cuprizone has been researched along with Multiple Sclerosis in 241 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (0.41) | 18.2507 |
| 2000's | 19 (7.88) | 29.6817 |
| 2010's | 115 (47.72) | 24.3611 |
| 2020's | 106 (43.98) | 2.80 |
| Authors | Studies |
|---|---|
| Gan, G; He, Y; Hu, Y; Liu, X; Yang, J; Yao, Y; Zhang, A; Zhang, C; Zhu, X | 1 |
| Abdi, M; Abouzaripour, M; Fathi, F; Kashani, IR; Mohamed, W; Nekoonam, S; Pasbakhsh, P; Sadeghi, A; Shabani, M; Zendedel, A; Zibara, K | 1 |
| Deng, W; Gregory, M; Guo, F; Hull, VL; Kim, B; Martinez-Cerdeno, V; Prabhu, P; Wang, Y; Xu, J; Zhan, X; Zhang, S; Zhang, Y | 1 |
| An, J; Chai, Z; Chen, YY; Ding, ZB; Han, QX; He, Y; Ma, CG; Song, LJ; Wang, Q; Xiao, BG; Yin, JJ; Yu, JZ | 1 |
| Chen, C; Dong, X; Gong, L; Jiang, P; Li, S; Shao, Y; Shen, W; Sun, Z; Xie, Y; Zeng, L; Zhu, T | 1 |
| Casaccia, P; Castro, K; Dansu, DK; Gacias, M; Inbar, B; Magri, L; Marechal, D; Moyon, S; Patzig, J | 1 |
| Arasteh, J; Ebrahimi, MT; Kazemi, F; Sadeghirashed, S; Taheri, S | 1 |
| Anyaegbu, C; Bartlett, CA; Fitzgerald, M; Hellewell, SC; Lins, B; McGonigle, T; Papini, M; Toomey, LM; Warnock, A; Wright, AJ | 1 |
| Alexander, T; Li, X; Liao, BY; Song, SJ; Wang, LB; Wang, ZH; Wu, WC; Wu, XY; Xiao, D; Xiao, Y; Zhang, Y; Zhao, ZH | 1 |
| Correale, JD; de Olmos, S; Di Pietro, AA; Igaz, LM; Marcora, MS; Marder, M; Pasquini, JM; Pasquini, LA; Silva Pinto, P; Vence, M; Wies Mancini, VSB | 1 |
| Khalili, M; Kiasalari, Z; Pourmohammadi, S; Roghani, M | 1 |
| Barati, S; Kashani, IR; Tahmasebi, F | 2 |
| Coorssen, JR; Mahns, DA; Sen, MK; Shortland, PJ | 1 |
| Anada, K; Honda, T; Murayama, T; Nakamura, H; Tanaka, A; Yasue, M | 1 |
| Jeffries, MA; Mather, ML; Wood, TL | 1 |
| Abdelkader, NF; Ammar, RA; Kamal, MM; Mohamed, AF; Safar, MM | 1 |
| Begum, Z; Gurusamy, K; Raghunath, G; Sivanesan, S; Subramanian, V; Vijayaraghavan, R | 1 |
| Crocker, SJ; Hardy, CC; Ramasamy, R; Smith, PP | 1 |
| Almeida, L; Ambrósio, AF; Castelo-Branco, M; Dinis, J; Henriques, S; Madeira, MH; Martins, J; Palavra, F; Pereira, FC; Petrella, L; Reis, F; Santiago, R; Sereno, J; Viana, SD | 1 |
| Almuslehi, MSM; Coorssen, JR; Mahns, DA; Sen, MK; Shortland, PJ | 2 |
| Bitar, Y; Frintrop, L; Joost, S; Kaddatz, H; Kipp, M; Staffeld, A; Wittekindt, M | 1 |
| Han, MH; Hashemi, E; Kono, M; Mehta, SB; Moreno, M; Proia, R; Tsai, HC; Yeh, LH; Yoseph, E | 1 |
| Bakhshaei, F; Bordbar, E; Namazi, F; Nazifi, S | 1 |
| Khadivi, F; Mohammadi, A; Mojaverrostami, S; Zarini, D | 1 |
| El-Naga, RN; Michel, HE; Naeem, AG | 1 |
| Bohlen, CJ; Friedman, BA; Hanson, JE; Kaminker, JS; Kotova, N; Laufer, BI; Lee, SH; Newton, DF; Otero-García, M; Pandey, S; Rezzonico, MG; Shen, K; Shen, YA; Vito, ST; Wang, Y; Yuen, TJ | 1 |
| Haruta, C; Iwasa, K; Maruyama, K; Matsumoto, M; Shimizu, K; Takeda, N; Yamamoto, S; Yamashina, K; Yoshikawa, K | 1 |
| Esfandiary, E; Ghanadian, M; Ghasemi, N; Moradi, V; Rashidi, B | 1 |
| Amirizadeh, S; Hashemi, M; Kashani, IR; Majidpoor, J; Mojaverrostami, S; Mortezaee, K; Omidi, A; Pasbakhsh, P; Shabani, M; Zarini, D | 1 |
| Amichi, AG; Asghari, A; Baloochi, M; Ebrahimi, P; Ghanbarzehi, V; Hashemzahi, E; Holaso, AS; Honardar, M; Hosseini, F; Iravankhah, M; Marzban, M; Rustamzadeh, A; Sadafi, P; Shahraki, M; Terme, Y; Yarmohammadi, A | 1 |
| Kashani, IR; Kazemzadeh, S; Madadi, S; Pasbakhsh, P; Shiri, E; Tahmasebi, F; Zibara, K | 1 |
| Benito-Cuesta, I; Feng, Y; Harris, RA; Sarlus, H; Sun, JX; Wang, DJ; Wang, J; Wang, YM; Wang, YQ; Wu, S; Zhang, MZ; Zhao, XQ; Zhong, QY; Zhu, KY; Zou, ZF | 1 |
| Giesler, P; Kipp, M; Lubrich, C | 1 |
| Jalili, C; Parnow, A; Sohrabi, P | 1 |
| Chang, L; Eguchi, A; Hashimoto, K; Ma, L; Mori, C; Qu, Y; Shan, J; Wan, X; Wang, X; Yang, J; Yang, Y | 1 |
| Dégano, IR; Enrich-Bengoa, J; Manich, G; Perálvarez-Marín, A | 1 |
| Albrecht, S; Groll, K; Herold, M; Hucke, S; Klotz, L; Kuhlmann, T; Thomas, C; Wallhorn, L; Yilmaz, EN | 1 |
| Kipp, M; Leo, H | 1 |
| Sun, J; Wang, D; Wang, J; Wang, Y; Wu, S; Zhang, H | 1 |
| Huang, JK; Kouki, T; Ohno, N; Osanai, Y; Yamazaki, R | 1 |
| Hassanpour, S; Tashakori, A; Vazir, B | 1 |
| ELBini, I; Neili, NE | 1 |
| Akin, AT; Akyuz, E; Doğanyiğit, Z; Okan, A; Uçar, S; Yılmaz, S | 1 |
| Chen, H; Chen, K; Lei, C | 1 |
| Ahmed, KA; Ibrahim Fouad, G | 1 |
| Hoshino, Y; Li, Y; Miyake, S; Mizuno, M; Noto, D; Yoshikawa, S | 1 |
| Calabresi, PA; Dawson, T; Dawson, VL; Galleguillos, D; Garton, T; Gharagozloo, M; Hussein, O; Jank, L; Kumar, S; Lee, S; Mace, JW; Potluri, S; Siu, C; Smith, MD; Sotirchos, ES; Taylor, M | 1 |
| Hassanpour, S; Hesaraki, S; Khosravi-Nezhad, S | 1 |
| Borhani-Haghighi, M; Mohamadi, Y | 1 |
| Rowhanirad, S; Taherianfard, M | 1 |
| A Abd-Elmawla, M; A Ahmed, K; Abdelmonem, M; Gad, ES; Ghaiad, HR | 1 |
| Haruta, C; Iwasa, K; Maruyama, K; Yamagishi, A; Yamamoto, S; Yoshikawa, K | 1 |
| Al-Sharabi, N; Bø, L; Costea, DE; Fromreide, S; Kråkenes, T; Kvistad, CE; Mohamed-Ahmed, S; Mustafa, K; Wergeland, S | 1 |
| Bao, H; Dai, L; Li, H; Qian, M; Sun, X; Wang, L; Yin, M; Zhao, Y | 1 |
| Kipp, M | 1 |
| Damsbo, K; Elkjaer, ML; Illes, Z; Kingo, C; Waede, MR | 1 |
| Brendel, M; Chrzanowski, U; Eckenweber, F; Fabisch, KH; Hecher, K; Hochstrasser, T; Kipp, M; Rühling, S; Sacher, C; Schmitz, C | 1 |
| Beyer, C; Clarner, T; Fragoulis, A; Nellessen, A; Nyamoya, S; Slowik, A; Wruck, C; Zendedel, A | 1 |
| Beiter, RM; Chappell, MS; Dupree, JL; Farber, E; Fernández-Castañeda, A; Gaultier, A; Johanson, DM; Liskey, D; Onengut-Gumuscu, S; Overall, CC; Rosen, DA; Seki, SM | 1 |
| Bando, Y; Geisler, JG | 1 |
| Amiri, M; Barati, M; Golab, F; Houshmand, F; Ramezani-Sefidar, S; Sanadgol, N; Tabatabaei, M; Tanbakooie, S | 1 |
| Alizadeh, R; Aryanpour, R; Beigi Boroujeni, F; Madadi, S; Mortezaee, K; Pasbakhsh, P; Pirhajati, V; Ragerdi Kashani, I | 1 |
| Bao, XQ; Liu, H; Zhang, D; Zhang, Z; Zhao, Z | 1 |
| Almuslehi, MSM; Coorssen, JR; Gyengesi, E; Mahns, DA; Myers, SJ; Sen, MK; Shortland, PJ | 1 |
| An, J; Ding, ZB; Han, QX; He, Y; Ma, CG; Miao, Q; Sui, RX; Wang, Q; Xiao, BG; Yin, JJ | 1 |
| Beyer, C; Chrzanowski, U; Kaye, J; Kipp, M; Nyamoya, S; Schmitz, C; Steinle, J | 1 |
| Abo Taleb, HA; Alghamdi, BS | 1 |
| Ho, C; Kim, Y; Lee, D; Ro, EJ; Suh, H; Trapp, BD; Zhang, H | 1 |
| Behrangi, N; Brendel, M; Jiangshan, Z; Kaye, J; Kipp, M; Nedelcu, J; Reinbach, C; Riedler, P; Rominger, A; Schmitz, C | 1 |
| Boucneau, T; Cao, P; Chaumeil, MM; Guglielmetti, C; Larson, PEZ; Van der Linden, A | 1 |
| Christian, ND; Dorfman, AR; Facer, BD; Facer, JD; Ho, KS; Hotchkin, MT; Karl, M; Karlik, S; Merzliakov, M; Miller, RH; Miller, SD; Mortenson, MG; Robinson, AP; Stewart, MG; Titus, HE; Watt, RK; Zhang, JZ | 1 |
| Alkhayer, K; Bottiglieri, T; Clements, R; Fleming, S; Freeman, EJ; McDonough, J; Popescu, D; Shelestak, J; Singhal, NK; Sternbach, S; Wasek, B; Weaver, A | 1 |
| Behrangi, N; Frank, M; Joost, S; Kipp, M; Mann, T; Zhan, J | 1 |
| Chen, WJ; Ciric, B; Curtis, MT; Li, X; Rostami, A; Zhang, GX; Zhang, Y | 1 |
| Gingele, S; Gudi, V; Heckers, S; Henkel, F; Hümmert, MW; Moellenkamp, TM; Skripuletz, T; Stangel, M | 1 |
| Ganji, R; Ghasemi, N; Mardani, M; Razavi, S | 1 |
| Forsman, M; Kärkkäinen, AM; Kaye, J; Kopanitsa, MV; Koponen, J; Lehtimäki, KK; Merenlender-Wagner, A; Nurmi, A; Orbach, A; Pavlidi, P; Piiponniemi, TO; Shatillo, A; Suhonen, A; Sweeney, PJ | 1 |
| Abdel-Maged, AE; Awad, AS; Azab, SS; Gad, AM; Mohamed, EA; Rashed, LA | 1 |
| Chrzanowski, U; Hochstrasser, T; Kipp, M; Pröbstl, N; Reinbach, C; Schmitz, C; Stadler, MS | 1 |
| Alizadeh, Z; Borhani-Haghighi, M; Kashani, IR; Mehdi, A; Mojaverrostami, S; Nekoonam, S; Pasbakhsh, P; Pirhajati Mahabadi, V; Shiri, E; Zibara, K | 1 |
| Calzado, MA; Feliú, A; García-Martin, A; Garrido-Rodríguez, M; Guaza, C; Mestre, L; Muñoz, E; Navarrete, C | 1 |
| Kashani, IR; Madadi, S; Mojaverrostami, S; Nekoonam, S; Noori, L; Pasbakhsh, P; Salama, M; Shiri, E; Zarini, D; Zibara, K | 1 |
| AboTaleb, HA; Alghamdi, BS | 1 |
| Aliomrani, M; Eftekhari, SM; Mazloumfard, F; Mirian, M | 1 |
| Dashti, PS; Meknatkhah, S; Mousavi, MS; Rad, HS; Raminfard, S; Riazi, GH | 1 |
| Jin, L; Liu, C; Loers, G; Petridis, AK; Siebert, HC; Wang, Z; Zhang, N; Zhang, R; Zheng, X | 1 |
| Iwasa, K; Maruyama, K; Sakemoto, C; Shimizu, K; Yamamoto, S; Yoshikawa, K | 1 |
| Amor, S; Greiner, T; Joost, S; Kipp, M; Rohr, SO; Schmitz, C; Valk, PV | 1 |
| Aliomrani, M; Eftekhari, SM; Gholami, S; Mirian, M | 1 |
| Abouhamzeh, B; Fattahi, N; Khalilian, B; Madadi, S | 1 |
| Del Valle, E; García-Álvarez, E; Larráyoz, IM; Martínez-Pinilla, E; Navarro, A; Peláez, R; Rubio-Sardón, N; Tolivia, J | 1 |
| Alberro, A; Castillo-Triviño, T; Egimendia, A; Iparraguirre, L; Moles, L; Muñoz-Culla, M; Osorio-Querejeta, I; Otaegui, D; Ramos-Cabrer, P; Sepúlveda, L; Suárez, J | 1 |
| Caprariello, AV; Geurts, JJG; Joseph, JT; Luchicchi, A; Morgan, ML; Schenk, GJ; Stys, PK; Teo, W | 1 |
| Baumlin, N; Farine, H; Marrie, J; Martinic, MM; Mentzel, U; Pouzol, L; Sassi, A; Tunis, M; Vezzali, E | 1 |
| Baltan, S; Battapady, HD; Chan, R; Chen, J; Chomyk, AM; Dutta, R; Jawaid, SS; Kidd, GJ; Trapp, BD | 1 |
| Foreman, O; Friedman, BA; Kyauk, RV; Modrusan, Z; Ngu, H; Reichelt, M; Shen, K; Shen, YA; Sheng, M; Yuen, TJ | 1 |
| Azizzadeh Pormehr, L; Meknatkhah, S; Mousavi, MS; Riazi, GH; Sharif Dashti, P | 1 |
| Ahmad, I; Barsnes, H; Berven, FS; Bø, L; Guldbrandsen, A; Kroksveen, AC; Lereim, RR; Myhr, KM; Oveland, E; Wergeland, S | 1 |
| Aliomrani, M; Danesh-Seta, T; Emami, F; Ghaedi, K; Nasr-Esfahani, MH | 1 |
| Amor, S; Denecke, B; Fegg, FN; Frenz, J; Hochstrasser, T; Kaddatz, H; Kipp, M; Ponsaerts, P; Rühling, S; Zhan, J | 1 |
| Chen, X; Ding, S; Du, S; Guo, Y; Han, Y; Li, Y; Yan, Z; Zhu, Q | 1 |
| Elmieh, A; Sajedi, D; Shabani, R | 1 |
| Karaszewski, B; Klejbor, I; Klimaszewska-Łata, J; Moryś, J; Rutkowska, A; Shimshek, DR; Szutowicz, A; Velasco-Estevez, M | 1 |
| Ahmed, SM; de Vries, SI; Dubey, M; Geurts, JJG; Gold, SM; Gommerman, JL; Huitinga, I; Kole, MHP; Lee, DSW; Malpede, MA; Petersen, N; Ramaglia, V; Schenk, GJ | 1 |
| Bassani, C; Bedogni, F; Colombo, E; Comi, G; Di Dario, M; Dina, G; Farina, C; Fermo, I; Fredrickx, E; Martinelli, V; Newcombe, J; Quattrini, A; Taveggia, C; Triolo, D | 1 |
| Avloniti, M; Fortosi, A; Kyrargyri, V; Probert, L; Roufagalas, I; Thomaidou, D; Xingi, E | 1 |
| Andrei, C; Chirita, C; Ciotu, CI; Fischer, MJM; Mihai, DP; Negres, S; Nitulescu, GM; Olaru, OT; Seremet, OC; Ungurianu, A; Zanfirescu, A; Zbarcea, CE | 1 |
| Aliomrani, M; Eftekhari, SM; Safaei, HA | 1 |
| Dehpour, AR; Khaledi, E; Mohammadi-Farani, A; Noori, T; Shirooie, S; Sobarzo-Sanchez, E; Sureda, A; Yousefi-Manesh, H | 1 |
| Ahmad, I; Bø, L; Oveland, E; Wergeland, S | 1 |
| Bello, AM; Caprariello, AV; Chakka, SK; Dunn, SE; Kotra, LP; Muthuramu, CM; Sarswat, A; Stys, PK; Wasilewski, E | 1 |
| Bahn, E; Brück, W; Junker, A; Scheidt, U; Schultz, V; Stadelmann, C; van der Meer, F; Wrzos, C | 1 |
| Folts, CJ; Hogestyn, JM; Mayer-Pröschel, M; Noble, MD; Piester, G; Scott-Hewitt, NJ | 1 |
| Anne Becker, K; Chami, M; Fassbender, K; Gulbins, E; Halmer, R; Meier, C; Schnoeder, L; Walter, S | 1 |
| Chaumeil, MM; Didonna, A; Guglielmetti, C; Najac, C; Ronen, SM; Van der Linden, A | 1 |
| Fujimura, H; Hamaguchi, M; Itoh, N; Konishi, M; Koyama, Y; Kuroda, M; Maedera, N; Mochizuki, H; Muramatsu, R; Yamashita, T; Yoshida, M | 1 |
| Baron, W; de Jonge, JC; Hoekstra, D; Jonker, JW; Klappe, K; Kok, JW; Nies, V; Qin, J; Sikkema, AH; van der Bij, K | 1 |
| Bosetti, F; Hashimoto, M; Ishikawa, M; Iwasa, K; Maruyama, K; Yamamoto, S; Yamashina, K; Yoshikawa, K | 1 |
| Bando, Y; Nomura, T; Tanaka, T; Yoshida, S; You, H | 1 |
| Azarnia, M; Mashayekhi, F; Salehi, Z; Semnani, M | 1 |
| Cao, T; Chen, N; Fan, H; Jiang, Z; Lu, G; Wu, M; Yao, R; Yu, H; Zhang, Y | 1 |
