curacin-d has been researched along with Colonic-Neoplasms* in 1 studies
1 other study(ies) available for curacin-d and Colonic-Neoplasms
Article | Year |
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Malevamide D: isolation and structure determination of an isodolastatin H analogue from the marine cyanobacterium Symploca hydnoides.
Malevamide D (1), a highly cytotoxic peptide ester, and the known compound curacin D (5) were isolated from a Hawaiian sample of Symploca hydnoides. The structure of 1 was elucidated by spectroscopic analysis including NMR and high-resolution MS/MS. Partial stereochemical assignments of 1 were made by chiral HPLC analysis of acid and base hydrolysates. Malevamide D (1) demonstrated toxicity against P-388, A-549, HT-29, and MEL-28 cell lines in the subnanomolar range, while curacin D (5) was weakly cytotoxic. Malevamide D (1) is closely related to isodolastatin H (2), which was previously isolated in low yield from the sea hare Dolabella auricularia. A second Hawaiian sample of S. hydnoides yielded curacin D (5) along with the known dolastatin-10 analogue symplostatin-1 (3). Topics: Animals; Antineoplastic Agents, Phytogenic; Chromatography, High Pressure Liquid; Colonic Neoplasms; Cyanobacteria; Depsipeptides; Drug Screening Assays, Antitumor; Hawaii; Hydrolysis; Inhibitory Concentration 50; Leukemia P388; Lung Neoplasms; Melanoma; Mice; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Oligopeptides; Stereoisomerism; Thiazoles; Tumor Cells, Cultured | 2002 |