Humans; Patch Tests

Contact dermatitis in connection with skin disinfection with yellow-coloured curcumin containing chlorhexidine solution prior to surgery is very rare. However, this case report presents a 59-year-old patient, who developed pruritic erythematous papules, patches and vesicles over the areas, where curcumin-containing disinfectant was applied. The diagnosis was made by allergic patch test, and the patient was treated with a topical steroid.

Topics: Chlorhexidine; Curcumin; Dermatitis, Allergic Contact; Disinfectants; Drug Eruptions; Humans; Middle Aged; Patch Tests

Kumkum, made with turmeric and slaked lime along with colour enhancing dyes is known to cause allergic contact dermatitis. The possible contact allergens in kumkum include turmeric, Sudan-1, 4-aminoazobenzene, brilliant lake red R and cananga oil. We report patch test results among patients with suspected contact hypersensitivity to kumkum.. To identify the allergen causing kumkum induced allergic contact dermatitis by patch testing and to advise patients about organic kumkum which doesnot contain colour enhancing dyes.. Eighteen patients with suspected contact hypersensitivity to kumkum were patch tested with undiluted kumkum, undiluted turmeric, Sudan-1 (95%), 4-aminoazobenzene and allergens of the Indian Standard Series.. Of the 18 patients, 14 patients had patch test positivity to kumkum and 4 had a negative reaction to kumkum. Patch test with other suspected contact allergens showed positive reaction to turmeric in 4 patients, Sudan-1 in 3 patients and 4-aminoazobenzene in 2 patients. Among the allergens of the Indian Standard Series, positivity to nickel and fragrance mix was seen in 5 and 2 patients respectively. Positive reaction to PPD, chlorocresol and parthenium was seen in 1 patient each.. Small sample size.. Allergic contact dermatitis to kumkum occurs both due to the dyes (added for enhancing the colour) and turmeric. All patients with suspected allergic contact dermatitis should be patch tested with kumkum, turmeric and dyes, based on which alternative non-allergic material could be advised. Kumkum dermatitis can also occur due to various other allergens, for which too patch testing should be done.

Topics: Adult; Aged; Calcium Hydroxide; Coloring Agents; Curcuma; Dermatitis, Allergic Contact; Female; Humans; Male; Middle Aged; Patch Tests; Young Adult

Contact dermatitis model involving repeated application of hapten is used as a tool to assess dermatitis, as characterized by thickening. Involvement of cell proliferation, elicited by repeated hapten-stimulation, in this swelling has been unclear. Curcumin is reported to reduce inflammation. We examined involvement of cell proliferation and the role of extracellular regulated kinase (ERK) in 2,4,6-trinitrochlorobenzene (TNCB) challenge-induced ear swelling. We also examined the effects of curcumin in this model.. Mice were sensitized with TNCB to the abdominal skin. Then, they were challenged with TNCB to the ear three times. The ERK activation inhibitor U0126 or curcumin was applied 30 min before each TNCB challenge.. TNCB challenge-induced increased epidermal cell number and dermal thickening. Gene expressions of epithelial mitogen (EPGN), amphiregulin (AREG) and heparin-binding-epidermal growth factor (HB-EGF) were increased in the ears after the last TNCB challenge. Ki-67 immunoreactivity was increased in the dermis in TNCB-challenged ears. TNCB-induced swelling was inhibited by U0126 and curcumin. Curcumin also attenuated TNCB-induced ERK phosphorylation and expression of EPGN and AREG genes.. Ear swelling induced by TNCB challenge might be mediated, in part, by the EPGN- and AREG-ERK proliferation pathway and was inhibited by curcumin.

Topics: Amphiregulin; Animals; Curcumin; Cytokines; Dermatitis, Allergic Contact; Epigen; Extracellular Signal-Regulated MAP Kinases; Female; Haptens; Intercellular Signaling Peptides and Proteins; Ki-67 Antigen; Mice, Inbred BALB C; Phosphorylation; Picryl Chloride; Skin; Up-Regulation

Topics: Coconut Oil; Curcuma; Dermatitis, Allergic Contact; Female; Humans; Leg Dermatoses; Massage; Middle Aged; Patch Tests; Plant Oils

Kumkum is a commonly used cosmetic in India, traditionally based on turmeric powder, and its ingredients can cause various types of dermatosis. We undertook a study to characterize kumkum-induced dermatitis clinically and to identify by patch testing the allergens involved. In total, 46 patients with kumkum-induced dermatitis (mean age of these cases 46.5 years; female : male ratio 1.8 : 1) were investigated. The forehead was the most commonly involved site (31/46), followed by the glabellar area (16/46), hair parting (6/46), abdomen (5/46), and neck (3/46). Pigmented contact dermatitis was seen in 35 patients (76.1%), and allergic contact dermatitis in 11 patients (23.9%). In total, 25 patients were patch tested. The commonest positive allergic reaction was to thimerosal (18/25, 72%), followed by gallate mix (12/25, 48%). Para-phenylenediamine, Kathon CG, benzotriazol, tert-butyl hydroquinone and parabens gave a reaction for one patient each (1/25, 4%). Patch testing with kumkum was positive in 7 of 13 patients tested.

Topics: Adult; Aged; Coloring Agents; Curcuma; Dermatitis, Allergic Contact; Female; Humans; India; Male; Middle Aged; Patch Tests

Topics: Allergens; Cosmetics; Curcumin; Dermatitis, Allergic Contact; Diagnosis, Differential; Eyelids; Facial Dermatoses; Female; Humans; Middle Aged; Patch Tests

Turmeric, a spice derived from the rhizome of the plant Curcuma longa, contains the chemical curcumin, which is responsible for turmeric's taste, color, and biologic properties. Curcumin is used as a spice in foods, as a treatment in traditional medicine, as a dye for fur, and as a component in nutritional supplements. A few cases of allergic contact dermatitis from curcumin have been reported. We report two cases of contact urticaria from curcumin. These cases are mediated by two different mechanisms of contact urticaria: nonimmunologic and immunologic (immunoglobulin-E mediated).

Topics: Adult; Coloring Agents; Curcumin; Dermatitis, Allergic Contact; Female; Humans; Urticaria

Topics: Allergens; Catheterization, Central Venous; Chlorhexidine; Curcumin; Dermatitis, Allergic Contact; Diagnosis, Differential; Disinfectants; Female; Humans; Male; Middle Aged; Orthopedic Procedures; Patch Tests; Preoperative Care

Topics: Allergens; Curcuma; Curcumin; Dermatitis, Allergic Contact; Diagnosis, Differential; Female; Humans; Middle Aged; Patch Tests; Sunscreening Agents

Topics: Coloring Agents; Curcumin; Dermatitis, Allergic Contact; Dermatitis, Occupational; Female; Flour; Food Coloring Agents; Humans; Middle Aged; Patch Tests

Topics: Adult; Curcumin; Dermatitis, Allergic Contact; Drug Eruptions; Drugs, Chinese Herbal; Female; Hand Dermatoses; Humans; Plant Oils