| Fukasawa, K; Gotoh, M; Ishikawa, M; Iwasa, K; Murakami-Murofushi, K; Shimizu, Y; Yamamoto, S; Yoshikawa, K | 1 |
| Bakhshayesh, M; Marzban, M; Mousavizadeh, K; Torkaman-Boutorabi, A; Vakilzadeh, G; Vousooghi, N | 1 |
| Akahoshi, N; Araki, K; Araki, M; Gotoh, M; Ishii, S; Murakami-Murofushi, K; Neyama, H; Sumida, H; Tsukahara, R; Tsukahara, T; Ueda, H; Yamamoto, S; Yamamura, KI; Yanagida, K; Yoshikawa, K | 1 |
| Abrahám, H; Ács, P; Horváth, A; Komoly, S; Miseta, A; Pandur, E; Sipos, K; Varga, E | 1 |
| Alkhayer, K; Clements, R; Freeman, E; McDonough, J; Shelestak, J; Singhal, NK | 1 |
| Amor, S; Bazinet, RP; Hildebrand, KD; Kipp, M; Nyamoya, SD; Trépanier, MO | 1 |
| Biton, I; Chappell-Maor, L; David, E; Eilam-Altstadter, R; Engel, A; Gross, M; Grozovski, J; Jung, S; Kim, JS; Levy-Efrati, L; Rotkopf, R; Shemer, A; Wolf, Y | 1 |
| Caprariello, AV; Dunn, JF; Hoghooghi, V; Koebel, A; Kotra, LP; Morgan, ML; Ousman, SS; Plemel, JR; Rogers, JA; Stys, PK; Tsutsui, S; Wee Yong, V | 1 |
| Albrecht, S; Budde, T; Cerina, M; Daldrup, T; Delank, A; Göbel, K; Gorji, A; Graebenitz, S; Herrmann, AM; Kleinschnitz, C; Kuhlmann, T; Meuth, P; Meuth, SG; Narayanan, V; Pape, HC; Seidenbecher, T; Speckmann, EJ; Wiendl, H | 1 |
| Caggiano, AO; Colburn, RW; Cui, C; Mullin, AP; Parry, TJ; Pavlopoulos, E; Wang, J | 1 |
| Becker, B; Beyer, C; Hustadt, F; Kipp, M; Leopold, P; Michel, A; Nyamoya, S; Schmitz, C | 1 |
| Nystad, AE; Torkildsen, Ø; Wergeland, S | 1 |
| Fang, Z; Huang, Q; Kong, J; Xu, H; Yang, L; Zhang, J | 1 |
| Acs, P; Alcaraz, N; Barbosa, EGV; Baumbach, J; Elkjaer, ML; Gallyas, F; Hegedus, Z; Illes, Z; Larsen, MR; Lassmann, H; Martin, NA; Molnar, T; Molnar, V; Nawrocki, A; Nielsen, HH; Palkovits, M; Sejbaek, T; Sellebjerg, F; Svenningsen, AF; Thygesen, EK | 1 |
| Azizi, M; Borhani-Haghighi, M; Kashani, IR; Madadi, S; Nekoonam, S; Noorzehi, G; Pasbakhsh, P; Tahmasebi, F | 1 |
| Clements, RJ; Freeman, EJ; Huang, H; McDonough, J; Popescu, DC; Shriver, L; Singhal, NK | 1 |
| Baharvand, H; Deng, W; Javan, M; Mokhtarzadeh Khanghahi, A; Satarian, L | 1 |
| Amor, S; Hochstrasser, T; Jiangshan, Z; Kipp, M; Kramer, F; Rühling, S; Schmitz, C; Schmutz, S | 1 |
| Baron, W; de Jong, CGHM; Gabius, HJ; Pinxterhuis, TH; Stancic, M; van Dam, AM; van Horssen, J | 1 |
| De Nicola, AF; Garay, LI; Gonzalez Deniselle, MC; Leicaj, ML; Lima, A; Pasquini, JM; Pasquini, LA | 1 |
| Cao, L; Ma, CG; Miao, Q; Song, LJ; Sui, RX; Wang, J; Wang, Q; Xiao, BG; Xiao, W; Yu, JW | 1 |
| Jinno, S; Ohgomori, T | 1 |
| Nissen, JC; Pretory, A; Thompson, KK; Tsirka, SE | 1 |
| Gu, Y; Huang, J; Huang, R; Jin, M; Li, Q; Wan, B; Xu, X; Zhang, Y | 1 |
| Barati, S; Kashani, IR; Madadi, S; Mortezaee, K; Pasbakhsh, P; Tahmasebi, F | 1 |
| Bartenstein, P; Beyer, C; Brendel, M; Daerr, M; Deussing, M; Focke, C; Hoornaert, C; Kipp, M; Nack, A; Nedelcu, J; Nyamoya, S; Ponsaerts, P; Rominger, A; Schmitz, C | 1 |
| Baumgartner, L; de Vries, R; Galeno, G; Good, A; Good, N; Hlavica, M; Hooijmans, CR; Ineichen, BV; Jung, T; Schneider, MP; Schuler, FAF | 1 |
| Brendel, MB; Melendez-Vasquez, CV; Urbanski, MM | 1 |
| Gadhave, DG; Kokare, CR | 1 |
| Glazacheva, VY; Khodanovich, MY; Krutenkova, EP; Pan, ES; Pishchelko, AO; Trusov, VB; Yarnykh, VL | 1 |
| Amor, S; Beyer, C; Bhattarai, S; Chrzanowski, U; Clarner, T; Denecke, B; Fallier-Becker, P; Hochstrasser, T; Horn-Bochtler, A; Kipp, M; Nyamoya, S; Rohr, SO; Scheld, M; Schmitz, C; Schweiger, F | 1 |
| Borhani-Haghighi, M; Kashani, IR; Largani, SHH; Mahabadi, VP; Nekoonam, S; Pasbakhsh, P; Shiri, E; Zendehdel, A | 1 |
| Itoh, N; Itoh, Y; Jang, E; Matsukawa, MA; Ren, E; Suen, TT; Tassoni, A; Tse, V; Voskuhl, RR | 1 |
| Connor, B; Kivell, B; La Flamme, AC; McCaughey-Chapman, A; Templeton, N | 1 |
| Bullitta, S; Buttari, F; Centonze, D; De Vito, F; Fresegna, D; Gentile, A; Guadalupi, L; Mandolesi, G; Musella, A; Rizzo, FR; Stampanoni Bassi, M; Vanni, V; Viscomi, MT | 1 |
| Fallier-Becker, P; Frommer-Kaestle, G; Pfeiffer, F | 1 |
| Dong, L; Huang, Q; Liao, Y; Sun, L; Tang, Y; Wu, Y | 1 |
| Atkinson, KC; Drew, A; Harris, NG; Hasselmann, JPC; Katzenellenbogen, JA; Kim, SH; Lee, JB; Obenaus, A; Soto, J; Tiwari-Woodruff, SK | 1 |
| Hadiyan, SP; Navidi, R; Salehi, Z | 1 |
| Atlasi, N; Baazm, M; Hedayatpour, A; Kafami, L; Mamoudi, R; Pasbakhsh, P; Pirhajati Mahabadi, V; Ragerdi Kashani, I | 1 |
| Bai, B; Baranzini, SE; Chang, A; Chomyk, AM; Deckard, SA; Doud, MK; Dutta, R; Edberg, DD; Fox, RJ; Li, M; Macklin, WB; Ribaudo, MV; Staugaitis, SM; Trapp, BD | 1 |
| Atlasi, MA; Azami Tameh, A; Beyer, C; Clarner, T; Hassanzadeh, G; Naderian, H | 1 |
| Rawji, KS; Yong, VW | 1 |
| Chew, LJ; Fauveau, M; Gallo, V; Hong, E; Kerninon, C; Klopstein, A; Moll, NM; Nait Oumesmar, B; Naruse, M; Seilhean, D; Tepavcevic, V | 1 |
| Albrecht, S; Antel J, J; Brück, W; Cui, QL; Hagemeier, K; Hoffmann, E; Hucke, S; Klassen, E; Klotz, L; Kuhlmann, T; Lürbke, A; Preisner, A | 1 |
| Ahmad, I; Deshmukh, VA; Gage, FH; Green, CC; Kerman, B; Kim, HJ; Kondo, T; Lairson, LL; Lawson, BR; Lyssiotis, CA; Padmanabhan, K; Schultz, PG; Swoboda, JG; Tardif, V; Theofilopoulos, AN | 1 |
| Basoglu, H; Boylu, NT; Kose, H | 1 |
| Buchpiguel, CA; Copray, S; de Paula Faria, D; de Vries, EF; Dierckx, RA; Sijbesma, JW | 1 |
| Aralica, G; Brcic, L; Drmic, D; Holjevac, J; Klicek, R; Kokot, A; Kolenc, D; Patrlj, L; Radic, B; Rucman, R; Seiwerth, S; Sever, M; Sikiric, P; Suran, J; Turudic, T | 1 |
| Bauer, J; Binder, CJ; Bradl, M; Haider, L; Hametner, S; Lassmann, H; Liblau, RS; Mahad, D; Probert, L; Schuh, C; Smith, KJ; Van Dam, AM; Wimmer, I | 1 |
| Akbari, M; Beyer, C; Eramsadati, MK; Hassanzadeh, G; Kashani, IR; Kipp, M; Mohseni, A; Rafiee, K; Rajabi, Z; Zendedel, A | 1 |
| Boucher, C; El-Etr, M; Ghoumari, AM; Kumar, N; Liere, P; Pianos, A; Rame, M; Schumacher, M; Sitruk-Ware, R | 1 |
| Awaji, T; Iwasa, K; Maruyama, K; Suzuki, S; Takahashi, M; Yagishita, S; Yamamoto, S; Yoshikawa, K | 1 |
| Goings, GE; Miller, SD; Robinson, AP; Rodgers, JM | 1 |
| Berneman, Z; Guglielmetti, C; Ponsaerts, P; Praet, J; Van der Linden, A | 1 |
| Coorssen, JR; Gopinath, S; Myers, SJ; Partridge, MA | 1 |
| Bando, Y; Bochimoto, H; Murakami, K; Nomura, T; Tanaka, T; Watanabe, T; Yoshida, S | 1 |
| Anastasiadou, S; Knöll, B; Liebenehm, S; Meyer zu Reckendorf, C; Moepps, B; Nordheim, A; Sinske, D | 1 |
| El-Akabawy, G; Rashed, LA | 1 |
| Boilesen, SN; LeSueur-Maluf, L; Medalha, CC; Monteiro de Castro, G; Prado de França Carvalho, C; Serra-de-Oliveira, N; Spadari, RC; Zollner, Rde L | 1 |
| Guglielmetti, C; Kara, F; Orije, J; Ponsaerts, P; Praet, J; Van der Linden, A; Verhoye, M | 1 |
| Abakumova, TO; Antonova, OM; Chekhonin, VP; Gubskii, IL; Kekelidze, ZI; Kuz'kina, AA; Nukolova, NV; Pozdeeva, DA; Shepeleva, II; Zharova, ME; Zharova, MV | 1 |
| Acs, P; Bognar, Z; Fekete, K; Gallyas, F; Illes, Z; Kvell, K; Solti, I; Szanto, A; Talaber, G; Veto, S; Zalan, P | 1 |
| Baumgärtner, W; Berner, G; Gingele, S; Gudi, V; Hansmann, F; Hoffmann, A; Jacobsen, K; Jungwirth, N; Prajeeth, CK; Salinas Tejedor, L; Skripuletz, T; Stangel, M | 1 |
| Dreyfus, CF; Eyo, UB; Liu, J; Murugan, M; Tian, D; Wang, W; Wu, LJ | 1 |
| Hadiyan, SP; Mashayekhi, F; Salehi, Z | 1 |
| Amor, S; Becker, B; Beyer, C; Große-Veldmann, R; Kipp, M; van der Valk, P | 1 |
| de Oliveira, WH; Nunes, AK; Peixoto, CA; Rapôso, C; Thomé, R; Tovar-Moll, F; Verinaud, L | 1 |
| El-Sawalhi, MM; Ghaiad, HR; Nooh, MM; Shaheen, AA | 1 |
| Beyer, C; Clarner, T; Hochstrasser, T; Höflich, KM; Kipp, M; Nyamoya, S; Schmitz, C | 1 |
| Beyer, C; Clarner, T; Denecke, B; Draheim, T; Fragoulis, A; Kensler, TW; Kipp, M; Liessem, A; Scheld, M; Weißflog, M; Wilms, F; Wruck, CJ; Zendedel, A | 1 |
| Amor, S; Hochstrasser, T; Kipp, M; Nyamoya, S | 1 |
| Barrette, B; Berghoff, SA; Böhler, C; Dibaj, P; Edgar, JM; Gerndt, N; Hosang, L; Liebetanz, D; Möbius, W; Odoardi, F; Ruhwedel, T; Saher, G; Stassart, R; Stumpf, SK; Winchenbach, J | 1 |
| Binder, DK; Hasselmann, JPC; Khalaj, AJ; Lapato, AS; Szu, JI; Tiwari-Woodruff, SK | 1 |
| Avila, R; Caporoso, J; Huang, H; Leeper, TC; Manandhar, E; Medicetty, S; Modarelli, DA; Shriver, LP; Taraboletti, A; Walker, T | 1 |
| Bollyky, PL; Han, MH; Kuipers, HF; Palmer, TD; Steinman, L; van Horssen, J; Yoon, J | 1 |
| Grund, LZ; Komegae, EN; Lima, C; Lopes-Ferreira, M; Souza, TA | 1 |
| Chew, LJ; Schmitz, T | 1 |
| Gilmore, W; Matsushima, GK; Taylor, LC | 1 |
| Baumgartner, W; Beyer, C; Braun, A; Clarner, T; Hieble, A; Johann, S; Kipp, M; Norkute, A | 1 |
| Gudi, V; Kotsiari, A; Koutsoudaki, PN; Moharregh-Khiabani, D; Skripuletz, T; Skuljec, J; Stangel, M; Trebst, C | 1 |
| Beyer, C; Clarner, T; Copray, S; Dang, J; Kipp, M | 1 |
| Brinkmann, BG; Brück, W; Glaser, R; Guedes, RC; Jürgens, T; Klinker, F; Liebetanz, D; Merkler, D; Paulus, W; Sereda, MW; Stadelmann-Nessler, C | 1 |
| Casaccia, P; Dietz, K; He, Y; Howell, O; Kim, JY; Reynolds, R; Shen, S | 1 |
| Belkadi, A; Choi, K; Cotleur, AC; Darnall, L; Drescher, C; He, T; Hu, T; Lane, TE; Liu, L; Miller, RH; Padovani-Claudio, D; Ransohoff, RM | 1 |
| Acs, P; Bauer, J; Berente, Z; Borgulya, G; Gallyas, F; Illes, Z; Komoly, S; Lassmann, H; Setalo, G; Sumegi, B; Veto, S | 1 |
| Dorsey, D; Klein, RS; McCandless, EE; Patel, JR | 1 |
| Beyer, C; Buschmann, JP; Clarner, T; Kipp, M | 1 |
| Amor, S; Berger, K; Beyer, C; Clarner, T; Kipp, M; Krauspe, B; Norkus, A; van der Valk, P | 1 |
| Bosetti, F; Palumbo, S; Parente, L; Toscano, CD; Weigert, R | 1 |
| Bosetti, F; Palumbo, S; Toscano, CD; Yoshikawa, K | 1 |
| Amor, S; Baumgartner, W; Beyer, C; Clarner, T; Denecke, B; Dreher, W; Gan, L; Gingele, S; Godbout, R; Kipp, M; Pfeifenbring, S; Pott, F; Siffrin, V; van der Valk, P; Zipp, F | 1 |
| Amor, S; Beyer, C; Clarner, T; Gingele, S; Kipp, M; Pott, F; van der Valk, P | 1 |
| Boretius, S; Brück, W; Dallenga, T; Escher, A; Frahm, J; Nessler, S; Stadelmann, C; Tammer, R; Wrzos, C | 1 |
| Baumgärtner, W; Beineke, A; Hansmann, F; Herder, V; Rohn, K; Schaudien, D; Stangel, M | 1 |
| Bordet, T; Bourbon, C; Cayre, M; Durbec, P; Khaldi, J; Magalon, K; Pruss, RM; Robles, I; Tardif, G; Viola, A; Zimmer, C | 1 |
| Kong, J; Schroedter, I; Vrontakis, M; Yu, W; Zhang, L | 1 |
| Awad, H; Berger, K; Beyer, C; Buschmann, JP; Clarner, T; Kipp, M | 1 |
| Amor, S; Berger, K; Beyer, C; Clarner, T; Denecke, B; Diederichs, F; Gan, L; Kipp, M; van der Valk, P | 1 |
| Gulen, MF; Kang, Z; Li, X; Liu, L; Ouyang, W; Ransohoff, RM; Spangler, R; Spear, C; Veenstra, M; Wang, C | 1 |
| Cruz-Höfling, MA; Luna, RL; Nunes, AK; Peixoto, CA; Rapôso, C | 1 |
| Bø, L; Myhr, KM; Mørk, SJ; Torkildsen, Ø; Wergeland, S | 1 |
| Acs, P; Kalman, B | 1 |
| Acs, P; Komoly, S | 1 |
| Azari, MF; Boyle, K; Cheema, SS; Gonzales, MF; Kilpatrick, TJ; Marriott, M; Minichiello, RA; Nicolaou, A; Petratos, S; Profyris, C; Shipham, KA | 1 |
| Alberta, JA; Arnett, HA; Fancy, SP; Franklin, RJ; Kaing, S; Plant, SR; Raine, CS; Rowitch, DH; Stiles, CD; Zhao, C | 1 |
| Komoly, S | 1 |
| Arnett, HA; Bergstralh, DT; Carson, MJ; Iovanna, JL; McMahon, EJ; Miller, SD; Plant, SR; Thrash, JC; Ting, JP; Vasseur, S; Wang, Y | 1 |
| Dupree, JL; Harding, HP; Kemper, A; Lin, W; Popko, B; Ron, D | 1 |
| Armstrong, RC; Flint, NC; Le, TQ; Vana, AC; Zhou, YX | 1 |
| Liebetanz, D; Merkler, D | 1 |
| Akita, M; Asou, H; Fukutake, M; Ishige, A; Sakai, R; Seiwa, C; Takeda, S; Tanaka, K; Ueki, T; Watanabe, K; Yagi, T; Yamamoto, M | 1 |
| Baumgärtner, W; Heine, S; Lienenklaus, S; Lindner, M; Stangel, M; Trebst, C; Weiss, S | 1 |
| Binder, M; Cate, HS; Egan, GF; Fang, K; Kemper, D; Kilpatrick, TJ; Marriott, M; Quick, MJ; Wang, HX; Wu, QZ; Yang, Q | 1 |
| Brunborg, LA; Bø, L; Myhr, KM; Torkildsen, O | 1 |
| Blakemore, WF; Irvine, KA | 1 |
| Ludwin, SK | 1 |
| Biswas, S; Emerson, MR; LeVine, SM | 1 |
