curcumin has been researched along with Ciliophora-Infections* in 2 studies
2 other study(ies) available for curcumin and Ciliophora-Infections
| Article | Year |
|---|---|
Outbreak of
Topics: Aeromonas hydrophila; Animals; Antioxidants; Catalase; Catfishes; Ciliophora Infections; Coinfection; Curcuma; Disease Outbreaks; Fish Diseases; Hemolysin Proteins; Hydrocortisone; Hymenostomatida; Immunoglobulin M; Interleukin-1beta; Iron-Dextran Complex; Oils, Volatile; RNA, Ribosomal, 16S; Superoxide Dismutase; Transferrins; Water | 2022 |
Combined antiparasitic and anti-inflammatory effects of the natural polyphenol curcumin on turbot scuticociliatosis.
The histiophagous scuticociliate Philasterides dicentrarchi is the aetiological agent of scuticociliatosis, a parasitic disease of farmed turbot. Curcumin, a polyphenol from Curcuma longa (turmeric), is known to have antioxidant and anti-inflammatory properties. We investigated the in vitro effects of curcumin on the growth of P. dicentrarchi and on the production of pro-inflammatory cytokines in turbot leucocytes activated by parasite cysteine proteases. At 100 μm, curcumin had a cytotoxic effect and completely inhibited the growth of the parasite. At 50 μm, curcumin inhibited the protease activity of the parasite and expression of genes encoding two virulence-associated proteases: leishmanolysin-like peptidase and cathepsin L-like. At concentrations between 25 and 50 μm, curcumin inhibited the expression of S-adenosyl-L-homocysteine hydrolase, an enzyme involved in the biosynthesis of the amino acids methionine and cysteine. At 100 μm, curcumin inhibited the expression of the cytokines tumour necrosis factor-alpha (TNF-α) and interleukin-1 beta (IL-1β) produced in turbot leucocytes activated by parasite proteases. Results show that curcumin has a dual effect on scuticociliatosis: an antiparasitic effect on the catabolism and anabolism of ciliate proteins, and an anti-inflammatory effect that inhibits the production of proinflammatory cytokines in the host. The present findings suggest the potential usefulness of this polyphenol in treating scuticociliatosis. Topics: Amino Acids; Animals; Antiprotozoal Agents; Ciliophora Infections; Curcumin; Fish Diseases; Flatfishes; Immunity, Innate; Oligohymenophorea; Peptide Hydrolases; Protozoan Proteins | 2017 |