curcumin and Carcinosarcoma

Numerous adverse effects limit the applicability of mitoxantrone for the treatment of drug-resistant tumors, including carcinosarcoma. Here, we estimated the additive effects of mitoxantrone and curcumin, a plant-derived biomolecule isolated from Curcuma longa, on the neoplastic and invasive potential of carcinosarcoma cells in vitro. Curcumin augmented the cytostatic, cytotoxic and anti-invasive effects of mitoxantrone on the Walker-256 cells. It also strengthened the inhibitory effects of mitoxantrone on the motility of drug-resistant Walker-256 cells that had retained viability after a long-term mitoxantrone/curcumin treatment. Thus, curcumin reduces the effective doses of mitoxantrone and augments its interference with the invasive potential of drug-resistant carcinosarcoma cells.

Topics: Animals; Antineoplastic Agents, Phytogenic; Carcinosarcoma; Cell Line, Tumor; Cell Movement; Cell Proliferation; Curcuma; Curcumin; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Drug Synergism; Mitoxantrone; Plant Extracts; Rats