18 review(s) available for cuprizone and Multiple Sclerosis
| Article | Year |
|---|---|
The roles of microglia and astrocytes in phagocytosis and myelination: Insights from the cuprizone model of multiple sclerosis.
Topics: Animals; Astrocytes; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mice; Mice, Inbred C57BL; Microglia; Multiple Sclerosis; Myelin Sheath; Phagocytosis | 2022 |
The mechanistic target of rapamycin as a regulator of metabolic function in oligodendroglia during remyelination.
Topics: Animals; Cuprizone; Demyelinating Diseases; Humans; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Oligodendroglia; Remyelination; Sirolimus; TOR Serine-Threonine Kinases | 2022 |
Disease-associated oligodendrocyte responses across neurodegenerative diseases.
Topics: Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Humans; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Neurodegenerative Diseases; Oligodendroglia | 2022 |
Stem cell therapy for cuprizone model of multiple sclerosis focusing on the effectiveness of different injection methods and cell labeling.
Topics: Animals; Brain; Cell- and Tissue-Based Therapy; Cuprizone; Disease Models, Animal; Mice; Mice, Inbred C57BL; Multiple Sclerosis | 2022 |
Motor Behavioral Deficits in the Cuprizone Model: Validity of the Rotarod Test Paradigm.
Topics: Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Sheath; Remyelination; Rotarod Performance Test | 2022 |
Remyelination in Multiple Sclerosis: Findings in the Cuprizone Model.
Topics: Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Humans; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Sheath; Remyelination; Reproducibility of Results | 2022 |
Astrocytes: Lessons Learned from the Cuprizone Model.
Topics: Animals; Astrocytes; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Humans; Mice; Mice, Inbred C57BL; Microglia; Multiple Sclerosis; Myelin Sheath; Oligodendroglia | 2023 |
The Cuprizone Model: Dos and Do Nots.
Topics: Animals; Body Weight; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Gene Expression Regulation; Multiple Sclerosis | 2020 |
Revisiting the Pathoetiology of Multiple Sclerosis: Has the Tail Been Wagging the Mouse?
Topics: Animals; Autoimmunity; Central Nervous System; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Disease Progression; Encephalomyelitis, Autoimmune, Experimental; Humans; Mice; Multiple Sclerosis; Oligodendroglia | 2020 |
Remyelination promoting therapies in multiple sclerosis animal models: a systematic review and meta-analysis.
Topics: Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Ethidium; Eye Proteins; Lysophosphatidylcholines; Mice; Multiple Sclerosis; Myelin Sheath; Nerve Growth Factors; Oligodendrocyte Precursor Cells; Oligodendroglia; Platelet-Derived Growth Factor; Remyelination; Serpins; Tocopherols | 2019 |
The benefits and detriments of macrophages/microglia in models of multiple sclerosis.
Topics: Animals; Cell Movement; Central Nervous System; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Humans; Immunologic Factors; Lysophosphatidylcholines; Macrophages; Microglia; Multiple Sclerosis; Neurons; Oligodendroglia; T-Lymphocytes | 2013 |
Cellular and molecular neuropathology of the cuprizone mouse model: clinical relevance for multiple sclerosis.
Topics: Animals; Brain; Cuprizone; Disease Models, Animal; Mice; Multiple Sclerosis; Myelin Sheath; Neuroglia; Neurons; Oxidative Stress | 2014 |
Multiple sclerosis animal models: a clinical and histopathological perspective.
Topics: Animals; Axons; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Disease Progression; Encephalomyelitis, Autoimmune, Experimental; Humans; Leukoencephalopathies; Multiple Sclerosis; Neurodegenerative Diseases; Spinal Cord | 2017 |
Cytokines and myelination in the central nervous system.
Topics: Alzheimer Disease; Animals; Brain; Brain Ischemia; Central Nervous System; Cuprizone; Cytokines; Demyelinating Diseases; Encephalomyelitis, Autoimmune, Experimental; Humans; Hyperoxia; Infant, Newborn; Inflammation; Multiple Sclerosis; Myelin Sheath; Schizophrenia; Signal Transduction | 2008 |
The cuprizone animal model: new insights into an old story.
Topics: Animals; Cuprizone; Disease Models, Animal; Multiple Sclerosis; Myelin Sheath | 2009 |
Brain lipid binding protein (FABP7) as modulator of astrocyte function.
Topics: Animals; Astrocytes; Carrier Proteins; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Fatty Acid-Binding Protein 7; Fatty Acid-Binding Proteins; Humans; Multiple Sclerosis; Myelin Sheath; Nerve Tissue Proteins; Signal Transduction; Tumor Suppressor Proteins | 2011 |
The cuprizone model for demyelination.
Topics: Animals; Chelating Agents; Cuprizone; Disease Models, Animal; Mice; Multiple Sclerosis; Myelin Sheath | 2008 |
Central nervous system remyelination: studies in chronically damaged tissue.
Topics: Animals; Cell Division; Central Nervous System; Cuprizone; Demyelinating Diseases; Mice; Multiple Sclerosis; Myelin Sheath; Nerve Degeneration; Nerve Regeneration; Oligodendroglia; Phagocytosis; Rats | 1994 |
1 trial(s) available for cuprizone and Multiple Sclerosis
| Article | Year |
|---|---|
The neuroprotective potential of mesenchymal stem cells from bone marrow and human exfoliated deciduous teeth in a murine model of demyelination.
Topics: Animals; Bone Marrow; Corpus Callosum; Cuprizone; Disease Models, Animal; Female; Humans; Inflammation; Mesenchymal Stem Cells; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Neuroprotection; Oligodendroglia; Tooth, Deciduous | 2023 |
222 other study(ies) available for cuprizone and Multiple Sclerosis
| Article | Year |
|---|---|
Valproic acid suppresses cuprizone-induced hippocampal demyelination and anxiety-like behavior by promoting cholesterol biosynthesis.
Topics: Animals; Anxiety; Cholesterol; Cuprizone; Demyelinating Diseases; Hippocampus; Male; Mice; Mice, Inbred C57BL; Monoamine Oxidase Inhibitors; Multiple Sclerosis; Neuroprotective Agents; Psychomotor Performance; Valproic Acid | 2021 |
Metformin Therapy Attenuates Pro-inflammatory Microglia by Inhibiting NF-κB in Cuprizone Demyelinating Mouse Model of Multiple Sclerosis.
Topics: Animals; Blotting, Western; Cuprizone; Disease Models, Animal; Male; Metformin; Mice; Mice, Inbred C57BL; Microglia; Multiple Sclerosis; Neuroinflammatory Diseases; Neuroprotective Agents; NF-kappa B; Transcriptome | 2021 |
PARP1-mediated PARylation activity is essential for oligodendroglial differentiation and CNS myelination.
Topics: Animals; Cell Differentiation; Cell Survival; Central Nervous System; Cuprizone; Female; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Multiple Sclerosis; Myelin Sheath; Nerve Tissue Proteins; Oligodendrocyte Precursor Cells; Oligodendrocyte Transcription Factor 2; Oligodendroglia; Poly (ADP-Ribose) Polymerase-1; Poly ADP Ribosylation; Remyelination; Repressor Proteins; RNA | 2021 |
Temporal and spatial evolution of various functional neurons during demyelination induced by cuprizone.
Topics: Animals; Astrocytes; Axons; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Glutamic Acid; Mice; Monoamine Oxidase Inhibitors; Multiple Sclerosis; Myelin Sheath; Neurons | 2021 |
TRPM2 contributes to neuroinflammation and cognitive deficits in a cuprizone-induced multiple sclerosis model via NLRP3 inflammasome.
Topics: Animals; Cognitive Dysfunction; Cuprizone; Disease Models, Animal; Inflammasomes; Mice; Mice, Knockout; Multiple Sclerosis; Neuroinflammatory Diseases; NLR Family, Pyrin Domain-Containing 3 Protein; Reactive Oxygen Species; TRPM Cation Channels | 2021 |
N-myc downstream regulated family member 1 (NDRG1) is enriched in myelinating oligodendrocytes and impacts myelin degradation in response to demyelination.
Topics: Animals; Cuprizone; Family; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Sheath; Oligodendroglia | 2022 |
A novel probiotic strain exerts therapeutic effects on mouse model of multiple sclerosis by altering the expression of inflammasome and IDO genes and modulation of T helper cytokine profile.
Topics: Animals; Cuprizone; Cytokines; Demyelinating Diseases; Disease Models, Animal; Inflammasomes; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Probiotics; T-Lymphocytes, Helper-Inducer | 2022 |
Cuprizone feed formulation influences the extent of demyelinating disease pathology.
Topics: Animal Feed; Animals; Astrocytes; Body Weight; Chelating Agents; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; DNA Damage; Gliosis; Inflammation; Male; Mice; Mice, Inbred C57BL; Microglia; Multiple Sclerosis; Oligodendroglia; Reproducibility of Results | 2021 |
Encapsulation of bryostatin-1 by targeted exosomes enhances remyelination and neuroprotection effects in the cuprizone-induced demyelinating animal model of multiple sclerosis.
Topics: Animals; Bryostatins; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Exosomes; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Neural Stem Cells; Neuroprotection; Neuroprotective Agents; Oligodendroglia; Remyelination | 2022 |
Colony-stimulating factor-1 receptor inhibition attenuates microgliosis and myelin loss but exacerbates neurodegeneration in the chronic cuprizone model.
Topics: Animals; Colony-Stimulating Factors; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mice; Mice, Inbred C57BL; Microglia; Multiple Sclerosis; Myelin Sheath | 2022 |
Paeonol Ameliorates Cuprizone-Induced Hippocampal Demyelination and Cognitive Deficits through Inhibition of Oxidative and Inflammatory Events.
Topics: Acetophenones; Animals; Cognition; Cuprizone; Disease Models, Animal; Hippocampus; Inflammation; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Oxidative Stress | 2022 |
The effects of mesenchymal stem cells transplantation on A1 neurotoxic reactive astrocyte and demyelination in the cuprizone model.
Topics: Animals; Astrocytes; Biomarkers; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Male; Mesenchymal Stem Cells; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Oligodendroglia | 2022 |
Ceramide kinase knockout ameliorates multiple sclerosis-like behaviors and demyelination in cuprizone-treated mice.
Topics: Age Factors; Animals; Behavior, Animal; Brain; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Female; Male; Mice, Inbred C57BL; Mice, Knockout; Multiple Sclerosis; Oligodendroglia; Phosphotransferases (Alcohol Group Acceptor); Proteins; Tail | 2022 |
Neuroprotective effect of liraglutide in an experimental mouse model of multiple sclerosis: role of AMPK/SIRT1 signaling and NLRP3 inflammasome.
Topics: AMP-Activated Protein Kinases; Animals; Beclin-1; Cuprizone; Disease Models, Animal; Inflammasomes; Liraglutide; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Neuroprotective Agents; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein; Sirtuin 1; Toll-Like Receptor 4 | 2022 |
Efficacy of different intensity of aquatic exercise in enhancing remyelination and neuronal plasticity using cuprizone model in male Wistar rats.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Glial Fibrillary Acidic Protein; Male; Methylprednisolone; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Basic Protein; Neuronal Plasticity; Neuroprotective Agents; Rats; Rats, Wistar; Remyelination | 2022 |
Cuprizone-mediated demyelination reversibly degrades voiding behavior in mice while sparing brainstem reflex.
Topics: Animals; Brain Stem; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Humans; Inflammation; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Sheath; Oligodendroglia; Quality of Life; Reflex; Urination | 2022 |
Defining milestones for the study of remyelination using the cuprizone mouse model: How early is early?
Topics: Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Humans; Male; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Sheath; Remyelination | 2022 |
Histological and Top-Down Proteomic Analyses of the Visual Pathway in the Cuprizone Demyelination Model.
Topics: Animals; Cuprizone; Disease Models, Animal; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Proteins; Proteomics; Visual Pathways | 2022 |
Different Methods for Evaluating Microglial Activation Using Anti-Ionized Calcium-Binding Adaptor Protein-1 Immunohistochemistry in the Cuprizone Model.
Topics: Animals; Astrocytes; Calcium; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Immunohistochemistry; Mice; Mice, Inbred C57BL; Microglia; Multiple Sclerosis | 2022 |
Visualizing Sphingosine-1-Phosphate Receptor 1(S1P
Topics: Animals; beta-Arrestins; Central Nervous System; Cuprizone; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Oligodendroglia; Receptors, Lysosphingolipid; Remyelination; Sphingosine-1-Phosphate Receptors | 2023 |
The effect of Urtica dioica extract on oxidative stress, heat shock proteins, and brain histopathology in multiple sclerosis model.
Topics: Animals; Antioxidants; Brain; Cuprizone; Disease Models, Animal; Heat-Shock Proteins; Male; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Oxidative Stress; Plant Extracts; Urtica dioica | 2022 |
Combination effects of mesenchymal stem cells transplantation and anodal transcranial direct current stimulation on a cuprizone-induced mouse model of multiple sclerosis.
Topics: Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mesenchymal Stem Cells; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Transcranial Direct Current Stimulation | 2022 |
Nebivolol elicits a neuroprotective effect in the cuprizone model of multiple sclerosis in mice: emphasis on M1/M2 polarization and inhibition of NLRP3 inflammasome activation.
Topics: Animals; Cell Polarity; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Inflammasomes; Macrophages; Mice; Mice, Inbred C57BL; Microglia; Multiple Sclerosis; Nebivolol; Neuroprotective Agents; NLR Family, Pyrin Domain-Containing 3 Protein | 2022 |
Suppressive Effect of Fruiting Bodies of Medicinal Mushrooms on Demyelination and Motor Dysfunction in a Cuprizone-Induced Multiple Sclerosis Mouse Model.
Topics: Agaricales; Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Fruiting Bodies, Fungal; Mice; Mice, Inbred C57BL; Multiple Sclerosis | 2022 |
The effect of Zingiber Officinale Extract on Preventing Demyelination of Corpus Callosum in a Rat Model of Multiple Sclerosis
Topics: Animals; Anti-Inflammatory Agents; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Fingolimod Hydrochloride; Male; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Sheath; Rats; Rats, Wistar; Zingiber officinale | 2022 |
Glial Response to Intranasal Mesenchymal Stem Cells in Intermittent Cuprizone Model of Demyelination.
Topics: Animals; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Interleukin-10; Mesenchymal Stem Cells; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Sheath; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha | 2022 |
Combination Therapy of Mesenchymal Stem Cell Transplantation and Astrocyte Ablation Improve Remyelination in a Cuprizone-Induced Demyelination Mouse Model.
Topics: Animals; Astrocytes; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mesenchymal Stem Cell Transplantation; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Sheath; Remyelination; RNA, Messenger | 2022 |
Activation of TRPV1 receptor facilitates myelin repair following demyelination via the regulation of microglial function.
Topics: Animals; Capsaicin; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Humans; Mice; Mice, Inbred C57BL; Microglia; Multiple Sclerosis; Myelin Sheath; TRPV Cation Channels | 2023 |
Treadmill aerobic training improve beam-walking test, up-regulate expression of main proteins of myelin and myelination in the hippocampus of cuprizone-fed mice.
Topics: Animals; Cuprizone; Disease Models, Animal; Female; Hippocampus; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Sheath; Walking | 2023 |
Key role of the gut-microbiota-brain axis via the subdiaphragmatic vagus nerve in demyelination of the cuprizone-treated mouse brain.
Topics: Animals; Brain; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mice; Mice, Inbred C57BL; Microbiota; Microglia; Multiple Sclerosis; Vagus Nerve | 2023 |
Deciphering the Genetic Crosstalk between Microglia and Oligodendrocyte Precursor Cells during Demyelination and Remyelination Using Transcriptomic Data.
Topics: Animals; Cell Differentiation; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Humans; Mice; Mice, Inbred C57BL; Microglia; Multiple Sclerosis; Myelin Sheath; Oligodendrocyte Precursor Cells; Oligodendroglia; Remyelination | 2022 |
Influx of T cells into corpus callosum increases axonal injury, but does not change the course of remyelination in toxic demyelination.
Topics: Animals; Axons; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Sheath; Oligodendroglia; Remyelination; T-Lymphocytes | 2023 |
Huperzine-A Improved Animal Behavior in Cuprizone-Induced Mouse Model by Alleviating Demyelination and Neuroinflammation.
Topics: Acetylcholinesterase; Animals; Behavior, Animal; Cuprizone; Cytokines; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Neuroinflammatory Diseases | 2022 |
Pharmacological treatment promoting remyelination enhances motor function after internal capsule demyelination in mice.
Topics: Animals; Clemastine; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Internal Capsule; Lysophosphatidylcholines; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Sheath; Oligodendroglia; Remyelination | 2023 |
Protective effect of crocin on cuprizone-induced model of multiple sclerosis in mice.
Topics: Animals; Antioxidants; Cuprizone; Disease Models, Animal; Male; Mice; Mice, Inbred C57BL; Multiple Sclerosis | 2023 |
Potassium channels at the crossroads of neuroinflammation and myelination in experimental models of multiple sclerosis.
Topics: 4-Aminopyridine; Animals; Cuprizone; Inflammation; Mice; Models, Theoretical; Multiple Sclerosis; Neuroinflammatory Diseases; Potassium Channels | 2023 |
Immunoreactivity of Kir3.1, muscarinic receptors 2 and 3 on the brainstem, vagus nerve and heart tissue under experimental demyelination.
Topics: Animals; Brain Stem; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Female; Male; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Sheath; Rats; Rats, Wistar; Receptors, Muscarinic; Vagus Nerve | 2023 |
Effects of Bone Marrow Mesenchymal Stem Cells on Myelin Repair and Emotional Changes of a Cuprizone-Induced Demyelination Model.
Topics: Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Male; Mesenchymal Stem Cells; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Sheath | 2023 |
Remyelinating activities of Carvedilol or alpha lipoic acid in the Cuprizone-Induced rat model of demyelination.
Topics: Animals; Carvedilol; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Neurodegenerative Diseases; Rats; Thioctic Acid | 2023 |
Immunoglobulin directly enhances differentiation of oligodendrocyte-precursor cells and remyelination.
Topics: Animals; Cell Differentiation; Cuprizone; Disease Models, Animal; Immunoglobulins; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Sheath; Oligodendroglia; Remyelination | 2023 |
The Effects of NLY01, a Novel Glucagon-Like Peptide-1 Receptor Agonist, on Cuprizone-Induced Demyelination and Remyelination: Challenges and Future Perspectives.
Topics: Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Glucagon-Like Peptide-1 Receptor; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Sheath; Remyelination | 2023 |
L-Theanine Improves Locomotor Function in a Model of Multiple Sclerosis Mice.
Topics: Animals; Antioxidants; Cuprizone; Glutathione Peroxidase; Male; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Rodent Diseases; Superoxide Dismutase | 2023 |
TGN020 application against aquaporin 4 improved multiple sclerosis by inhibiting astrocytes, microglia, and NLRP3 inflammasome in a cuprizone mouse model.
Topics: Animals; Aquaporin 4; Astrocytes; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Inflammasomes; Male; Mice; Mice, Inbred C57BL; Microglia; Multiple Sclerosis; NLR Family, Pyrin Domain-Containing 3 Protein | 2023 |
The neuroprotective effects of Chalcones from Ashitaba on cuprizone-induced demyelination via modulation of brain-derived neurotrophic factor and tumor necrosis factor α.
Topics: Animals; Brain-Derived Neurotrophic Factor; Chalcones; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Neuroprotective Agents; Tumor Necrosis Factor-alpha | 2023 |
Modulating miR-146a Expression by Hydrogen Sulfide Ameliorates Motor Dysfunction and Axonal Demyelination in Cuprizone-Induced Multiple Sclerosis.
Topics: Animals; Cuprizone; Hydrogen Sulfide; Inflammation; Male; Mice; Mice, Inbred C57BL; MicroRNAs; Multiple Sclerosis; NF-kappa B | 2023 |
Microglial depletion exacerbates axonal damage and motor dysfunction in mice with cuprizone-induced demyelination.
Topics: Animals; Axons; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mice; Mice, Inbred C57BL; Microglia; Multiple Sclerosis | 2023 |
FKBP5 activates mitophagy by ablating PPAR-γ to shape a benign remyelination environment.
Topics: Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mice; Mice, Inbred C57BL; Mitophagy; Multiple Sclerosis; Myelin Sheath; Neurodegenerative Diseases; PPAR gamma; Remyelination | 2023 |
Expression of Bruton´s tyrosine kinase in different type of brain lesions of multiple sclerosis patients and during experimental demyelination.
Topics: Agammaglobulinaemia Tyrosine Kinase; Animals; Corpus Callosum; Cuprizone; Humans; Macrophages; Mice; Microglia; Multiple Sclerosis | 2023 |
Stereological Investigation of Regional Brain Volumes after Acute and Chronic Cuprizone-Induced Demyelination.
Topics: Animals; Atrophy; Brain; Chelating Agents; Cuprizone; Fluorodeoxyglucose F18; Male; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Positron-Emission Tomography; Radiopharmaceuticals | 2019 |
Nrf2 deficiency increases oligodendrocyte loss, demyelination, neuroinflammation and axonal damage in an MS animal model.
Topics: Animals; Axons; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Inflammation; Mice; Mice, Knockout; Multiple Sclerosis; NF-E2-Related Factor 2; Oligodendroglia; Oxidative Stress | 2020 |
The active contribution of OPCs to neuroinflammation is mediated by LRP1.
Topics: Animals; Cell Culture Techniques; Cell Differentiation; Cuprizone; Encephalomyelitis, Autoimmune, Experimental; Histocompatibility Antigens Class I; Humans; Low Density Lipoprotein Receptor-Related Protein-1; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Oligodendrocyte Precursor Cells | 2020 |
Disease modifying mitochondrial uncouplers, MP101, and a slow release ProDrug, MP201, in models of Multiple Sclerosis.
Topics: 2,4-Dinitrophenol; Animals; Axons; Brain-Derived Neurotrophic Factor; Cuprizone; Cytokines; Delayed-Action Preparations; Demyelinating Diseases; Encephalitis; Encephalomyelitis, Autoimmune, Experimental; Female; Immunization; Mice; Mice, Inbred C57BL; Mitochondria; Multiple Sclerosis; Nerve Growth Factors; Paralysis; Prodrugs; Uncoupling Agents | 2019 |
Metformin-induced AMPK activation stimulates remyelination through induction of neurotrophic factors, downregulation of NogoA and recruitment of Olig2+ precursor cells in the cuprizone murine model of multiple sclerosis.
Topics: AMP-Activated Protein Kinases; Animals; Cuprizone; Disease Models, Animal; Down-Regulation; Enzyme Activation; Gene Expression Regulation, Neoplastic; Male; Metformin; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Nerve Growth Factors; Oligodendrocyte Transcription Factor 2 | 2019 |
Intranasal delivery of SDF-1α-preconditioned bone marrow mesenchymal cells improves remyelination in the cuprizone-induced mouse model of multiple sclerosis.
Topics: Administration, Intranasal; Animals; Cell Movement; Chemokine CXCL12; Cuprizone; Disease Models, Animal; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mice; Mice, Inbred C57BL; Monoamine Oxidase Inhibitors; Multiple Sclerosis; Remyelination; Transplantation Conditioning | 2020 |
Phloroglucinol derivative compound 21 attenuates cuprizone-induced multiple sclerosis mice through promoting remyelination and inhibiting neuroinflammation.
Topics: Animals; Astrocytes; Brain; Cuprizone; Cytokines; Disease Models, Animal; Drug Discovery; Inflammation; Male; Mice; Mice, Inbred C57BL; Microglia; Multiple Sclerosis; Myelin Basic Protein; Oligodendroglia; Phloroglucinol; Remyelination; Treatment Outcome | 2020 |
Suppression of the Peripheral Immune System Limits the Central Immune Response Following Cuprizone-Feeding: Relevance to Modelling Multiple Sclerosis.
Topics: Adaptive Immunity; Animals; Brain; Computational Biology; Cuprizone; Cytokines; Demyelinating Diseases; Disease Models, Animal; Gliosis; Immune System; Male; Mice; Mice, Inbred C57BL; Microglia; Mitochondria; Multiple Sclerosis; Oligodendroglia | 2019 |
Ethyl pyruvate enhances spontaneous remyelination by targeting microglia phagocytosis.
Topics: Animals; Behavior, Animal; Cell Line; Cell Movement; Cell Survival; Cuprizone; Cytokines; Demyelinating Diseases; Disease Models, Animal; Male; Mice, Inbred C57BL; Microglia; Multiple Sclerosis; Phagocytosis; Pyruvates; Remyelination | 2019 |
Laquinimod Supports Remyelination in Non-Supportive Environments.
Topics: Animals; Brain; Cell Differentiation; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mice; Mice, Inbred C57BL; Microglia; Multiple Sclerosis; Myelin Sheath; Oligodendrocyte Transcription Factor 2; Oligodendroglia; Quinolones; Remyelination | 2019 |
Neuroprotective Effects of Melatonin during Demyelination and Remyelination Stages in a Mouse Model of Multiple Sclerosis.
Topics: Animals; Antioxidants; Cuprizone; Female; Interleukin-1beta; Locomotion; Male; Melatonin; Mice; Multiple Sclerosis; Myelin Sheath; Neuroprotective Agents; Oxidative Stress; Sex Factors; Tumor Necrosis Factor-alpha | 2020 |
Hippocampal Neurogenesis and Neural Circuit Formation in a Cuprizone-Induced Multiple Sclerosis Mouse Model.
Topics: Animals; Cell Proliferation; Cognitive Dysfunction; Cuprizone; Disease Models, Animal; Hippocampus; Male; Mice; Mice, Inbred C57BL; Monoamine Oxidase Inhibitors; Multiple Sclerosis; Neural Pathways; Neural Stem Cells; Neurogenesis; Neurons | 2020 |
Laquinimod ameliorates secondary brain inflammation.
Topics: Animals; Brain; Cuprizone; Disease Models, Animal; Encephalitis; Female; Gliosis; Mice, Inbred C57BL; Multiple Sclerosis; Quinolones | 2020 |
Longitudinal evaluation of demyelinated lesions in a multiple sclerosis model using ultrashort echo time magnetization transfer (UTE-MT) imaging.
Topics: Animals; Cerebral Cortex; Cuprizone; Disease Models, Animal; Female; Gray Matter; Magnetic Resonance Imaging; Mice; Monoamine Oxidase Inhibitors; Multiple Sclerosis; Myelin Sheath; Neuroimaging; Remyelination; White Matter | 2020 |
Nanocatalytic activity of clean-surfaced, faceted nanocrystalline gold enhances remyelination in animal models of multiple sclerosis.
Topics: Animals; Apoptosis; Biomechanical Phenomena; Cell Movement; Cuprizone; Disease Models, Animal; Gene Expression Profiling; Gold; Metal Nanoparticles; Mice; Movement; Multiple Sclerosis; Oligodendrocyte Precursor Cells; Remyelination; Signal Transduction | 2020 |
Betaine restores epigenetic control and supports neuronal mitochondria in the cuprizone mouse model of multiple sclerosis.
Topics: Animals; Betaine; Betaine-Homocysteine S-Methyltransferase; Cell Respiration; Cells, Cultured; Chromatin Assembly and Disassembly; Cuprizone; Epigenesis, Genetic; Histone Code; Male; Mice; Mice, Inbred C57BL; Mitochondria; Multiple Sclerosis; Neurons; Rats; Rats, Sprague-Dawley | 2020 |
A dual effect of ursolic acid to the treatment of multiple sclerosis through both immunomodulation and direct remyelination.
Topics: Animals; Astrocytes; Cell Differentiation; Corpus Callosum; Cuprizone; Encephalomyelitis, Autoimmune, Experimental; Female; Gene Expression Regulation; Humans; Immunomodulation; Male; Mice; Multiple Sclerosis; Myelin Sheath; Oligodendroglia; PPAR gamma; Remyelination; Triterpenes; Ursolic Acid | 2020 |
Delayed Demyelination and Impaired Remyelination in Aged Mice in the Cuprizone Model.
