cuprizone has been researched along with Disease Models, Animal in 434 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (0.23) | 18.2507 |
| 2000's | 48 (11.06) | 29.6817 |
| 2010's | 236 (54.38) | 24.3611 |
| 2020's | 149 (34.33) | 2.80 |
| Authors | Studies |
|---|---|
| Abdi, M; Abouzaripour, M; Fathi, F; Kashani, IR; Mohamed, W; Nekoonam, S; Pasbakhsh, P; Sadeghi, A; Shabani, M; Zendedel, A; Zibara, K | 1 |
| Bao-Guo, X; Lei, Z; Meng-Ru, Z; Ming-Yang, Y; Ruo-Xuan, S; Tong, T; Ying-Bo, Y | 1 |
| An, J; Chai, Z; Chen, YY; Ding, ZB; Han, QX; He, Y; Ma, CG; Song, LJ; Wang, Q; Xiao, BG; Yin, JJ; Yu, JZ | 1 |
| Chen, C; Dong, X; Gong, L; Jiang, P; Li, S; Shao, Y; Shen, W; Sun, Z; Xie, Y; Zeng, L; Zhu, T | 1 |
| Arasteh, J; Ebrahimi, MT; Kazemi, F; Sadeghirashed, S; Taheri, S | 1 |
| Anyaegbu, C; Bartlett, CA; Fitzgerald, M; Hellewell, SC; Lins, B; McGonigle, T; Papini, M; Toomey, LM; Warnock, A; Wright, AJ | 1 |
| Chen, L; Feng, Z; Gao, Z; Liu, Z; Yang, K; Yang, Y; Yao, R; Zhang, C | 1 |
| Alexander, T; Li, X; Liao, BY; Song, SJ; Wang, LB; Wang, ZH; Wu, WC; Wu, XY; Xiao, D; Xiao, Y; Zhang, Y; Zhao, ZH | 1 |
| Correale, JD; de Olmos, S; Di Pietro, AA; Igaz, LM; Marcora, MS; Marder, M; Pasquini, JM; Pasquini, LA; Silva Pinto, P; Vence, M; Wies Mancini, VSB | 1 |
| Khalili, M; Kiasalari, Z; Pourmohammadi, S; Roghani, M | 1 |
| Barati, S; Kashani, IR; Tahmasebi, F | 2 |
| Hahn, KR; Hwang, IK; Jung, HY; Kim, DW; Kim, W; Kwon, HJ; Yoon, YS | 2 |
| Gao, R; Gao, YH; Guo, YX; He, J; Li, X; Wang, LB; Xiao, Y; Zhang, Y; Zhao, ZH | 1 |
| Hong, L; Liu, M; Xu, H; Yang, F; Yu, X; Zhang, W; Zheng, M; Zheng, P | 1 |
| Chang, L; Hashimoto, K; Ma, L; Qu, Y; Shan, J; Tan, Y; Wan, X; Wang, X; Yang, Y | 1 |
| Dunn, JF; Hashem, M; Rho, JM; Shafqat, Q; Wu, Y | 1 |
| Coorssen, JR; Mahns, DA; Sen, MK; Shortland, PJ | 2 |
| Anada, K; Honda, T; Murayama, T; Nakamura, H; Tanaka, A; Yasue, M | 1 |
| Chen, X; Gu, LH; Li, L; Ma, DL; Sun, ZY; Zhang, L | 1 |
| Abdelkader, NF; Ammar, RA; Kamal, MM; Mohamed, AF; Safar, MM | 1 |
| Castillo-Rodriguez, MLA; Gingele, S; Gudi, V; Möllenkamp, T; Schröder, LJ; Skripuletz, T; Stangel, M | 1 |
| Almolda, B; Castellano, B; Enrich-Bengoa, J; González, B; Manich, G; Perálvarez-Marín, A; Sanchez-Molina, P; Saura, J; Solà, C; Valente, T | 1 |
| Assinck, P; Caprariello, AV; Plemel, JR; Sizov, A; Zirngibl, M | 1 |
| Cardona, AE; Cardona, SM; Church, KA; Garcia, SA; Kokovay, E; Lin, CA; Lira, SA; Macklin, W; Mendiola, AS; Ransohoff, RM; Vanegas, D | 1 |
| Begum, Z; Gurusamy, K; Raghunath, G; Sivanesan, S; Subramanian, V; Vijayaraghavan, R | 1 |
| Crocker, SJ; Hardy, CC; Ramasamy, R; Smith, PP | 1 |
| Almeida, L; Ambrósio, AF; Castelo-Branco, M; Dinis, J; Henriques, S; Madeira, MH; Martins, J; Palavra, F; Pereira, FC; Petrella, L; Reis, F; Santiago, R; Sereno, J; Viana, SD | 1 |
| Almuslehi, MSM; Coorssen, JR; Mahns, DA; Sen, MK; Shortland, PJ | 3 |
| Bitar, Y; Frintrop, L; Joost, S; Kaddatz, H; Kipp, M; Staffeld, A; Wittekindt, M | 1 |
| Bauch, J; Faissner, A | 1 |
| Isonishi, A; Kawabe, Y; Nakahara, K; Tanaka, T; Tatsumi, K; Wanaka, A | 1 |
| Bakhshaei, F; Bordbar, E; Namazi, F; Nazifi, S | 1 |
| Khadivi, F; Mohammadi, A; Mojaverrostami, S; Zarini, D | 1 |
| Han, J; Liu, B; Loers, G; Siebert, HC; Sun, W; Wang, Z; Wen, M; Yang, J; Zhang, N; Zhang, R; Zheng, X | 1 |
| El-Naga, RN; Michel, HE; Naeem, AG | 1 |
| Akkermann, R; Azim, K; de Amorim, VCM; Göttle, P; Gruchot, J; Han, S; Küry, P; Lewen, I; Reiche, L; Schira-Heinen, J; Silva Oliveira Junior, M | 1 |
| Han, X; Huang, F; Jin, H; Liang, J; Shi, H; Tao, Y; Wu, H; Wu, X; Xu, N; Yang, L; Yuan, J; Zhang, X | 1 |
| Bakhtiari, N; Hojati, V; Honarvar, F; Javan, M; Zare, L | 1 |
| Chen, Y; Du, X; Guo, Y; Li, M; Li, Q; Li, Y; Liu, L; Liu, Q; Ran, Q; Sun, L; Yang, L; Yang, Q; Zhu, X | 1 |
| Bohlen, CJ; Friedman, BA; Hanson, JE; Kaminker, JS; Kotova, N; Laufer, BI; Lee, SH; Newton, DF; Otero-García, M; Pandey, S; Rezzonico, MG; Shen, K; Shen, YA; Vito, ST; Wang, Y; Yuen, TJ | 1 |
| Haruta, C; Iwasa, K; Maruyama, K; Matsumoto, M; Shimizu, K; Takeda, N; Yamamoto, S; Yamashina, K; Yoshikawa, K | 1 |
| Esfandiary, E; Ghanadian, M; Ghasemi, N; Moradi, V; Rashidi, B | 1 |
| Amirizadeh, S; Hashemi, M; Kashani, IR; Majidpoor, J; Mojaverrostami, S; Mortezaee, K; Omidi, A; Pasbakhsh, P; Shabani, M; Zarini, D | 1 |
| Amichi, AG; Asghari, A; Baloochi, M; Ebrahimi, P; Ghanbarzehi, V; Hashemzahi, E; Holaso, AS; Honardar, M; Hosseini, F; Iravankhah, M; Marzban, M; Rustamzadeh, A; Sadafi, P; Shahraki, M; Terme, Y; Yarmohammadi, A | 1 |
| Chen, M; Han, M; Zhang, Y; Zhu, Y | 1 |
| Kashani, IR; Kazemzadeh, S; Madadi, S; Pasbakhsh, P; Shiri, E; Tahmasebi, F; Zibara, K | 1 |
| Benito-Cuesta, I; Feng, Y; Harris, RA; Sarlus, H; Sun, JX; Wang, DJ; Wang, J; Wang, YM; Wang, YQ; Wu, S; Zhang, MZ; Zhao, XQ; Zhong, QY; Zhu, KY; Zou, ZF | 1 |
| Giesler, P; Kipp, M; Lubrich, C | 1 |
| Bonzheim, I; Fallier-Becker, P; Pfeiffer, F | 1 |
| Jalili, C; Parnow, A; Sohrabi, P | 1 |
| Alsop, DC; Buron, J; Cayre, M; Duhamel, G; Durbec, P; Girard, OM; Hertanu, A; Le Priellec, J; Le Troter, A; Prevost, VH; Ranjeva, JP; Soustelle, L; Varma, G | 1 |
| Chang, L; Eguchi, A; Hashimoto, K; Ma, L; Mori, C; Qu, Y; Shan, J; Wan, X; Wang, X; Yang, J; Yang, Y | 1 |
| Dégano, IR; Enrich-Bengoa, J; Manich, G; Perálvarez-Marín, A | 1 |
| Albrecht, S; Groll, K; Herold, M; Hucke, S; Klotz, L; Kuhlmann, T; Thomas, C; Wallhorn, L; Yilmaz, EN | 1 |
| Baaklini, CS; Burr, MK; Caprariello, AV; Hammond, BP; Ho, MFS; Kerr, BJ; Lee, KV; Mainali, A; Panda, SP; Plemel, JR; Power, C; Simmen, T; Sizov, A; Williams, S; Zia, S; Zirngibl, M | 1 |
| Kipp, M; Leo, H | 1 |
| Sun, J; Wang, D; Wang, J; Wang, Y; Wu, S; Zhang, H | 1 |
| Huang, JK; Kouki, T; Ohno, N; Osanai, Y; Yamazaki, R | 1 |
| Beckmann, N; Berth, R; Doelemeyer, A; Feuerbach, D; Frieauff, W; Gasparini, F; Joller, S; Neuhaus, A; Neumann, U; Patino, C; Rudin, S; Schweizer, T; Shimshek, DR; Volkmer, P; Zurbruegg, S | 1 |
| Hassanpour, S; Tashakori, A; Vazir, B | 1 |
| Barnett, SC; Goodyear, CS; Kipp, M; Lindsay, SL; McCanney, GA; Scheld, M; Smith, RS; Turnbull, JE; Yates, EA; Zhan, J | 1 |
| Andhey, PS; Artyomov, MN; Cai, Z; Chen, Y; Colonna, M; Fitzpatrick, JAJ; Gilfillan, S; Guimaraes, RM; Hou, J; Kim, DH; Qiu, T; Strout, G; Sviben, S; Swain, A; Terekhova, M; Ulezko Antonova, A; Van Dyken, SJ; Zhou, Y | 1 |
| Sun, J; Wang, D; Wang, J; Wang, Y; Wu, S; Zhang, H; Zhao, X; Zhu, K | 1 |
| Akin, AT; Akyuz, E; Doğanyiğit, Z; Okan, A; Uçar, S; Yılmaz, S | 1 |
| Chen, H; Chen, K; Lei, C | 1 |
| Bizen, N; Hashimoto, Y; Hirase, H; Iguchi, M; Kakita, A; Kanai, K; Kanekiyo, K; Kawaguchi, Y; Kitazume, S; Matsuda, N; Muto, Y; Ogawa, H; Sakuda, K; Takahashi, K; Takebayashi, H; Uzuki, M | 1 |
| Ahmed, KA; Ibrahim Fouad, G | 1 |
| Abdelmonsif, DA; Hassaan, PS; Mohamed, DY; Saleh, SR; Samy, DM; Zaki, EI | 1 |
| Hoshino, Y; Li, Y; Miyake, S; Mizuno, M; Noto, D; Yoshikawa, S | 1 |
| Calabresi, PA; Dawson, T; Dawson, VL; Galleguillos, D; Garton, T; Gharagozloo, M; Hussein, O; Jank, L; Kumar, S; Lee, S; Mace, JW; Potluri, S; Siu, C; Smith, MD; Sotirchos, ES; Taylor, M | 1 |
| Bauer, J; Berger, J; Forss-Petter, S; Kunze, M; Martinović, K | 1 |
| Borhani-Haghighi, M; Mohamadi, Y | 1 |
| Rowhanirad, S; Taherianfard, M | 1 |
| Baumann, L; Beecken, M; Greiner, T; Heinig, L; Joost, S; Kipp, M; Manzhula, K; Schauerte, S; Vankriekelsvenne, E | 1 |
| Gudi, V; Kalinke, U; Mulenge, F; Pavlou, A; Schröder, LJ; Skripuletz, T; Stangel, M | 1 |
| Haruta, C; Iwasa, K; Maruyama, K; Yamagishi, A; Yamamoto, S; Yoshikawa, K | 1 |
| Kim, KW; Ljunggren-Rose, Å; Matta, P; Sriram, S; Toki, S | 1 |
| Al-Sharabi, N; Bø, L; Costea, DE; Fromreide, S; Kråkenes, T; Kvistad, CE; Mohamed-Ahmed, S; Mustafa, K; Wergeland, S | 1 |
| Wang, W; Wen, C; Xu, Z | 1 |
| Bao, H; Dai, L; Li, H; Qian, M; Sun, X; Wang, L; Yin, M; Zhao, Y | 1 |
| Kipp, M | 1 |
| Hahn, KR; Hwang, IK; Jung, HY; Kim, DW; Kim, JW; Kim, W; Kwon, HJ; Nam, SM; Park, JH; Won, MH; Yoo, DY; Yoon, YS | 1 |
| Labunets, IF; Rodnichenko, AE | 1 |
| Beyer, C; Clarner, T; Fragoulis, A; Nellessen, A; Nyamoya, S; Slowik, A; Wruck, C; Zendedel, A | 1 |
| Akulov, A; Anan'ina, T; Glazacheva, V; Khodanovich, M; Pan, E; Pishchelko, A; Svetlik, M; Tyumentseva, Y; Yarnykh, V | 1 |
| Heidari, R; Khodaei, F; Khoshnoud, MJ; Rashedinia, M; Rezaei, M | 1 |
| Amiri, M; Barati, M; Golab, F; Houshmand, F; Ramezani-Sefidar, S; Sanadgol, N; Tabatabaei, M; Tanbakooie, S | 1 |
| Alizadeh, R; Aryanpour, R; Beigi Boroujeni, F; Madadi, S; Mortezaee, K; Pasbakhsh, P; Pirhajati, V; Ragerdi Kashani, I | 1 |
| Bao, XQ; Liu, H; Zhang, D; Zhang, Z; Zhao, Z | 1 |
| Almuslehi, MSM; Coorssen, JR; Gyengesi, E; Mahns, DA; Myers, SJ; Sen, MK; Shortland, PJ | 1 |
| An, J; Ding, ZB; Han, QX; He, Y; Ma, CG; Miao, Q; Sui, RX; Wang, Q; Xiao, BG; Yin, JJ | 1 |
| Beyer, C; Chrzanowski, U; Kaye, J; Kipp, M; Nyamoya, S; Schmitz, C; Steinle, J | 1 |
| Ho, C; Kim, Y; Lee, D; Ro, EJ; Suh, H; Trapp, BD; Zhang, H | 1 |
| An, J; He, Y; Ma, CG; Miao, Q; Shi, FD; Sui, RX; Wang, Q; Xiao, BG; Yin, JJ; Yu, JW; Yu, JZ | 1 |
| Behrangi, N; Brendel, M; Jiangshan, Z; Kaye, J; Kipp, M; Nedelcu, J; Reinbach, C; Riedler, P; Rominger, A; Schmitz, C | 1 |
| Boucneau, T; Cao, P; Chaumeil, MM; Guglielmetti, C; Larson, PEZ; Van der Linden, A | 1 |
| Ács, P; Berente, Z; Bölcskei, K; Komoly, S; Kriszta, G; Nemes, B; Pintér, E; Sándor, Z | 1 |
| Han, SR; Jeon, H; Kang, YH; Lee, MS; Lee, S; Lee, SH; Min, SS; Park, SJ; Song, DY; Yoo, SM | 1 |
| Christian, ND; Dorfman, AR; Facer, BD; Facer, JD; Ho, KS; Hotchkin, MT; Karl, M; Karlik, S; Merzliakov, M; Miller, RH; Miller, SD; Mortenson, MG; Robinson, AP; Stewart, MG; Titus, HE; Watt, RK; Zhang, JZ | 1 |
| Brink, LE; Cambi, F; Dubaniewicz, MT; Guzman, K; Kozai, TDY; Li, L; Sridhar, S; Stieger, KC; Wellman, SM | 1 |
| Laflamme, N; Pons, V; Préfontaine, P; Rivest, S | 1 |
| Anandakumar, J; Babbs, RK; Beierle, JA; Bryant, CD; Chen, MM; Johnson, WE; Kelliher, JC; Medeiros, AR; Shah, AA; Yao, EJ | 1 |
| Behrangi, N; Frank, M; Joost, S; Kipp, M; Mann, T; Zhan, J | 1 |
| Gingele, S; Gudi, V; Heckers, S; Henkel, F; Hümmert, MW; Moellenkamp, TM; Skripuletz, T; Stangel, M | 1 |
| Ding, J; He, QX; Liu, J; Liu, Q; Lv, HW; Ma, QR; Shao, Y; Zhang, C | 1 |
| Clements, R; Frankle, L; Freeman, E; McDonough, J; Shelestak, J; Singhal, N; Sternbach, S; Tomor, R | 1 |
| Chrzanowski, U; Hochstrasser, T; Kipp, M; Pröbstl, N; Reinbach, C; Schmitz, C; Stadler, MS | 1 |
| Jin, L; Li, Y; Liu, C; Loers, G; Petridis, AK; Siebert, HC; Wang, Z; Yin, X; Zhang, N; Zhang, R; Zheng, X | 1 |
| Alizadeh, Z; Borhani-Haghighi, M; Kashani, IR; Mehdi, A; Mojaverrostami, S; Nekoonam, S; Pasbakhsh, P; Pirhajati Mahabadi, V; Shiri, E; Zibara, K | 1 |
| Calzado, MA; Feliú, A; García-Martin, A; Garrido-Rodríguez, M; Guaza, C; Mestre, L; Muñoz, E; Navarrete, C | 1 |
| Kashani, IR; Madadi, S; Mojaverrostami, S; Nekoonam, S; Noori, L; Pasbakhsh, P; Salama, M; Shiri, E; Zarini, D; Zibara, K | 1 |
| AboTaleb, HA; Alghamdi, BS | 1 |
| Babashah, S; Javan, M; Motavaf, M; Sadeghizadeh, M; Zare, L | 1 |
| Caprariello, AV; Kaushik, DK; Morgan, ML; Stys, PK | 1 |
| Branton, WG; Doan, MAL; Fernandes, JP; Major, EO; Monaco, MC; Power, C; Saito, LB; Schmitt, LM; Smith, MJ; Wuest, F; Wuest, M | 1 |
| Liu, JC; Liu, L; Ma, QR; Peng, ZW; Qin, JH; Tan, QR; Wang, HN; Xue, F; Xue, SS; Zhou, CH | 1 |
| Jin, L; Liu, C; Loers, G; Petridis, AK; Siebert, HC; Wang, Z; Zhang, N; Zhang, R; Zheng, X | 1 |
| Iwasa, K; Maruyama, K; Sakemoto, C; Shimizu, K; Yamamoto, S; Yoshikawa, K | 1 |
| Barati, S; Kashani, IR; Madadi, S; Pasbakhsh, P; Tahmasebi, F | 1 |
| Amor, S; Greiner, T; Joost, S; Kipp, M; Rohr, SO; Schmitz, C; Valk, PV | 1 |
| An, J; Ding, ZB; Han, QX; He, Y; Huang, JJ; Ma, CG; Miao, Q; Sui, RX; Xiao, BG; Yin, JJ | 1 |
| Aliomrani, M; Eftekhari, SM; Gholami, S; Mirian, M | 1 |
| Abouhamzeh, B; Fattahi, N; Khalilian, B; Madadi, S | 1 |
| Amor, S; Chrzanowski, U; Frenz, J; Gingele, S; Greiner, T; Gudi, V; Joost, S; Kaddatz, H; Kipp, M; Müller, M; Müller-Hilke, B; Nedelcu, J; Santrau, E; Schmitz, C; Stangel, M; van der Valk, P; Zhan, J | 1 |
| Carrete, A; Jafarian-Tehrani, M; Meffre, D; Padilla-Ferrer, A; Simon, A | 1 |
| Branchi, I; Cisbani, G; Laflamme, N; Poggini, S; Pons, V; Rivest, S; Tremblay, MÈ | 1 |
| Heo, H; Kim, JK; Kim, KW; Lee, DH; Lee, DW; Woo, CW; Woo, DC | 1 |
| Buonvicino, D; Chiarugi, A; Ranieri, G | 1 |
| Del Valle, E; García-Álvarez, E; Larráyoz, IM; Martínez-Pinilla, E; Navarro, A; Peláez, R; Rubio-Sardón, N; Tolivia, J | 1 |
| Alberro, A; Castillo-Triviño, T; Egimendia, A; Iparraguirre, L; Moles, L; Muñoz-Culla, M; Osorio-Querejeta, I; Otaegui, D; Ramos-Cabrer, P; Sepúlveda, L; Suárez, J | 1 |
| Baumlin, N; Farine, H; Marrie, J; Martinic, MM; Mentzel, U; Pouzol, L; Sassi, A; Tunis, M; Vezzali, E | 1 |
| Brügger-Verdon, V; Liddelow, S; Marzan, DE; Salzer, JL; Samanta, J; West, BL | 1 |
| Baltan, S; Battapady, HD; Chan, R; Chen, J; Chomyk, AM; Dutta, R; Jawaid, SS; Kidd, GJ; Trapp, BD | 1 |
| Foreman, O; Friedman, BA; Kyauk, RV; Modrusan, Z; Ngu, H; Reichelt, M; Shen, K; Shen, YA; Sheng, M; Yuen, TJ | 1 |
| Azizzadeh Pormehr, L; Meknatkhah, S; Mousavi, MS; Riazi, GH; Sharif Dashti, P | 1 |
| Heo, H; Kim, JK; Lee, DH; Lee, DW; Woo, DC | 1 |
| Chan, JR; Chen, Y; Kunjamma, RB; Popko, B; Weiner, M | 1 |
| Amani, S; Aryanpour, R; Ghanbari, A; Jame'ei, SB; Kashani, IR; Mahmoudi, R; Namjoo, Z; Pasbakhsh, P; Zibara, K | 1 |
| Atangulov, G; Borodin, A; Gadzhiibragimova, Z; Kachanov, D; Usov, S | 1 |
| Chai, Z; Chu, GG; Ding, ZB; Guo, MF; Han, QX; Li, XY; Ma, CG; Song, LJ; Wang, Q; Xiao, BG; Yu, JZ | 1 |
| Gan, G; Li, X; Liu, X; Yang, J; Yao, Y; Zhang, A; Zhang, C; Zhu, X | 1 |
| Chen, X; Ding, S; Du, S; Guo, Y; Han, Y; Li, Y; Yan, Z; Zhu, Q | 1 |
| Elmieh, A; Sajedi, D; Shabani, R | 1 |
| Chen, NH; Chu, SF; Dong, YX; Du, YS; He, WB; Tian, YJ; Wang, SS; Wang, ZZ; Yan, X; Zhang, Z | 1 |
| Karaszewski, B; Klejbor, I; Klimaszewska-Łata, J; Moryś, J; Rutkowska, A; Shimshek, DR; Szutowicz, A; Velasco-Estevez, M | 1 |
| Ahmed, SM; de Vries, SI; Dubey, M; Geurts, JJG; Gold, SM; Gommerman, JL; Huitinga, I; Kole, MHP; Lee, DSW; Malpede, MA; Petersen, N; Ramaglia, V; Schenk, GJ | 1 |
| Bassani, C; Bedogni, F; Colombo, E; Comi, G; Di Dario, M; Dina, G; Farina, C; Fermo, I; Fredrickx, E; Martinelli, V; Newcombe, J; Quattrini, A; Taveggia, C; Triolo, D | 1 |
| Avloniti, M; Fortosi, A; Kyrargyri, V; Probert, L; Roufagalas, I; Thomaidou, D; Xingi, E | 1 |
| Andrei, C; Chirita, C; Ciotu, CI; Fischer, MJM; Mihai, DP; Negres, S; Nitulescu, GM; Olaru, OT; Seremet, OC; Ungurianu, A; Zanfirescu, A; Zbarcea, CE | 1 |
| Aliomrani, M; Eftekhari, SM; Safaei, HA | 1 |
| Eliav, U; Navon, G; Nevo, U; Sasson, E; Wilczynski, E | 1 |
| Don, AS; Duncan, T; Lee, JY; McEwen, HP; Song, H; Teo, JD | 1 |
| Dehpour, AR; Khaledi, E; Mohammadi-Farani, A; Noori, T; Shirooie, S; Sobarzo-Sanchez, E; Sureda, A; Yousefi-Manesh, H | 1 |
| Ahmad, I; Bø, L; Oveland, E; Wergeland, S | 1 |
| Chen, WC; Foxley, S; Kleinnijenhuis, M; Miller, KL; Xu, T | 1 |
| Brickey, WJ; David, CN; Freeman, L; Guo, H; Jha, S; Ting, JP | 1 |
| Akulov, AE; Glazacheva, VY; Khodanovich, MY; Mustafina, LR; Nemirovich-Danchenko, NM; Romashchenko, AV; Sorokina, IV; Tolstikova, TG; Yarnykh, VL | 1 |
| Al-Ebraheem, A; Bock, NA; Farquharson, MJ; Oakden, W; Stanisz, GJ | 1 |
| Ai, H; Chang, H; Chen, G; Liu, J; Wang, F; Wu, Y; Yin, L; Zhang, L; Zhang, Y | 1 |
| Bahn, E; Brück, W; Junker, A; Scheidt, U; Schultz, V; Stadelmann, C; van der Meer, F; Wrzos, C | 1 |
| Caggiano, AO; Colburn, RW; Cui, C; Mullin, AP; Parry, TJ; Pavlopoulos, E; Troy, E; Wang, J; Wang, Y | 1 |
| Anne Becker, K; Chami, M; Fassbender, K; Gulbins, E; Halmer, R; Meier, C; Schnoeder, L; Walter, S | 1 |
| Becker, P; Beisswenger, C; Hainz, N; Meier, C; Rapp, D; Tschernig, T; Wagenpfeil, S; Wonnenberg, B | 1 |
| Gonzalez-Perez, O; Mendez-Victoriano, G; Morales-Luckie, RA; Vega-Riquer, JM | 1 |
| Gotoh, M; Ishikawa, M; Iwasa, K; Maruyama, K; Murakami-Murofushi, K; Yagishita, S; Yamamoto, S; Yamashina, K; Yoshikawa, K | 1 |
| Chaumeil, MM; Didonna, A; Guglielmetti, C; Najac, C; Ronen, SM; Van der Linden, A | 1 |
| Campbell, IL; Castellano, B; Gonzalez, B; Petković, F | 2 |
| Bosetti, F; Hashimoto, M; Ishikawa, M; Iwasa, K; Maruyama, K; Yamamoto, S; Yamashina, K; Yoshikawa, K | 1 |
| DuBois, JC; Gruber, RC; Gulinello, ME; Guzik, HM; Kozakiewicz, L; Perumal, G; Raine, C; Ray, AK; Shafit-Zagardo, B; Williamson, J | 1 |
| Bando, Y; Nomura, T; Tanaka, T; Yoshida, S; You, H | 1 |
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| Darvishi, M; Ghadiri, T; Ghaemi, A; Gorji, A; Khodagholi, F; Noorbakhsh, F; Sharifzadeh, M; Vakilzadeh, G | 1 |
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| Harada, C; Harada, T; Kimura, A; Matsumoto, Y; Namekata, K; Yoshida, H | 1 |
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| Berneman, Z; Daans, J; Guglielmetti, C; Hens, N; Kara, F; Orije, J; Ponsaerts, P; Praet, J; Santermans, E; Van der Linden, A; Verhoye, M | 1 |
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| Baxi, EG; Calabresi, PA; DeBruin, J; Fairchild, AN; Gocke, AR; Grishkan, IV; Kirby, LA; Smith, MD; Strasburger, HJ; Tosi, DM | 1 |
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| Amor, S; Becker, B; Beyer, C; Große-Veldmann, R; Kipp, M; van der Valk, P | 1 |
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| Daans, J; Delgado Y Palacios, R; Fieremans, E; Guglielmetti, C; Mai, Z; Naeyaert, M; Ponsaerts, P; Praet, J; Roelant, E; Sijbers, J; Van Audekerke, J; Van der Linden, A; Vanhoutte, G; Veraart, J; Verhoye, M | 1 |
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| Bai, F; Ren, Q; Sun, J; Zhang, Z; Zhou, H | 1 |
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| Budde, T; Cerina, M; Ghaffarian, N; Göbel, K; Gorji, A; Mesgari, M; Meuth, SG; Speckmann, EJ | 1 |
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| Mashayekhi, F; Salehi, Z | 1 |
| Amor, S; Hochstrasser, T; Kipp, M; Nyamoya, S | 1 |
| Bienert, T; Harsan, LA; Hennig, J; Hübner, NS; Lee, HL; Mechling, AE; Reisert, M; von Elverfeldt, D | 1 |
| Chao, FL; Cheng, GH; Li, YD; Peng, C; Tang, Y; Wang, Y; Xiu, Y | 1 |
| Campbell, IL; Emrich, M; Heneka, MT; Krauthausen, M; Müller, M; Nitsch, L; Saxe, S; Zimmermann, J | 1 |
| Paul, F; Rothe, M; Siegert, E; Weylandt, KH | 1 |
| Barrette, B; Berghoff, SA; Böhler, C; Dibaj, P; Edgar, JM; Gerndt, N; Hosang, L; Liebetanz, D; Möbius, W; Odoardi, F; Ruhwedel, T; Saher, G; Stassart, R; Stumpf, SK; Winchenbach, J | 1 |
| Gingele, S; Gudi, V; Skripuletz, T; Stangel, M; Tejedor, LS; Wostradowski, T | 1 |
| Chen, LX; Dong, FX; Fan, HB; Gao, DS; Qu, XB; Ren, CL; Wu, XX; Yao, RQ; Zhang, BL | 1 |
| Binder, DK; Hasselmann, JPC; Khalaj, AJ; Lapato, AS; Szu, JI; Tiwari-Woodruff, SK | 1 |
| Avila, R; Caporoso, J; Huang, H; Leeper, TC; Manandhar, E; Medicetty, S; Modarelli, DA; Shriver, LP; Taraboletti, A; Walker, T | 1 |
| Bollyky, PL; Han, MH; Kuipers, HF; Palmer, TD; Steinman, L; van Horssen, J; Yoon, J | 1 |
| Grund, LZ; Komegae, EN; Lima, C; Lopes-Ferreira, M; Souza, TA | 1 |
| Exner, GL; Hochstrasser, T; Kipp, M; Nyamoya, S; Schmitz, C | 1 |
| Casaccia-Bonnefil, P; DeVellis, J; Ghiani, CA; Kim, JY; Li, J; Liu, A; Sandoval, J | 1 |
| Bi, X; He, J; Jiang, W; Kong, J; Li, X; Li, XM; Wang, Y; Xiao, L; Xu, H; Yan, B; Zhang, Y | 1 |
| Bando, Y; Ito, S; Kashiwayanagi, M; Takakusaki, K; Terayama, R; Yoshida, S | 1 |
| Brunborg, LA; Bø, L; Myhr, KM; Mørk, SJ; Stangel, M; Thorsen, F; Torkildsen, Ø | 1 |
| Gilmore, W; Matsushima, GK; Taylor, LC | 1 |
| Baumgartner, W; Beyer, C; Braun, A; Clarner, T; Hieble, A; Johann, S; Kipp, M; Norkute, A | 1 |
| Acs, P; Berente, Z; Beyer, C; Braun, A; Clarner, T; Johann, S; Kipp, M; Komoly, S; Norkute, A | 1 |
| Brunborg, LA; Bø, L; Milde, AM; Myhr, KM; Mørk, SJ; Torkildsen, Ø | 1 |
| Gudi, V; Hildebrandt, H; Koutsoudaki, PN; Moharregh-Khiabani, D; Skripuletz, T; Stangel, M; Trebst, C | 1 |
| Agin, A; Boehm, N; Ghandour, MS; Grucker, D; Guignard, B; Harsan, LA; Miller, RH; Parizel, N; Poulet, P; Sapin, R; Steibel, J; Zaremba, A | 1 |
| Brück, W; Klinker, F; Krauss, S; Merkler, D; Prinz, M; Raasch, J; Schmidt, H | 1 |
| Casaccia-Bonnefil, P; Dupree, J; Franklin, RJ; Li, J; Sandoval, J; Shen, S; Swiss, VA | 1 |
| Baumgartner, W; Beyer, C; Clarner, T; Dang, J; Groebe, A; Kipp, M | 1 |
| Millet, V; Moiola, CP; Pasquini, JM; Pasquini, LA; Soto, EF | 1 |
| Bernard, F; Chédotal, A; Franklin, RJ; Hu, B; Ji, B; Jung, V; Lee, X; Mason, J; Mi, S; Miklasz, S; Miller, RH; Pepinsky, B; Roulois, A; Shao, Z; Shea, D; Shields, CB; Tang, W; Wu, W; Xu, J; Zhang, Y | 1 |
| Correcha, M; Fordham, SA; Liñares, D; Maña, P; Silva, D; Staykova, MA; Willenborg, DO | 1 |
| Bussmann, JH; Gudi, V; Koutsoudaki, PN; Lindner, M; Moharregh-Khiabani, D; Pul, R; Skripuletz, T; Stangel, M | 1 |
| Gudi, V; Kotsiari, A; Koutsoudaki, PN; Moharregh-Khiabani, D; Skripuletz, T; Skuljec, J; Stangel, M; Trebst, C | 1 |
| Beyer, C; Clarner, T; Copray, S; Dang, J; Kipp, M | 1 |
| Brück, W; Hao, Z; Held, J; Hesse, A; Kuhlmann, T; Salinas-Riester, G; Wagner, M; Waisman, A | 1 |
| Belkadi, A; Choi, K; Cotleur, AC; Darnall, L; Drescher, C; He, T; Hu, T; Lane, TE; Liu, L; Miller, RH; Padovani-Claudio, D; Ransohoff, RM | 1 |
| Acs, P; Bauer, J; Berente, Z; Borgulya, G; Gallyas, F; Illes, Z; Komoly, S; Lassmann, H; Setalo, G; Sumegi, B; Veto, S | 1 |
| Baertling, F; Beyer, C; Brandenburg, LO; Clarner, T; Kipp, M; Kokozidou, M; Pufe, T; Windoffer, R; Wruck, CJ | 1 |
| Gilmore, W; Matsushima, GK; Puranam, K; Taylor, LC; Ting, JP | 1 |
| Broderick, CL; Duffin, KL; Higgs, RE; Saha, JK; Smith, RC; Werner, SR; Zhen, EY | 1 |
| Dorsey, D; Klein, RS; McCandless, EE; Patel, JR | 1 |
| Armstrong, RC; Budde, MD; Chen, CI; Cross, AH; McDaniel, DP; Song, SK; Tobin, JE; Trinkaus, K; Xie, M | 1 |
| Catania, A; Cicirata, F; Cicirata, V; La Delia, F; Parenti, R; Tress, O; Willecke, K; Zappalà, A | 1 |
| Beyer, C; Buschmann, JP; Clarner, T; Kipp, M | 1 |
| Choi, K; Darnall, L; Hu, T; Lane, TE; Liu, L; Ransohoff, RM | 1 |
| Benetti, F; Carbonera, D; Ceola, S; D'Angelo, P; Maffia, M; Mammi, S; Salmini, B; Salvato, B; Spisni, E; Urso, E; Ventura, M; Zitolo, A | 1 |
| Herring, NR; Konradi, C | 1 |
| Macklin, WB; Miller, RH; Popescu, DC; Wang, C; Wang, Y; Wu, C; Zhu, J | 1 |
| Amor, S; Berger, K; Beyer, C; Clarner, T; Kipp, M; Krauspe, B; Norkus, A; van der Valk, P | 1 |
| Apicco, D; Guckian, K; Hu, Y; Ji, B; Lee, X; Mi, S; Miller, RH; Pepinsky, RB | 1 |
| Amor, S; Beyer, C; Clarner, T; Gingele, S; Kipp, M; Pott, F; van der Valk, P | 1 |
| Armstrong, RC; Le, TQ; Pannu, R; Zhou, YX | 1 |
| Baumgärtner, W; Frichert, K; Gudi, V; Pul, R; Skuljec, J; Stangel, M; Ulrich, R; Voss, EV; Wissel, K; Yildiz, O | 1 |
| Gudi, V; Hackstette, D; Skripuletz, T; Stangel, M | 1 |
| Li, J; Steelman, AJ; Thompson, JP | 1 |
| Brück, W; Friedman, H; Hagemeier, K; Held, J; Kuhlmann, T; Lürbke, A; Peterson, A; Rena Hesse, A | 1 |
| Marder, M; Millet, V; Pasquini, LA | 1 |
| Baumgärtner, W; Beineke, A; Hansmann, F; Herder, V; Rohn, K; Schaudien, D; Stangel, M | 1 |
| Bordet, T; Bourbon, C; Cayre, M; Durbec, P; Khaldi, J; Magalon, K; Pruss, RM; Robles, I; Tardif, G; Viola, A; Zimmer, C | 1 |
| Brück, W; Grønborg, M; Jürgens, T; Kreutzfeldt, M; Kuhlmann, T; Manrique-Hoyos, N; Merkler, D; Schedensack, M; Schrick, C; Simons, M; Urlaub, H | 1 |
| Kong, J; Schroedter, I; Vrontakis, M; Yu, W; Zhang, L | 1 |
| Awad, H; Berger, K; Beyer, C; Buschmann, JP; Clarner, T; Kipp, M | 1 |
| Bi, X; He, J; Jiang, W; Kong, J; Li, XM; Tan, Q; Wang, J; Wang, L; Xiao, L; Xu, H; Zhang, D; Zhang, H; Zhang, R; Zhang, Y; Zhu, S | 1 |
| Amor, S; Berger, K; Beyer, C; Clarner, T; Denecke, B; Diederichs, F; Gan, L; Kipp, M; van der Valk, P | 1 |
| Gulen, MF; Kang, Z; Li, X; Liu, L; Ouyang, W; Ransohoff, RM; Spangler, R; Spear, C; Veenstra, M; Wang, C | 1 |
| Cruz-Höfling, MA; Luna, RL; Nunes, AK; Peixoto, CA; Rapôso, C | 1 |
| Chen, LP; Guo, L; Li, R; Li, ZF; Liu, J; Ping, M; Song, XJ; Xie, XH | 1 |
| Bernard, F; Chédotal, A; Dumas, L; Fouquet, S; Heitz-Marchaland, C; Lee, X; Mi, S; Moreau-Fauvarque, C; Shao, Z; Zagar, Y | 1 |
| Horiuchi, M; Itoh, A; Itoh, T; Kawai, K; Ozato, K; Pleasure, D; Wakayama, K | 1 |
| Armstrong, RC; Hibbits, N; Le, TQ; Yoshino, J | 1 |
| Acs, P; Komoly, S | 1 |
| Kockara, NT; Meng, F; Pereira, GB; Wight, PA; Yang, B | 1 |
| Crawford, DK; Hannsun, G; Molaie, D; Moore, S; Patel, R; Sasidhar, MV; Tan, K; Tiwari-Woodruff, SK | 1 |
| Armstrong, RC; Borke, RC; Frost, EE; Le, TQ; Vana, AC | 1 |
| Franklin, RJ; Genoud, S; Mantei, N; Stidworthy, MF; Suter, U | 1 |
| Arnett, HA; Matsushima, GK; Suzuki, K; Ting, JP; Wang, Y | 1 |
| Franklin, RJ; Fruttiger, M; Richardson, WD; Woodruff, RH | 1 |
| Avellana-Adalid, V; Baron Van Evercooren, A; Bernasconi, L; Boschert, U; Cirillo, R; Feger, G; Graber, P; Kadi, L; Kosco-Vilbois, M; Losberger, C; Papoian, R; Picard-Riera, N; Selvaraju, R | 1 |
| Bacia, A; Soliven, B; Wollmann, R | 1 |
| Arnett, HA; Plant, SR; Ting, JP | 1 |
| Boretius, S; Brück, W; Ernsting, T; Frahm, J; Merkler, D; Michaelis, T; Stadelmann, C | 1 |
| Balasubramaniyan, V; Boddeke, E; Copray, S; de Bruijn, J; Levenga, J; Liem, R | 1 |
| Fordham, S; Liñares, D; Maña, P; Staykova, M; Willenborg, D | 1 |
| Armstrong, RC; Flint, NC; Le, TQ; Vana, AC; Zhou, YX | 1 |
| Liebetanz, D; Merkler, D | 1 |
| Bando, Y; Ito, S; Jiang, YP; Kishibe, M; Mitrovic, B; Nagai, Y; Takahashi, T; Terayama, R; Yoshida, S | 1 |
| Bédard, A; Chernomoretz, A; Tremblay, P; Vallières, L | 1 |
| Akita, M; Asou, H; Fukutake, M; Ishige, A; Sakai, R; Seiwa, C; Takeda, S; Tanaka, K; Ueki, T; Watanabe, K; Yagi, T; Yamamoto, M | 1 |
| Colomina, MT; Franco-Pons, N; Torrente, M; Vilella, E | 1 |
| Kusnecov, AW; Urbach-Ross, D | 1 |
| Barnum, SR; Briggs, DT; Ingersoll, SA; Martin, BK; Martin, CB | 1 |
| Adachi, E; Hashimoto, N; Inagawa-Ogashiwa, M; Kato, C; Moriya-Sato, A; Song, SY; Umeda, R | 1 |
| Baumgärtner, W; Heine, S; Lienenklaus, S; Lindner, M; Stangel, M; Trebst, C; Weiss, S | 1 |
| Binder, M; Cate, HS; Egan, GF; Fang, K; Kemper, D; Kilpatrick, TJ; Marriott, M; Quick, MJ; Wang, HX; Wu, QZ; Yang, Q | 1 |
| Gröticke, I; Hoffmann, K; Lindner, M; Löscher, W; Stangel, M | 1 |
| Binder, MD; Butzkueven, H; Cate, HS; Egan, G; Emery, B; Gordon, IR; Kemper, D; Kilpatrick, TJ; Kolbe, S; Marriott, MP; Murray, S; Wang, H; Wu, Q | 1 |
| Fokuhl, J; Garde, N; Kotsiari, A; Lindner, M; Linsmeier, F; Skripuletz, T; Stangel, M; Trebst, C | 1 |
| Brunborg, LA; Bø, L; Myhr, KM; Torkildsen, O | 1 |
| Binder, MD; Butzkueven, H; Carmeliet, P; Cate, HS; Cipriani, T; Gresle, MM; Jokubaitis, VG; Kemper, D; Kilpatrick, TJ; Prieto, AL | 1 |
| Cammer, W; Tansey, FA; Zhang, H | 1 |
| D'Ercole, AJ; Gao, X; Gillig, TA; Matsushima, GK; Popko, B; Ye, P | 1 |
| Langaman, C; Mason, JL; Matsushima, GK; Morell, P; Suzuki, K | 1 |
| Arnett, HA; Marino, M; Mason, J; Matsushima, GK; Suzuki, K; Ting, JP | 1 |
| Hostettler, J; Jurevics, H; Kleindienst, A; Largent, C; Matsushima, GK; Morell, P; Sammond, DW; Toews, AD | 1 |
21 review(s) available for cuprizone and Disease Models, Animal
| Article | Year |
|---|---|
The roles of microglia and astrocytes in phagocytosis and myelination: Insights from the cuprizone model of multiple sclerosis.
Topics: Animals; Astrocytes; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mice; Mice, Inbred C57BL; Microglia; Multiple Sclerosis; Myelin Sheath; Phagocytosis | 2022 |
Oligodendrocyte death and myelin loss in the cuprizone model: an updated overview of the intrinsic and extrinsic causes of cuprizone demyelination.
Topics: Animals; Astrocytes; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mice; Mice, Inbred C57BL; Microglia; Myelin Sheath; Oligodendroglia | 2022 |
Disease-associated oligodendrocyte responses across neurodegenerative diseases.
Topics: Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Humans; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Neurodegenerative Diseases; Oligodendroglia | 2022 |
Stem cell therapy for cuprizone model of multiple sclerosis focusing on the effectiveness of different injection methods and cell labeling.
Topics: Animals; Brain; Cell- and Tissue-Based Therapy; Cuprizone; Disease Models, Animal; Mice; Mice, Inbred C57BL; Multiple Sclerosis | 2022 |
Motor Behavioral Deficits in the Cuprizone Model: Validity of the Rotarod Test Paradigm.
Topics: Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Sheath; Remyelination; Rotarod Performance Test | 2022 |
Remyelination in Multiple Sclerosis: Findings in the Cuprizone Model.
Topics: Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Humans; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Sheath; Remyelination; Reproducibility of Results | 2022 |
Astrocytes: Lessons Learned from the Cuprizone Model.
Topics: Animals; Astrocytes; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Humans; Mice; Mice, Inbred C57BL; Microglia; Multiple Sclerosis; Myelin Sheath; Oligodendroglia | 2023 |
Behavioural phenotypes in the cuprizone model of central nervous system demyelination.
Topics: Animals; Behavior, Animal; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Myelin Sheath; Oligodendroglia | 2019 |
The Cuprizone Model: Dos and Do Nots.
Topics: Animals; Body Weight; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Gene Expression Regulation; Multiple Sclerosis | 2020 |
Revisiting the Pathoetiology of Multiple Sclerosis: Has the Tail Been Wagging the Mouse?
Topics: Animals; Autoimmunity; Central Nervous System; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Disease Progression; Encephalomyelitis, Autoimmune, Experimental; Humans; Mice; Multiple Sclerosis; Oligodendroglia | 2020 |
Five Decades of Cuprizone, an Updated Model to Replicate Demyelinating Diseases.
Topics: Animals; Brain; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Oligodendroglia; Reproducibility of Results | 2019 |
Remyelination promoting therapies in multiple sclerosis animal models: a systematic review and meta-analysis.
Topics: Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Ethidium; Eye Proteins; Lysophosphatidylcholines; Mice; Multiple Sclerosis; Myelin Sheath; Nerve Growth Factors; Oligodendrocyte Precursor Cells; Oligodendroglia; Platelet-Derived Growth Factor; Remyelination; Serpins; Tocopherols | 2019 |
The benefits and detriments of macrophages/microglia in models of multiple sclerosis.
Topics: Animals; Cell Movement; Central Nervous System; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Humans; Immunologic Factors; Lysophosphatidylcholines; Macrophages; Microglia; Multiple Sclerosis; Neurons; Oligodendroglia; T-Lymphocytes | 2013 |
[Cuprizone short-term exposure: glial activation and psychosis-like behavior].
Topics: Animals; Brain; Cuprizone; Cytokines; Disease Models, Animal; Drug Discovery; Encephalitis; Humans; Inflammation Mediators; Mice; Schizophrenia | 2013 |
Cellular and molecular neuropathology of the cuprizone mouse model: clinical relevance for multiple sclerosis.
Topics: Animals; Brain; Cuprizone; Disease Models, Animal; Mice; Multiple Sclerosis; Myelin Sheath; Neuroglia; Neurons; Oxidative Stress | 2014 |
Multiple sclerosis animal models: a clinical and histopathological perspective.
Topics: Animals; Axons; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Disease Progression; Encephalomyelitis, Autoimmune, Experimental; Humans; Leukoencephalopathies; Multiple Sclerosis; Neurodegenerative Diseases; Spinal Cord | 2017 |
The cuprizone animal model: new insights into an old story.
Topics: Animals; Cuprizone; Disease Models, Animal; Multiple Sclerosis; Myelin Sheath | 2009 |
Myelin, copper, and the cuprizone model of schizophrenia.
Topics: Animals; Biological Evolution; Copper; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Humans; Mice; Myelin Sheath; Oligodendroglia; Schizophrenia | 2011 |
Brain lipid binding protein (FABP7) as modulator of astrocyte function.
Topics: Animals; Astrocytes; Carrier Proteins; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Fatty Acid-Binding Protein 7; Fatty Acid-Binding Proteins; Humans; Multiple Sclerosis; Myelin Sheath; Nerve Tissue Proteins; Signal Transduction; Tumor Suppressor Proteins | 2011 |
De- and remyelination in the CNS white and grey matter induced by cuprizone: the old, the new, and the unexpected.
Topics: Animals; Central Nervous System; Chelating Agents; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Female; Male; Mice; Mice, Inbred C57BL; Myelin Sheath; Neuroprotective Agents; Neurotoxicity Syndromes; Species Specificity | 2011 |
The cuprizone model for demyelination.
Topics: Animals; Chelating Agents; Cuprizone; Disease Models, Animal; Mice; Multiple Sclerosis; Myelin Sheath | 2008 |
1 trial(s) available for cuprizone and Disease Models, Animal
| Article | Year |
|---|---|
The neuroprotective potential of mesenchymal stem cells from bone marrow and human exfoliated deciduous teeth in a murine model of demyelination.
Topics: Animals; Bone Marrow; Corpus Callosum; Cuprizone; Disease Models, Animal; Female; Humans; Inflammation; Mesenchymal Stem Cells; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Neuroprotection; Oligodendroglia; Tooth, Deciduous | 2023 |
412 other study(ies) available for cuprizone and Disease Models, Animal
| Article | Year |
|---|---|
Metformin Therapy Attenuates Pro-inflammatory Microglia by Inhibiting NF-κB in Cuprizone Demyelinating Mouse Model of Multiple Sclerosis.
Topics: Animals; Blotting, Western; Cuprizone; Disease Models, Animal; Male; Metformin; Mice; Mice, Inbred C57BL; Microglia; Multiple Sclerosis; Neuroinflammatory Diseases; Neuroprotective Agents; NF-kappa B; Transcriptome | 2021 |
Antagonizing astrocytic platelet activating factor receptor-neuroinflammation for total flavone of epimedium in response to cuprizone demyelination.
Topics: Administration, Oral; Animals; Astrocytes; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Epimedium; Flavones; Humans; Male; Mice; Myelin Sheath; Neuroinflammatory Diseases; Plant Extracts; Platelet Membrane Glycoproteins; Receptors, G-Protein-Coupled | 2021 |
Temporal and spatial evolution of various functional neurons during demyelination induced by cuprizone.
Topics: Animals; Astrocytes; Axons; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Glutamic Acid; Mice; Monoamine Oxidase Inhibitors; Multiple Sclerosis; Myelin Sheath; Neurons | 2021 |
TRPM2 contributes to neuroinflammation and cognitive deficits in a cuprizone-induced multiple sclerosis model via NLRP3 inflammasome.
Topics: Animals; Cognitive Dysfunction; Cuprizone; Disease Models, Animal; Inflammasomes; Mice; Mice, Knockout; Multiple Sclerosis; Neuroinflammatory Diseases; NLR Family, Pyrin Domain-Containing 3 Protein; Reactive Oxygen Species; TRPM Cation Channels | 2021 |
A novel probiotic strain exerts therapeutic effects on mouse model of multiple sclerosis by altering the expression of inflammasome and IDO genes and modulation of T helper cytokine profile.
Topics: Animals; Cuprizone; Cytokines; Demyelinating Diseases; Disease Models, Animal; Inflammasomes; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Probiotics; T-Lymphocytes, Helper-Inducer | 2022 |
Cuprizone feed formulation influences the extent of demyelinating disease pathology.
Topics: Animal Feed; Animals; Astrocytes; Body Weight; Chelating Agents; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; DNA Damage; Gliosis; Inflammation; Male; Mice; Mice, Inbred C57BL; Microglia; Multiple Sclerosis; Oligodendroglia; Reproducibility of Results | 2021 |
C1q inhibits differentiation of oligodendrocyte progenitor cells via Wnt/β-catenin signaling activation in a cuprizone-induced mouse model of multiple sclerosis.
Topics: Adult; Animals; Cell Differentiation; Cells, Cultured; Chelating Agents; Complement C1q; Cuprizone; Disease Models, Animal; Female; Gene Knockdown Techniques; Humans; Male; Mice; Mice, Inbred C57BL; Middle Aged; Multiple Sclerosis, Relapsing-Remitting; Oligodendrocyte Precursor Cells; Rats; Rats, Sprague-Dawley; Wnt Signaling Pathway | 2022 |
Encapsulation of bryostatin-1 by targeted exosomes enhances remyelination and neuroprotection effects in the cuprizone-induced demyelinating animal model of multiple sclerosis.
Topics: Animals; Bryostatins; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Exosomes; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Neural Stem Cells; Neuroprotection; Neuroprotective Agents; Oligodendroglia; Remyelination | 2022 |
Colony-stimulating factor-1 receptor inhibition attenuates microgliosis and myelin loss but exacerbates neurodegeneration in the chronic cuprizone model.
Topics: Animals; Colony-Stimulating Factors; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mice; Mice, Inbred C57BL; Microglia; Multiple Sclerosis; Myelin Sheath | 2022 |
Paeonol Ameliorates Cuprizone-Induced Hippocampal Demyelination and Cognitive Deficits through Inhibition of Oxidative and Inflammatory Events.
Topics: Acetophenones; Animals; Cognition; Cuprizone; Disease Models, Animal; Hippocampus; Inflammation; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Oxidative Stress | 2022 |
The effects of mesenchymal stem cells transplantation on A1 neurotoxic reactive astrocyte and demyelination in the cuprizone model.
Topics: Animals; Astrocytes; Biomarkers; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Male; Mesenchymal Stem Cells; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Oligodendroglia | 2022 |
Comparison of the Effects of Cuprizone on Demyelination in the Corpus Callosum and Hippocampal Progenitors in Young Adult and Aged Mice.
Topics: Animals; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Hippocampus; Mice; Mice, Inbred C57BL; Oligodendroglia | 2022 |
A targeted extracellular vesicles loaded with montelukast in the treatment of demyelinating diseases.
Topics: Acetates; Animals; Cell Differentiation; Cell Lineage; Cuprizone; Cyclopropanes; Demyelinating Diseases; Disease Models, Animal; Drug Delivery Systems; Exosomes; Extracellular Vesicles; In Vitro Techniques; Ligands; Male; Mice; Mice, Inbred C57BL; Myelin Basic Protein; Myelin Sheath; Neurons; Oligodendrocyte Precursor Cells; Oligodendroglia; Phagocytosis; Quinolines; Receptor, Platelet-Derived Growth Factor alpha; Regeneration; Stem Cells; Sulfides | 2022 |
Cuprizone-induced dopaminergic hyperactivity and locomotor deficit in zebrafish larvae.
Topics: Animals; Behavior, Animal; Cuprizone; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Motor Activity; Synaptic Transmission; Zebrafish | 2022 |
(R)-ketamine ameliorates demyelination and facilitates remyelination in cuprizone-treated mice: A role of gut-microbiota-brain axis.
Topics: Animals; Brain; Cuprizone; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Humans; Ketamine; Mice; Mice, Inbred C57BL; Microbiota; Microglia; Myelin Sheath; Oligodendroglia; Remyelination; RNA, Ribosomal, 16S | 2022 |
Abnormal oxidative metabolism in the cuprizone mouse model of demyelination: An in vivo NIRS-MRI study.
Topics: Animals; Cell Hypoxia; Cerebral Cortex; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Magnetic Resonance Imaging; Male; Mice; Mice, Inbred C57BL; Mitochondria; Oxidative Stress; Remyelination; Spectroscopy, Near-Infrared; Spin Labels | 2022 |
Ceramide kinase knockout ameliorates multiple sclerosis-like behaviors and demyelination in cuprizone-treated mice.
Topics: Age Factors; Animals; Behavior, Animal; Brain; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Female; Male; Mice, Inbred C57BL; Mice, Knockout; Multiple Sclerosis; Oligodendroglia; Phosphotransferases (Alcohol Group Acceptor); Proteins; Tail | 2022 |
DHF-7 Ameliorates Behavioral Disorders and White Matter Lesions by Regulating BDNF and Fyn in a Mouse Model of Schizophrenia Induced by Cuprizone and MK-801.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cuprizone; Disease Models, Animal; Dizocilpine Maleate; Humans; Mice; Mice, Inbred C57BL; Proto-Oncogene Proteins c-fyn; Schizophrenia; White Matter | 2022 |
Neuroprotective effect of liraglutide in an experimental mouse model of multiple sclerosis: role of AMPK/SIRT1 signaling and NLRP3 inflammasome.
Topics: AMP-Activated Protein Kinases; Animals; Beclin-1; Cuprizone; Disease Models, Animal; Inflammasomes; Liraglutide; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Neuroprotective Agents; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein; Sirtuin 1; Toll-Like Receptor 4 | 2022 |
Astroglial and oligodendroglial markers in the cuprizone animal model for de- and remyelination.
Topics: Animals; Astrocytes; Biomarkers; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mice; Mice, Inbred C57BL; Myelin Sheath; Oligodendroglia; Remyelination; Vimentin | 2022 |
TRPV2: A Key Player in Myelination Disorders of the Central Nervous System.
Topics: Animals; Calcium Channels; Central Nervous System; Cuprizone; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Humans; Inflammation; Mice; Mice, Inbred C57BL; Myelin Sheath; Oligodendroglia; Remyelination; TRPV Cation Channels | 2022 |
Defective fractalkine-CX3CR1 signaling aggravates neuroinflammation and affects recovery from cuprizone-induced demyelination.
Topics: Animals; Chemokine CX3CL1; Cuprizone; CX3C Chemokine Receptor 1; Demyelinating Diseases; Disease Models, Animal; Humans; Mice; Mice, Inbred C57BL; Microglia; Myelin Sheath; Neuroinflammatory Diseases; Remyelination | 2022 |
Efficacy of different intensity of aquatic exercise in enhancing remyelination and neuronal plasticity using cuprizone model in male Wistar rats.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Glial Fibrillary Acidic Protein; Male; Methylprednisolone; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Basic Protein; Neuronal Plasticity; Neuroprotective Agents; Rats; Rats, Wistar; Remyelination | 2022 |
Cuprizone-mediated demyelination reversibly degrades voiding behavior in mice while sparing brainstem reflex.
Topics: Animals; Brain Stem; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Humans; Inflammation; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Sheath; Oligodendroglia; Quality of Life; Reflex; Urination | 2022 |
Defining milestones for the study of remyelination using the cuprizone mouse model: How early is early?
Topics: Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Humans; Male; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Sheath; Remyelination | 2022 |
Histological and Top-Down Proteomic Analyses of the Visual Pathway in the Cuprizone Demyelination Model.
Topics: Animals; Cuprizone; Disease Models, Animal; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Proteins; Proteomics; Visual Pathways | 2022 |
Different Methods for Evaluating Microglial Activation Using Anti-Ionized Calcium-Binding Adaptor Protein-1 Immunohistochemistry in the Cuprizone Model.
Topics: Animals; Astrocytes; Calcium; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Immunohistochemistry; Mice; Mice, Inbred C57BL; Microglia; Multiple Sclerosis | 2022 |
The Extracellular Matrix Proteins Tenascin-C and Tenascin-R Retard Oligodendrocyte Precursor Maturation and Myelin Regeneration in a Cuprizone-Induced Long-Term Demyelination Animal Model.
Topics: Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Extracellular Matrix; Mice; Mice, Inbred C57BL; Mice, Knockout; Myelin Sheath; Oligodendrocyte Precursor Cells; Tenascin | 2022 |
Characterization of Glial Populations in the Aging and Remyelinating Mouse Corpus Callosum.
Topics: Animals; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mice; Mice, Inbred C57BL; Myelin Sheath; Oligodendroglia | 2022 |
The effect of Urtica dioica extract on oxidative stress, heat shock proteins, and brain histopathology in multiple sclerosis model.
Topics: Animals; Antioxidants; Brain; Cuprizone; Disease Models, Animal; Heat-Shock Proteins; Male; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Oxidative Stress; Plant Extracts; Urtica dioica | 2022 |
Combination effects of mesenchymal stem cells transplantation and anodal transcranial direct current stimulation on a cuprizone-induced mouse model of multiple sclerosis.
Topics: Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mesenchymal Stem Cells; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Transcranial Direct Current Stimulation | 2022 |
HDAC3 Inhibitor RGFP966 Ameliorated Neuroinflammation in the Cuprizone-Induced Demyelinating Mouse Model and LPS-Stimulated BV2 Cells by Downregulating the P2X7R/STAT3/NF-κB65/NLRP3 Activation.
Topics: Acrylamides; Animals; Caspase 1; Cuprizone; Disease Models, Animal; Enzyme Inhibitors; Histone Deacetylases; Interleukin-18; Lipopolysaccharides; Mice; Microglia; Neuroinflammatory Diseases; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein; Phenylenediamines | 2022 |
Nebivolol elicits a neuroprotective effect in the cuprizone model of multiple sclerosis in mice: emphasis on M1/M2 polarization and inhibition of NLRP3 inflammasome activation.
Topics: Animals; Cell Polarity; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Inflammasomes; Macrophages; Mice; Mice, Inbred C57BL; Microglia; Multiple Sclerosis; Nebivolol; Neuroprotective Agents; NLR Family, Pyrin Domain-Containing 3 Protein | 2022 |
Myelin repair is fostered by the corticosteroid medrysone specifically acting on astroglial subpopulations.
Topics: Adrenal Cortex Hormones; Animals; Astrocytes; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mice; Mice, Inbred C57BL; Myelin Sheath; Oligodendroglia; Pregnenediones | 2022 |
Total astragalosides promote oligodendrocyte precursor cell differentiation and enhance remyelination in cuprizone-induced mice through suppression of Wnt/β-catenin signaling pathway.
Topics: Animals; beta Catenin; Cell Differentiation; Cuprizone; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Humans; Mice; Mice, Inbred C57BL; Myelin Sheath; Oligodendrocyte Precursor Cells; Oligodendroglia; Remyelination; Wnt Signaling Pathway | 2022 |
Ursolic Acid Enhances Myelin Repair in Adult Mice Brains and Stimulates Exhausted Oligodendrocyte Progenitors to Remyelinate.
Topics: Animals; Anti-Inflammatory Agents; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Glial Fibrillary Acidic Protein; Gliosis; Inflammation; Interleukin-10; Mice; Mice, Inbred C57BL; Myelin Sheath; Oligodendrocyte Precursor Cells; Oligodendroglia; Tumor Necrosis Factor-alpha; Ursolic Acid | 2022 |
Ginsenoside Rg1 promotes remyelination and functional recovery in demyelinating disease by enhancing oligodendrocyte precursor cells-mediated myelin repair.
Topics: Animals; beta Catenin; Cell Differentiation; Cuprizone; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Ginsenosides; Glycogen Synthase Kinase 3 beta; Mice; Mice, Inbred C57BL; Myelin Sheath; Oligodendrocyte Precursor Cells; Remyelination | 2022 |
Suppressive Effect of Fruiting Bodies of Medicinal Mushrooms on Demyelination and Motor Dysfunction in a Cuprizone-Induced Multiple Sclerosis Mouse Model.
Topics: Agaricales; Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Fruiting Bodies, Fungal; Mice; Mice, Inbred C57BL; Multiple Sclerosis | 2022 |
The effect of Zingiber Officinale Extract on Preventing Demyelination of Corpus Callosum in a Rat Model of Multiple Sclerosis
Topics: Animals; Anti-Inflammatory Agents; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Fingolimod Hydrochloride; Male; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Sheath; Rats; Rats, Wistar; Zingiber officinale | 2022 |
Glial Response to Intranasal Mesenchymal Stem Cells in Intermittent Cuprizone Model of Demyelination.
Topics: Animals; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Interleukin-10; Mesenchymal Stem Cells; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Sheath; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha | 2022 |
Stemazole Promotes Oligodendrocyte Precursor Cell Survival In Vitro and Remyelination In Vivo.
Topics: Animals; Cell Differentiation; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Hydrazines; Mice; Mice, Inbred C57BL; Myelin Sheath; Oligodendrocyte Precursor Cells; Oligodendroglia; Oxadiazoles; Remyelination | 2022 |
Combination Therapy of Mesenchymal Stem Cell Transplantation and Astrocyte Ablation Improve Remyelination in a Cuprizone-Induced Demyelination Mouse Model.
Topics: Animals; Astrocytes; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mesenchymal Stem Cell Transplantation; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Sheath; Remyelination; RNA, Messenger | 2022 |
Activation of TRPV1 receptor facilitates myelin repair following demyelination via the regulation of microglial function.
Topics: Animals; Capsaicin; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Humans; Mice; Mice, Inbred C57BL; Microglia; Multiple Sclerosis; Myelin Sheath; TRPV Cation Channels | 2023 |
Cuprizone feeding induces swollen astrocyte endfeet.
Topics: Animals; Astrocytes; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mice; Mice, Inbred C57BL | 2022 |
Treadmill aerobic training improve beam-walking test, up-regulate expression of main proteins of myelin and myelination in the hippocampus of cuprizone-fed mice.
Topics: Animals; Cuprizone; Disease Models, Animal; Female; Hippocampus; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Sheath; Walking | 2023 |
Inhomogeneous Magnetization Transfer (ihMT) imaging in the acute cuprizone mouse model of demyelination/remyelination.
Topics: Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Magnetic Resonance Imaging; Mice; Mice, Inbred C57BL; Myelin Sheath; Remyelination | 2023 |
Key role of the gut-microbiota-brain axis via the subdiaphragmatic vagus nerve in demyelination of the cuprizone-treated mouse brain.
Topics: Animals; Brain; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mice; Mice, Inbred C57BL; Microbiota; Microglia; Multiple Sclerosis; Vagus Nerve | 2023 |
Deciphering the Genetic Crosstalk between Microglia and Oligodendrocyte Precursor Cells during Demyelination and Remyelination Using Transcriptomic Data.
Topics: Animals; Cell Differentiation; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Humans; Mice; Mice, Inbred C57BL; Microglia; Multiple Sclerosis; Myelin Sheath; Oligodendrocyte Precursor Cells; Oligodendroglia; Remyelination | 2022 |
Influx of T cells into corpus callosum increases axonal injury, but does not change the course of remyelination in toxic demyelination.
Topics: Animals; Axons; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Sheath; Oligodendroglia; Remyelination; T-Lymphocytes | 2023 |
Single-cell microglial transcriptomics during demyelination defines a microglial state required for lytic carcass clearance.
Topics: Acridine Orange; Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mice; Mice, Inbred C57BL; Microglia; Transcriptome | 2022 |
Huperzine-A Improved Animal Behavior in Cuprizone-Induced Mouse Model by Alleviating Demyelination and Neuroinflammation.
Topics: Acetylcholinesterase; Animals; Behavior, Animal; Cuprizone; Cytokines; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Neuroinflammatory Diseases | 2022 |
Pharmacological treatment promoting remyelination enhances motor function after internal capsule demyelination in mice.
Topics: Animals; Clemastine; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Internal Capsule; Lysophosphatidylcholines; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Sheath; Oligodendroglia; Remyelination | 2023 |
Genetic models of cleavage-reduced and soluble TREM2 reveal distinct effects on myelination and microglia function in the cuprizone model.
Topics: Animals; Cuprizone; Cytokines; Demyelinating Diseases; Disease Models, Animal; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia; Models, Genetic; Myelin Sheath; Neuroinflammatory Diseases; Receptors, Immunologic | 2023 |
Protective effect of crocin on cuprizone-induced model of multiple sclerosis in mice.
Topics: Animals; Antioxidants; Cuprizone; Disease Models, Animal; Male; Mice; Mice, Inbred C57BL; Multiple Sclerosis | 2023 |
Cu,Zn-Superoxide Dismutase has Minimal Effects Against Cuprizone-Induced Demyelination, Microglial Activation, and Neurogenesis Defects in the C57BL/6 Mouse Hippocampus.
Topics: Animals; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Doublecortin Domain Proteins; Hippocampus; Ki-67 Antigen; Mice; Mice, Inbred C57BL; Microglia; Neurogenesis; Superoxide Dismutase-1; Zinc | 2023 |
Low sulfated heparan sulfate mimetic differentially affects repair in immune-mediated and toxin-induced experimental models of demyelination.
Topics: Animals; Central Nervous System Diseases; Corpus Callosum; Cuprizone; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Heparitin Sulfate; Mice; Mice, Inbred C57BL; Myelin Sheath; Oligodendroglia; Sulfates | 2023 |
Transcriptomic atlas and interaction networks of brain cells in mouse CNS demyelination and remyelination.
Topics: Animals; Brain; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mice; Mice, Inbred C57BL; Microglia; Myelin Sheath; Oligodendroglia; Remyelination; Transcriptome | 2023 |
Microglial aryl hydrocarbon receptor enhances phagocytic function via SYK and promotes remyelination in the cuprizone mouse model of demyelination.
Topics: Animals; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mice; Mice, Inbred C57BL; Microglia; Myelin Sheath; Receptors, Aryl Hydrocarbon; Remyelination | 2023 |
Immunoreactivity of Kir3.1, muscarinic receptors 2 and 3 on the brainstem, vagus nerve and heart tissue under experimental demyelination.
Topics: Animals; Brain Stem; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Female; Male; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Sheath; Rats; Rats, Wistar; Receptors, Muscarinic; Vagus Nerve | 2023 |
Effects of Bone Marrow Mesenchymal Stem Cells on Myelin Repair and Emotional Changes of a Cuprizone-Induced Demyelination Model.
Topics: Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Male; Mesenchymal Stem Cells; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Sheath | 2023 |
Brain-specific glycosylation of protein tyrosine phosphatase receptor type Z (PTPRZ) marks a demyelination-associated astrocyte subtype.
Topics: Animals; Astrocytes; Brain; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Glycosylation; Mice; Mice, Inbred C57BL; Polysaccharides; Protein Tyrosine Phosphatases | 2023 |
Remyelinating activities of Carvedilol or alpha lipoic acid in the Cuprizone-Induced rat model of demyelination.
Topics: Animals; Carvedilol; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Neurodegenerative Diseases; Rats; Thioctic Acid | 2023 |
Neurobehavioral, biochemical and histological assessment of the effects of resveratrol on cuprizone-induced demyelination in mice: role of autophagy modulation.
Topics: Animals; Autophagy; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mice; Mice, Inbred C57BL; Myelin Sheath; Resveratrol | 2023 |
Immunoglobulin directly enhances differentiation of oligodendrocyte-precursor cells and remyelination.
Topics: Animals; Cell Differentiation; Cuprizone; Disease Models, Animal; Immunoglobulins; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Sheath; Oligodendroglia; Remyelination | 2023 |
The Effects of NLY01, a Novel Glucagon-Like Peptide-1 Receptor Agonist, on Cuprizone-Induced Demyelination and Remyelination: Challenges and Future Perspectives.
Topics: Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Glucagon-Like Peptide-1 Receptor; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Sheath; Remyelination | 2023 |
Abcd1 deficiency accelerates cuprizone-induced oligodendrocyte loss and axonopathy in a demyelinating mouse model of X-linked adrenoleukodystrophy.
Topics: Adrenoleukodystrophy; Animals; ATP Binding Cassette Transporter, Subfamily D, Member 1; ATP-Binding Cassette Transporters; Cuprizone; Disease Models, Animal; Mice; Mice, Inbred C57BL; Myelin Sheath; Oligodendroglia | 2023 |
TGN020 application against aquaporin 4 improved multiple sclerosis by inhibiting astrocytes, microglia, and NLRP3 inflammasome in a cuprizone mouse model.
Topics: Animals; Aquaporin 4; Astrocytes; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Inflammasomes; Male; Mice; Mice, Inbred C57BL; Microglia; Multiple Sclerosis; NLR Family, Pyrin Domain-Containing 3 Protein | 2023 |
The neuroprotective effects of Chalcones from Ashitaba on cuprizone-induced demyelination via modulation of brain-derived neurotrophic factor and tumor necrosis factor α.
Topics: Animals; Brain-Derived Neurotrophic Factor; Chalcones; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Neuroprotective Agents; Tumor Necrosis Factor-alpha | 2023 |
The Cuprizone Mouse Model: A Comparative Study of Cuprizone Formulations from Different Manufacturers.
Topics: Animals; Body Weight; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Gliosis; Male; Mice; Mice, Inbred C57BL; Myelin Sheath | 2023 |
Dynamics of reactive astrocytes fosters tissue regeneration after cuprizone-induced demyelination.
Topics: Animals; Astrocytes; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mice; Mice, Inbred C57BL; Myelin Sheath; Neuroglia; Oligodendroglia | 2023 |
Microglial depletion exacerbates axonal damage and motor dysfunction in mice with cuprizone-induced demyelination.
Topics: Animals; Axons; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mice; Mice, Inbred C57BL; Microglia; Multiple Sclerosis | 2023 |
Inhibition of SUMOylation promotes remyelination and reduces IL-17 mediated autoimmune inflammation: Novel approach toward treatment of inflammatory CNS demyelinating disease.
Topics: Animals; Cell Differentiation; Central Nervous System Diseases; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Humans; Inflammation; Interleukin-17; Mice; Mice, Inbred C57BL; Myelin Sheath; Oligodendroglia; Remyelination; Sumoylation; Transcription Factors | 2023 |
Role of MAPK and PI3K-Akt signaling pathways in cuprizone-induced demyelination and cognitive impairment in mice.
Topics: Animals; Cognitive Dysfunction; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mice; Mice, Inbred C57BL; Myelin Sheath; Oligodendroglia; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction | 2024 |
FKBP5 activates mitophagy by ablating PPAR-γ to shape a benign remyelination environment.
Topics: Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mice; Mice, Inbred C57BL; Mitophagy; Multiple Sclerosis; Myelin Sheath; Neurodegenerative Diseases; PPAR gamma; Remyelination | 2023 |
Melatonin ameliorates cuprizone-induced reduction of hippocampal neurogenesis, brain-derived neurotrophic factor, and phosphorylation of cyclic AMP response element-binding protein in the mouse dentate gyrus.
Topics: Animals; Antioxidants; Blotting, Western; Brain-Derived Neurotrophic Factor; Cuprizone; Cyclic AMP Response Element-Binding Protein; Dentate Gyrus; Disease Models, Animal; Doublecortin Protein; Hippocampus; Male; Melatonin; Mice; Mice, Inbred C57BL; Neural Stem Cells; Neurogenesis; Phosphorylation; Temporal Lobe | 2019 |
[Melatonin effects in young and aged mice with toxic cuprizone-induced model of demyelination.]
Topics: Animals; Antioxidants; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Melatonin; Mice; Mice, Inbred C57BL; Neurons | 2019 |
Nrf2 deficiency increases oligodendrocyte loss, demyelination, neuroinflammation and axonal damage in an MS animal model.
Topics: Animals; Axons; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Inflammation; Mice; Mice, Knockout; Multiple Sclerosis; NF-E2-Related Factor 2; Oligodendroglia; Oxidative Stress | 2020 |
Quantitative Imaging of White and Gray Matter Remyelination in the Cuprizone Demyelination Model Using the Macromolecular Proton Fraction.
Topics: Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Gray Matter; Magnetic Resonance Imaging; Male; Mesothelin; Mice; Myelin Basic Protein; Oligodendrocyte Precursor Cells; Oligodendroglia; Remyelination; White Matter | 2019 |
Ellagic acid improves muscle dysfunction in cuprizone-induced demyelinated mice via mitochondrial Sirt3 regulation.
Topics: Animals; Behavior, Animal; Chelating Agents; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Ellagic Acid; Male; Mice; Mice, Inbred C57BL; Mitochondria, Muscle; Muscular Diseases; Oxidative Stress; Sirtuin 3 | 2019 |
Metformin-induced AMPK activation stimulates remyelination through induction of neurotrophic factors, downregulation of NogoA and recruitment of Olig2+ precursor cells in the cuprizone murine model of multiple sclerosis.
Topics: AMP-Activated Protein Kinases; Animals; Cuprizone; Disease Models, Animal; Down-Regulation; Enzyme Activation; Gene Expression Regulation, Neoplastic; Male; Metformin; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Nerve Growth Factors; Oligodendrocyte Transcription Factor 2 | 2019 |
Intranasal delivery of SDF-1α-preconditioned bone marrow mesenchymal cells improves remyelination in the cuprizone-induced mouse model of multiple sclerosis.
Topics: Administration, Intranasal; Animals; Cell Movement; Chemokine CXCL12; Cuprizone; Disease Models, Animal; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mice; Mice, Inbred C57BL; Monoamine Oxidase Inhibitors; Multiple Sclerosis; Remyelination; Transplantation Conditioning | 2020 |
Phloroglucinol derivative compound 21 attenuates cuprizone-induced multiple sclerosis mice through promoting remyelination and inhibiting neuroinflammation.
Topics: Animals; Astrocytes; Brain; Cuprizone; Cytokines; Disease Models, Animal; Drug Discovery; Inflammation; Male; Mice; Mice, Inbred C57BL; Microglia; Multiple Sclerosis; Myelin Basic Protein; Oligodendroglia; Phloroglucinol; Remyelination; Treatment Outcome | 2020 |
Suppression of the Peripheral Immune System Limits the Central Immune Response Following Cuprizone-Feeding: Relevance to Modelling Multiple Sclerosis.
Topics: Adaptive Immunity; Animals; Brain; Computational Biology; Cuprizone; Cytokines; Demyelinating Diseases; Disease Models, Animal; Gliosis; Immune System; Male; Mice; Mice, Inbred C57BL; Microglia; Mitochondria; Multiple Sclerosis; Oligodendroglia | 2019 |
Ethyl pyruvate enhances spontaneous remyelination by targeting microglia phagocytosis.
Topics: Animals; Behavior, Animal; Cell Line; Cell Movement; Cell Survival; Cuprizone; Cytokines; Demyelinating Diseases; Disease Models, Animal; Male; Mice, Inbred C57BL; Microglia; Multiple Sclerosis; Phagocytosis; Pyruvates; Remyelination | 2019 |
Laquinimod Supports Remyelination in Non-Supportive Environments.
Topics: Animals; Brain; Cell Differentiation; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mice; Mice, Inbred C57BL; Microglia; Multiple Sclerosis; Myelin Sheath; Oligodendrocyte Transcription Factor 2; Oligodendroglia; Quinolones; Remyelination | 2019 |
Hippocampal Neurogenesis and Neural Circuit Formation in a Cuprizone-Induced Multiple Sclerosis Mouse Model.
Topics: Animals; Cell Proliferation; Cognitive Dysfunction; Cuprizone; Disease Models, Animal; Hippocampus; Male; Mice; Mice, Inbred C57BL; Monoamine Oxidase Inhibitors; Multiple Sclerosis; Neural Pathways; Neural Stem Cells; Neurogenesis; Neurons | 2020 |
Temporal and Spatial Dynamics of Astroglial Reaction and Immune Response in Cuprizone-Induced Demyelination.
Topics: Animals; Astrocytes; Blood-Brain Barrier; Brain; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Male; Mice, Inbred C57BL; Myelin Sheath; T-Lymphocytes | 2020 |
Laquinimod ameliorates secondary brain inflammation.
Topics: Animals; Brain; Cuprizone; Disease Models, Animal; Encephalitis; Female; Gliosis; Mice, Inbred C57BL; Multiple Sclerosis; Quinolones | 2020 |
Longitudinal evaluation of demyelinated lesions in a multiple sclerosis model using ultrashort echo time magnetization transfer (UTE-MT) imaging.
Topics: Animals; Cerebral Cortex; Cuprizone; Disease Models, Animal; Female; Gray Matter; Magnetic Resonance Imaging; Mice; Monoamine Oxidase Inhibitors; Multiple Sclerosis; Myelin Sheath; Neuroimaging; Remyelination; White Matter | 2020 |
Investigation of Cuprizone-Induced Demyelination in mGFAP-Driven Conditional Transient Receptor Potential Ankyrin 1 (TRPA1) Receptor Knockout Mice.
Topics: Animals; Astrocytes; Brain; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Disease Susceptibility; Gene Expression; Glial Fibrillary Acidic Protein; Immunohistochemistry; Magnetic Resonance Imaging; Mice; Mice, Knockout; Microglia; RNA, Messenger; TRPA1 Cation Channel | 2019 |
Differential Expression of miRNAs and Behavioral Change in the Cuprizone-Induced Demyelination Mouse Model.
Topics: Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Exploratory Behavior; Female; Gene Expression Regulation; Gene Regulatory Networks; Male; Mice; Mice, Inbred C57BL; MicroRNAs; Rotarod Performance Test | 2020 |
Behavioural and histological changes in cuprizone-fed mice.
Topics: Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mice; Mice, Inbred C57BL; Oligodendroglia | 2020 |
Nanocatalytic activity of clean-surfaced, faceted nanocrystalline gold enhances remyelination in animal models of multiple sclerosis.
Topics: Animals; Apoptosis; Biomechanical Phenomena; Cell Movement; Cuprizone; Disease Models, Animal; Gene Expression Profiling; Gold; Metal Nanoparticles; Mice; Movement; Multiple Sclerosis; Oligodendrocyte Precursor Cells; Remyelination; Signal Transduction | 2020 |
Cuprizone-induced oligodendrocyte loss and demyelination impairs recording performance of chronically implanted neural interfaces.
Topics: Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mice; Mice, Inbred C57BL; Myelin Sheath; Oligodendroglia | 2020 |
Role of Macrophage Colony-Stimulating Factor Receptor on the Proliferation and Survival of Microglia Following Systemic Nerve and Cuprizone-Induced Injuries.
Topics: Animals; Brain; Cell Proliferation; Cell Survival; Chimera; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Hypoglossal Nerve Injuries; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor | 2020 |
The effect of the demyelinating agent cuprizone on binge-like eating of sweetened palatable food in female and male C57BL/6 substrains.
Topics: Animals; Binge-Eating Disorder; Corpus Striatum; Cuprizone; Disease Models, Animal; Female; Male; Mice; Mice, Inbred C57BL; Myelin Sheath; Nerve Tissue Proteins; Sex Characteristics | 2020 |
Delayed Demyelination and Impaired Remyelination in Aged Mice in the Cuprizone Model.
Topics: Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Male; Mice; Monoamine Oxidase Inhibitors; Multiple Sclerosis; Remyelination | 2020 |
Effect of Sox10 on remyelination of the hippocampus in cuprizone-induced demyelinated mice.
Topics: Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Hippocampus; Male; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Myelin Sheath; Oligodendroglia; Remyelination; SOXE Transcription Factors | 2020 |
Increased blood-brain barrier hyperpermeability coincides with mast cell activation early under cuprizone administration.
Topics: Animals; Blood-Brain Barrier; Capillary Permeability; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mast Cells; Mice; Mice, Inbred C57BL; Tight Junction Proteins | 2020 |
CD44 expression in the cuprizone model.
Topics: Animals; Brain; Chelating Agents; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Hyaluronan Receptors; Mice; Mice, Inbred C57BL; Multiple Sclerosis; White Matter | 2020 |
Amelioration of clinical course and demyelination in the cuprizone mouse model in relation to ketogenic diet.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Astrocytes; Body Weight; Brain; Chemokine CXCL10; Cuprizone; Cytokines; Demyelinating Diseases; Diet, Ketogenic; Disease Models, Animal; Down-Regulation; Glial Fibrillary Acidic Protein; Histone Deacetylases; Inflammasomes; Male; Mice; Mice, Inbred C57BL; Microglia; Myelin Basic Protein; NLR Family, Pyrin Domain-Containing 3 Protein; Signal Transduction; Weight Loss | 2020 |
Mesenchymal Stem Cells Ameliorate Cuprizone-Induced Demyelination by Targeting Oxidative Stress and Mitochondrial Dysfunction.
Topics: Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Humans; Male; Mesenchymal Stem Cells; Mice, Inbred C57BL; Mitochondria; Multiple Sclerosis; Myelin Sheath; Oligodendroglia; Oxidative Stress; Remyelination | 2021 |
Effects of EHP-101 on inflammation and remyelination in murine models of Multiple sclerosis.
Topics: Animals; Cannabinoid Receptor Agonists; Cannabinoids; Chelating Agents; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Inflammation; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Remyelination; Spinal Cord | 2020 |
Calorie restriction promotes remyelination in a Cuprizone-Induced demyelination mouse model of multiple sclerosis.
Topics: Animals; Astrocytes; Brain; Caloric Restriction; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mice; Microglia; Motor Skills; Multiple Sclerosis; Myelin Sheath; Remyelination | 2020 |
Melatonin improves memory defects in a mouse model of multiple sclerosis by up-regulating cAMP-response element-binding protein and synapse-associated proteins in the prefrontal cortex.
Topics: Animals; Behavior, Animal; Cuprizone; Cyclic AMP Response Element-Binding Protein; Disease Models, Animal; Disks Large Homolog 4 Protein; Gene Expression; Melatonin; Memory Disorders; Mice; Monoamine Oxidase Inhibitors; Multiple Sclerosis; Neuroprotective Agents; Prefrontal Cortex; Recognition, Psychology; Spatial Learning; Synaptophysin | 2020 |
Dendrosomal nanocurcumin promotes remyelination through induction of oligodendrogenesis in experimental demyelination animal model.
Topics: Acute Disease; Animals; Astrocytes; Cell Differentiation; Cell Lineage; Cell Proliferation; Cell Survival; Cells, Cultured; Chronic Disease; Cuprizone; Curcumin; Demyelinating Diseases; Disease Models, Animal; Embryo, Mammalian; Male; Mice, Inbred C57BL; Nanoparticles; Neural Stem Cells; Neurogenesis; Oligodendroglia; Remyelination | 2020 |
Autofluorescence spectroscopy as a proxy for chronic white matter pathology.
Topics: Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Humans; Mice; Mice, Inbred C57BL; Myelin Sheath; Spectrum Analysis; White Matter | 2021 |
Intranasal anti-caspase-1 therapy preserves myelin and glucose metabolism in a model of progressive multiple sclerosis.
Topics: Animals; Caspase 1; Cuprizone; Disease Models, Animal; Fluorodeoxyglucose F18; Glucose; Humans; Inflammation; Mice; Mice, Inbred C57BL; Multiple Sclerosis, Chronic Progressive; Myelin Sheath | 2021 |
The impact of quetiapine on the brain lipidome in a cuprizone-induced mouse model of schizophrenia.
Topics: Animals; Brain; Cognition; Cuprizone; Disease Models, Animal; Lipidomics; Male; Mice; Mice, Inbred C57BL; Quetiapine Fumarate; Schizophrenia | 2020 |
Cuprizone-Induced Demyelination in Mouse Hippocampus Is Alleviated by Ketogenic Diet.
Topics: Animals; Astrocytes; Cuprizone; Demyelinating Diseases; Diet, Ketogenic; Disease Models, Animal; Glutathione; Hippocampus; Humans; Male; Malondialdehyde; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Oligodendroglia; PPAR gamma; Sirtuin 1 | 2020 |
Ursolic acid treatment suppresses cuprizone-induced demyelination and motor dysfunction via upregulation of IGF-1.
Topics: Administration, Oral; Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Gene Expression; Insulin-Like Growth Factor I; Mice; Motor Activity; Multiple Sclerosis; Triterpenes; Up-Regulation; Ursolic Acid | 2020 |
The effect of microglial ablation and mesenchymal stem cell transplantation on a cuprizone-induced demyelination model.
Topics: Aminopyridines; Animals; Behavior, Animal; Biomarkers; Calcium-Binding Proteins; Chemokine CX3CL1; Corpus Callosum; Cuprizone; CX3C Chemokine Receptor 1; Demyelinating Diseases; Disease Models, Animal; Glial Fibrillary Acidic Protein; Injections, Intraventricular; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mice, Inbred C57BL; Microfilament Proteins; Microglia; Myelin Sheath; Pyrroles | 2021 |
Aquaporin-4 Expression during Toxic and Autoimmune Demyelination.
Topics: Animals; Aquaporin 4; Autoimmune Diseases; Brain; Brain Injuries; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Gene Expression Regulation; Humans; Inflammation; Mice; Multiple Sclerosis; Myelin Sheath; Neuromyelitis Optica | 2020 |
Ethyl Pyruvate-Derived Transdifferentiation of Astrocytes to Oligodendrogenesis in Cuprizone-Induced Demyelinating Model.
Topics: Animals; Astrocytes; Cell Transdifferentiation; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Oligodendroglia; Phagocytosis; Pyruvates; Receptors, Interleukin-1 | 2021 |
Apamin administration impact on miR-219 and miR-155-3p expression in cuprizone induced multiple sclerosis model.
Topics: Animals; Apamin; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Gene Expression Regulation; Male; Mice, Inbred C57BL; MicroRNAs; Multiple Sclerosis; Myelin Sheath | 2020 |
Coenzyme Q10 enhances remyelination and regulate inflammation effects of cuprizone in corpus callosum of chronic model of multiple sclerosis.
Topics: Animals; Behavior, Animal; Biomarkers; Chronic Disease; Corpus Callosum; Cuprizone; Cytokines; Demyelinating Diseases; Disease Models, Animal; Inflammation; Inflammation Mediators; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Sheath; Oxidative Stress; Remyelination; Ubiquinone | 2021 |
Cuprizone-induced demyelination triggers a CD8-pronounced T cell recruitment.
Topics: Animals; CD8-Positive T-Lymphocytes; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mice; Mice, Inbred C57BL; Oligodendroglia | 2021 |
Effect of Etazolate upon Cuprizone-induced Demyelination In Vivo: Behavioral and Myelin Gene Analysis.
Topics: Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Etazolate; Mice; Mice, Inbred C57BL; Myelin Sheath; Oligodendroglia; Phosphodiesterase Inhibitors; Remyelination | 2021 |
The Intellicage system provides a reproducible and standardized method to assess behavioral changes in cuprizone-induced demyelination mouse model.
Topics: Animals; Behavior, Animal; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Housing, Animal; Mice; Monoamine Oxidase Inhibitors; Neuropsychological Tests; Neurotoxicity Syndromes | 2021 |
Temporal Changes in In Vivo Glutamate Signal during Demyelination and Remyelination in the Corpus Callosum: A Glutamate-Weighted Chemical Exchange Saturation Transfer Imaging Study.
Topics: Administration, Oral; Animals; Axons; Brain; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Glutamic Acid; Immunohistochemistry; Magnetic Resonance Imaging; Male; Microscopy, Electron, Transmission; Myelin Sheath; Rats; Rats, Sprague-Dawley; Remyelination | 2020 |
Cuprizone-Dependent De/Remyelination Responses and Functional Correlates in Mouse Strains Adopted to Model Relapsing, Chronic and Progressive Experimental Autoimmune Encephalomyelitis.
Topics: Animals; Chelating Agents; Chronic Disease; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Disease Progression; Encephalomyelitis, Autoimmune, Experimental; Female; Mice; Mice, Inbred C57BL; Mice, Inbred NOD; Myelin Sheath; Remyelination | 2021 |
Neuroprotective Effect of Apolipoprotein D in Cuprizone-Induced Cell Line Models: A Potential Therapeutic Approach for Multiple Sclerosis and Demyelinating Diseases.
Topics: Animals; Apolipoproteins D; Cell Line; Cell Survival; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Humans; Mice; Multiple Sclerosis; Neuroprotective Agents; Oligodendroglia; Reactive Oxygen Species | 2021 |
Gut Microbiota Changes in Experimental Autoimmune Encephalomyelitis and Cuprizone Mice Models.
Topics: Animals; Cuprizone; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Gastrointestinal Microbiome; Humans; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Neurodegenerative Diseases | 2021 |
ACT-1004-1239, a first-in-class CXCR7 antagonist with both immunomodulatory and promyelinating effects for the treatment of inflammatory demyelinating diseases.
Topics: Animals; Cell Differentiation; Cuprizone; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Immunomodulation; Inflammation; Male; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Sheath; Myelin-Oligodendrocyte Glycoprotein; Oligodendroglia; Receptors, CXCR; Stem Cells | 2021 |
Activated microglia drive demyelination via CSF1R signaling.
Topics: Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Macrophages; Mice; Microglia; Receptors, Colony-Stimulating Factor; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; Signal Transduction | 2021 |
Neuronal hibernation following hippocampal demyelination.
Topics: Animals; Astrocytes; Cognitive Dysfunction; Cuprizone; Demyelinating Diseases; Dendritic Spines; Disease Models, Animal; Hippocampus; Long-Term Potentiation; Magnetic Resonance Imaging; Male; Mice; Mice, Inbred C57BL; Microscopy, Electron; Multiple Sclerosis; Neurons; Post-Synaptic Density; Sequence Analysis, RNA | 2021 |
Multiple sclerosis risk gene Mertk is required for microglial activation and subsequent remyelination.
Topics: Animals; c-Mer Tyrosine Kinase; Cell Differentiation; Cell Movement; Cuprizone; Cyclin-Dependent Kinase Inhibitor p21; Demyelinating Diseases; Disease Models, Animal; Interferon-gamma; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia; Multiple Sclerosis; Myelin Sheath; Oligodendroglia; Phagocytosis; Remyelination | 2021 |
The brain 3β-HSD up-regulation in response to deteriorating effects of background emotional stress: an animal model of multiple sclerosis.
Topics: 3-Hydroxysteroid Dehydrogenases; Animals; Anxiety; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Electroshock; Female; Maze Learning; Multiple Sclerosis; Neuroprotection; Psychological Distress; Psychomotor Performance; Rats; Rats, Wistar; RNA, Messenger; Up-Regulation | 2021 |
Amide Proton Transfer-weighted 7-T MRI Contrast of Myelination after Cuprizone Administration.
Topics: Amides; Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Magnetic Resonance Imaging; Male; Protons; Rats; Rats, Wistar; White Matter | 2021 |
Prolonging the integrated stress response enhances CNS remyelination in an inflammatory environment.
Topics: Animals; Axons; Central Nervous System; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Inflammation; Interferon-gamma; Male; Mice; Oligodendroglia; Remyelination | 2021 |
17β-Estradiol Reduces Demyelination in Cuprizone-fed Mice by Promoting M2 Microglia Polarity and Regulating NLRP3 Inflammasome.
Topics: Animals; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Estradiol; Inflammasomes; Mice; Mice, Inbred C57BL; Microglia; NLR Family, Pyrin Domain-Containing 3 Protein | 2021 |
THYROID STATUS: IS IT POSSIBLE TO RESTORE MYELIN?
Topics: Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mice; Mice, Inbred C57BL; Myelin Sheath; Oligodendroglia; Rats; Thyroid Gland | 2021 |
Fasudil enhances the phagocytosis of myelin debris and the expression of neurotrophic factors in cuprizone-induced demyelinating mice.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Brain-Derived Neurotrophic Factor; Cell Differentiation; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Glial Cell Line-Derived Neurotrophic Factor; Humans; Male; Mice; Microglia; Myelin Sheath; Oligodendroglia; Phagocytosis; Remyelination | 2021 |
ADAM10 suppresses demyelination and reduces seizure susceptibility in cuprizone-induced demyelination model.
Topics: ADAM10 Protein; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Membrane Proteins; Mice; Mice, Inbred C57BL; Seizures | 2021 |
Demyelination and remyelination detected in an alternative cuprizone mouse model of multiple sclerosis with 7.0 T multiparameter magnetic resonance imaging.
Topics: Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Magnetic Resonance Imaging; Male; Mice; Multiple Sclerosis; Myelin Sheath; Remyelination | 2021 |
Changes in leptin, serotonin, and cortisol after eight weeks of aerobic exercise with probiotic intake in a cuprizone-induced demyelination mouse model of multiple sclerosis.
Topics: Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Female; Hydrocortisone; Inflammation; Leptin; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Physical Conditioning, Animal; Probiotics; Serotonin | 2021 |
Rg1 exerts protective effect in CPZ-induced demyelination mouse model via inhibiting CXCL10-mediated glial response.
Topics: Animals; Chemokine CXCL10; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Dose-Response Relationship, Drug; Ginsenosides; Hypokinesia; Inflammation Mediators; Male; Mice; Mice, Inbred C57BL; Microglia; NF-kappa B; Panax; Phagocytosis; RNA, Small Interfering | 2022 |
EBI2 is expressed in glial cells in multiple sclerosis lesions, and its knock-out modulates remyelination in the cuprizone model.
Topics: Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Sheath; Neuroglia; Oligodendroglia; Remyelination; Sclerosis | 2021 |
Complement-associated loss of CA2 inhibitory synapses in the demyelinated hippocampus impairs memory.
Topics: Aged; Animals; CA2 Region, Hippocampal; Case-Control Studies; Complement C1q; Cuprizone; Disease Models, Animal; Humans; Male; Mice; Mice, Inbred C57BL; Middle Aged; Multiple Sclerosis; Synapses | 2021 |
Dysregulated copper transport in multiple sclerosis may cause demyelination via astrocytes.
Topics: Animals; Astrocytes; Biological Transport; Chronic Disease; Cicatrix; Copper; Cuprizone; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Humans; Inflammation; Ligands; Membrane Transport Proteins; Mice, Knockout; Multiple Sclerosis; Myelin Sheath; Nerve Growth Factors; Receptor, trkB; Up-Regulation; White Matter | 2021 |
Novel cell-based analysis reveals region-dependent changes in microglial dynamics in grey matter in a cuprizone model of demyelination.
Topics: Animals; CA1 Region, Hippocampal; Cell Enlargement; Cell Proliferation; Cerebral Cortex; Chelating Agents; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Gray Matter; Hippocampus; Imaging, Three-Dimensional; Mice; Mice, Knockout; Microglia; Microscopy, Confocal; Multiple Sclerosis; Optical Imaging; Phagocytosis; Potassium Channels, Tandem Pore Domain; Remyelination | 2021 |
Effect of CSF1R inhibitor on glial cells population and remyelination in the cuprizone model.
Topics: Aminopyridines; Animals; Cuprizone; Disease Models, Animal; Male; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Sheath; Neuroglia; Pyrroles; Receptor, Macrophage Colony-Stimulating Factor; Remyelination | 2021 |
Effects of Venlafaxine, Risperidone and Febuxostat on Cuprizone-Induced Demyelination, Behavioral Deficits and Oxidative Stress.
Topics: Animals; Corpus Callosum; Cuprizone; Disease Models, Animal; Drug Evaluation, Preclinical; Febuxostat; Female; HEK293 Cells; Humans; Mice, Inbred C57BL; Motor Activity; Multiple Sclerosis; Neurotransmitter Agents; Risperidone; TRPA1 Cation Channel; Venlafaxine Hydrochloride | 2021 |
Analysis of platelet-derived growth factor receptor A and oligodendrocyte transcription factor 2 markers following Hydroxychloroquine administration in animal induced multiple sclerosis model.
Topics: Animals; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Hydroxychloroquine; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Sheath; Oligodendrocyte Transcription Factor 2; Oligodendroglia; Receptors, Platelet-Derived Growth Factor | 2021 |
An in vivo implementation of the MEX MRI for myelin fraction of mice brain.
Topics: Animals; Brain; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Magnetic Resonance Imaging; Mice; Mice, Inbred C57BL; Myelin Sheath; Protons; White Matter | 2022 |
Sphingosine kinase 2 is essential for remyelination following cuprizone intoxication.
Topics: Animals; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mice; Mice, Inbred C57BL; Myelin Sheath; Oligodendroglia; Phosphotransferases (Alcohol Group Acceptor); Remyelination | 2021 |
Trifluoperazine reduces cuprizone-induced demyelination via targeting Nrf2 and IKB in mice.
Topics: Animals; Cuprizone; Disease Models, Animal; Humans; I-kappa B Proteins; Male; Mice; Multiple Sclerosis; Myelin Sheath; NF-E2-Related Factor 2; Oxidative Stress; Prefrontal Cortex; Signal Transduction; Trifluoperazine | 2021 |
A higher proportion of ermin-immunopositive oligodendrocytes in areas of remyelination.
Topics: Animals; Brain; Cerebral Cortex; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Female; Gray Matter; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Basic Protein; Myelin Proteins; Myelin Sheath; Oligodendroglia; Remyelination; White Matter | 2021 |
The effect of realistic geometries on the susceptibility-weighted MR signal in white matter.
Topics: Algorithms; Animals; Anisotropy; Axons; Biophysics; Computer Simulation; Cuprizone; Demyelinating Diseases; Diffusion Tensor Imaging; Disease Models, Animal; Fourier Analysis; Magnetic Resonance Imaging; Mice; Mice, Inbred C57BL; Myelin Sheath; White Matter | 2018 |
NLR members NLRC4 and NLRP3 mediate sterile inflammasome activation in microglia and astrocytes.
Topics: Animals; Apoptosis Regulatory Proteins; Astrocytes; Calcium-Binding Proteins; Cuprizone; Disease Models, Animal; Inflammasomes; Inflammation; Lysophosphatidylcholines; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia; NLR Family, Pyrin Domain-Containing 3 Protein | 2017 |
Histological validation of fast macromolecular proton fraction mapping as a quantitative myelin imaging method in the cuprizone demyelination model.
Topics: Animals; Brain; Brain Mapping; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Gray Matter; Humans; Indoles; Macromolecular Substances; Magnetic Resonance Imaging; Mesothelin; Mice, Inbred C57BL; Myelin Sheath; Protons; White Matter | 2017 |
Early regional cuprizone-induced demyelination in a rat model revealed with MRI.
Topics: Animals; Contrast Media; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Iron; Liver; Magnetic Resonance Imaging; Male; Myelin Sheath; Rats, Wistar; Signal Processing, Computer-Assisted | 2017 |
Increased central dopaminergic activity might be involved in the behavioral abnormality of cuprizone exposure mice.
Topics: Animals; Astrocytes; Behavior, Animal; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Dopamine; Male; Memory, Short-Term; Mice, Inbred C57BL; Microglia; Oligodendroglia; Schizophrenia | 2017 |
Acutely damaged axons are remyelinated in multiple sclerosis and experimental models of demyelination.
Topics: Amyloid beta-Protein Precursor; Animals; Axons; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Female; Glial Fibrillary Acidic Protein; Lysophosphatidylcholines; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Microglia; Monoamine Oxidase Inhibitors; Multiple Sclerosis; Myelin Sheath; Rats; Rats, Inbred Lew; Statistics, Nonparametric; Time Factors | 2017 |
rHIgM22 enhances remyelination in the brain of the cuprizone mouse model of demyelination.
Topics: Analysis of Variance; Animals; Cell Differentiation; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Immunoglobulin M; Male; Mice; Mice, Inbred C57BL; Monoamine Oxidase Inhibitors; Myelin Basic Protein; Myelin Sheath; Oligodendrocyte Transcription Factor 2; Oligodendroglia; Optic Nerve; Receptor, Platelet-Derived Growth Factor alpha; Remyelination; Time Factors | 2017 |
Acid sphingomyelinase deficiency enhances myelin repair after acute and chronic demyelination.
Topics: Amitriptyline; Amyloid Precursor Protein Secretases; Animals; Astrocytes; Axons; Cell Count; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Enzyme Inhibitors; Gene Expression Regulation; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia; Multiple Sclerosis; Nerve Regeneration; Oligodendroglia; Recovery of Function; Sphingomyelin Phosphodiesterase; Synaptophysin | 2017 |
Probenecid-treatment reduces demyelination induced by cuprizone feeding.
Topics: Animals; Cuprizone; Demyelinating Diseases; Diet; Disease Models, Animal; Leukocytes; Lymphocytes; Mice; Optic Nerve; Probenecid | 2017 |
Protective and therapeutic role of 2-carba-cyclic phosphatidic acid in demyelinating disease.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Cell Differentiation; Cell Line, Transformed; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Female; Gene Expression Regulation; Humans; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Monoamine Oxidase Inhibitors; Myelin Sheath; NLR Family, Pyrin Domain-Containing 3 Protein; p38 Mitogen-Activated Protein Kinases; Phosphatidic Acids; Proto-Oncogene Proteins c-bcl-2 | 2017 |
Hyperpolarized
Topics: Animals; Carbon Isotopes; Cuprizone; Disease Models, Animal; Female; Lactic Acid; Magnetic Resonance Imaging; Mice; Mice, Transgenic; Multiple Sclerosis | 2017 |
Reduced cuprizone-induced cerebellar demyelination in mice with astrocyte-targeted production of IL-6 is associated with chronically activated, but less responsive microglia.
Topics: Animals; Astrocytes; Calcium-Binding Proteins; Cerebellum; Cuprizone; Cytokines; Demyelinating Diseases; Disease Models, Animal; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Interleukin-6; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microfilament Proteins; Microglia; Myelin Basic Protein; Time Factors | 2017 |
The flavonoid Baicalein attenuates cuprizone-induced demyelination via suppression of neuroinflammation.
Topics: Animals; Astrocytes; Cuprizone; Cytokines; Demyelinating Diseases; Disease Models, Animal; Flavanones; Flavonoids; Male; Mice; Mice, Inbred C57BL; Microglia; Multiple Sclerosis; Myelin Sheath; Neuroimmunomodulation; Oligodendroglia; Tumor Necrosis Factor-alpha | 2017 |
Loss of Gas6 and Axl signaling results in extensive axonal damage, motor deficits, prolonged neuroinflammation, and less remyelination following cuprizone exposure.
Topics: Animals; Axl Receptor Tyrosine Kinase; Axons; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Encephalitis; Gene Expression Regulation; Intercellular Signaling Peptides and Proteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Monoamine Oxidase Inhibitors; Movement Disorders; Myelin Sheath; Nerve Tissue Proteins; Proprioception; Proto-Oncogene Proteins; Psychomotor Performance; Receptor Protein-Tyrosine Kinases; Reflex, Righting; Remyelination; Signal Transduction | 2017 |
Yokukansan Reduces Cuprizone-Induced Demyelination in the Corpus Callosum Through Anti-inflammatory Effects on Microglia.
Topics: Animals; Anti-Inflammatory Agents; Astrocytes; Corpus Callosum; Cuprizone; Cytokines; Demyelinating Diseases; Disease Models, Animal; Drugs, Chinese Herbal; Female; Inflammation; Mice, Inbred C57BL; Microglia; Multiple Sclerosis; Oligodendroglia | 2017 |
Lineage tracing reveals dynamic changes in oligodendrocyte precursor cells following cuprizone-induced demyelination.
Topics: Age Factors; Animals; Autophagy-Related Proteins; Bacterial Proteins; Cell Differentiation; Cell Lineage; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Hippocampus; Intracellular Signaling Peptides and Proteins; Luminescent Proteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Monoamine Oxidase Inhibitors; Oligodendrocyte Precursor Cells; Receptor, Platelet-Derived Growth Factor alpha; Remyelination; RNA, Untranslated | 2017 |
Effects of green tea epigallocatechin-3-gallate on the proteolipid protein and oligodendrocyte transcription factor 1 messenger RNA gene expression in a mouse model of multiple sclerosis.
Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Brain; Catechin; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mice, Inbred C57BL; Multiple Sclerosis; Oligodendroglia; RNA, Messenger; Tea | 2017 |
Olig2 Silence Ameliorates Cuprizone-Induced Schizophrenia-Like Symptoms in Mice.
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Basic Helix-Loop-Helix Transcription Factors; Brain; Cuprizone; Disease Models, Animal; Glial Fibrillary Acidic Protein; Mice; Mice, Inbred C57BL; Myelin Basic Protein; Myelin Sheath; Nerve Tissue Proteins; Oligodendrocyte Transcription Factor 2; Oligodendroglia; Schizophrenia; Up-Regulation | 2017 |
Quantitative temporal changes in DTI values coupled with histological properties in cuprizone-induced demyelination and remyelination.
Topics: Animals; Astrocytes; Brain; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Male; Mice, Inbred C57BL; Microglia; Myelin Sheath; Oligodendroglia; Remyelination; White Matter | 2018 |
Prednisone alleviates demyelination through regulation of the NLRP3 inflammasome in a C57BL/6 mouse model of cuprizone-induced demyelination.
Topics: Animals; Astrocytes; Corpus Callosum; Cuprizone; Cytokines; Demyelinating Diseases; Disease Models, Animal; Inflammasomes; Male; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Basic Protein; Myelin Sheath; NLR Family, Pyrin Domain-Containing 3 Protein; Oligodendroglia; Prednisone; Signal Transduction | 2018 |
The function of contactin-2/TAG-1 in oligodendrocytes in health and demyelinating pathology.
Topics: Animals; Axons; Brain; Calcium Channels; Cells, Cultured; Contactin 2; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Gene Expression Regulation; Male; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Neural Conduction; Neural Stem Cells; Oligodendroglia; Tissue Culture Techniques | 2018 |
Functional antagonism of sphingosine-1-phosphate receptor 1 prevents cuprizone-induced demyelination.
Topics: Animals; Apoptosis; Brain; Chimera; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Fingolimod Hydrochloride; Gene Expression; Gliosis; Indans; Inflammation; Male; Mice, Inbred C57BL; Mice, Transgenic; Neuroglia; Neuroprotective Agents; Oxadiazoles; Receptors, Lysosphingolipid; Sphingosine-1-Phosphate Receptors; White Matter | 2018 |
Blood-brain barrier hyperpermeability precedes demyelination in the cuprizone model.
Topics: Animals; Aquaporin 4; Blood-Brain Barrier; Brain; Cells, Cultured; Cuprizone; Cytokines; Demyelinating Diseases; Disease Models, Animal; Endothelial Cells; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Monoamine Oxidase Inhibitors; Occludin; Oligodendrocyte Transcription Factor 2; Platelet Endothelial Cell Adhesion Molecule-1; Rats; Receptors, CXCR3; Time Factors | 2017 |
MMP9 Gene Expression Variation by Ingesting Tart Cherry and P-Coumaric Acid During Remyelination in the Cuprizone Mouse Model.
Topics: Animals; Brain; Coumaric Acids; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Female; Male; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Myelin Sheath; Propionates; Remyelination | 2017 |
Toll-Like Receptor 2-Mediated Glial Cell Activation in a Mouse Model of Cuprizone-Induced Demyelination.
Topics: Animals; Astrocytes; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Hippocampus; Lymphocyte Count; Lymphocytes; Mice, Inbred C57BL; Microglia; Neuroglia; Oligodendroglia; RNA, Messenger; Toll-Like Receptor 2 | 2018 |
Effect of Multiple Intraperitoneal Injections of Human Bone Marrow Mesenchymal Stem Cells on Cuprizone Model of Multiple Sclerosis
Topics: Animals; Cell Differentiation; Chelating Agents; Cuprizone; Disease Models, Animal; Humans; Injections, Intraperitoneal; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mice; Mice, Inbred C57BL; Multiple Sclerosis | 2018 |
LPA5 signaling is involved in multiple sclerosis-mediated neuropathic pain in the cuprizone mouse model.
Topics: Animals; Corpus Callosum; Cuprizone; Disease Models, Animal; Female; Gene Expression; Lysophospholipids; Male; Mice, Inbred Strains; Multiple Sclerosis; Neuralgia; Receptors, Lysophosphatidic Acid; Signal Transduction | 2018 |
Vitamin C promotes oligodendrocytes generation and remyelination.
Topics: Animals; Antioxidants; Ascorbic Acid; Brain; Cell Differentiation; Coculture Techniques; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Ganglia, Spinal; Mice; Mice, Inbred C57BL; Neurons; Neuroprotective Agents; Oligodendroglia; Remyelination; Time Factors | 2018 |
Differential local tissue permissiveness influences the final fate of GPR17-expressing oligodendrocyte precursors in two distinct models of demyelination.
Topics: Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Female; Green Fluorescent Proteins; Male; Mice, Inbred C57BL; Mice, Transgenic; Myelin-Oligodendrocyte Glycoprotein; Nerve Tissue Proteins; Oligodendrocyte Precursor Cells; Peptide Fragments; Receptors, G-Protein-Coupled; Remyelination; Spinal Cord | 2018 |
Brain region-specific enhancement of remyelination and prevention of demyelination by the CSF1R kinase inhibitor BLZ945.
Topics: Animals; Axons; Benzothiazoles; Brain; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Female; Longitudinal Studies; Magnetic Resonance Imaging; Membrane Glycoproteins; Mice, Inbred C57BL; Mice, Knockout; Microglia; Neuroprotective Agents; Picolinic Acids; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; Receptors, Immunologic; Remyelination; Spinal Cord | 2018 |
Cuprizone Administration Alters the Iron Metabolism in the Mouse Model of Multiple Sclerosis.
Topics: Animals; Axons; Cation Transport Proteins; Corpus Callosum; Cuprizone; Cytosol; Disease Models, Animal; Gene Expression Regulation; Hepcidins; Iron; Lipid Metabolism; Liver; Magnetic Resonance Imaging; Male; Mice, Inbred C57BL; Mitochondria; Multiple Sclerosis; Myelin Basic Protein; Myelin Sheath; Neuroglia; RNA, Messenger | 2018 |
Erythropoietin Upregulates Brain Hemoglobin Expression and Supports Neuronal Mitochondrial Activity.
Topics: Animals; Aspartic Acid; Brain; Cell Respiration; Cuprizone; Disease Models, Animal; Electron Transport Complex III; Erythropoietin; Hemoglobins; Histones; Lysine; Male; Methylation; Mice, Inbred C57BL; Mitochondria; Models, Biological; Multiple Sclerosis; Myelin Basic Protein; Myelin Sheath; Neurons; Up-Regulation | 2018 |
Microglial MHC class II is dispensable for experimental autoimmune encephalomyelitis and cuprizone-induced demyelination.
Topics: Animals; Antigen Presentation; Cell Proliferation; Central Nervous System; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Histocompatibility Antigens Class II; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia; Multiple Sclerosis | 2018 |
Biochemically altered myelin triggers autoimmune demyelination.
Topics: Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Encephalitis; Hashimoto Disease; Humans; Hydrolases; Inflammation; Male; Mice; Mice, Inbred C57BL; Monoamine Oxidase Inhibitors; Multiple Sclerosis; Myelin Sheath | 2018 |
Protective potential of dimethyl fumarate in a mouse model of thalamocortical demyelination.
Topics: Animals; Anxiety; Auditory Cortex; Behavior Rating Scale; Cuprizone; Dimethyl Fumarate; Disease Models, Animal; Electric Stimulation; Immunosuppressive Agents; Locomotion; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Nerve Net; Neuronal Plasticity; NF-E2-Related Factor 2; Remyelination; Voltage-Sensitive Dye Imaging | 2018 |
Behavioural alterations and morphological changes are attenuated by the lack of TRPA1 receptors in the cuprizone-induced demyelination model in mice.
Topics: Animals; Behavior, Animal; Brain; Chelating Agents; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; TRPA1 Cation Channel | 2018 |
Conditional depletion of GSK3b protects oligodendrocytes from apoptosis and lessens demyelination in the acute cuprizone model.
Topics: Animals; Apoptosis; Astrocytes; Caspases; Cell Nucleus; Cell Proliferation; Cell Survival; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Female; Glycogen Synthase Kinase 3 beta; Male; Mice, Inbred C57BL; Mice, Transgenic; Microglia; Myelin Sheath; Oligodendroglia | 2018 |
The antibody rHIgM22 facilitates hippocampal remyelination and ameliorates memory deficits in the cuprizone mouse model of demyelination.
Topics: Animals; Antibodies; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Hippocampus; Male; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Sheath; Oligodendroglia; Remyelination | 2018 |
Neuroprotective effect of linagliptin against cuprizone-induced demyelination and behavioural dysfunction in mice: A pivotal role of AMPK/SIRT1 and JAK2/STAT3/NF-κB signalling pathway modulation.
Topics: AMP-Activated Protein Kinases; Animals; Behavior, Animal; Brain; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Janus Kinase 2; Linagliptin; Male; Mice, Inbred C57BL; Motor Activity; Myelin Sheath; Neuroprotective Agents; NF-kappa B; Oxidative Stress; Remyelination; Signal Transduction; Sirtuin 1; STAT3 Transcription Factor | 2018 |
G-Protein-Coupled Receptor Gpr17 Expression in Two Multiple Sclerosis Remyelination Models.
Topics: Animals; Cerebral Cortex; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Gray Matter; Male; Mice; Multiple Sclerosis; Myelin Sheath; Nerve Tissue Proteins; Receptors, G-Protein-Coupled; Remyelination; White Matter | 2019 |
Effects of vitamin D on axonal damage during de- and remyelination in the cuprizone model.
Topics: Animals; Axons; Chelating Agents; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Female; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Random Allocation; Remyelination; Vitamin D | 2018 |
Expression Profiles of Metallothionein I/II and Megalin in Cuprizone Model of De- and Remyelination.
Topics: Animals; Brain; Cerebral Cortex; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Female; Gene Expression Profiling; Gene Expression Regulation; Low Density Lipoprotein Receptor-Related Protein-2; Metallothionein; Mice, Inbred C57BL; Neural Stem Cells; Neuroglia; Neurons; Remyelination | 2018 |
Impairment of frequency-specific responses associated with altered electrical activity patterns in auditory thalamus following focal and general demyelination.
Topics: Acoustic Stimulation; Action Potentials; Animals; Auditory Cortex; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Female; Functional Laterality; Geniculate Bodies; Gliosis; Gray Matter; Lysophosphatidylcholines; Mice; Mice, Inbred C57BL; Monoamine Oxidase Inhibitors; Myelin Proteolipid Protein; Neurons; Psychoacoustics; Thalamus | 2018 |
Orthologous proteins of experimental de- and remyelination are differentially regulated in the CSF proteome of multiple sclerosis subtypes.
Topics: Animals; Axl Receptor Tyrosine Kinase; Axons; Cerebrospinal Fluid Proteins; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Gene Expression Regulation; Humans; Mice; Multiple Sclerosis; Myelin Sheath; Proteome; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; Remyelination; Tissue Inhibitor of Metalloproteinase-1 | 2018 |
N-Phenylquinazolin-2-amine Yhhu4952 as a novel promotor for oligodendrocyte differentiation and myelination.
Topics: Animals; Cell Differentiation; Cells, Cultured; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Dose-Response Relationship, Drug; Myelin Basic Protein; Myelin Sheath; Oligodendroglia; Quinazolines; Rats; Remyelination; Signal Transduction; Time Factors | 2018 |
Galectin-4, a Negative Regulator of Oligodendrocyte Differentiation, Is Persistently Present in Axons and Microglia/Macrophages in Multiple Sclerosis Lesions.
Topics: Animals; Axons; Brain; Calcium-Binding Proteins; Cells, Cultured; Cuprizone; Cytokines; Disease Models, Animal; Galectin 4; Gene Expression Regulation; Lectins; Lipopolysaccharides; Macrophages; Male; Mice; Mice, Inbred C57BL; Microfilament Proteins; Microglia; Monoamine Oxidase Inhibitors; Multiple Sclerosis; Myelin-Oligodendrocyte Glycoprotein; Peptide Fragments; Rats; RNA, Messenger; Time Factors | 2018 |
Maladaptive cortical hyperactivity upon recovery from experimental autoimmune encephalomyelitis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbazoles; Cells, Cultured; Cerebral Cortex; Cuprizone; Disease Models, Animal; Egtazic Acid; Encephalomyelitis, Autoimmune, Experimental; Excitatory Amino Acid Antagonists; Female; Freund's Adjuvant; Hyperkinesis; Membrane Potentials; Mice; Mice, Transgenic; Microglia; Myelin Proteolipid Protein; Peptide Fragments; Proto-Oncogene Proteins c-fos; Quinoxalines; Recovery of Function; Sodium Channel Blockers; Tetrodotoxin | 2018 |
Changes in neurosteroidogenesis during demyelination and remyelination in cuprizone-treated mice.
Topics: 3-Hydroxysteroid Dehydrogenases; Animals; Brain; Cholestenone 5 alpha-Reductase; Cuprizone; Cytochrome P-450 Enzyme System; Disease Models, Animal; Female; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Sheath; Neuroglia; Phosphoproteins; Receptors, GABA; Remyelination; Voltage-Dependent Anion Channel 1 | 2018 |
Protective and therapeutic role of Bilobalide in cuprizone-induced demyelination.
Topics: Animals; Autoantibodies; Behavior, Animal; Corpus Callosum; Cuprizone; Cyclopentanes; Cytokines; Demyelinating Diseases; Disease Models, Animal; Furans; Ginkgolides; Humans; Immunity, Humoral; Inflammation; Inflammation Mediators; Male; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin-Oligodendrocyte Glycoprotein; Neuroprotective Agents; Oligodendroglia | 2019 |
The guanine nucleotide exchange factor Vav3 modulates oligodendrocyte precursor differentiation and supports remyelination in white matter lesions.
Topics: Animals; Caspase 3; Cell Differentiation; Cells, Cultured; Chelating Agents; Cuprizone; Disease Models, Animal; GTP Phosphohydrolases; Ki-67 Antigen; Leukoencephalopathies; Mice; Mice, Inbred C57BL; Mice, Knockout; Myelin Basic Protein; Nerve Fibers, Myelinated; Oligodendrocyte Precursor Cells; Organ Culture Techniques; Proto-Oncogene Proteins c-vav; Remyelination; rhoA GTP-Binding Protein | 2019 |
Microglial modulation through colony-stimulating factor-1 receptor inhibition attenuates demyelination.
Topics: Amyloid beta-Peptides; Animals; Benzothiazoles; Brain; Bromodeoxyuridine; Cuprizone; Cytokines; Demyelinating Diseases; Disease Models, Animal; Male; Mice; Mice, Inbred C57BL; Microglia; Microscopy, Electron, Transmission; Myelin Basic Protein; Nerve Tissue Proteins; Nitric Oxide Synthase Type II; Picolinic Acids; Receptors, Colony-Stimulating Factor; Time Factors | 2019 |
Cuprizone-induced demyelination in the mouse hippocampus is alleviated by phytoestrogen genistein.
Topics: Animals; Cell Differentiation; Cell Survival; Cuprizone; Disease Models, Animal; Down-Regulation; Female; Genistein; Hippocampus; Humans; Male; Mice; Mice, Inbred C57BL; Microglia; Multiple Sclerosis; Myelin Sheath; Phagocytosis; Phytoestrogens; Treatment Outcome | 2019 |
Defining Changes in the Spatial Distribution and Composition of Brain Lipids in the Shiverer and Cuprizone Mouse Models of Myelin Disease.
Topics: Animals; Ceramides; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Immunohistochemistry; Lipid Metabolism; Male; Mice; Mice, Transgenic; Myelin Sheath; Phosphatidylcholines; Spectrometry, Mass, Electrospray Ionization; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Sulfoglycosphingolipids; White Matter | 2019 |
Amyloid precursor protein and amyloid precursor-like protein 2 have distinct roles in modulating myelination, demyelination, and remyelination of axons.
Topics: Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Axons; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Male; Mice; Mice, Knockout; Myelin Sheath; Oligodendroglia; Optic Nerve; Remyelination | 2019 |
Cuprizone-induced graded oligodendrocyte vulnerability is regulated by the transcription factor DNA damage-inducible transcript 3.
Topics: Animals; Animals, Newborn; Astrocytes; Calcium-Binding Proteins; Cells, Cultured; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Endoplasmic Reticulum Stress; Gene Expression Regulation; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microfilament Proteins; Microscopy, Electron, Scanning; Monoamine Oxidase Inhibitors; Nerve Tissue Proteins; Oligodendroglia; Transcription Factor CHOP | 2019 |
Psychological stress effects on myelin degradation in the cuprizone-induced model of demyelination.
Topics: Animals; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Female; Myelin Sheath; Rats, Wistar; Stress, Psychological | 2019 |
Tuftsin Combines With Remyelinating Therapy and Improves Outcomes in Models of CNS Demyelinating Disease.
Topics: Animals; Benztropine; Cuprizone; Disease Models, Animal; Drug Therapy, Combination; Encephalomyelitis, Autoimmune, Experimental; Mice; Multiple Sclerosis; Myelin Sheath; Tuftsin | 2018 |
Leonurine suppresses neuroinflammation through promoting oligodendrocyte maturation.
Topics: Animals; Cell Differentiation; Central Nervous System; Cuprizone; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Gallic Acid; Humans; Inflammation; Jumonji Domain-Containing Histone Demethylases; Mice; Microglia; Multiple Sclerosis; Myelin Sheath; Neurogenesis; Oligodendroglia; Remyelination | 2019 |
Arecoline attenuates memory impairment and demyelination in a cuprizone-induced mouse model of schizophrenia.
Topics: Animals; Arecoline; Chelating Agents; Cholinergic Agonists; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Maze Learning; Memory Disorders; Mice; Mice, Inbred C57BL; Schizophrenia | 2019 |
Evaluation strategy to determine reliable demyelination in the cuprizone model.
Topics: Animals; Brain; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Male; Mice, Inbred C57BL; Myelin Basic Protein; Myelin Sheath; Oligodendroglia | 2019 |
Effect of the CSF1R inhibitor PLX3397 on remyelination of corpus callosum in a cuprizone-induced demyelination mouse model.
Topics: Aminopyridines; Animals; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Gene Expression Regulation; Indoles; Macrophage Colony-Stimulating Factor; Male; Mice, Inbred C57BL; Microglia; Microscopy, Electron, Transmission; Multiple Sclerosis; Myelin Sheath; Pyrroles; Real-Time Polymerase Chain Reaction; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; Rotarod Performance Test | 2019 |
In vivo conversion of astrocytes to oligodendrocyte lineage cells in adult mice demyelinated brains by Sox2.
Topics: Animals; Astrocytes; Brain; Cell Differentiation; Cell Lineage; Cells, Cultured; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Genetic Vectors; Lentivirus; Male; Mice, Inbred C57BL; Neural Stem Cells; Oligodendroglia; Regeneration; SOXB1 Transcription Factors | 2019 |
Astrocyte ablation induced by La-aminoadipate (L-AAA) potentiates remyelination in a cuprizone demyelinating mouse model.
Topics: Animals; Astrocytes; Brain; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Male; Mice, Inbred C57BL; Microglia; Oligodendroglia; Remyelination | 2019 |
Hydroxyfasudil alleviates demyelination through the inhibition of MOG antibody and microglia activation in cuprizone mouse model.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Behavior, Animal; Brain; CD4-Positive T-Lymphocytes; Cuprizone; Cytokines; Demyelinating Diseases; Disease Models, Animal; Macrophages; Male; Mice, Inbred C57BL; Motor Activity; Spleen | 2019 |
The PTN-PTPRZ signal activates the AFAP1L2-dependent PI3K-AKT pathway for oligodendrocyte differentiation: Targeted inactivation of PTPRZ activity in mice.
Topics: Adaptor Proteins, Signal Transducing; Animals; Carrier Proteins; Cell Differentiation; Cuprizone; Cytokines; Demyelinating Diseases; Disease Models, Animal; HEK293 Cells; Humans; Immunoprecipitation; In Situ Nick-End Labeling; Luminescent Proteins; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microfilament Proteins; Myelin Proteins; Oligodendroglia; Proto-Oncogene Proteins c-akt; Receptor-Like Protein Tyrosine Phosphatases, Class 5; Red Fluorescent Protein; RNA, Small Interfering; Signal Detection, Psychological; Signal Transduction; Transfection; X-Ray Microtomography | 2019 |
Expression of Translocator Protein and [18F]-GE180 Ligand Uptake in Multiple Sclerosis Animal Models.
Topics: Animals; Astrocytes; Axons; Biomarkers; Carbazoles; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Inflammation; Ligands; Mice, Inbred C57BL; Mitochondria; Monocytes; Multiple Sclerosis; Neuroglia; Receptors, GABA; RNA, Messenger | 2019 |
Nanostructured lipid carriers engineered for intranasal delivery of teriflunomide in multiple sclerosis: optimization and in vivo studies.
Topics: Adhesiveness; Administration, Intranasal; Administration, Oral; Animals; Biocompatible Materials; Biomarkers; Crotonates; Cuprizone; Disease Models, Animal; Drug Carriers; Drug Liberation; Humans; Hydroxybutyrates; Lipids; Liver; Male; Multiple Sclerosis; Nanoparticles; Nasal Mucosa; Nitriles; Particle Size; Polymers; Rats; Rats, Wistar; Sheep; Toluidines; Toxicity Tests, Subacute | 2019 |
Long lasting behavioural effects on cuprizone fed mice after neurotoxicant withdrawal.
Topics: Animals; Behavior, Animal; Brain; Central Nervous System; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Grooming; Male; Mice; Mice, Inbred C57BL; Motor Skills; Myelin Sheath; Oligodendroglia | 2019 |
The antipsychotic-like effects of clozapine in C57BL/6 mice exposed to cuprizone: Decreased glial activation.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Clozapine; Cuprizone; Disease Models, Animal; Male; Mice; Mice, Inbred C57BL; Neuroglia; Schizophrenia | 2019 |
Therapeutic effect of oligomeric proanthocyanidin in cuprizone-induced demyelination.
Topics: Animals; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mice; Oligodendroglia; Proanthocyanidins; Treatment Outcome | 2019 |
Toxin-Based Models to Investigate Demyelination and Remyelination.
Topics: Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Ethidium; Lysophosphatidylcholines; Mice; Mice, Inbred C57BL; Rats; Remyelination | 2019 |
Plant polyprenols reduce demyelination and recover impaired oligodendrogenesis and neurogenesis in the cuprizone murine model of multiple sclerosis.
Topics: Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Hippocampus; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Neurogenesis; Phosphotransferases (Alcohol Group Acceptor); Plants | 2019 |
Animal Weight Is an Important Variable for Reliable Cuprizone-Induced Demyelination.
Topics: Animals; Body Weight; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Female; Male; Mice; Mice, Inbred C57BL; Reproducibility of Results | 2019 |
Impaired Remyelination in a Mouse Model of Huntington Disease.
Topics: Animals; Axons; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Humans; Huntington Disease; Male; Mice, Transgenic; Neuroglia; Remyelination | 2019 |
Mesenchymal stem cell mediated effects on microglial phenotype in cuprizone-induced demyelination model.
Topics: Animals; Chemokine CX3CL1; Corpus Callosum; Cuprizone; CX3C Chemokine Receptor 1; Demyelinating Diseases; Disease Models, Animal; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mice, Inbred C57BL; Microglia; Phenotype; Remyelination; Signal Transduction | 2019 |
Probing demyelination and remyelination of the cuprizone mouse model using multimodality MRI.
Topics: Animals; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Imaging, Three-Dimensional; Mice; Multiparametric Magnetic Resonance Imaging; Prospective Studies; Remyelination; Sensitivity and Specificity; White Matter | 2019 |
Oligoprotective effect of metformin through the AMPK-dependent on restoration of mitochondrial hemostasis in the cuprizone-induced multiple sclerosis model.
Topics: AMP-Activated Protein Kinase Kinases; Animals; Axons; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Hemostasis; Humans; Metformin; Mice; Mitochondria; Multiple Sclerosis; Oligodendroglia; Oxidative Stress; Protein Kinases; Signal Transduction | 2019 |
Clozapine administration enhanced functional recovery after cuprizone demyelination.
Topics: Animals; Astrocytes; Central Nervous System; Clozapine; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Sheath | 2019 |
Voluntary running wheel attenuates motor deterioration and brain damage in cuprizone-induced demyelination.
Topics: Animals; Brain; Cuprizone; Demyelinating Autoimmune Diseases, CNS; Disease Models, Animal; Female; Mice; Mice, Inbred C57BL; Monoamine Oxidase Inhibitors; Multiple Sclerosis; Physical Conditioning, Animal | 2019 |
Structural adaption of axons during de- and remyelination in the Cuprizone mouse model.
Topics: Animals; Axons; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mice; Mice, Inbred C57BL; Mice, Transgenic; Multiple Sclerosis; Myelin Sheath; NAV1.6 Voltage-Gated Sodium Channel; Neurons; Oligodendroglia; Ranvier's Nodes; Remyelination; Sodium Channels | 2019 |
Multiple functional therapeutic effects of DL-3-n-butylphthalide in the cuprizone model of demyelination.
Topics: Animals; Astrocytes; Axons; Benzofurans; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Gene Expression Regulation; Male; Mice; Mice, Inbred C57BL; Microglia; Multiple Sclerosis; Myelin Sheath; Neuroprotective Agents; NF-kappa B; Oligodendroglia; Signal Transduction | 2019 |
The effects of a combination of ion channel inhibitors on pathology in a model of demyelinating disease.
Topics: Animals; Calcium; Cations, Divalent; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Drug Therapy, Combination; Ion Channels; Male; Mice, Inbred C57BL; Neuroglia; Neuroprotective Agents; Oxidative Stress; Random Allocation | 2019 |
Correlations of quantitative MRI metrics with myelin basic protein (MBP) staining in a murine model of demyelination.
Topics: Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Fluorescence; Magnetic Resonance Imaging; Mice, Inbred C57BL; Myelin Basic Protein | 2019 |
Diffusion tensor imaging identifies aspects of therapeutic estrogen receptor β ligand-induced remyelination in a mouse model of multiple sclerosis.
Topics: Animals; Corpus Callosum; Cuprizone; Demyelinating Diseases; Diffusion Tensor Imaging; Disease Models, Animal; Estrogen Receptor beta; Female; Indazoles; Magnetic Resonance Imaging; Male; Mice; Multiple Sclerosis; Neuroprotective Agents; Remyelination | 2019 |
The Spatial and Temporal Characters of Demyelination and Remyelination in the Cuprizone Animal Model.
Topics: Animals; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Hippocampus; Mice; Mice, Inbred C57BL; Microglia; Monoamine Oxidase Inhibitors; Myelin Sheath; Remyelination; Spatio-Temporal Analysis | 2019 |
Cuprizone-treated mice, a possible model of schizophrenia, highlighting the simultaneous abnormalities of GABA, serine and glycine in hippocampus.
Topics: Animals; Cuprizone; Disease Models, Animal; gamma-Aminobutyric Acid; Glycine; Hippocampus; Male; Metabolomics; Mice; Mice, Inbred C57BL; Monoamine Oxidase Inhibitors; Schizophrenia; Serine | 2019 |
Cordycepin (3'-deoxyadenosine) promotes remyelination via suppression of neuroinflammation in a cuprizone-induced mouse model of demyelination.
Topics: Animals; Anti-Inflammatory Agents; Astrocytes; Corpus Callosum; Cuprizone; Cytokines; Demyelinating Diseases; Deoxyadenosines; Disease Models, Animal; Hippocampus; Male; Mice; Mice, Inbred C57BL; Neuroglia; Neuroprotective Agents; Remyelination | 2019 |
17β-Estradiol enhances the efficacy of adipose-derived mesenchymal stem cells on remyelination in mouse model of multiple sclerosis.
Topics: Adipose Tissue; Animals; Basic Helix-Loop-Helix Transcription Factors; Calcium-Binding Proteins; Cell Differentiation; Cell Lineage; Cell Movement; Cells, Cultured; Combined Modality Therapy; Corpus Callosum; Cuprizone; Disease Models, Animal; Drug Implants; Estradiol; Flow Cytometry; Glial Fibrillary Acidic Protein; Male; Mesenchymal Stem Cell Transplantation; Mice; Mice, Inbred C57BL; Microfilament Proteins; Multiple Sclerosis; Myelin Sheath; Nerve Fibers, Myelinated; Nerve Tissue Proteins; Oligodendrocyte Transcription Factor 2; Time Factors | 2012 |
Cuprizone-induced demyelination in mice: age-related vulnerability and exploratory behavior deficit.
Topics: Age Factors; Analysis of Variance; Animals; Antigens, CD; Cell Adhesion Molecules; Chelating Agents; Cohort Studies; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Exploratory Behavior; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Mental Disorders; Mice; Mice, Inbred C57BL; Myelin Basic Protein; Oligodendroglia | 2013 |
Hippocampal demyelination and memory dysfunction are associated with increased levels of the neuronal microRNA miR-124 and reduced AMPA receptors.
Topics: Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Gene Expression Regulation; Hippocampus; Humans; Immunosuppressive Agents; Memory Disorders; Mice; MicroRNAs; Monoamine Oxidase Inhibitors; Multiple Sclerosis; Neurons; Postmortem Changes; Receptors, AMPA; RNA, Messenger; Sirolimus | 2013 |
Loss of branched O-mannosyl glycans in astrocytes accelerates remyelination.
Topics: Age Factors; Animals; Astrocytes; Brain; CD11b Antigen; Cells, Cultured; Clathrin Heavy Chains; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Embryo, Mammalian; Mice; Mice, Inbred C57BL; Mice, Transgenic; N-Acetylglucosaminyltransferases; Nerve Tissue Proteins; Neurons; Oligodendroglia; Polysaccharides; Receptor-Like Protein Tyrosine Phosphatases, Class 3 | 2013 |
Alterations of juxtaparanodal domains in two rodent models of CNS demyelination.
Topics: Animals; Central Nervous System; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Male; Mice, Inbred C57BL; Nerve Fibers, Myelinated; Protein Structure, Tertiary | 2013 |
Cuprizone short-term exposure: astrocytic IL-6 activation and behavioral changes relevant to psychosis.
Topics: Animals; Astrocytes; Brain; Central Nervous System Stimulants; Chelating Agents; Copper; Cuprizone; Disease Models, Animal; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Hallucinogens; Hyperkinesis; Interleukin-6; Male; Methamphetamine; Mice; Mice, Inbred C57BL; Phencyclidine; Psychotic Disorders; Time Factors | 2013 |
Distribution of oligodendrocyte loss and mitochondrial toxicity in the cuprizone-induced experimental demyelination model.
Topics: Animals; Cell Death; Chelating Agents; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Male; Mice; Mice, Inbred C57BL; Mitochondria; Oligodendroglia; Spinal Cord; Superoxide Dismutase | 2013 |
SOX17 is expressed in regenerating oligodendrocytes in experimental models of demyelination and in multiple sclerosis.
Topics: Aged; Animals; Antigens; Autophagy-Related Proteins; Basic Helix-Loop-Helix Transcription Factors; Brain; Bromodeoxyuridine; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Female; Humans; Intracellular Signaling Peptides and Proteins; Leukocyte Common Antigens; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Middle Aged; Monoamine Oxidase Inhibitors; Multiple Sclerosis; Myelin Basic Protein; Nerve Tissue Proteins; Oligodendrocyte Transcription Factor 2; Oligodendroglia; Proteoglycans; SOXF Transcription Factors; Time Factors; Up-Regulation | 2013 |
Puma, but not noxa is essential for oligodendroglial cell death.
Topics: Adult; Aged; Analysis of Variance; Animals; Animals, Newborn; Apoptosis Regulatory Proteins; Brain; Cell Death; Cells, Cultured; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Female; Flow Cytometry; Gene Expression Profiling; Gene Expression Regulation; Humans; In Situ Nick-End Labeling; Interferon-gamma; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Middle Aged; Multiple Sclerosis; Oligodendroglia; Peptide Fragments; Proto-Oncogene Proteins c-bcl-2; Tumor Suppressor Proteins | 2013 |
Quantitative MRI and ultrastructural examination of the cuprizone mouse model of demyelination.
Topics: Animals; Axons; Corpus Callosum; Cuprizone; Demyelinating Diseases; Diet; Disease Models, Animal; Female; Magnetic Resonance Imaging; Mice; Mice, Inbred C57BL; Myelin Sheath; Perfusion; Signal Processing, Computer-Assisted; Statistics, Nonparametric | 2013 |
Mesenchymal stromal-cell transplants induce oligodendrocyte progenitor migration and remyelination in a chronic demyelination model.
Topics: Animals; Axons; Cell Differentiation; Cell Movement; Chronic Disease; Cuprizone; Demyelinating Diseases; Dentate Gyrus; Disease Models, Animal; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mice; Models, Biological; Myelin Sheath; Nerve Fibers; Nerve Growth Factors; Neural Conduction; Neurogenesis; Oligodendroglia; Stem Cell Niche | 2013 |
Locomotor activity and anxiety status, but not spatial working memory, are affected in mice after brief exposure to cuprizone.
Topics: Animals; Anxiety; Brain; Chelating Agents; Cuprizone; Disease Models, Animal; Male; Memory, Short-Term; Mental Disorders; Mice; Mice, Inbred C57BL; Motor Activity; Nerve Fibers, Myelinated; Oligodendroglia | 2013 |
Cuprizone-induced demyelination in Wistar rats; electrophysiological and histological assessment.
Topics: Animals; Cuprizone; Disease Models, Animal; Electric Stimulation; Male; Multiple Sclerosis; Neural Conduction; Rats; Rats, Wistar; Spinal Nerves | 2013 |
PET imaging of demyelination and remyelination in the cuprizone mouse model for multiple sclerosis: a comparison between [11C]CIC and [11C]MeDAS.
Topics: Animals; Carbon Radioisotopes; Chelating Agents; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Male; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Positron-Emission Tomography; Radiopharmaceuticals | 2014 |
Deep gray matter demyelination detected by magnetization transfer ratio in the cuprizone model.
Topics: Animals; Brain; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Female; Magnetic Resonance Imaging; Mice; Mice, Inbred C57BL; Time Factors | 2013 |
Disruption of myelin leads to ectopic expression of K(V)1.1 channels with abnormal conductivity of optic nerve axons in a cuprizone-induced model of demyelination.
Topics: Action Potentials; Animals; Axons; Brain; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Immunoenzyme Techniques; Kv1.1 Potassium Channel; Kv1.2 Potassium Channel; Mice; Mice, Inbred C57BL; Monoamine Oxidase Inhibitors; Myelin Sheath; Optic Nerve | 2014 |
Concurrent changes in ¹H MRS metabolites and antioxidant enzymes in the brain of C57BL/6 mouse short-termly exposed to cuprizone: possible implications for schizophrenia.
Topics: Animals; Antioxidants; Brain; Chelating Agents; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Hydrogen Peroxide; Male; Mice, Inbred C57BL; Oligodendroglia; Schizophrenia | 2014 |
Oxidative tissue injury in multiple sclerosis is only partly reflected in experimental disease models.
Topics: Aging; Animals; CD4 Antigens; CD8 Antigens; Coronavirus Infections; Cuprizone; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Gene Expression; Iron; Lipopolysaccharides; Macrophages; Mice, Inbred C57BL; Microglia; Multiple Sclerosis; Myelin-Oligodendrocyte Glycoprotein; Oxidative Stress; Peptide Fragments; Rats; Rats, Inbred Lew; Respiratory Burst; T-Lymphocytes | 2014 |
Protective effects of melatonin against mitochondrial injury in a mouse model of multiple sclerosis.
Topics: Animals; Antioxidants; Cuprizone; Cyclooxygenase 2; Disease Models, Animal; Gene Expression Regulation; Glutathione; Lipid Peroxidation; Male; Melatonin; Mice; Mice, Inbred C57BL; Microscopy, Electron, Transmission; Mitochondria; Mitochondrial Proton-Translocating ATPases; Monoamine Oxidase Inhibitors; Multiple Sclerosis; Myelin Proteolipid Protein; Oxidative Stress; Oxidoreductases | 2014 |
Gender influence on schizophrenia-relevant abnormalities in a cuprizone demyelination model.
Topics: Animals; Astrocytes; Brain; Cuprizone; Demyelinating Diseases; Diet; Disease Models, Animal; Dopamine; Female; Male; Microglia; Motor Activity; Rats, Wistar; Recognition, Psychology; Schizophrenia; Serotonin; Sex Characteristics; Social Behavior; Tyrosine 3-Monooxygenase | 2014 |
Long-term impact of neonatal inflammation on demyelination and remyelination in the central nervous system.
Topics: Animals; Animals, Newborn; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Female; Inflammation; Lipopolysaccharides; Male; Mice, Inbred C57BL; Microglia; Myelin Sheath; Oligodendroglia; Pregnancy; Random Allocation; RNA, Messenger | 2014 |
Astrocyte-derived BDNF supports myelin protein synthesis after cuprizone-induced demyelination.
Topics: Animals; Astrocytes; Brain-Derived Neurotrophic Factor; Cuprizone; Demyelinating Diseases; Dioxolanes; Disease Models, Animal; Estrogen Antagonists; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Humans; Mice; Mice, Inbred C57BL; Mice, Transgenic; Myelin Proteins; Purines; Receptors, Metabotropic Glutamate; RNA, Untranslated; Signal Transduction; Tamoxifen | 2014 |
Cyclic phosphatidic acid treatment suppress cuprizone-induced demyelination and motor dysfunction in mice.
Topics: Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Heterocyclic Compounds, 1-Ring; Male; Mice; Mice, Inbred C57BL; Motor Activity; Motor Skills Disorders; Phosphatidic Acids; Treatment Outcome | 2014 |
Progesterone and nestorone promote myelin regeneration in chronic demyelinating lesions of corpus callosum and cerebral cortex.
Topics: Animals; Cerebral Cortex; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Female; Mice, Inbred C57BL; Mice, Knockout; Multiple Sclerosis; Myelin Basic Protein; Myelin Proteolipid Protein; Myelin Sheath; Oligodendroglia; Progesterone; Stem Cells | 2015 |
Protective Effect of a cAMP Analogue on Behavioral Deficits and Neuropathological Changes in Cuprizone Model of Demyelination.
Topics: Animals; Apoptosis; Behavior, Animal; Biomarkers; Bucladesine; Cuprizone; Cyclic AMP; Demyelinating Diseases; Disease Models, Animal; Dose-Response Relationship, Drug; Heme Oxygenase-1; Injections, Intraperitoneal; Interleukin-6; Male; Mice, Inbred C57BL; Movement; Myelin Sheath; Neurons; Neuroprotective Agents; NF-kappa B; Nociception | 2015 |
A pivotal role of nonmuscle myosin II during microglial activation.
Topics: Animals; Animals, Newborn; Brain; Cell Movement; Cells, Cultured; Chemokine CCL2; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Dose-Response Relationship, Drug; Heterocyclic Compounds, 4 or More Rings; Male; Mice, Inbred C57BL; Microglia; Monoamine Oxidase Inhibitors; Myosin Heavy Chains; Nonmuscle Myosin Type IIB; Phagocytosis; Rats; Rats, Sprague-Dawley | 2014 |
Dock3 protects myelin in the cuprizone model for demyelination.
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Carrier Proteins; Cells, Cultured; Chelating Agents; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Electroretinography; Extracellular Signal-Regulated MAP Kinases; Guanine Nucleotide Exchange Factors; Mice; Mice, Inbred C57BL; Mice, Transgenic; Myelin Basic Protein; Nerve Tissue Proteins; Oligodendroglia; Optic Nerve; Retina; Signal Transduction | 2014 |
Prostaglandin F2α FP receptor inhibitor reduces demyelination and motor dysfunction in a cuprizone-induced multiple sclerosis mouse model.
Topics: Animals; Corpus Callosum; Cuprizone; Demyelinating Diseases; Dinoprost; Disease Models, Animal; Humans; Mice; Motor Activity; Multiple Sclerosis; Myelin Sheath; Oligodendroglia; Prostaglandin H2; Receptors, Prostaglandin; Tumor Necrosis Factor-alpha | 2014 |
A new model of cuprizone-mediated demyelination/remyelination.
Topics: Analysis of Variance; Animals; Basic Helix-Loop-Helix Transcription Factors; Body Weight; Brain; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Immunosuppressive Agents; Ki-67 Antigen; Male; Mice; Mice, Inbred C57BL; Monoamine Oxidase Inhibitors; Myelin Sheath; Myelin-Oligodendrocyte Glycoprotein; Nerve Tissue Proteins; Oligodendrocyte Transcription Factor 2; Oligodendroglia; Receptor, Platelet-Derived Growth Factor alpha; Sirolimus | 2014 |
Thyroid hormone alleviates demyelination induced by cuprizone through its role in remyelination during the remission period.
Topics: Animals; Astrocytes; Axons; Cell Differentiation; Cell Lineage; Cell Proliferation; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Humans; Male; Mice; Mice, Inbred C57BL; Microglia; Multiple Sclerosis, Relapsing-Remitting; Myelin Sheath; Oligodendroglia; Thyroid Hormones | 2015 |
Abnormal morphology of myelin and axon pathology in murine models of multiple sclerosis.
Topics: Animals; Autopsy; Axons; Brain; Cuprizone; Disease Models, Animal; Female; Humans; Mice; Mice, Inbred C57BL; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Multiple Sclerosis; Myelin Sheath; Spinal Cord | 2015 |
TREM2 regulates microglial cell activation in response to demyelination in vivo.
Topics: Animals; Brain; Cell Proliferation; Chelating Agents; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Immunohistochemistry; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia; Microscopy, Immunoelectron; Oligonucleotide Array Sequence Analysis; Real-Time Polymerase Chain Reaction; Receptors, Immunologic | 2015 |
Neuronal expression of the transcription factor serum response factor modulates myelination in a mouse multiple sclerosis model.
Topics: Animals; Astrocytes; Cells, Cultured; Chemokine CCL2; Cuprizone; Disease Models, Animal; Male; Mice, Inbred C57BL; Mice, Transgenic; Microglia; Multiple Sclerosis; Myelin Sheath; Neurons; Oligodendroglia; RNA, Messenger; Serum Response Factor | 2015 |
Galanin is an autocrine myelin and oligodendrocyte trophic signal induced by leukemia inhibitory factor.
Topics: Animals; Astrocytes; Brain; Cell Survival; Cells, Cultured; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Galanin; Gene Expression; Leukemia Inhibitory Factor; MAP Kinase Signaling System; Mice, Inbred C57BL; Mice, Knockout; Myelin Sheath; Neural Stem Cells; Oligodendroglia; Optic Nerve; Rats, Sprague-Dawley; RNA, Messenger | 2015 |
Beneficial effects of bone marrow-derived mesenchymal stem cell transplantation in a non-immune model of demyelination.
Topics: Animals; Autoimmune Diseases of the Nervous System; Cell Differentiation; Cells, Cultured; Cuprizone; Disease Models, Animal; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Treatment Outcome | 2015 |
Absence of CCL2 and CCL3 Ameliorates Central Nervous System Grey Matter But Not White Matter Demyelination in the Presence of an Intact Blood-Brain Barrier.
Topics: Animals; Astrocytes; Blood-Brain Barrier; Brain; Cells, Cultured; Chemokine CCL2; Chemokine CCL3; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Female; Gliosis; Gray Matter; Macrophages, Peritoneal; Mice; Mice, Inbred C57BL; Mice, Knockout; Viscera; White Matter | 2016 |
CXCL10 triggers early microglial activation in the cuprizone model.
Topics: Animals; Astrocytes; Cell Movement; Chemokine CXCL10; Chemokines; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Gene Expression; Gene Expression Profiling; Immunohistochemistry; Lactate Dehydrogenases; Mice; Mice, Knockout; Microglia; Oligodendroglia; Phagocytosis; Rats | 2015 |
Cuprizone-induced demyelination and demyelination-associated inflammation result in different proton magnetic resonance metabolite spectra.
Topics: Animals; Aspartic Acid; Brain Chemistry; Choline; Creatine; Cuprizone; Demyelinating Diseases; Dipeptides; Disease Models, Animal; Female; Gliosis; Magnetic Resonance Imaging; Male; Mice; Mice, Inbred C57BL; Neuroimaging; Oligodendroglia; Phosphocreatine; Proton Magnetic Resonance Spectroscopy | 2015 |
Behavioural changes observed in demyelination model shares similarities with white matter abnormalities in humans.
Topics: Animals; Anxiety; Behavior, Animal; Corpus Callosum; Cuprizone; Disease Models, Animal; Encephalitis; Humans; Male; Microglia; Motor Activity; Multiple Sclerosis; Myelin Sheath; Oligodendroglia; Rats; Rats, Inbred Lew; White Matter | 2015 |
Longitudinal monitoring of metabolic alterations in cuprizone mouse model of multiple sclerosis using 1H-magnetic resonance spectroscopy.
Topics: Animals; Corpus Callosum; Cuprizone; Disease Models, Animal; Female; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Sheath; Proton Magnetic Resonance Spectroscopy | 2015 |
TREM2 sustains microglial expansion during aging and response to demyelination.
Topics: Aging; Animals; Axons; Brain; Cell Count; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Gene Expression Profiling; Genes, Reporter; Humans; Lipodystrophy; Membrane Glycoproteins; Mice; Mice, Knockout; Microglia; Myelin Sheath; Nerve Tissue Proteins; Osteochondrodysplasias; Phagocytosis; Receptors, Immunologic; Regeneration; Subacute Sclerosing Panencephalitis; Transcription, Genetic | 2015 |
Fibroblast growth factor signaling in oligodendrocyte-lineage cells facilitates recovery of chronically demyelinated lesions but is redundant in acute lesions.
Topics: 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase; Animals; Animals, Newborn; Basic Helix-Loop-Helix Transcription Factors; Cell Differentiation; Cell Lineage; Cells, Cultured; Chelating Agents; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Fibroblast Growth Factors; Lysophosphatidylcholines; Mice; Mice, Inbred C57BL; Mice, Transgenic; Oligodendroglia; Receptor, Fibroblast Growth Factor, Type 1; Receptor, Fibroblast Growth Factor, Type 2; Recovery of Function; Signal Transduction; Spinal Cord | 2015 |
Oncostatin M protects against demyelination by inducing a protective microglial phenotype.
Topics: Animals; Calcium-Binding Proteins; Central Nervous System; Chelating Agents; Cuprizone; Cytokines; Demyelinating Diseases; Disease Models, Animal; Glial Fibrillary Acidic Protein; Growth Inhibitors; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microfilament Proteins; Microglia; Oncostatin M; Oncostatin M Receptor beta Subunit; Phenotype; Time Factors; Transduction, Genetic; Up-Regulation | 2015 |
Non-steroidal anti-inflammatory drug indometacin enhances endogenous remyelination.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Differentiation; Cell Line, Tumor; Cells, Cultured; Cerebellum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Indomethacin; Male; Mice, Inbred C57BL; Mice, Transgenic; Myelin Sheath; Neural Stem Cells; Neuroprotective Agents; Oligodendroglia; Tissue Culture Techniques; Wnt Signaling Pathway | 2015 |
Cuprizone Model as a Tool for Preclinical Studies of the Efficacy of Multiple Sclerosis Diagnosis and Therapy.
Topics: Animals; Brain; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Female; Glial Fibrillary Acidic Protein; Magnetic Resonance Imaging; Male; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Sheath; Nerve Tissue Proteins; Radiography | 2015 |
Transfer of myelin-reactive th17 cells impairs endogenous remyelination in the central nervous system of cuprizone-fed mice.
Topics: Adoptive Transfer; Animals; Cell Polarity; Cells, Cultured; Central Nervous System; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Freund's Adjuvant; Interleukin-17; Leukocyte Common Antigens; Mice; Mice, Inbred C57BL; Mice, Transgenic; Monoamine Oxidase Inhibitors; Monocytes; Myelin Proteins; Myelin Sheath; Myelin-Oligodendrocyte Glycoprotein; Neutrophil Infiltration; Peptide Fragments; Regeneration; Th17 Cells; Time Factors | 2015 |
Thymic Atrophy and Apoptosis of CD4+CD8+ Thymocytes in the Cuprizone Model of Multiple Sclerosis.
Topics: Animals; Apoptosis; Atrophy; CD4 Antigens; CD8 Antigens; Cuprizone; Disease Models, Animal; Immunophenotyping; Lymphocyte Count; Male; Mice; Mitochondria; Mitogen-Activated Protein Kinases; Multiple Sclerosis; Phenotype; T-Lymphocyte Subsets; Thymocytes; Thymus Gland | 2015 |
Remyelination After Cuprizone-Induced Demyelination Is Accelerated in Juvenile Mice.
Topics: Aging; Animals; Brain; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Immunohistochemistry; Mice; Mice, Inbred C57BL; Microscopy, Electron, Transmission; Monoamine Oxidase Inhibitors; Nerve Regeneration; Oligodendroglia | 2015 |
Fingolimod does not enhance cerebellar remyelination in the cuprizone model.
Topics: Animals; Cerebellum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Female; Fingolimod Hydrochloride; Immunosuppressive Agents; Mice; Mice, Inbred C57BL; Propylene Glycols; Sphingosine | 2015 |
Administration of leukemia inhibitory factor increases Opalin and myelin oligodendrocyte glycoprotein expression in the cerebral cortex in a cuprizone-induced model of demyelination.
Topics: Animals; Blotting, Western; Cerebral Cortex; Chelating Agents; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Leukemia Inhibitory Factor; Mice; Mice, Inbred BALB C; Multiple Sclerosis; Myelin Proteins; Myelin-Oligodendrocyte Glycoprotein | 2015 |
Clemastine rescues behavioral changes and enhances remyelination in the cuprizone mouse model of demyelination.
Topics: Animals; Behavior, Animal; Brain; Cell Differentiation; Clemastine; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Exploratory Behavior; Male; Mice; Mice, Inbred C57BL; Motor Activity; Myelin Basic Protein; Myelin Sheath; Oligodendroglia; Schizophrenia | 2015 |
The Effect of Melatonin on Behavioral, Molecular, and Histopathological Changes in Cuprizone Model of Demyelination.
Topics: Animals; Antioxidants; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Dose-Response Relationship, Drug; Inflammation Mediators; Injections, Intraperitoneal; Male; Melatonin; Mice; Mice, Inbred C57BL; Pain Measurement; Random Allocation | 2016 |
Quetiapine mitigates the neuroinflammation and oligodendrocyte loss in the brain of C57BL/6 mouse following cuprizone exposure for one week.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Cuprizone; Disease Models, Animal; Encephalitis; Enzyme-Linked Immunosorbent Assay; Exploratory Behavior; Immunohistochemistry; Interleukin-6; Male; Maze Learning; Mice, Inbred C57BL; Motor Activity; Oligodendroglia; Quetiapine Fumarate; Tumor Necrosis Factor-alpha | 2015 |
Inactivation of Protein Tyrosine Phosphatase Receptor Type Z by Pleiotrophin Promotes Remyelination through Activation of Differentiation of Oligodendrocyte Precursor Cells.
Topics: Amyloid beta-Protein Precursor; Animals; Antigens; Carrier Proteins; Cell Differentiation; Cells, Cultured; Corpus Callosum; Cuprizone; Cytokines; Demyelinating Diseases; Disease Models, Animal; Gene Expression Regulation; Mice; Mice, Inbred C57BL; Mice, Transgenic; Myelin Basic Protein; Nerve Tissue Proteins; Oligodendroglia; Proteoglycans; Receptor-Like Protein Tyrosine Phosphatases, Class 5; Stem Cells; Tumor Suppressor Protein p53 | 2015 |
The cuprizone-induced changes in (1)H-MRS metabolites and oxidative parameters in C57BL/6 mouse brain: Effects of quetiapine.
Topics: Animals; Antipsychotic Agents; Brain; Chelating Agents; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Hydrogen Peroxide; Male; Mice, Inbred C57BL; Neurons; Oligodendroglia; Quetiapine Fumarate | 2015 |
Developmental expression and function analysis of protein tyrosine phosphatase receptor type D in oligodendrocyte myelination.
Topics: Animals; Blotting, Western; Brain; Cell Differentiation; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Evoked Potentials, Motor; Immunohistochemistry; In Situ Hybridization; Mice, Transgenic; Motor Activity; Mutation; Oligodendroglia; Receptor-Like Protein Tyrosine Phosphatases, Class 2; Spinal Cord; Transcranial Magnetic Stimulation | 2015 |
Lesion Expansion in Experimental Demyelination Animal Models and Multiple Sclerosis Lesions.
Topics: Aged; Aged, 80 and over; Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Female; Humans; Male; Mice; Mice, Inbred C57BL; Middle Aged; Multiple Sclerosis; Myelin Sheath; White Matter | 2016 |
Involvement of AMPK, IKβα-NFκB and eNOS in the sildenafil anti-inflammatory mechanism in a demyelination model.
Topics: AMP-Activated Protein Kinases; Animals; Anti-Inflammatory Agents; Chelating Agents; Cuprizone; Cytokines; Demyelinating Diseases; Disease Models, Animal; Encephalitis; Enzyme Inhibitors; Glial Fibrillary Acidic Protein; Male; Mice; Mice, Inbred C57BL; NF-kappa B; Nitric Oxide Synthase Type III; Sildenafil Citrate | 2015 |
The antiviral drug ganciclovir does not inhibit microglial proliferation and activation.
Topics: Animals; Animals, Newborn; Antiviral Agents; Brain; Cell Proliferation; Cells, Cultured; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Encephalomyelitis; Ganciclovir; Host-Pathogen Interactions; Humans; Immunohistochemistry; Macrophage Activation; Mice, Inbred C57BL; Microglia; Theilovirus; Vesicular Stomatitis; Vesiculovirus | 2015 |
Diffusion kurtosis imaging probes cortical alterations and white matter pathology following cuprizone induced demyelination and spontaneous remyelination.
Topics: Animals; Cerebral Cortex; Chelating Agents; Cuprizone; Demyelinating Diseases; Diffusion Tensor Imaging; Disease Models, Animal; Female; Mice; Mice, Inbred C57BL; White Matter | 2016 |
Regulatory effect of triiodothyronine on brain myelination and astrogliosis after cuprizone-induced demyelination in mice.
Topics: Animals; Brain; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Gliosis; Male; Mice, Inbred C57BL; Myelin Proteins; Myelin Sheath; Oligodendroglia; Triiodothyronine | 2016 |
Thymosin beta4 promotes oligodendrogenesis in the demyelinating central nervous system.
Topics: Animals; Cell Differentiation; Cell Proliferation; Cells, Cultured; Chelating Agents; Cuprizone; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Enzyme Inhibitors; ErbB Receptors; Female; Mice; Mice, Inbred C57BL; Myelin Basic Protein; Myelin Proteolipid Protein; Oligodendroglia; Peptide Fragments; Proteoglycans; Quinazolines; Stem Cells; Thymosin; Time Factors; Tyrphostins | 2016 |
Neurodegeneration Triggers Peripheral Immune Cell Recruitment into the Forebrain.
Topics: Adoptive Transfer; Animals; Calcium-Binding Proteins; CD3 Complex; Chelating Agents; Cuprizone; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Freund's Adjuvant; Lymph Nodes; Lymphocytes; Mice; Mice, Inbred C57BL; Microfilament Proteins; Monocytes; Myelin-Oligodendrocyte Glycoprotein; Neurodegenerative Diseases; Peptide Fragments; Pertussis Toxin; Prosencephalon | 2016 |
The Cannabinoid CB1/CB2 Agonist WIN55212.2 Promotes Oligodendrocyte Differentiation In Vitro and Neuroprotection During the Cuprizone-Induced Central Nervous System Demyelination.
Topics: Animals; Benzoxazines; Cell Differentiation; Cell Line, Transformed; Central Nervous System; Chelating Agents; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Dose-Response Relationship, Drug; Gene Expression Regulation; Male; Mice; Mice, Inbred C57BL; Morpholines; Myelin Basic Protein; Naphthalenes; Neuroprotective Agents; Oligodendroglia; Prepulse Inhibition; Transcriptome | 2016 |
Dimensional assessment of behavioral changes in the cuprizone short-term exposure model for psychosis.
Topics: Affect; Animals; Behavior, Animal; Cognition; Cuprizone; Disease Models, Animal; Executive Function; Male; Mice, Inbred C57BL; Psychotic Disorders; Social Behavior | 2016 |
Auraptene induces oligodendrocyte lineage precursor cells in a cuprizone-induced animal model of demyelination.
Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Brain; Coumarins; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Drug Evaluation, Preclinical; Gene Expression; Injections, Intraperitoneal; Male; Mice, 129 Strain; Mice, Inbred C57BL; Microglia; Myelin Basic Protein; Nerve Tissue Proteins; Neuroprotective Agents; Oligodendrocyte Transcription Factor 2; Oligodendroglia; Receptor, Platelet-Derived Growth Factor alpha; Stem Cells | 2016 |
Spatio-Temporal Patterns of Demyelination and Remyelination in the Cuprizone Mouse Model.
Topics: Animals; Body Weight; Brain; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Mice, Inbred C57BL; Myelin Sheath; Transcriptome | 2016 |
Resveratrol Promotes Remyelination in Cuprizone Model of Multiple Sclerosis: Biochemical and Histological Study.
Topics: Animals; Biomarkers; Brain; Cuprizone; Disease Models, Animal; Inflammation; Male; Mice, Inbred C57BL; Mitochondria; Motor Activity; Multiple Sclerosis; Myelin Sheath; Oxidative Stress; Remyelination; Resveratrol; Stilbenes | 2017 |
Compromised axon initial segment integrity in EAE is preceded by microglial reactivity and contact.
Topics: Animals; Animals, Genetically Modified; Autoimmune Diseases of the Nervous System; Axon Initial Segment; Axons; CD11b Antigen; Cell Death; Cells, Cultured; Cuprizone; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Gene Expression Regulation; Hydroxamic Acids; Macrophage Colony-Stimulating Factor; Mice; Mice, Inbred C57BL; Microglia; Monoamine Oxidase Inhibitors; Nitric Oxide Synthase Type II; Thy-1 Antigens; Tumor Necrosis Factor-alpha | 2016 |
Myelin injury induces axonal transport impairment but not AD-like pathology in the hippocampus of cuprizone-fed mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antibodies, Monoclonal; Axonal Transport; Axons; Cognition; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Fluorescent Antibody Technique; Hippocampus; Humans; Kinesins; Male; Maze Learning; Membrane Proteins; Mice; Mice, Inbred C57BL; Microtubule-Associated Proteins; Myelin Basic Protein; Myelin Sheath; Nerve Tissue Proteins; Neurofilament Proteins; Phosphorylation; tau Proteins | 2016 |
Intraventricular injections of mesenchymal stem cells activate endogenous functional remyelination in a chronic demyelinating murine model.
Topics: Animals; Bone Marrow Cells; Cell Differentiation; Cell- and Tissue-Based Therapy; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Gene Expression; Humans; Injections, Intraventricular; Intercellular Signaling Peptides and Proteins; Lateral Ventricles; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mice; Myelin Sheath; Neural Stem Cells; Oligodendroglia; Paracrine Communication; Signal Transduction | 2016 |
Thalamocortical-auditory network alterations following cuprizone-induced demyelination.
Topics: Action Potentials; Animals; Auditory Cortex; Auditory Pathways; Biophysics; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Electric Stimulation; In Vitro Techniques; Mice; Mice, Inbred C57BL; Monoamine Oxidase Inhibitors; Myelin Proteolipid Protein; Neurons; Patch-Clamp Techniques; Synaptic Potentials; Thalamus; Time Factors | 2016 |
A mouse model for testing remyelinating therapies.
Topics: Animals; Axons; Brain; Calcium-Binding Proteins; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Glial Fibrillary Acidic Protein; Gliosis; Immunosuppressive Agents; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Microfilament Proteins; Monoamine Oxidase Inhibitors; Myelin Proteolipid Protein; Regeneration; Sirolimus; Time Factors; Triiodothyronine; White Matter | 2016 |
Astrocyte-targeted production of interleukin-6 reduces astroglial and microglial activation in the cuprizone demyelination model: Implications for myelin clearance and oligodendrocyte maturation.
Topics: Amyloid beta-Protein Precursor; Animals; Astrocytes; Calcium-Binding Proteins; Caspase 3; Cuprizone; Cytokines; Demyelinating Diseases; Disease Models, Animal; Green Fluorescent Proteins; Interleukin-6; Male; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microfilament Proteins; Microglia; Monoamine Oxidase Inhibitors; Myelin Basic Protein; Myelin Sheath; Nerve Tissue Proteins; Receptors, Immunologic | 2016 |
Cuprizone demyelination induces a unique inflammatory response in the subventricular zone.
Topics: Animals; Animals, Newborn; Calcium-Binding Proteins; Cell Proliferation; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Female; Galectin 3; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Inflammation; Lateral Ventricles; Male; Mice; Mice, Transgenic; Microfilament Proteins; Monoamine Oxidase Inhibitors; Olfactory Bulb; Oligodendroglia | 2016 |
TRPA1 deficiency is protective in cuprizone-induced demyelination-A new target against oligodendrocyte apoptosis.
Topics: Adenomatous Polyposis Coli; Animals; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; Body Weight; Brain; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Fibroblast Growth Factor 2; Gene Expression Regulation; Gliosis; Mice; Mice, Knockout; Monoamine Oxidase Inhibitors; Myelin Basic Protein; Nerve Tissue Proteins; Oligodendroglia; Signal Transduction; TRPA1 Cation Channel | 2016 |
Cyclin-dependent kinase inhibitor flavopiridol promotes remyelination in a cuprizone induced demyelination model.
Topics: Animals; Astrocytes; Cell Cycle; Cell Cycle Proteins; Cell Proliferation; Cuprizone; Cyclin-Dependent Kinases; Demyelinating Diseases; Disease Models, Animal; Flavonoids; Gene Expression Regulation; Male; Memory Disorders; Memory, Short-Term; Mice, Inbred C57BL; Microglia; Myelin Sheath; Oligodendroglia; Piperidines; Protein Kinase Inhibitors; Stem Cells; Up-Regulation | 2016 |
The crucial role of Erk2 in demyelinating inflammation in the central nervous system.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; Cuprizone; Cytokines; Demyelinating Autoimmune Diseases, CNS; Disease Models, Animal; Embryo, Mammalian; Enzyme Activation; Female; Gene Expression Regulation; Gliosis; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mitogen-Activated Protein Kinase 1; Monoamine Oxidase Inhibitors; Motor Disorders; Myelin Basic Protein; Nestin; Neuroglia; Neurons; Rats; Rats, Wistar | 2016 |
Activation of the astrocytic Nrf2/ARE system ameliorates the formation of demyelinating lesions in a multiple sclerosis animal model.
Topics: Animals; Astrocytes; Brain; Chemokine CXCL10; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Glutamate-Cysteine Ligase; Heme Oxygenase-1; Kelch-Like ECH-Associated Protein 1; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Monoamine Oxidase Inhibitors; Multiple Sclerosis; NF-E2-Related Factor 2; Oxidative Stress; Thioredoxin Reductase 1 | 2016 |
Interleukin-13 immune gene therapy prevents CNS inflammation and demyelination via alternative activation of microglia and macrophages.
Topics: Animals; Antigens, Differentiation; Bone Marrow Transplantation; Cuprizone; Cytokines; Demyelinating Diseases; Disease Models, Animal; Encephalitis; Genetic Therapy; Green Fluorescent Proteins; Interleukin-13; Macrophages; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microglia; Monoamine Oxidase Inhibitors; Myelin Proteins; Nerve Tissue Proteins; Transduction, Genetic | 2016 |
Administration of vitamin D3 induces CNPase and myelin oligodendrocyte glycoprotein expression in the cerebral cortex of the murine model of cuprizone-induced demyelination.
Topics: Animals; Cerebral Cortex; Cholecalciferol; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mice; Mice, Inbred BALB C; Myelin Basic Protein; Myelin-Oligodendrocyte Glycoprotein; Oligodendroglia | 2016 |
The connectomics of brain demyelination: Functional and structural patterns in the cuprizone mouse model.
Topics: Animals; Brain; Connectome; Cuprizone; Demyelinating Diseases; Diffusion Tensor Imaging; Disease Models, Animal; Female; Magnetic Resonance Imaging; Mice, Inbred C57BL; Neural Pathways | 2017 |
Ultrastructural abnormalities and loss of myelinated fibers in the corpus callosum of demyelinated mice induced by cuprizone.
Topics: Animals; Chelating Agents; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Exploratory Behavior; Male; Maze Learning; Mice; Mice, Inbred C57BL; Microscopy, Electron, Transmission; Myelin Basic Protein; Nerve Fibers, Myelinated; Rotarod Performance Test | 2017 |
IL-17A Promotes Granulocyte Infiltration, Myelin Loss, Microglia Activation, and Behavioral Deficits During Cuprizone-Induced Demyelination.
Topics: Animals; Anxiety; Astrocytes; Behavior, Animal; Cell Proliferation; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Granulocytes; Interleukin-17; Mice; Mice, Transgenic; Microglia; Myelin Sheath | 2018 |
The effect of omega-3 fatty acids on central nervous system remyelination in fat-1 mice.
Topics: Animals; Brain; Cadherins; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Docosahexaenoic Acids; Eicosapentaenoic Acid; Fatty Acids, Omega-3; Fatty Acids, Omega-6; Female; Mice, Inbred C57BL; Mice, Transgenic; Nerve Regeneration | 2017 |
Dietary cholesterol promotes repair of demyelinated lesions in the adult brain.
Topics: Animals; Axons; Biomarkers; Brain; Cell Differentiation; Cell Proliferation; Cells, Cultured; Cholesterol; Cholesterol, Dietary; Cuprizone; Dietary Supplements; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Humans; Male; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Proteins; Oligodendroglia; Primary Cell Culture; Stem Cells | 2017 |
The Effect of Stereotactic Injections on Demyelination and Remyelination: a Study in the Cuprizone Model.
Topics: Animals; Blood-Brain Barrier; Cerebral Cortex; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Gliosis; Gray Matter; Injections, Intraventricular; Lymphocytes; Male; Mice; Mice, Inbred C57BL; Monoamine Oxidase Inhibitors; Myelin Sheath; Stereotaxic Techniques | 2017 |
Transplanted miR-219-overexpressing oligodendrocyte precursor cells promoted remyelination and improved functional recovery in a chronic demyelinated model.
Topics: Animals; Axons; Cell Differentiation; Cell Lineage; Cell Proliferation; Cell Survival; Chronic Disease; Coculture Techniques; Cognition Disorders; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mice; MicroRNAs; Oligodendrocyte Precursor Cells; Pluripotent Stem Cells; Recovery of Function; Remyelination | 2017 |
Chronic demyelination-induced seizures.
Topics: Animals; Aquaporin 4; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Electroencephalography; Gliosis; Hippocampus; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microglia; Multiple Sclerosis; Neurons; Seizures | 2017 |
Cuprizone Intoxication Induces Cell Intrinsic Alterations in Oligodendrocyte Metabolism Independent of Copper Chelation.
Topics: Amino Acids; Animals; Brain; Brain Chemistry; Cell Line; Chelating Agents; Copper; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Energy Metabolism; Male; Metabolome; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Oligodendroglia; Pyridoxal Phosphate | 2017 |
Phosphorylation of αB-crystallin supports reactive astrogliosis in demyelination.
Topics: alpha-Crystallin B Chain; Animals; Astrocytes; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Humans; Male; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Nerve Tissue Proteins; Oligodendroglia; Phosphorylation | 2017 |
Multiple functional therapeutic effects of TnP: A small stable synthetic peptide derived from fish venom in a mouse model of multiple sclerosis.
Topics: Amino Acid Sequence; Animals; Antigens, Differentiation; Brazil; Cuprizone; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Fish Venoms; Gene Expression Regulation; Immunologic Factors; Interferon-gamma; Interleukin-10; Interleukin-17; Macrophages; Matrix Metalloproteinase 9; Mice; Multiple Sclerosis; Peptides; Perciformes; Spinal Cord; T-Lymphocytes, Regulatory; Th1 Cells; Th17 Cells | 2017 |
Cuprizone-Containing Pellets Are Less Potent to Induce Consistent Demyelination in the Corpus Callosum of C57BL/6 Mice.
Topics: Administration, Oral; Animals; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Drug Implants; Male; Mice; Mice, Inbred C57BL | 2017 |
Inhibition of p53 transcriptional activity: a potential target for future development of therapeutic strategies for primary demyelination.
Topics: Animals; Benzothiazoles; Cells, Cultured; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Enzyme Inhibitors; Lateral Ventricles; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia; Oligodendroglia; Oligonucleotide Array Sequence Analysis; Toluene; Transcription, Genetic; Tumor Suppressor Protein p53 | 2008 |
Quetiapine alleviates the cuprizone-induced white matter pathology in the brain of C57BL/6 mouse.
Topics: Animals; Antipsychotic Agents; Astrocytes; Blotting, Western; Brain; Brain Diseases; Chelating Agents; Cuprizone; Demyelinating Diseases; Dibenzothiazepines; Disease Models, Animal; Mice; Mice, Inbred C57BL; Microglia; Oligodendroglia; Quetiapine Fumarate | 2008 |
Differential changes in axonal conduction following CNS demyelination in two mouse models.
Topics: Animals; Axons; Central Nervous System; Chelating Agents; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Electric Stimulation; Mice; Mice, Inbred BALB C; Mice, Knockout; Mice, Neurologic Mutants; Motor Cortex; Myelin Basic Protein; Nerve Fibers, Myelinated; Neural Conduction; Neural Pathways; Reaction Time; Wallerian Degeneration | 2008 |
Effects of dietary intervention on MRI activity, de- and remyelination in the cuprizone model for demyelination.
Topics: Animals; Antigens, Differentiation; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Fatty Acids, Unsaturated; Female; Glial Fibrillary Acidic Protein; Indoles; Injections, Intravenous; Magnetic Resonance Imaging; Mice; Mice, Inbred C57BL; Myelin Proteolipid Protein; Recovery of Function; Statistics, Nonparametric | 2009 |
SJL mice exposed to cuprizone intoxication reveal strain and gender pattern differences in demyelination.
Topics: Animals; Astrocytes; Brain; Cell Count; Chelating Agents; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Female; Immunohistochemistry; Male; Mice; Microglia; Multiple Sclerosis; Oligodendroglia; Sex Characteristics; Stem Cells | 2009 |
Cuprizone treatment induces demyelination and astrocytosis in the mouse hippocampus.
Topics: Aging; Animals; Astrocytes; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Gliosis; Hippocampus; Immunohistochemistry; Indoles; Male; Mice; Mice, Inbred C57BL; Microglia; Microscopy, Electron; Multiple Sclerosis; Myelin Sheath; Oligodendroglia; Reverse Transcriptase Polymerase Chain Reaction | 2009 |
17beta-estradiol and progesterone prevent cuprizone provoked demyelination of corpus callosum in male mice.
Topics: Analysis of Variance; Animals; Corpus Callosum; Cuprizone; Cytoskeleton; Demyelinating Diseases; Disease Models, Animal; Drug Administration Schedule; Estradiol; Estrogens; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Insulin-Like Growth Factor I; Magnetic Resonance Imaging; Male; Mice; Mice, Inbred C57BL; Myelin Proteins; Progesterone; Receptor, Platelet-Derived Growth Factor alpha | 2009 |
A salmon based diet protects mice from behavioural changes in the cuprizone model for demyelination.
Topics: Animals; Behavior, Animal; Brain; Cod Liver Oil; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Fatty Acids, Omega-3; Female; Immunohistochemistry; Mice; Mice, Inbred C57BL; Random Allocation; Salmon; Seafood; Soybean Oil | 2009 |
Demyelination of the hippocampus is prominent in the cuprizone model.
Topics: Animals; Astrocytes; Biomarkers; Chelating Agents; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Gliosis; Hippocampus; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Microglia; Nerve Fibers, Myelinated; Nerve Tissue Proteins; Neurotoxins; Wallerian Degeneration | 2009 |
Recovery from chronic demyelination by thyroid hormone therapy: myelinogenesis induction and assessment by diffusion tensor magnetic resonance imaging.
Topics: Animals; Brain Mapping; Carbonic Anhydrase II; Chronic Disease; Cuprizone; Demyelinating Diseases; Diffusion Magnetic Resonance Imaging; Disease Models, Animal; Female; Hedgehog Proteins; Leukocyte Common Antigens; Mice; Mice, Inbred C57BL; Microscopy, Electron, Transmission; Myelin Sheath; Nerve Tissue Proteins; Neural Cell Adhesion Molecule L1; Proliferating Cell Nuclear Antigen; Recovery of Function; Sialic Acids; Thyroid Hormones; Time Factors; Triiodothyronine | 2008 |
Type I interferon receptor signalling is induced during demyelination while its function for myelin damage and repair is redundant.
Topics: Animals; Central Nervous System; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Female; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Motor Skills; Myelin Sheath; Receptor, Interferon alpha-beta; Signal Transduction; Specific Pathogen-Free Organisms | 2009 |
Age-dependent epigenetic control of differentiation inhibitors is critical for remyelination efficiency.
Topics: Aging; Animals; Animals, Newborn; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Cell Differentiation; Cells, Cultured; Cerebral Cortex; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Enzyme Inhibitors; Epigenesis, Genetic; Glial Fibrillary Acidic Protein; Histone Deacetylases; Mice; Mice, Inbred C57BL; Microglia; Microscopy, Electron, Transmission; Myelin Proteins; Neurosecretory Systems; Rats; Regeneration; Stem Cells; Time Factors; Transcription Factors; Transcription, Genetic; Valproic Acid | 2008 |
Cuprizone treatment induces distinct demyelination, astrocytosis, and microglia cell invasion or proliferation in the mouse cerebellum.
Topics: Animals; Cell Proliferation; Cerebellum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Glial Fibrillary Acidic Protein; Gliosis; Male; Mice; Mice, Inbred C57BL; Microscopy, Electron, Transmission; Monoamine Oxidase Inhibitors; Myelin Proteolipid Protein; RNA, Messenger; Time Factors | 2009 |
Partial inhibition of proteasome activity enhances remyelination after cuprizone-induced demyelination.
Topics: Acetylcysteine; Animals; Corpus Callosum; Cuprizone; Cysteine Proteinase Inhibitors; Demyelinating Diseases; Disease Models, Animal; Gliosis; Male; Mice; Myelin Sheath; Nerve Fibers, Myelinated; Nerve Regeneration; Neurotoxins; NF-kappa B; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Treatment Outcome | 2009 |
Promotion of central nervous system remyelination by induced differentiation of oligodendrocyte precursor cells.
Topics: Animals; Animals, Newborn; Antibodies; Cell Differentiation; Cells, Cultured; Cuprizone; Demyelinating Autoimmune Diseases, CNS; Disease Models, Animal; Ganglia, Spinal; Lysophosphatidylcholines; Membrane Proteins; Mice; Myelin Proteins; Myelin Sheath; Nerve Tissue Proteins; Oligodendroglia; Organ Culture Techniques; Rats; Rats, Sprague-Dawley; Stem Cells | 2009 |
Demyelination caused by the copper chelator cuprizone halts T cell mediated autoimmune neuroinflammation.
Topics: Animals; Antibody Specificity; Antigens; Chelating Agents; Cuprizone; Cytokines; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Glycoproteins; Immune Tolerance; Lymphocyte Activation; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myelin Proteins; Myelin Sheath; Myelin-Oligodendrocyte Glycoprotein; Peptide Fragments; T-Lymphocytes | 2009 |
Cerebellar cortical demyelination in the murine cuprizone model.
Topics: Animals; Astrocytes; Cerebellar Cortex; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Gliosis; Male; Mice; Mice, Inbred C57BL; Microglia; Myelin Sheath; Nerve Fibers, Myelinated; Oligodendroglia; Time Factors | 2010 |
Regional differences between grey and white matter in cuprizone induced demyelination.
Topics: Animals; Astrocytes; Brain; Cerebral Cortex; Chelating Agents; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Disease Progression; Gliosis; Male; Mice; Mice, Inbred C57BL; Microglia; Multiple Sclerosis; Nerve Fibers, Myelinated; Nerve Regeneration; Neurotoxins; Oligodendroglia; Stem Cells; Time Factors | 2009 |
In toxic demyelination oligodendroglial cell death occurs early and is FAS independent.
Topics: Animals; Caspase 3; Cell Death; Corpus Callosum; Cuprizone; Cytotoxins; Demyelinating Diseases; Disease Models, Animal; Down-Regulation; fas Receptor; Female; Gene Expression Regulation; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Myelin Proteins; Nerve Fibers, Myelinated; Oligodendroglia; RNA, Messenger; Signal Transduction | 2010 |
CXCR2-positive neutrophils are essential for cuprizone-induced demyelination: relevance to multiple sclerosis.
Topics: Animals; Chimera; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Monoamine Oxidase Inhibitors; Multiple Sclerosis; Myelin Proteins; Myelin Sheath; Neutrophils; Oligodendroglia; Receptors, Interleukin-8B; RNA, Messenger | 2010 |
Inhibiting poly(ADP-ribose) polymerase: a potential therapy against oligodendrocyte death.
Topics: Active Transport, Cell Nucleus; Animals; Apoptosis; Apoptosis Inducing Factor; Brain; Cell Death; Cell Nucleus; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Male; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Sheath; Oligodendroglia; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Signal Transduction | 2010 |
ADAM12 is expressed by astrocytes during experimental demyelination.
Topics: ADAM Proteins; ADAM12 Protein; Animals; Astrocytes; Cells, Cultured; Cerebral Cortex; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Gene Expression Regulation, Enzymologic; Glial Fibrillary Acidic Protein; Glutamates; Lipopolysaccharides; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Neurofilament Proteins; NF-kappaB-Inducing Kinase; Protein Serine-Threonine Kinases; Signal Transduction; Tumor Necrosis Factor-alpha | 2010 |
17beta-estradiol protects male mice from cuprizone-induced demyelination and oligodendrocyte loss.
Topics: Animals; Antigens; Cell Count; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Drug Interactions; Estradiol; Estrogens; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Glutathione Transferase; Indoles; Insulin-Like Growth Factor I; Macrophages; Male; Mice; Mice, Inbred C57BL; Microglia; Monoamine Oxidase Inhibitors; Oligodendroglia; Periodic Acid; Plant Lectins; Proteoglycans; Stem Cells; Tumor Necrosis Factor-alpha | 2010 |
Proteomic analysis of demyelinated and remyelinating brain tissue following dietary cuprizone administration.
Topics: Administration, Oral; Animals; Behavior, Animal; Brain; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Food, Formulated; Male; Mice; Mice, Inbred C57BL; Monoamine Oxidase Inhibitors; Nerve Fibers, Myelinated; Nerve Regeneration; Neurotoxins; Proteomics; Recovery of Function | 2010 |
CXCR4 promotes differentiation of oligodendrocyte progenitors and remyelination.
Topics: Adult Stem Cells; Animals; Astrocytes; Base Sequence; Cell Differentiation; Chelating Agents; Chemokine CXCL12; Corpus Callosum; Cuprizone; Disease Models, Animal; Humans; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Sheath; Neuroglia; Oligodendroglia; Receptors, CXCR4; RNA Interference; RNA, Messenger; RNA, Small Interfering | 2010 |
Rostrocaudal analysis of corpus callosum demyelination and axon damage across disease stages refines diffusion tensor imaging correlations with pathological features.
Topics: Animals; CD11b Antigen; Corpus Callosum; Cuprizone; Demyelinating Diseases; Diffuse Axonal Injury; Diffusion Magnetic Resonance Imaging; Disease Models, Animal; Disease Progression; Glial Fibrillary Acidic Protein; Indoles; Luminescent Proteins; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microglia; Microscopy, Electron, Transmission; Myelin Proteins; Myelin-Associated Glycoprotein; Myelin-Oligodendrocyte Glycoprotein; Neurofilament Proteins; Statistics as Topic; Time Factors | 2010 |
Dynamic expression of Cx47 in mouse brain development and in the cuprizone model of myelin plasticity.
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Animals, Newborn; Brain; Connexins; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Embryo, Mammalian; Enzyme-Linked Immunosorbent Assay; Female; Gene Expression Regulation, Developmental; Gliosis; HeLa Cells; Humans; Immunoprecipitation; Mice; Mice, Inbred C57BL; Myelin Basic Protein; Myelin Sheath; Neuronal Plasticity; Oligodendroglia; Transfection | 2010 |
Glial amyloid precursor protein expression is restricted to astrocytes in an experimental toxic model of multiple sclerosis.
Topics: Amyloid beta-Protein Precursor; Animals; Astrocytes; Cerebral Cortex; Cuprizone; Disease Models, Animal; Male; Mice; Mice, Inbred C57BL; Monoamine Oxidase Inhibitors; Multiple Sclerosis; RNA, Messenger | 2011 |
Myelin repair is accelerated by inactivating CXCR2 on nonhematopoietic cells.
Topics: Animals; Animals, Newborn; Antibodies; Bone Marrow; Cell Differentiation; Central Nervous System Stimulants; Cerebellum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Flow Cytometry; Freund's Adjuvant; Glycoproteins; In Vitro Techniques; Leukocyte Common Antigens; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Mice, Knockout; Microscopy, Electron, Transmission; Myelin Basic Protein; Myelin Proteolipid Protein; Myelin Sheath; Myelin-Oligodendrocyte Glycoprotein; Nerve Regeneration; Neurologic Examination; Oligodendroglia; Peptide Fragments; Picrotoxin; Proliferating Cell Nuclear Antigen; Receptors, Interleukin-8B; Recovery of Function; Severity of Illness Index; Stem Cells; Time Factors | 2010 |
Cuprizone neurotoxicity, copper deficiency and neurodegeneration.
Topics: Animals; Brain; Cell Cycle; Cell Line, Tumor; Cell Membrane Permeability; Ceruloplasmin; Chemical Phenomena; Copper; Cuprizone; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Liver; Mass Spectrometry; Mice; Monoamine Oxidase Inhibitors; Nerve Degeneration; Neuroblastoma; Neurotoxicity Syndromes; Oxidoreductases; Spectrophotometry, Atomic | 2010 |
Longitudinal near-infrared imaging of myelination.
Topics: Analysis of Variance; Animals; Benzothiazoles; Carbocyanines; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Longitudinal Studies; Mice; Mice, Inbred C57BL; Mice, Neurologic Mutants; Mice, Transgenic; Myelin Basic Protein; Myelin Proteolipid Protein; Myelin Sheath; Permeability; Protein Binding; Proto-Oncogene Proteins c-akt; Spectroscopy, Near-Infrared; Time Factors | 2011 |
The hippocampal fimbria of cuprizone-treated animals as a structure for studying neuroprotection in multiple sclerosis.
Topics: Animals; Chelating Agents; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Hippocampus; Humans; Male; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Nerve Fibers, Myelinated; Neuroprotective Agents; Young Adult | 2011 |
Sphingosine 1-phosphate receptor modulator fingolimod (FTY720) does not promote remyelination in vivo.
Topics: Animals; Chelating Agents; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Mice; Mice, Inbred C57BL; Myelin Sheath; Nerve Regeneration; Propylene Glycols; Rats; Rats, Sprague-Dawley; Receptors, Lysosphingolipid; Sphingosine | 2011 |
Fibroblast growth factor 1 (FGFR1) modulation regulates repair capacity of oligodendrocyte progenitor cells following chronic demyelination.
Topics: Animals; Axons; Cell Count; Cell Differentiation; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Fibroblast Growth Factor 1; Mice; Mice, Transgenic; Myelin Sheath; Oligodendroglia; Receptor, Fibroblast Growth Factor, Type 1; Signal Transduction; Stem Cells | 2012 |
Matrix metalloproteinases and their tissue inhibitors in cuprizone-induced demyelination and remyelination of brain white and gray matter.
Topics: Animals; Antigens, CD; Brain; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Male; Matrix Metalloproteinases; Mice; Mice, Inbred C57BL; Microdissection; Microglia; Monoamine Oxidase Inhibitors; RNA, Messenger; Statistics, Nonparametric; Tissue Inhibitor of Metalloproteinases | 2011 |
Demyelination and remyelination in anatomically distinct regions of the corpus callosum following cuprizone intoxication.
Topics: Animals; Axons; Brain; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Glial Fibrillary Acidic Protein; Gliosis; Male; Mice; Mice, Inbred C57BL; Microglia; Myelin Sheath; Nerve Tissue Proteins; Oligodendroglia; Weight Loss | 2012 |
XIAP protects oligodendrocytes against cell death in vitro but has no functional role in toxic demyelination.
Topics: Animals; Animals, Genetically Modified; Cell Line; Chelating Agents; Cuprizone; Cytoprotection; Demyelinating Diseases; Disease Models, Animal; Down-Regulation; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Fibers, Myelinated; Neural Pathways; Oligodendroglia; Primary Cell Culture; Rats; Up-Regulation; X-Linked Inhibitor of Apoptosis Protein | 2012 |
Adult CNP::EGFP transgenic mouse shows pronounced hypomyelination and an increased vulnerability to cuprizone-induced demyelination.
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Aldehydes; Animals; Brain; CD11b Antigen; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Ectodysplasins; Exploratory Behavior; Gene Expression Regulation; Green Fluorescent Proteins; Interleukin-1beta; Male; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microscopy, Electron, Transmission; Mitochondria; Monoamine Oxidase Inhibitors; Motor Activity; Myelin Proteins; Nerve Tissue Proteins; Oligodendroglia; Psychomotor Performance; Reactive Oxygen Species; Stem Cells; Time Factors; Tumor Necrosis Factor-alpha | 2012 |
Cuprizone inhibits demyelinating leukomyelitis by reducing immune responses without virus exacerbation in an infectious model of multiple sclerosis.
Topics: Animals; Chelating Agents; Cuprizone; Cytokines; Disease Models, Animal; Female; Mice; Multiple Sclerosis; Theilovirus | 2012 |
Olesoxime accelerates myelination and promotes repair in models of demyelination.
Topics: Animals; Cholestenones; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Magnetic Resonance Imaging; Mice; Mice, Inbred C57BL; Monoamine Oxidase Inhibitors; Multiple Sclerosis; Myelin Sheath; Oligodendroglia; Rats; Rats, Sprague-Dawley | 2012 |
Late motor decline after accomplished remyelination: impact for progressive multiple sclerosis.
Topics: Aging; Animals; Axons; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Humans; Mice; Mice, Inbred C57BL; Monoamine Oxidase Inhibitors; Motor Skills; Multiple Sclerosis, Chronic Progressive; Myelin Sheath; Time Factors | 2012 |
Galanin transgenic mice with elevated circulating galanin levels alleviate demyelination in a cuprizone-induced MS mouse model.
Topics: Animals; Cuprizone; Disease Models, Animal; Galanin; Mice; Mice, Transgenic; Monoamine Oxidase Inhibitors; Multiple Sclerosis; Oligodendroglia | 2012 |
Inflammatory response and chemokine expression in the white matter corpus callosum and gray matter cortex region during cuprizone-induced demyelination.
Topics: Animals; Cerebral Cortex; Chemokine CCL2; Chemokine CCL3; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Encephalitis; Gene Expression Regulation; Male; Mice; Mice, Inbred C57BL; Microglia; Monoamine Oxidase Inhibitors; Multiple Sclerosis; Oligodendroglia | 2012 |
Quetiapine enhances oligodendrocyte regeneration and myelin repair after cuprizone-induced demyelination.
Topics: Animals; Antipsychotic Agents; Chelating Agents; Cuprizone; Demyelinating Diseases; Dibenzothiazepines; Disease Models, Animal; Memory, Short-Term; Mice; Mice, Inbred C57BL; Motor Activity; Myelin Sheath; Oligodendroglia; Quetiapine Fumarate; Regeneration; Schizophrenia | 2012 |
Myelin debris regulates inflammatory responses in an experimental demyelination animal model and multiple sclerosis lesions.
Topics: Adult; Aged; Aged, 80 and over; Analysis of Variance; Animals; Calcium-Binding Proteins; Chelating Agents; Corpus Callosum; Cuprizone; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Encephalitis; Female; Gliosis; Histocompatibility Antigens Class II; Humans; Macrophages; Male; Mice; Mice, Inbred C57BL; Microfilament Proteins; Microglia; Middle Aged; Multiple Sclerosis; Myelin Proteolipid Protein; Myelin Sheath; Nerve Fibers, Myelinated; Nerve Tissue Proteins; RNA, Messenger | 2012 |
IL-17-induced Act1-mediated signaling is critical for cuprizone-induced demyelination.
Topics: Animals; Astrocytes; CD3 Complex; Chelating Agents; Connexin 43; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Female; Gene Knockdown Techniques; Interleukin-17; Mice; Mice, Inbred C57BL; Microglia; Multiple Sclerosis; Oligodendroglia; Peptide Fragments; Receptors, Interleukin-17; Signal Transduction; T-Lymphocytes | 2012 |
Sildenafil (Viagra®) down regulates cytokines and prevents demyelination in a cuprizone-induced MS mouse model.
Topics: Animals; Cerebellum; Cuprizone; Cyclooxygenase 2; Cytokines; Demyelinating Diseases; Disease Models, Animal; Down-Regulation; Fluorescent Antibody Technique; Glial Fibrillary Acidic Protein; Immunoblotting; Male; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Piperazines; Purines; Sildenafil Citrate; Sulfones | 2012 |
Regulation of Olig2 during astroglial differentiation in the subventricular zone of a cuprizone-induced demyelination mouse model.
Topics: Adult Stem Cells; Amidines; Animals; Animals, Newborn; Astrocytes; Basic Helix-Loop-Helix Transcription Factors; Bone Morphogenetic Protein 2; Bone Morphogenetic Protein 4; Bromodeoxyuridine; Cell Differentiation; Cells, Cultured; Cerebral Ventricles; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Gangliosides; Gene Expression Regulation; Inhibitor of Differentiation Protein 2; Inhibitor of Differentiation Proteins; Mice; Monoamine Oxidase Inhibitors; Nerve Tissue Proteins; Oligodendrocyte Transcription Factor 2; Rats, Sprague-Dawley | 2012 |
Role of transmembrane semaphorin Sema6A in oligodendrocyte differentiation and myelination.
Topics: Age Factors; Animals; Animals, Newborn; Antigens, Differentiation; Basic Helix-Loop-Helix Transcription Factors; Brain; Bromodeoxyuridine; Cell Differentiation; Cells, Cultured; Coculture Techniques; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Embryo, Mammalian; Female; Ganglia, Spinal; Gene Expression Regulation, Developmental; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Monoamine Oxidase Inhibitors; Mutation; Myelin Basic Protein; Myelin Proteolipid Protein; Myelin Sheath; Nerve Tissue Proteins; Neurons; Oligodendrocyte Transcription Factor 2; Oligodendroglia; Pregnancy; Ranvier's Nodes; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Cell Surface; RNA, Messenger; Semaphorins; Stem Cells; Time Factors; Transcription Factors | 2012 |
Interferon regulatory factor 8/interferon consensus sequence binding protein is a critical transcription factor for the physiological phenotype of microglia.
Topics: Animals; Animals, Newborn; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Brain; Calcium-Binding Proteins; CD11b Antigen; Cell Proliferation; Cells, Cultured; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Flow Cytometry; Gene Expression Regulation; Interferon Regulatory Factors; Mice; Mice, Inbred C57BL; Mice, Knockout; Microfilament Proteins; Microglia; Monoamine Oxidase Inhibitors; Myelin Sheath; Phagocytosis; Phenotype; Phenylurea Compounds; Spinal Cord | 2012 |
Astrogliosis during acute and chronic cuprizone demyelination and implications for remyelination.
Topics: Animals; Cell Proliferation; Chondroitin Sulfate Proteoglycans; Cicatrix; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Gliosis; Male; Mice; Mice, Inbred C57BL; Monoamine Oxidase Inhibitors; Myelin Basic Protein; Statistics as Topic; Time Factors | 2012 |
Selective ultrastructural vulnerability in the cuprizone-induced experimental demyelination.
Topics: Animals; Apoptosis; Astrocytes; Cerebellum; Chelating Agents; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Humans; Macrophages; Mice; Mice, Inbred C57BL; Microscopy, Electron; Multiple Sclerosis; Myelin Sheath; Oligodendroglia | 2012 |
Targeted deletion of the antisilencer/enhancer (ASE) element from intron 1 of the myelin proteolipid protein gene (Plp1) in mouse reveals that the element is dispensable for Plp1 expression in brain during development and remyelination.
Topics: Age Factors; Animals; Animals, Newborn; Brain; Cell Line, Transformed; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Enhancer Elements, Genetic; Female; Gene Expression Regulation, Developmental; Introns; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Monoamine Oxidase Inhibitors; Myelin Proteolipid Protein; Oligodendroglia; Sequence Deletion; Transfection | 2013 |
Attenuation of corpus callosum axon myelination and remyelination in the absence of circulating sex hormones.
Topics: Action Potentials; Animals; Animals, Newborn; Castration; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Estradiol; Female; Glial Fibrillary Acidic Protein; Gonadal Steroid Hormones; Green Fluorescent Proteins; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Monoamine Oxidase Inhibitors; Myelin Proteolipid Protein; Myelin Sheath; Reaction Time; Sex Characteristics | 2013 |
Absence of fibroblast growth factor 2 promotes oligodendroglial repopulation of demyelinated white matter.
Topics: Animals; Antibodies; Cell Count; Cell Differentiation; Cell Division; Cell Lineage; Cells, Cultured; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Female; Fibroblast Growth Factor 2; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Murine hepatitis virus; Myelin Sheath; Nerve Regeneration; Oligodendroglia; Stem Cells | 2002 |
Quantifying the early stages of remyelination following cuprizone-induced demyelination.
Topics: Animals; Axons; Chelating Agents; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Hippocampus; Mice; Mice, Inbred C57BL; Mice, Knockout; Microscopy, Electron; Myelin Sheath; Prosencephalon; Regression Analysis; Sex Characteristics; Time Factors | 2003 |
Functional genomic analysis of remyelination reveals importance of inflammation in oligodendrocyte regeneration.
Topics: Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Gene Expression; Gene Expression Profiling; Gene Expression Regulation; Histocompatibility Antigens Class I; Histocompatibility Antigens Class II; Inflammation; Mice; Mice, Inbred C57BL; Mice, Knockout; Myelin Sheath; Oligodendroglia; Oligonucleotide Array Sequence Analysis; Regeneration; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Necrosis Factor-alpha | 2003 |
Platelet-derived growth factor regulates oligodendrocyte progenitor numbers in adult CNS and their response following CNS demyelination.
Topics: Animals; Central Nervous System; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Glial Fibrillary Acidic Protein; Lysophosphatidylcholines; Mice; Mice, Transgenic; Nerve Regeneration; Oligodendroglia; Platelet-Derived Growth Factor; Promoter Regions, Genetic; Stem Cells; Up-Regulation | 2004 |
Osteopontin is upregulated during in vivo demyelination and remyelination and enhances myelin formation in vitro.
Topics: Animals; Astrocytes; Brain; Cell Division; Cells, Cultured; Coculture Techniques; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Female; Gene Expression Regulation, Developmental; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia; Myelin Proteins; Myelin Sheath; Nerve Regeneration; Oligodendroglia; Osteopontin; Rats; Recombinant Fusion Proteins; Sialoglycoproteins; Stem Cells; Up-Regulation | 2004 |
K+ channel blockade impairs remyelination in the cuprizone model.
Topics: 4-Aminopyridine; Animals; Astrocytes; Chelating Agents; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Gliosis; Male; Mice; Mice, Inbred C57BL; Microscopy, Electron, Transmission; Myelin Basic Protein; Myelin Sheath; Nerve Regeneration; Neuroglia; Oligodendroglia; Potassium Channel Blockers; Potassium Channels; Stem Cells | 2004 |
Astroglial-derived lymphotoxin-alpha exacerbates inflammation and demyelination, but not remyelination.
Topics: Animals; Astrocytes; Cell Count; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Encephalitis; Gliosis; Glutathione S-Transferase pi; Glutathione Transferase; Inflammation Mediators; Isoenzymes; Lymphotoxin-alpha; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia; Nerve Regeneration; Oligodendroglia; Signal Transduction; Time Factors; Tumor Necrosis Factor-alpha | 2005 |
Multicontrast MRI of remyelination in the central nervous system.
Topics: Animals; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Image Enhancement; Magnetic Resonance Imaging; Male; Mice; Mice, Inbred C57BL; Nerve Fibers, Myelinated; Nerve Regeneration | 2005 |
Olig2 overexpression induces the in vitro differentiation of neural stem cells into mature oligodendrocytes.
Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Cell Differentiation; Chelating Agents; Cuprizone; Disease Models, Animal; Gene Expression; Homeobox Protein Nkx-2.2; Homeodomain Proteins; In Vitro Techniques; Mice; Mice, Inbred C57BL; Microscopy, Electron; Multiple Sclerosis, Relapsing-Remitting; Myelin Sheath; Nerve Tissue Proteins; Neurons; Oligodendrocyte Transcription Factor 2; Oligodendroglia; Stem Cells; Transcription Factors; Transfection; Zebrafish Proteins | 2006 |
Deleterious role of IFNgamma in a toxic model of central nervous system demyelination.
Topics: Animals; Brain; Central Nervous System; Corpus Callosum; Cuprizone; Cytokines; Demyelinating Diseases; Disease Models, