curcumin and Altitude-Sickness

curcumin has been researched along with Altitude-Sickness* in 3 studies

Trials

1 trial(s) available for curcumin and Altitude-Sickness

ArticleYear
Tetrahydrocurcumin mitigates acute hypobaric hypoxia-induced cerebral oedema and inflammation through the NF-κB/VEGF/MMP-9 pathway.
    Phytotherapy research : PTR, 2020, Volume: 34, Issue:11

    Topics: Altitude Sickness; Animals; Brain Edema; Cell Hypoxia; Curcumin; Disease Models, Animal; Humans; Inflammation; Male; Mice; NF-kappa B; Vascular Endothelial Growth Factor A

2020

Other Studies

2 other study(ies) available for curcumin and Altitude-Sickness

ArticleYear
High altitude mediated skeletal muscle atrophy: Protective role of curcumin.
    Biochimie, 2019, Volume: 156

    Chronic hypobaric hypoxia induced muscle atrophy results in decreased physical performance at high altitude. Curcumin has been shown to have muscle sparing effects under cachectic conditions. However, the protective effects of curcumin under chronic hypobaric hypoxia have not been studied till now. Therefore, the present study aims at evaluating the effects of curcumin administration on muscle atrophy under chronic hypobaric hypoxia. Male Sprague Dawley rats were divided into four groups: Control (C)-normoxia exposed, Control Treated (CT)-normoxia exposed and administered with curcumin at a dose of 100 mg/kg body weight for 14 days, Hypoxia (H)-exposed to hypobaric hypoxia for 14 days and Hypoxia Treated (HT)-exposed to hypobaric hypoxia and administered with curcumin for 14 days. Oxidative stress, muscle protein degradation, proteolytic pathways, myosin heavy chain (MHC), CPK activity and muscle histology were performed in gastrocnemius muscle samples of the exposed rats. In addition, fatigue time on treadmill running was also evaluated to observe the effects of curcumin administration on physical performance of the rats. As previously shown, hypobaric hypoxia increased muscle protein degradation via upregulated calpain and ubiquitin-proteolytic pathways. An enhanced oxidative stress has been linked to upregulation of these pathways under hypoxic conditions. Curcumin administration resulted in reduced oxidative stress as well as reduced activity of the proteolytic pathways in HT group as compared to H group thereby resulting in reduced muscle protein degradation under hypobaric hypoxia. Histology of rat muscle revealed an increased number of muscle fibres in HT as compared to H group. Thus, increased number of muscle fibres and decreased muscle proteolysis following curcumin administration, lead to enhanced muscle mass under hypobaric hypoxia resulting in improved physical performance of the rats.

    Topics: Altitude; Altitude Sickness; Animals; Curcumin; Hypoxia; Male; Muscular Atrophy; Rats; Rats, Sprague-Dawley

2019
Chronic Hypobaric Hypoxia Induces Right Ventricular Hypertrophy and Apoptosis in Rats: Therapeutic Potential of Nanocurcumin in Improving Adaptation.
    High altitude medicine & biology, 2016, Volume: 17, Issue:4

    Topics: Acclimatization; Altitude Sickness; Animals; Antioxidants; Apoptosis; Curcumin; Hypertrophy, Right Ventricular; Male; Nanostructures; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Signal Transduction

2016