Topics: Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Male; Mice; Monoamine Oxidase Inhibitors; Multiple Sclerosis; Remyelination | 2020 |
Improvement of Remyelination in Demyelinated Corpus Callosum Using Human Adipose-Derived Stem Cells (hADSCs) and Pregnenolone in the Cuprizone Rat Model of Multiple Sclerosis.
Topics: Adipose Tissue; Animals; Cell Differentiation; Cells, Cultured; Corpus Callosum; Cuprizone; Humans; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Multiple Sclerosis; Myelin Basic Protein; Myelin Sheath; Myelin-Oligodendrocyte Glycoprotein; Pregnenolone; Rats; Rats, Wistar | 2020 |
Cognitive disturbances in the cuprizone model of multiple sclerosis.
Topics: Animals; Cognition; Conditioning, Operant; Corpus Callosum; Cuprizone; Female; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Visual Perception | 2021 |
Repurposing of Secukinumab as Neuroprotective in Cuprizone-Induced Multiple Sclerosis Experimental Model via Inhibition of Oxidative, Inflammatory, and Neurodegenerative Signaling.
Topics: Animals; Anti-Inflammatory Agents; Antibodies, Monoclonal, Humanized; Cuprizone; Demyelinating Diseases; Inflammation; Male; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Sheath; Neurodegenerative Diseases; Neuroprotective Agents; Oligodendroglia; Oxidative Stress; Remyelination | 2020 |
CD44 expression in the cuprizone model.
Topics: Animals; Brain; Chelating Agents; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Hyaluronan Receptors; Mice; Mice, Inbred C57BL; Multiple Sclerosis; White Matter | 2020 |
Mesenchymal Stem Cells Ameliorate Cuprizone-Induced Demyelination by Targeting Oxidative Stress and Mitochondrial Dysfunction.
Topics: Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Humans; Male; Mesenchymal Stem Cells; Mice, Inbred C57BL; Mitochondria; Multiple Sclerosis; Myelin Sheath; Oligodendroglia; Oxidative Stress; Remyelination | 2021 |
Effects of EHP-101 on inflammation and remyelination in murine models of Multiple sclerosis.
Topics: Animals; Cannabinoid Receptor Agonists; Cannabinoids; Chelating Agents; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Inflammation; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Remyelination; Spinal Cord | 2020 |
Calorie restriction promotes remyelination in a Cuprizone-Induced demyelination mouse model of multiple sclerosis.
Topics: Animals; Astrocytes; Brain; Caloric Restriction; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mice; Microglia; Motor Skills; Multiple Sclerosis; Myelin Sheath; Remyelination | 2020 |
Melatonin improves memory defects in a mouse model of multiple sclerosis by up-regulating cAMP-response element-binding protein and synapse-associated proteins in the prefrontal cortex.
Topics: Animals; Behavior, Animal; Cuprizone; Cyclic AMP Response Element-Binding Protein; Disease Models, Animal; Disks Large Homolog 4 Protein; Gene Expression; Melatonin; Memory Disorders; Mice; Monoamine Oxidase Inhibitors; Multiple Sclerosis; Neuroprotective Agents; Prefrontal Cortex; Recognition, Psychology; Spatial Learning; Synaptophysin | 2020 |
Hydroxychloroquine effects on miR-155-3p and miR-219 expression changes in animal model of multiple sclerosis.
Topics: Animals; Cuprizone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression; Hydroxychloroquine; Male; Mice; Mice, Inbred C57BL; MicroRNAs; Multiple Sclerosis; Remyelination | 2020 |
The Changes in
Topics: Animals; Aspartic Acid; Creatine; Cuprizone; Female; Glycerylphosphorylcholine; Metabolome; Multiple Sclerosis; Phosphorylcholine; Proton Magnetic Resonance Spectroscopy; Rats; Rats, Wistar; Stress, Psychological | 2021 |
Cuprizone-Induced Demyelination in Mouse Hippocampus Is Alleviated by Ketogenic Diet.
Topics: Animals; Astrocytes; Cuprizone; Demyelinating Diseases; Diet, Ketogenic; Disease Models, Animal; Glutathione; Hippocampus; Humans; Male; Malondialdehyde; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Oligodendroglia; PPAR gamma; Sirtuin 1 | 2020 |
Ursolic acid treatment suppresses cuprizone-induced demyelination and motor dysfunction via upregulation of IGF-1.
Topics: Administration, Oral; Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Gene Expression; Insulin-Like Growth Factor I; Mice; Motor Activity; Multiple Sclerosis; Triterpenes; Up-Regulation; Ursolic Acid | 2020 |
Aquaporin-4 Expression during Toxic and Autoimmune Demyelination.
Topics: Animals; Aquaporin 4; Autoimmune Diseases; Brain; Brain Injuries; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Gene Expression Regulation; Humans; Inflammation; Mice; Multiple Sclerosis; Myelin Sheath; Neuromyelitis Optica | 2020 |
Apamin administration impact on miR-219 and miR-155-3p expression in cuprizone induced multiple sclerosis model.
Topics: Animals; Apamin; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Gene Expression Regulation; Male; Mice, Inbred C57BL; MicroRNAs; Multiple Sclerosis; Myelin Sheath | 2020 |
Coenzyme Q10 enhances remyelination and regulate inflammation effects of cuprizone in corpus callosum of chronic model of multiple sclerosis.
Topics: Animals; Behavior, Animal; Biomarkers; Chronic Disease; Corpus Callosum; Cuprizone; Cytokines; Demyelinating Diseases; Disease Models, Animal; Inflammation; Inflammation Mediators; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Sheath; Oxidative Stress; Remyelination; Ubiquinone | 2021 |
Neuroprotective Effect of Apolipoprotein D in Cuprizone-Induced Cell Line Models: A Potential Therapeutic Approach for Multiple Sclerosis and Demyelinating Diseases.
Topics: Animals; Apolipoproteins D; Cell Line; Cell Survival; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Humans; Mice; Multiple Sclerosis; Neuroprotective Agents; Oligodendroglia; Reactive Oxygen Species | 2021 |
Gut Microbiota Changes in Experimental Autoimmune Encephalomyelitis and Cuprizone Mice Models.
Topics: Animals; Cuprizone; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Gastrointestinal Microbiome; Humans; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Neurodegenerative Diseases | 2021 |
Nile Red fluorescence spectroscopy reports early physicochemical changes in myelin with high sensitivity.
Topics: Aged; Animals; Case-Control Studies; Cell Line; Cuprizone; Demyelinating Diseases; Fluorescent Dyes; Gray Matter; Humans; Lipids; Male; Mice, Inbred C57BL; Middle Aged; Multiple Sclerosis; Myelin Sheath; Oligodendroglia; Oxazines; Spectrometry, Fluorescence; White Matter | 2021 |
ACT-1004-1239, a first-in-class CXCR7 antagonist with both immunomodulatory and promyelinating effects for the treatment of inflammatory demyelinating diseases.
Topics: Animals; Cell Differentiation; Cuprizone; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Immunomodulation; Inflammation; Male; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Sheath; Myelin-Oligodendrocyte Glycoprotein; Oligodendroglia; Receptors, CXCR; Stem Cells | 2021 |
Neuronal hibernation following hippocampal demyelination.
Topics: Animals; Astrocytes; Cognitive Dysfunction; Cuprizone; Demyelinating Diseases; Dendritic Spines; Disease Models, Animal; Hippocampus; Long-Term Potentiation; Magnetic Resonance Imaging; Male; Mice; Mice, Inbred C57BL; Microscopy, Electron; Multiple Sclerosis; Neurons; Post-Synaptic Density; Sequence Analysis, RNA | 2021 |
Multiple sclerosis risk gene Mertk is required for microglial activation and subsequent remyelination.
Topics: Animals; c-Mer Tyrosine Kinase; Cell Differentiation; Cell Movement; Cuprizone; Cyclin-Dependent Kinase Inhibitor p21; Demyelinating Diseases; Disease Models, Animal; Interferon-gamma; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia; Multiple Sclerosis; Myelin Sheath; Oligodendroglia; Phagocytosis; Remyelination | 2021 |
The brain 3β-HSD up-regulation in response to deteriorating effects of background emotional stress: an animal model of multiple sclerosis.
Topics: 3-Hydroxysteroid Dehydrogenases; Animals; Anxiety; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Electroshock; Female; Maze Learning; Multiple Sclerosis; Neuroprotection; Psychological Distress; Psychomotor Performance; Rats; Rats, Wistar; RNA, Messenger; Up-Regulation | 2021 |
Cuprizone and EAE mouse frontal cortex proteomics revealed proteins altered in multiple sclerosis.
Topics: Adult; Aged; Aged, 80 and over; Animals; Biomarkers; Complement C1q; Cuprizone; Cysteine Endopeptidases; Encephalomyelitis, Autoimmune, Experimental; Female; Frontal Lobe; Gene Expression Regulation; Hemopexin; Humans; Immunohistochemistry; Male; Mice; Middle Aged; Multiple Sclerosis; Proteomics; Young Adult | 2021 |
Bee Venom-Derived BBB Shuttle and its Correlation with Oligodendrocyte Proliferation Markers in Mice Model of Multiple Sclerosis.
Topics: Animals; Bee Venoms; Blood-Brain Barrier; Brain; Cell Proliferation; Chelating Agents; Cuprizone; Male; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Oligodendrocyte Transcription Factor 2; Oligodendroglia; Receptor, Platelet-Derived Growth Factor alpha | 2021 |
Focal white matter lesions induce long-lasting axonal degeneration, neuroinflammation and behavioral deficits.
Topics: Animals; Axons; Brain; Chelating Agents; Cuprizone; Humans; Inflammation Mediators; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Multiple Sclerosis; Nerve Degeneration; White Matter | 2021 |
Demyelination and remyelination detected in an alternative cuprizone mouse model of multiple sclerosis with 7.0 T multiparameter magnetic resonance imaging.
Topics: Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Magnetic Resonance Imaging; Male; Mice; Multiple Sclerosis; Myelin Sheath; Remyelination | 2021 |
Changes in leptin, serotonin, and cortisol after eight weeks of aerobic exercise with probiotic intake in a cuprizone-induced demyelination mouse model of multiple sclerosis.
Topics: Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Female; Hydrocortisone; Inflammation; Leptin; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Physical Conditioning, Animal; Probiotics; Serotonin | 2021 |
EBI2 is expressed in glial cells in multiple sclerosis lesions, and its knock-out modulates remyelination in the cuprizone model.
Topics: Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Sheath; Neuroglia; Oligodendroglia; Remyelination; Sclerosis | 2021 |
Complement-associated loss of CA2 inhibitory synapses in the demyelinated hippocampus impairs memory.
Topics: Aged; Animals; CA2 Region, Hippocampal; Case-Control Studies; Complement C1q; Cuprizone; Disease Models, Animal; Humans; Male; Mice; Mice, Inbred C57BL; Middle Aged; Multiple Sclerosis; Synapses | 2021 |
Dysregulated copper transport in multiple sclerosis may cause demyelination via astrocytes.
Topics: Animals; Astrocytes; Biological Transport; Chronic Disease; Cicatrix; Copper; Cuprizone; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Humans; Inflammation; Ligands; Membrane Transport Proteins; Mice, Knockout; Multiple Sclerosis; Myelin Sheath; Nerve Growth Factors; Receptor, trkB; Up-Regulation; White Matter | 2021 |
Novel cell-based analysis reveals region-dependent changes in microglial dynamics in grey matter in a cuprizone model of demyelination.
Topics: Animals; CA1 Region, Hippocampal; Cell Enlargement; Cell Proliferation; Cerebral Cortex; Chelating Agents; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Gray Matter; Hippocampus; Imaging, Three-Dimensional; Mice; Mice, Knockout; Microglia; Microscopy, Confocal; Multiple Sclerosis; Optical Imaging; Phagocytosis; Potassium Channels, Tandem Pore Domain; Remyelination | 2021 |
Effect of CSF1R inhibitor on glial cells population and remyelination in the cuprizone model.
Topics: Aminopyridines; Animals; Cuprizone; Disease Models, Animal; Male; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Sheath; Neuroglia; Pyrroles; Receptor, Macrophage Colony-Stimulating Factor; Remyelination | 2021 |
Effects of Venlafaxine, Risperidone and Febuxostat on Cuprizone-Induced Demyelination, Behavioral Deficits and Oxidative Stress.
Topics: Animals; Corpus Callosum; Cuprizone; Disease Models, Animal; Drug Evaluation, Preclinical; Febuxostat; Female; HEK293 Cells; Humans; Mice, Inbred C57BL; Motor Activity; Multiple Sclerosis; Neurotransmitter Agents; Risperidone; TRPA1 Cation Channel; Venlafaxine Hydrochloride | 2021 |
Analysis of platelet-derived growth factor receptor A and oligodendrocyte transcription factor 2 markers following Hydroxychloroquine administration in animal induced multiple sclerosis model.
Topics: Animals; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Hydroxychloroquine; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Sheath; Oligodendrocyte Transcription Factor 2; Oligodendroglia; Receptors, Platelet-Derived Growth Factor | 2021 |
Trifluoperazine reduces cuprizone-induced demyelination via targeting Nrf2 and IKB in mice.
Topics: Animals; Cuprizone; Disease Models, Animal; Humans; I-kappa B Proteins; Male; Mice; Multiple Sclerosis; Myelin Sheath; NF-E2-Related Factor 2; Oxidative Stress; Prefrontal Cortex; Signal Transduction; Trifluoperazine | 2021 |
A higher proportion of ermin-immunopositive oligodendrocytes in areas of remyelination.
Topics: Animals; Brain; Cerebral Cortex; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Female; Gray Matter; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Basic Protein; Myelin Proteins; Myelin Sheath; Oligodendroglia; Remyelination; White Matter | 2021 |
Inhibitors of protein arginine deiminases and their efficacy in animal models of multiple sclerosis.
Topics: Animals; Brain; Catalytic Domain; Cuprizone; Demyelinating Diseases; Encephalitis; Enzyme Inhibitors; Female; Half-Life; Humans; Hydantoins; Hydrolases; Imidazoles; Isoenzymes; Male; Mice, Inbred C57BL; Molecular Docking Simulation; Multiple Sclerosis; Myelitis; Neuroprotective Agents; Spinal Cord; Tetrazoles | 2017 |
Acutely damaged axons are remyelinated in multiple sclerosis and experimental models of demyelination.
Topics: Amyloid beta-Protein Precursor; Animals; Axons; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Female; Glial Fibrillary Acidic Protein; Lysophosphatidylcholines; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Microglia; Monoamine Oxidase Inhibitors; Multiple Sclerosis; Myelin Sheath; Rats; Rats, Inbred Lew; Statistics, Nonparametric; Time Factors | 2017 |
Heterozygote galactocerebrosidase (GALC) mutants have reduced remyelination and impaired myelin debris clearance following demyelinating injury.
Topics: Animals; Cuprizone; Demyelinating Diseases; Galactosylceramidase; Genome-Wide Association Study; Heterozygote; Membrane Glycoproteins; Mice; Microglia; Multiple Sclerosis; Myelin Sheath; Receptors, Immunologic; Remyelination | 2017 |
Acid sphingomyelinase deficiency enhances myelin repair after acute and chronic demyelination.
Topics: Amitriptyline; Amyloid Precursor Protein Secretases; Animals; Astrocytes; Axons; Cell Count; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Enzyme Inhibitors; Gene Expression Regulation; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia; Multiple Sclerosis; Nerve Regeneration; Oligodendroglia; Recovery of Function; Sphingomyelin Phosphodiesterase; Synaptophysin | 2017 |
Hyperpolarized
Topics: Animals; Carbon Isotopes; Cuprizone; Disease Models, Animal; Female; Lactic Acid; Magnetic Resonance Imaging; Mice; Mice, Transgenic; Multiple Sclerosis | 2017 |
Peripherally derived FGF21 promotes remyelination in the central nervous system.
Topics: Animals; Blood-Brain Barrier; Cell Differentiation; Cell Proliferation; Central Nervous System; Cuprizone; Demyelinating Diseases; Female; Fibroblast Growth Factors; Humans; Kinetics; Klotho Proteins; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Multiple Sclerosis; Myelin Sheath; Nerve Regeneration; Oligodendroglia; Permeability; Regenerative Medicine; Stem Cells | 2017 |
GD1a Overcomes Inhibition of Myelination by Fibronectin via Activation of Protein Kinase A: Implications for Multiple Sclerosis.
Topics: Animals; Axons; Cells, Cultured; Cuprizone; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Demyelinating Diseases; Enzyme Activation; Fibronectins; Gangliosides; Male; Mice; Multiple Sclerosis; Myelin Sheath; Neural Stem Cells; Oligodendroglia; Rats; Signal Transduction | 2017 |
The flavonoid Baicalein attenuates cuprizone-induced demyelination via suppression of neuroinflammation.
Topics: Animals; Astrocytes; Cuprizone; Cytokines; Demyelinating Diseases; Disease Models, Animal; Flavanones; Flavonoids; Male; Mice; Mice, Inbred C57BL; Microglia; Multiple Sclerosis; Myelin Sheath; Neuroimmunomodulation; Oligodendroglia; Tumor Necrosis Factor-alpha | 2017 |
Yokukansan Reduces Cuprizone-Induced Demyelination in the Corpus Callosum Through Anti-inflammatory Effects on Microglia.
Topics: Animals; Anti-Inflammatory Agents; Astrocytes; Corpus Callosum; Cuprizone; Cytokines; Demyelinating Diseases; Disease Models, Animal; Drugs, Chinese Herbal; Female; Inflammation; Mice, Inbred C57BL; Microglia; Multiple Sclerosis; Oligodendroglia | 2017 |
Effects of green tea epigallocatechin-3-gallate on the proteolipid protein and oligodendrocyte transcription factor 1 messenger RNA gene expression in a mouse model of multiple sclerosis.
Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Brain; Catechin; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mice, Inbred C57BL; Multiple Sclerosis; Oligodendroglia; RNA, Messenger; Tea | 2017 |
Prednisone alleviates demyelination through regulation of the NLRP3 inflammasome in a C57BL/6 mouse model of cuprizone-induced demyelination.
Topics: Animals; Astrocytes; Corpus Callosum; Cuprizone; Cytokines; Demyelinating Diseases; Disease Models, Animal; Inflammasomes; Male; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Basic Protein; Myelin Sheath; NLR Family, Pyrin Domain-Containing 3 Protein; Oligodendroglia; Prednisone; Signal Transduction | 2018 |
Quantitative determination of cyclic phosphatidic acid and its carba analog in mouse organs and plasma using LC-MS/MS.
Topics: Animals; Chromatography, Liquid; Cuprizone; Heterocyclic Compounds, 1-Ring; Limit of Detection; Linear Models; Male; Mice; Multiple Sclerosis; Organ Specificity; Phosphatidic Acids; Reproducibility of Results; Tandem Mass Spectrometry | 2018 |
Effect of Multiple Intraperitoneal Injections of Human Bone Marrow Mesenchymal Stem Cells on Cuprizone Model of Multiple Sclerosis
Topics: Animals; Cell Differentiation; Chelating Agents; Cuprizone; Disease Models, Animal; Humans; Injections, Intraperitoneal; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mice; Mice, Inbred C57BL; Multiple Sclerosis | 2018 |
LPA5 signaling is involved in multiple sclerosis-mediated neuropathic pain in the cuprizone mouse model.
Topics: Animals; Corpus Callosum; Cuprizone; Disease Models, Animal; Female; Gene Expression; Lysophospholipids; Male; Mice, Inbred Strains; Multiple Sclerosis; Neuralgia; Receptors, Lysophosphatidic Acid; Signal Transduction | 2018 |
Cuprizone Administration Alters the Iron Metabolism in the Mouse Model of Multiple Sclerosis.
Topics: Animals; Axons; Cation Transport Proteins; Corpus Callosum; Cuprizone; Cytosol; Disease Models, Animal; Gene Expression Regulation; Hepcidins; Iron; Lipid Metabolism; Liver; Magnetic Resonance Imaging; Male; Mice, Inbred C57BL; Mitochondria; Multiple Sclerosis; Myelin Basic Protein; Myelin Sheath; Neuroglia; RNA, Messenger | 2018 |
Erythropoietin Upregulates Brain Hemoglobin Expression and Supports Neuronal Mitochondrial Activity.
Topics: Animals; Aspartic Acid; Brain; Cell Respiration; Cuprizone; Disease Models, Animal; Electron Transport Complex III; Erythropoietin; Hemoglobins; Histones; Lysine; Male; Methylation; Mice, Inbred C57BL; Mitochondria; Models, Biological; Multiple Sclerosis; Myelin Basic Protein; Myelin Sheath; Neurons; Up-Regulation | 2018 |
Phosphatidylcholine 36:1 concentration decreases along with demyelination in the cuprizone animal model and in post-mortem multiple sclerosis brain tissue.
Topics: Adult; Aged; Aged, 80 and over; Animals; Brain; Chelating Agents; Corpus Callosum; Cuprizone; Demyelinating Diseases; Female; Humans; Lipid Metabolism; Male; Mice; Mice, Inbred C57BL; Middle Aged; Multiple Sclerosis; Myelin Sheath; Oleic Acid; Phosphatidylcholines; Postmortem Changes | 2018 |
Microglial MHC class II is dispensable for experimental autoimmune encephalomyelitis and cuprizone-induced demyelination.
Topics: Animals; Antigen Presentation; Cell Proliferation; Central Nervous System; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Histocompatibility Antigens Class II; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia; Multiple Sclerosis | 2018 |
Biochemically altered myelin triggers autoimmune demyelination.
Topics: Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Encephalitis; Hashimoto Disease; Humans; Hydrolases; Inflammation; Male; Mice; Mice, Inbred C57BL; Monoamine Oxidase Inhibitors; Multiple Sclerosis; Myelin Sheath | 2018 |
Protective potential of dimethyl fumarate in a mouse model of thalamocortical demyelination.
Topics: Animals; Anxiety; Auditory Cortex; Behavior Rating Scale; Cuprizone; Dimethyl Fumarate; Disease Models, Animal; Electric Stimulation; Immunosuppressive Agents; Locomotion; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Nerve Net; Neuronal Plasticity; NF-E2-Related Factor 2; Remyelination; Voltage-Sensitive Dye Imaging | 2018 |
The antibody rHIgM22 facilitates hippocampal remyelination and ameliorates memory deficits in the cuprizone mouse model of demyelination.
Topics: Animals; Antibodies; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Hippocampus; Male; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Sheath; Oligodendroglia; Remyelination | 2018 |
G-Protein-Coupled Receptor Gpr17 Expression in Two Multiple Sclerosis Remyelination Models.
Topics: Animals; Cerebral Cortex; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Gray Matter; Male; Mice; Multiple Sclerosis; Myelin Sheath; Nerve Tissue Proteins; Receptors, G-Protein-Coupled; Remyelination; White Matter | 2019 |
Effects of vitamin D on axonal damage during de- and remyelination in the cuprizone model.
Topics: Animals; Axons; Chelating Agents; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Female; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Random Allocation; Remyelination; Vitamin D | 2018 |
Adenosine Promotes the Recovery of Mice from the Cuprizone-Induced Behavioral and Morphological Changes while Effecting on Microglia and Inflammatory Cytokines in the Brain.
Topics: Adenosine; Animals; Behavior, Animal; Brain Chemistry; Cerebral Cortex; Chelating Agents; Cuprizone; Cytokines; Demyelinating Diseases; Dose-Response Relationship, Drug; Gliosis; Hippocampus; Male; Mice; Mice, Inbred C57BL; Microglia; Multiple Sclerosis; Oligodendroglia; Psychomotor Performance; Schizophrenia | 2018 |
Orthologous proteins of experimental de- and remyelination are differentially regulated in the CSF proteome of multiple sclerosis subtypes.
Topics: Animals; Axl Receptor Tyrosine Kinase; Axons; Cerebrospinal Fluid Proteins; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Gene Expression Regulation; Humans; Mice; Multiple Sclerosis; Myelin Sheath; Proteome; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; Remyelination; Tissue Inhibitor of Metalloproteinase-1 | 2018 |
Microglia polarization by methylprednizolone acetate accelerates cuprizone induced demyelination.
Topics: Animals; Chemokine CXCL10; Cuprizone; Demyelinating Diseases; Inflammation; Methylprednisolone; Mice; Microglia; Multiple Sclerosis | 2018 |
Vitamin K enhances the production of brain sulfatides during remyelination.
Topics: Animals; Brain; Cuprizone; Encephalomyelitis, Autoimmune, Experimental; Galactosylceramides; Male; Mice, Inbred C57BL; Multiple Sclerosis; Neuroprotective Agents; Remyelination; Sulfoglycosphingolipids; Swine; Vitamin D; Vitamin K | 2018 |
In vivo conversion of astrocytes into oligodendrocyte lineage cells with transcription factor Sox10; Promise for myelin repair in multiple sclerosis.
Topics: Animals; Astrocytes; Cell Lineage; Cells, Cultured; Cuprizone; Encephalomyelitis, Autoimmune, Experimental; Green Fluorescent Proteins; HEK293 Cells; Humans; Male; Mice, Inbred C57BL; Multiple Sclerosis; Oligodendroglia; SOXE Transcription Factors | 2018 |
Visualization of the Breakdown of the Axonal Transport Machinery: a Comparative Ultrastructural and Immunohistochemical Approach.
Topics: Animals; Axonal Transport; Axons; Biomarkers; Cuprizone; Demyelinating Diseases; Humans; Immunohistochemistry; Mice, Inbred C57BL; Mice, Transgenic; Mitochondrial Proteins; Multiple Sclerosis; Myelin Sheath; Nerve Tissue Proteins; Neuroglia; Spheroids, Cellular | 2019 |
Galectin-4, a Negative Regulator of Oligodendrocyte Differentiation, Is Persistently Present in Axons and Microglia/Macrophages in Multiple Sclerosis Lesions.
Topics: Animals; Axons; Brain; Calcium-Binding Proteins; Cells, Cultured; Cuprizone; Cytokines; Disease Models, Animal; Galectin 4; Gene Expression Regulation; Lectins; Lipopolysaccharides; Macrophages; Male; Mice; Mice, Inbred C57BL; Microfilament Proteins; Microglia; Monoamine Oxidase Inhibitors; Multiple Sclerosis; Myelin-Oligodendrocyte Glycoprotein; Peptide Fragments; Rats; RNA, Messenger; Time Factors | 2018 |
Changes in neurosteroidogenesis during demyelination and remyelination in cuprizone-treated mice.
Topics: 3-Hydroxysteroid Dehydrogenases; Animals; Brain; Cholestenone 5 alpha-Reductase; Cuprizone; Cytochrome P-450 Enzyme System; Disease Models, Animal; Female; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Sheath; Neuroglia; Phosphoproteins; Receptors, GABA; Remyelination; Voltage-Dependent Anion Channel 1 | 2018 |
Protective and therapeutic role of Bilobalide in cuprizone-induced demyelination.
Topics: Animals; Autoantibodies; Behavior, Animal; Corpus Callosum; Cuprizone; Cyclopentanes; Cytokines; Demyelinating Diseases; Disease Models, Animal; Furans; Ginkgolides; Humans; Immunity, Humoral; Inflammation; Inflammation Mediators; Male; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin-Oligodendrocyte Glycoprotein; Neuroprotective Agents; Oligodendroglia | 2019 |
Cuprizone-induced demyelination in the mouse hippocampus is alleviated by phytoestrogen genistein.
Topics: Animals; Cell Differentiation; Cell Survival; Cuprizone; Disease Models, Animal; Down-Regulation; Female; Genistein; Hippocampus; Humans; Male; Mice; Mice, Inbred C57BL; Microglia; Multiple Sclerosis; Myelin Sheath; Phagocytosis; Phytoestrogens; Treatment Outcome | 2019 |
Tuftsin Combines With Remyelinating Therapy and Improves Outcomes in Models of CNS Demyelinating Disease.
Topics: Animals; Benztropine; Cuprizone; Disease Models, Animal; Drug Therapy, Combination; Encephalomyelitis, Autoimmune, Experimental; Mice; Multiple Sclerosis; Myelin Sheath; Tuftsin | 2018 |
Leonurine suppresses neuroinflammation through promoting oligodendrocyte maturation.
Topics: Animals; Cell Differentiation; Central Nervous System; Cuprizone; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Gallic Acid; Humans; Inflammation; Jumonji Domain-Containing Histone Demethylases; Mice; Microglia; Multiple Sclerosis; Myelin Sheath; Neurogenesis; Oligodendroglia; Remyelination | 2019 |
Effect of the CSF1R inhibitor PLX3397 on remyelination of corpus callosum in a cuprizone-induced demyelination mouse model.
Topics: Aminopyridines; Animals; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Gene Expression Regulation; Indoles; Macrophage Colony-Stimulating Factor; Male; Mice, Inbred C57BL; Microglia; Microscopy, Electron, Transmission; Multiple Sclerosis; Myelin Sheath; Pyrroles; Real-Time Polymerase Chain Reaction; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; Rotarod Performance Test | 2019 |
Expression of Translocator Protein and [18F]-GE180 Ligand Uptake in Multiple Sclerosis Animal Models.
Topics: Animals; Astrocytes; Axons; Biomarkers; Carbazoles; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Inflammation; Ligands; Mice, Inbred C57BL; Mitochondria; Monocytes; Multiple Sclerosis; Neuroglia; Receptors, GABA; RNA, Messenger | 2019 |
Acute and chronic demyelinated CNS lesions exhibit opposite elastic properties.
Topics: Acute Disease; Animals; Biomechanical Phenomena; Central Nervous System Diseases; Chronic Disease; Corpus Callosum; Cuprizone; Demyelinating Diseases; Elasticity; Extracellular Matrix; Female; Humans; Mice; Middle Aged; Models, Biological; Multiple Sclerosis | 2019 |
Nanostructured lipid carriers engineered for intranasal delivery of teriflunomide in multiple sclerosis: optimization and in vivo studies.
Topics: Adhesiveness; Administration, Intranasal; Administration, Oral; Animals; Biocompatible Materials; Biomarkers; Crotonates; Cuprizone; Disease Models, Animal; Drug Carriers; Drug Liberation; Humans; Hydroxybutyrates; Lipids; Liver; Male; Multiple Sclerosis; Nanoparticles; Nasal Mucosa; Nitriles; Particle Size; Polymers; Rats; Rats, Wistar; Sheep; Toluidines; Toxicity Tests, Subacute | 2019 |
Plant polyprenols reduce demyelination and recover impaired oligodendrogenesis and neurogenesis in the cuprizone murine model of multiple sclerosis.
Topics: Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Hippocampus; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Neurogenesis; Phosphotransferases (Alcohol Group Acceptor); Plants | 2019 |
Oligodendrocyte degeneration and concomitant microglia activation directs peripheral immune cells into the forebrain.
Topics: Animals; Cuprizone; Encephalomyelitis, Autoimmune, Experimental; Female; Immunity, Cellular; Male; Mice; Mice, Inbred C57BL; Microglia; Multiple Sclerosis; Myelin-Oligodendrocyte Glycoprotein; Oligodendroglia; Peptide Fragments; Prosencephalon | 2019 |
Oligoprotective effect of metformin through the AMPK-dependent on restoration of mitochondrial hemostasis in the cuprizone-induced multiple sclerosis model.
Topics: AMP-Activated Protein Kinase Kinases; Animals; Axons; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Hemostasis; Humans; Metformin; Mice; Mitochondria; Multiple Sclerosis; Oligodendroglia; Oxidative Stress; Protein Kinases; Signal Transduction | 2019 |
Gene expression in oligodendrocytes during remyelination reveals cholesterol homeostasis as a therapeutic target in multiple sclerosis.
Topics: Animals; Case-Control Studies; Cholesterol; Cuprizone; Encephalomyelitis, Autoimmune, Experimental; Estrogen Receptor beta; Female; Gene Expression; Homeostasis; Humans; Mice, Inbred C57BL; Middle Aged; Multiple Sclerosis; Oligodendroglia; Remyelination; Sequence Analysis, RNA | 2019 |
Clozapine administration enhanced functional recovery after cuprizone demyelination.
Topics: Animals; Astrocytes; Central Nervous System; Clozapine; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Sheath | 2019 |
Voluntary running wheel attenuates motor deterioration and brain damage in cuprizone-induced demyelination.
Topics: Animals; Brain; Cuprizone; Demyelinating Autoimmune Diseases, CNS; Disease Models, Animal; Female; Mice; Mice, Inbred C57BL; Monoamine Oxidase Inhibitors; Multiple Sclerosis; Physical Conditioning, Animal | 2019 |
Structural adaption of axons during de- and remyelination in the Cuprizone mouse model.
Topics: Animals; Axons; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mice; Mice, Inbred C57BL; Mice, Transgenic; Multiple Sclerosis; Myelin Sheath; NAV1.6 Voltage-Gated Sodium Channel; Neurons; Oligodendroglia; Ranvier's Nodes; Remyelination; Sodium Channels | 2019 |
Multiple functional therapeutic effects of DL-3-n-butylphthalide in the cuprizone model of demyelination.
Topics: Animals; Astrocytes; Axons; Benzofurans; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Gene Expression Regulation; Male; Mice; Mice, Inbred C57BL; Microglia; Multiple Sclerosis; Myelin Sheath; Neuroprotective Agents; NF-kappa B; Oligodendroglia; Signal Transduction | 2019 |
Diffusion tensor imaging identifies aspects of therapeutic estrogen receptor β ligand-induced remyelination in a mouse model of multiple sclerosis.
Topics: Animals; Corpus Callosum; Cuprizone; Demyelinating Diseases; Diffusion Tensor Imaging; Disease Models, Animal; Estrogen Receptor beta; Female; Indazoles; Magnetic Resonance Imaging; Male; Mice; Multiple Sclerosis; Neuroprotective Agents; Remyelination | 2019 |
Ciliary neurotrophic factor role in myelin oligodendrocyte glycoprotein expression in Cuprizone-induced multiple sclerosis mice.
Topics: Animals; Blotting, Western; Cerebral Cortex; Ciliary Neurotrophic Factor; Cuprizone; Immunoblotting; Mice; Mice, Inbred BALB C; Multiple Sclerosis; Myelin-Oligodendrocyte Glycoprotein | 2013 |
17β-Estradiol enhances the efficacy of adipose-derived mesenchymal stem cells on remyelination in mouse model of multiple sclerosis.
Topics: Adipose Tissue; Animals; Basic Helix-Loop-Helix Transcription Factors; Calcium-Binding Proteins; Cell Differentiation; Cell Lineage; Cell Movement; Cells, Cultured; Combined Modality Therapy; Corpus Callosum; Cuprizone; Disease Models, Animal; Drug Implants; Estradiol; Flow Cytometry; Glial Fibrillary Acidic Protein; Male; Mesenchymal Stem Cell Transplantation; Mice; Mice, Inbred C57BL; Microfilament Proteins; Multiple Sclerosis; Myelin Sheath; Nerve Fibers, Myelinated; Nerve Tissue Proteins; Oligodendrocyte Transcription Factor 2; Time Factors | 2012 |
Hippocampal demyelination and memory dysfunction are associated with increased levels of the neuronal microRNA miR-124 and reduced AMPA receptors.
Topics: Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Gene Expression Regulation; Hippocampus; Humans; Immunosuppressive Agents; Memory Disorders; Mice; MicroRNAs; Monoamine Oxidase Inhibitors; Multiple Sclerosis; Neurons; Postmortem Changes; Receptors, AMPA; RNA, Messenger; Sirolimus | 2013 |
Regional regulation of glutamate signaling during cuprizone-induced demyelination in the brain.
Topics: Amino Acid Transport System X-AG; Animals; Blotting, Western; Brain; Cells, Cultured; Chelating Agents; Corpus Callosum; Cuprizone; Demyelinating Diseases; Fluorescent Antibody Technique; Glutamic Acid; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Protein Array Analysis; Real-Time Polymerase Chain Reaction; Receptors, Glutamate; Signal Transduction | 2013 |
SOX17 is expressed in regenerating oligodendrocytes in experimental models of demyelination and in multiple sclerosis.
Topics: Aged; Animals; Antigens; Autophagy-Related Proteins; Basic Helix-Loop-Helix Transcription Factors; Brain; Bromodeoxyuridine; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Female; Humans; Intracellular Signaling Peptides and Proteins; Leukocyte Common Antigens; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Middle Aged; Monoamine Oxidase Inhibitors; Multiple Sclerosis; Myelin Basic Protein; Nerve Tissue Proteins; Oligodendrocyte Transcription Factor 2; Oligodendroglia; Proteoglycans; SOXF Transcription Factors; Time Factors; Up-Regulation | 2013 |
Puma, but not noxa is essential for oligodendroglial cell death.
Topics: Adult; Aged; Analysis of Variance; Animals; Animals, Newborn; Apoptosis Regulatory Proteins; Brain; Cell Death; Cells, Cultured; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Female; Flow Cytometry; Gene Expression Profiling; Gene Expression Regulation; Humans; In Situ Nick-End Labeling; Interferon-gamma; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Middle Aged; Multiple Sclerosis; Oligodendroglia; Peptide Fragments; Proto-Oncogene Proteins c-bcl-2; Tumor Suppressor Proteins | 2013 |
A regenerative approach to the treatment of multiple sclerosis.
Topics: Animals; Antiparkinson Agents; Benztropine; Cell Differentiation; Coculture Techniques; Cuprizone; Encephalomyelitis, Autoimmune, Experimental; Female; Fingolimod Hydrochloride; Immune System; Mice; Mice, Inbred C57BL; Models, Biological; Multiple Sclerosis; Myelin Proteolipid Protein; Myelin Sheath; Oligodendroglia; Optic Nerve; Propylene Glycols; Rats; Receptor, Muscarinic M1; Receptor, Muscarinic M3; Recurrence; Regeneration; Sphingosine; Stem Cells | 2013 |
Cuprizone-induced demyelination in Wistar rats; electrophysiological and histological assessment.
Topics: Animals; Cuprizone; Disease Models, Animal; Electric Stimulation; Male; Multiple Sclerosis; Neural Conduction; Rats; Rats, Wistar; Spinal Nerves | 2013 |
PET imaging of demyelination and remyelination in the cuprizone mouse model for multiple sclerosis: a comparison between [11C]CIC and [11C]MeDAS.
Topics: Animals; Carbon Radioisotopes; Chelating Agents; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Male; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Positron-Emission Tomography; Radiopharmaceuticals | 2014 |
Stable gastric pentadecapeptide BPC 157 heals cysteamine-colitis and colon-colon-anastomosis and counteracts cuprizone brain injuries and motor disability.
Topics: Anastomosis, Surgical; Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Ataxia; Behavior, Animal; Brain; Brain Injuries; Colitis, Ulcerative; Colon; Cuprizone; Cysteamine; Forelimb; Inflammatory Bowel Diseases; Male; Multiple Sclerosis; Neuroprotective Agents; Peptide Fragments; Proteins; Rats; Rats, Wistar | 2013 |
Oxidative tissue injury in multiple sclerosis is only partly reflected in experimental disease models.
Topics: Aging; Animals; CD4 Antigens; CD8 Antigens; Coronavirus Infections; Cuprizone; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Gene Expression; Iron; Lipopolysaccharides; Macrophages; Mice, Inbred C57BL; Microglia; Multiple Sclerosis; Myelin-Oligodendrocyte Glycoprotein; Oxidative Stress; Peptide Fragments; Rats; Rats, Inbred Lew; Respiratory Burst; T-Lymphocytes | 2014 |
Protective effects of melatonin against mitochondrial injury in a mouse model of multiple sclerosis.
Topics: Animals; Antioxidants; Cuprizone; Cyclooxygenase 2; Disease Models, Animal; Gene Expression Regulation; Glutathione; Lipid Peroxidation; Male; Melatonin; Mice; Mice, Inbred C57BL; Microscopy, Electron, Transmission; Mitochondria; Mitochondrial Proton-Translocating ATPases; Monoamine Oxidase Inhibitors; Multiple Sclerosis; Myelin Proteolipid Protein; Oxidative Stress; Oxidoreductases | 2014 |
Progesterone and nestorone promote myelin regeneration in chronic demyelinating lesions of corpus callosum and cerebral cortex.
Topics: Animals; Cerebral Cortex; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Female; Mice, Inbred C57BL; Mice, Knockout; Multiple Sclerosis; Myelin Basic Protein; Myelin Proteolipid Protein; Myelin Sheath; Oligodendroglia; Progesterone; Stem Cells | 2015 |
Prostaglandin F2α FP receptor inhibitor reduces demyelination and motor dysfunction in a cuprizone-induced multiple sclerosis mouse model.
Topics: Animals; Corpus Callosum; Cuprizone; Demyelinating Diseases; Dinoprost; Disease Models, Animal; Humans; Mice; Motor Activity; Multiple Sclerosis; Myelin Sheath; Oligodendroglia; Prostaglandin H2; Receptors, Prostaglandin; Tumor Necrosis Factor-alpha | 2014 |
Characterization of oligodendroglial populations in mouse demyelinating disease using flow cytometry: clues for MS pathogenesis.
Topics: Animals; Antibodies; Antigens; Cells, Cultured; Cuprizone; Demyelinating Diseases; Encephalomyelitis, Autoimmune, Experimental; Female; Flow Cytometry; Humans; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Oligodendroglia; Stem Cells | 2014 |
Proteomics of a conundrum: Thoughts on addressing the aetiology versus progression of multiple sclerosis.
Topics: Animals; Cuprizone; Demyelinating Diseases; Encephalomyelitis, Autoimmune, Experimental; Humans; Multiple Sclerosis; Proteomics | 2015 |
Abnormal morphology of myelin and axon pathology in murine models of multiple sclerosis.
Topics: Animals; Autopsy; Axons; Brain; Cuprizone; Disease Models, Animal; Female; Humans; Mice; Mice, Inbred C57BL; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Multiple Sclerosis; Myelin Sheath; Spinal Cord | 2015 |
Neuronal expression of the transcription factor serum response factor modulates myelination in a mouse multiple sclerosis model.
Topics: Animals; Astrocytes; Cells, Cultured; Chemokine CCL2; Cuprizone; Disease Models, Animal; Male; Mice, Inbred C57BL; Mice, Transgenic; Microglia; Multiple Sclerosis; Myelin Sheath; Neurons; Oligodendroglia; RNA, Messenger; Serum Response Factor | 2015 |
Beneficial effects of bone marrow-derived mesenchymal stem cell transplantation in a non-immune model of demyelination.
Topics: Animals; Autoimmune Diseases of the Nervous System; Cell Differentiation; Cells, Cultured; Cuprizone; Disease Models, Animal; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Treatment Outcome | 2015 |
Behavioural changes observed in demyelination model shares similarities with white matter abnormalities in humans.
Topics: Animals; Anxiety; Behavior, Animal; Corpus Callosum; Cuprizone; Disease Models, Animal; Encephalitis; Humans; Male; Microglia; Motor Activity; Multiple Sclerosis; Myelin Sheath; Oligodendroglia; Rats; Rats, Inbred Lew; White Matter | 2015 |
Longitudinal monitoring of metabolic alterations in cuprizone mouse model of multiple sclerosis using 1H-magnetic resonance spectroscopy.
Topics: Animals; Corpus Callosum; Cuprizone; Disease Models, Animal; Female; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Sheath; Proton Magnetic Resonance Spectroscopy | 2015 |
Cuprizone Model as a Tool for Preclinical Studies of the Efficacy of Multiple Sclerosis Diagnosis and Therapy.
Topics: Animals; Brain; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Female; Glial Fibrillary Acidic Protein; Magnetic Resonance Imaging; Male; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Sheath; Nerve Tissue Proteins; Radiography | 2015 |
Thymic Atrophy and Apoptosis of CD4+CD8+ Thymocytes in the Cuprizone Model of Multiple Sclerosis.
Topics: Animals; Apoptosis; Atrophy; CD4 Antigens; CD8 Antigens; Cuprizone; Disease Models, Animal; Immunophenotyping; Lymphocyte Count; Male; Mice; Mitochondria; Mitogen-Activated Protein Kinases; Multiple Sclerosis; Phenotype; T-Lymphocyte Subsets; Thymocytes; Thymus Gland | 2015 |
Mesenchymal stem cells do not exert direct beneficial effects on CNS remyelination in the absence of the peripheral immune system.
Topics: Animals; Corpus Callosum; Cuprizone; Dogs; Humans; Immune System; Injections, Intraventricular; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mice; Mice, Inbred C57BL; Microglia; Multiple Sclerosis; Myelin Sheath; Oligodendroglia | 2015 |
Microglial Hv1 proton channel promotes cuprizone-induced demyelination through oxidative damage.
Topics: Animals; Chelating Agents; Cuprizone; Demyelinating Diseases; Ion Channels; Macrophage Activation; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia; Multiple Sclerosis; Myelin Basic Protein; NADPH Oxidases; Neural Stem Cells; Oxidative Stress; Postural Balance; Reactive Oxygen Species | 2015 |
Administration of leukemia inhibitory factor increases Opalin and myelin oligodendrocyte glycoprotein expression in the cerebral cortex in a cuprizone-induced model of demyelination.
Topics: Animals; Blotting, Western; Cerebral Cortex; Chelating Agents; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Leukemia Inhibitory Factor; Mice; Mice, Inbred BALB C; Multiple Sclerosis; Myelin Proteins; Myelin-Oligodendrocyte Glycoprotein | 2015 |
Lesion Expansion in Experimental Demyelination Animal Models and Multiple Sclerosis Lesions.
Topics: Aged; Aged, 80 and over; Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Female; Humans; Male; Mice; Mice, Inbred C57BL; Middle Aged; Multiple Sclerosis; Myelin Sheath; White Matter | 2016 |
Phosphodiesterase-5 inhibition promotes remyelination by MCP-1/CCR-2 and MMP-9 regulation in a cuprizone-induced demyelination model.
Topics: Animals; Chemokine CCL2; Cuprizone; Demyelinating Diseases; Matrix Metalloproteinase 9; Mice; Multiple Sclerosis; Myelin Sheath; Phosphodiesterase 5 Inhibitors; Receptors, CCR2; Signal Transduction; Sildenafil Citrate | 2016 |
Resveratrol Promotes Remyelination in Cuprizone Model of Multiple Sclerosis: Biochemical and Histological Study.
Topics: Animals; Biomarkers; Brain; Cuprizone; Disease Models, Animal; Inflammation; Male; Mice, Inbred C57BL; Mitochondria; Motor Activity; Multiple Sclerosis; Myelin Sheath; Oxidative Stress; Remyelination; Resveratrol; Stilbenes | 2017 |
Acute axonal damage in three different murine models of multiple sclerosis: A comparative approach.
Topics: Amyloid beta-Protein Precursor; Animals; Axons; Brain; Corpus Callosum; Cuprizone; Demyelinating Diseases; Encephalomyelitis, Autoimmune, Experimental; Immunohistochemistry; Inflammation; Mice; Mice, Inbred C57BL; Microglia; Models, Animal; Multiple Sclerosis; Myelin Sheath; Nerve Degeneration; Spinal Cord | 2016 |
Activation of the astrocytic Nrf2/ARE system ameliorates the formation of demyelinating lesions in a multiple sclerosis animal model.
Topics: Animals; Astrocytes; Brain; Chemokine CXCL10; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Glutamate-Cysteine Ligase; Heme Oxygenase-1; Kelch-Like ECH-Associated Protein 1; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Monoamine Oxidase Inhibitors; Multiple Sclerosis; NF-E2-Related Factor 2; Oxidative Stress; Thioredoxin Reductase 1 | 2016 |
Dietary cholesterol promotes repair of demyelinated lesions in the adult brain.
Topics: Animals; Axons; Biomarkers; Brain; Cell Differentiation; Cell Proliferation; Cells, Cultured; Cholesterol; Cholesterol, Dietary; Cuprizone; Dietary Supplements; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Humans; Male; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Proteins; Oligodendroglia; Primary Cell Culture; Stem Cells | 2017 |
Chronic demyelination-induced seizures.
Topics: Animals; Aquaporin 4; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Electroencephalography; Gliosis; Hippocampus; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microglia; Multiple Sclerosis; Neurons; Seizures | 2017 |
Cuprizone Intoxication Induces Cell Intrinsic Alterations in Oligodendrocyte Metabolism Independent of Copper Chelation.
Topics: Amino Acids; Animals; Brain; Brain Chemistry; Cell Line; Chelating Agents; Copper; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Energy Metabolism; Male; Metabolome; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Oligodendroglia; Pyridoxal Phosphate | 2017 |
Phosphorylation of αB-crystallin supports reactive astrogliosis in demyelination.
Topics: alpha-Crystallin B Chain; Animals; Astrocytes; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Humans; Male; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Nerve Tissue Proteins; Oligodendroglia; Phosphorylation | 2017 |
Multiple functional therapeutic effects of TnP: A small stable synthetic peptide derived from fish venom in a mouse model of multiple sclerosis.
Topics: Amino Acid Sequence; Animals; Antigens, Differentiation; Brazil; Cuprizone; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Fish Venoms; Gene Expression Regulation; Immunologic Factors; Interferon-gamma; Interleukin-10; Interleukin-17; Macrophages; Matrix Metalloproteinase 9; Mice; Multiple Sclerosis; Peptides; Perciformes; Spinal Cord; T-Lymphocytes, Regulatory; Th1 Cells; Th17 Cells | 2017 |
SJL mice exposed to cuprizone intoxication reveal strain and gender pattern differences in demyelination.
Topics: Animals; Astrocytes; Brain; Cell Count; Chelating Agents; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Female; Immunohistochemistry; Male; Mice; Microglia; Multiple Sclerosis; Oligodendroglia; Sex Characteristics; Stem Cells | 2009 |
Cuprizone treatment induces demyelination and astrocytosis in the mouse hippocampus.
Topics: Aging; Animals; Astrocytes; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Gliosis; Hippocampus; Immunohistochemistry; Indoles; Male; Mice; Mice, Inbred C57BL; Microglia; Microscopy, Electron; Multiple Sclerosis; Myelin Sheath; Oligodendroglia; Reverse Transcriptase Polymerase Chain Reaction | 2009 |
Regional differences between grey and white matter in cuprizone induced demyelination.
Topics: Animals; Astrocytes; Brain; Cerebral Cortex; Chelating Agents; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Disease Progression; Gliosis; Male; Mice; Mice, Inbred C57BL; Microglia; Multiple Sclerosis; Nerve Fibers, Myelinated; Nerve Regeneration; Neurotoxins; Oligodendroglia; Stem Cells; Time Factors | 2009 |
Propagation of spreading depression inversely correlates with cortical myelin content.
Topics: Animals; Astrocytes; Cerebral Cortex; Cortical Spreading Depression; Cuprizone; Demyelinating Diseases; Electroencephalography; Encephalomyelitis, Autoimmune, Experimental; Female; Functional Laterality; Glial Fibrillary Acidic Protein; Gliosis; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Transgenic; Multiple Sclerosis; Myelin Basic Protein; Myelin Sheath; Neuregulin-1; Rats; Rats, Inbred Lew | 2009 |
HDAC1 nuclear export induced by pathological conditions is essential for the onset of axonal damage.
Topics: Active Transport, Cell Nucleus; Animals; Axons; Brain; Cell Nucleus; Cells, Cultured; Cuprizone; Demyelinating Diseases; Exportin 1 Protein; Glutamic Acid; Histone Deacetylase 1; Humans; Karyopherins; Mice; Mice, Inbred C57BL; Mitochondria; Multiple Sclerosis; Neurons; Rats; Receptors, Cytoplasmic and Nuclear; Time Factors; Tumor Necrosis Factor-alpha | 2010 |
CXCR2-positive neutrophils are essential for cuprizone-induced demyelination: relevance to multiple sclerosis.
Topics: Animals; Chimera; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Monoamine Oxidase Inhibitors; Multiple Sclerosis; Myelin Proteins; Myelin Sheath; Neutrophils; Oligodendroglia; Receptors, Interleukin-8B; RNA, Messenger | 2010 |
Inhibiting poly(ADP-ribose) polymerase: a potential therapy against oligodendrocyte death.
Topics: Active Transport, Cell Nucleus; Animals; Apoptosis; Apoptosis Inducing Factor; Brain; Cell Death; Cell Nucleus; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Male; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Sheath; Oligodendroglia; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Signal Transduction | 2010 |
CXCR4 promotes differentiation of oligodendrocyte progenitors and remyelination.
Topics: Adult Stem Cells; Animals; Astrocytes; Base Sequence; Cell Differentiation; Chelating Agents; Chemokine CXCL12; Corpus Callosum; Cuprizone; Disease Models, Animal; Humans; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Sheath; Neuroglia; Oligodendroglia; Receptors, CXCR4; RNA Interference; RNA, Messenger; RNA, Small Interfering | 2010 |
Glial amyloid precursor protein expression is restricted to astrocytes in an experimental toxic model of multiple sclerosis.
Topics: Amyloid beta-Protein Precursor; Animals; Astrocytes; Cerebral Cortex; Cuprizone; Disease Models, Animal; Male; Mice; Mice, Inbred C57BL; Monoamine Oxidase Inhibitors; Multiple Sclerosis; RNA, Messenger | 2011 |
The hippocampal fimbria of cuprizone-treated animals as a structure for studying neuroprotection in multiple sclerosis.
Topics: Animals; Chelating Agents; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Hippocampus; Humans; Male; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Nerve Fibers, Myelinated; Neuroprotective Agents; Young Adult | 2011 |
Time-dependent changes in the brain arachidonic acid cascade during cuprizone-induced demyelination and remyelination.
Topics: Animals; Arachidonic Acids; Astrocytes; Cerebral Cortex; Cuprizone; Cyclooxygenase 1; Cyclooxygenase 2; Demyelinating Diseases; Gene Expression Regulation, Enzymologic; Group V Phospholipases A2; Macrophages; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Microglia; Multiple Sclerosis; Myelin Sheath; Nerve Tissue Proteins; Neurons; Phospholipases A2, Cytosolic; RNA, Messenger; Time Factors | 2011 |
Inhibition of 5-lipoxygenase activity in mice during cuprizone-induced demyelination attenuates neuroinflammation, motor dysfunction and axonal damage.
Topics: Animals; Arachidonate 5-Lipoxygenase; Ataxia; Biomarkers; Cerebral Cortex; Corpus Callosum; Cuprizone; Demyelinating Diseases; Gene Expression Regulation, Enzymologic; Indoles; Interleukin-6; Lipoxygenase Inhibitors; Male; Mice; Mice, Inbred C57BL; Microglia; Multiple Sclerosis; Nerve Tissue Proteins; Neuritis; Neurons; RNA, Messenger | 2011 |
BLBP-expression in astrocytes during experimental demyelination and in human multiple sclerosis lesions.
Topics: Adult; Aged; Animals; Astrocytes; Blotting, Western; Carrier Proteins; Cell Count; Cell Line, Tumor; Cuprizone; Demyelinating Diseases; Encephalomyelitis, Autoimmune, Experimental; Fatty Acid-Binding Protein 7; Fatty Acid-Binding Proteins; Female; Fibroblast Growth Factor 2; Fluorescent Antibody Technique, Indirect; Glial Fibrillary Acidic Protein; Humans; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Middle Aged; Multiple Sclerosis; Nerve Tissue Proteins; Oligonucleotide Array Sequence Analysis; Osteopontin; Platelet-Derived Growth Factor; Real-Time Polymerase Chain Reaction; RNA, Messenger; Transfection; Tumor Suppressor Proteins | 2011 |
Assessment of lesion pathology in a new animal model of MS by multiparametric MRI and DTI.
Topics: Animals; Axons; Blood-Brain Barrier; Brain; Cuprizone; Demyelinating Diseases; Diffusion Tensor Imaging; Discriminant Analysis; Encephalomyelitis, Autoimmune, Experimental; Female; Gliosis; Image Processing, Computer-Assisted; Inflammation; Magnetic Resonance Imaging; Mice; Mice, Inbred C57BL; Monoamine Oxidase Inhibitors; Multiple Sclerosis; Pertussis Toxin | 2012 |
Cuprizone inhibits demyelinating leukomyelitis by reducing immune responses without virus exacerbation in an infectious model of multiple sclerosis.
Topics: Animals; Chelating Agents; Cuprizone; Cytokines; Disease Models, Animal; Female; Mice; Multiple Sclerosis; Theilovirus | 2012 |
Olesoxime accelerates myelination and promotes repair in models of demyelination.
Topics: Animals; Cholestenones; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Magnetic Resonance Imaging; Mice; Mice, Inbred C57BL; Monoamine Oxidase Inhibitors; Multiple Sclerosis; Myelin Sheath; Oligodendroglia; Rats; Rats, Sprague-Dawley | 2012 |
Galanin transgenic mice with elevated circulating galanin levels alleviate demyelination in a cuprizone-induced MS mouse model.
Topics: Animals; Cuprizone; Disease Models, Animal; Galanin; Mice; Mice, Transgenic; Monoamine Oxidase Inhibitors; Multiple Sclerosis; Oligodendroglia | 2012 |
Inflammatory response and chemokine expression in the white matter corpus callosum and gray matter cortex region during cuprizone-induced demyelination.
Topics: Animals; Cerebral Cortex; Chemokine CCL2; Chemokine CCL3; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Encephalitis; Gene Expression Regulation; Male; Mice; Mice, Inbred C57BL; Microglia; Monoamine Oxidase Inhibitors; Multiple Sclerosis; Oligodendroglia | 2012 |
Myelin debris regulates inflammatory responses in an experimental demyelination animal model and multiple sclerosis lesions.
Topics: Adult; Aged; Aged, 80 and over; Analysis of Variance; Animals; Calcium-Binding Proteins; Chelating Agents; Corpus Callosum; Cuprizone; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Encephalitis; Female; Gliosis; Histocompatibility Antigens Class II; Humans; Macrophages; Male; Mice; Mice, Inbred C57BL; Microfilament Proteins; Microglia; Middle Aged; Multiple Sclerosis; Myelin Proteolipid Protein; Myelin Sheath; Nerve Fibers, Myelinated; Nerve Tissue Proteins; RNA, Messenger | 2012 |
IL-17-induced Act1-mediated signaling is critical for cuprizone-induced demyelination.
Topics: Animals; Astrocytes; CD3 Complex; Chelating Agents; Connexin 43; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Female; Gene Knockdown Techniques; Interleukin-17; Mice; Mice, Inbred C57BL; Microglia; Multiple Sclerosis; Oligodendroglia; Peptide Fragments; Receptors, Interleukin-17; Signal Transduction; T-Lymphocytes | 2012 |
Sildenafil (Viagra®) down regulates cytokines and prevents demyelination in a cuprizone-induced MS mouse model.
Topics: Animals; Cerebellum; Cuprizone; Cyclooxygenase 2; Cytokines; Demyelinating Diseases; Disease Models, Animal; Down-Regulation; Fluorescent Antibody Technique; Glial Fibrillary Acidic Protein; Immunoblotting; Male; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Piperazines; Purines; Sildenafil Citrate; Sulfones | 2012 |
The cuprizone model: regional heterogeneity of pathology.
Topics: Animals; Cerebral Cortex; Complement System Proteins; Corpus Callosum; Cuprizone; Demyelinating Diseases; Female; Gliosis; Hypoxia-Inducible Factor 1, alpha Subunit; Lymphocytes; Macrophages; Mice; Mice, Inbred C57BL; Microglia; Mitochondria; Multiple Sclerosis; Myelin Sheath; Oligodendroglia | 2012 |
Pathogenesis of multiple sclerosis: what can we learn from the cuprizone model.
Topics: Animals; Apoptosis; Cuprizone; Demyelinating Diseases; Gene Expression Regulation; Humans; Immunohistochemistry; Immunologic Techniques; Mice; Mice, Inbred C57BL; Models, Biological; Multiple Sclerosis; Myelin Basic Protein; Oligodendroglia | 2012 |
Selective ultrastructural vulnerability in the cuprizone-induced experimental demyelination.
Topics: Animals; Apoptosis; Astrocytes; Cerebellum; Chelating Agents; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Humans; Macrophages; Mice; Mice, Inbred C57BL; Microscopy, Electron; Multiple Sclerosis; Myelin Sheath; Oligodendroglia | 2012 |
Expression of the low-affinity neurotrophin receptor, p75(NTR), is upregulated by oligodendroglial progenitors adjacent to the subventricular zone in response to demyelination.
Topics: Adult; Aged; Aged, 80 and over; Animals; Brain; Brain Chemistry; Carrier Proteins; Cell Death; Chelating Agents; Cuprizone; Demyelinating Diseases; Female; Humans; Image Processing, Computer-Assisted; Immunohistochemistry; In Situ Nick-End Labeling; Male; Mice; Mice, Inbred C57BL; Middle Aged; Multiple Sclerosis; Nerve Tissue Proteins; Oligodendroglia; Phenotype; Receptors, Growth Factor; Receptors, Nerve Growth Factor; Stem Cells; Tissue Fixation; Up-Regulation | 2004 |
bHLH transcription factor Olig1 is required to repair demyelinated lesions in the CNS.
Topics: Animals; Animals, Newborn; Basic Helix-Loop-Helix Transcription Factors; Brain; Cell Nucleus; Cuprizone; Cytoplasm; Demyelinating Diseases; DNA-Binding Proteins; Ethidium; Humans; Lysophosphatidylcholines; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Sheath; Nerve Tissue Proteins; Oligodendrocyte Transcription Factor 2; Oligodendroglia; Rats; Rats, Sprague-Dawley; Spinal Cord; Stem Cells; Transcription Factors | 2004 |
Experimental demyelination caused by primary oligodendrocyte dystrophy. Regional distribution of the lesions in the nervous system of mice [corrected].
Topics: Animals; Brain; Chelating Agents; Cuprizone; Demyelinating Diseases; Humans; Immunohistochemistry; In Situ Hybridization; Male; Mice; Multiple Sclerosis; Oligodendroglia; Optic Nerve; Sciatic Nerve; Spinal Cord; Time Factors | 2005 |
Upregulation of the stress-associated gene p8 in mouse models of demyelination and in multiple sclerosis tissues.
Topics: Animals; Apoptosis; Cell Death; Chelating Agents; Corpus Callosum; Cuprizone; Demyelinating Diseases; Encephalomyelitis, Autoimmune, Experimental; Immunohistochemistry; In Situ Hybridization; Macrophages; Mice; Mice, Inbred C57BL; Mice, Knockout; Multiple Sclerosis; Reverse Transcriptase Polymerase Chain Reaction; RNA; Stress, Psychological; Up-Regulation | 2006 |
Interferon-gamma inhibits central nervous system remyelination through a process modulated by endoplasmic reticulum stress.
Topics: Animals; Cuprizone; Demyelinating Diseases; eIF-2 Kinase; Encephalomyelitis, Autoimmune, Experimental; Endoplasmic Reticulum; Female; Interferon-gamma; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Multiple Sclerosis; Myelin Sheath; Nerve Regeneration; Oligodendroglia; Reverse Transcriptase Polymerase Chain Reaction; Stress, Physiological | 2006 |
Endogenous cell repair of chronic demyelination.
Topics: Animals; Chelating Agents; Corpus Callosum; Cuprizone; Disease Models, Animal; Fibroblast Growth Factor 2; Humans; In Situ Hybridization; Mice; Mice, Inbred C57BL; Mice, Knockout; Multiple Sclerosis; Myelin Sheath; Oligodendroglia; Regeneration; Stem Cells | 2006 |
Effects of commissural de- and remyelination on motor skill behaviour in the cuprizone mouse model of multiple sclerosis.
Topics: Analysis of Variance; Animals; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Female; Immunohistochemistry; Mice; Mice, Inbred C57BL; Monoamine Oxidase Inhibitors; Motor Skills; Multiple Sclerosis; Time Factors | 2006 |
Restoration of FcRgamma/Fyn signaling repairs central nervous system demyelination.
Topics: Aging; Animals; Anti-Inflammatory Agents; Central Nervous System; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Drugs, Chinese Herbal; Female; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Monoamine Oxidase Inhibitors; Multiple Sclerosis; Myelin Basic Protein; Myelin Sheath; Nerve Regeneration; Neuroprotective Agents; Neurotoxins; Proto-Oncogene Proteins c-fyn; Receptors, IgG; Recovery of Function; Signal Transduction | 2007 |
Lack of interferon-beta leads to accelerated remyelination in a toxic model of central nervous system demyelination.
Topics: Animals; Astrocytes; Axons; Chelating Agents; Cuprizone; Disease Models, Animal; Gliosis; Interferon-beta; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia; Microscopy, Electron, Transmission; Multiple Sclerosis; Myelin Sheath; Recovery of Function | 2007 |
MRI identification of the rostral-caudal pattern of pathology within the corpus callosum in the cuprizone mouse model.
Topics: Animals; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Immunohistochemistry; Magnetic Resonance Imaging; Mice; Mice, Inbred C57BL; Monoamine Oxidase Inhibitors; Multiple Sclerosis | 2008 |
Remyelination protects axons from demyelination-associated axon degeneration.
Topics: Animals; Axons; Corpus Callosum; Cuprizone; Demyelinating Diseases; Diffusion Magnetic Resonance Imaging; Female; Green Fluorescent Proteins; Immunohistochemistry; Mice; Mice, Inbred C57BL; Mice, Transgenic; Models, Animal; Multiple Sclerosis; Myelin Sheath; Nerve Degeneration; Nerve Regeneration; Stem Cell Transplantation; X-Rays | 2008 |
Cuprizone and piperonyl butoxide, proposed inhibitors of T-cell function, attenuate experimental allergic encephalomyelitis in SJL mice.
Topics: Animals; CD4-CD8 Ratio; Chelating Agents; Chronic Disease; Cuprizone; Encephalomyelitis, Autoimmune, Experimental; Female; Graft vs Host Disease; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Multiple Sclerosis; Pesticide Synergists; Piperonyl Butoxide; Survival Rate; T-Lymphocytes | 2001 |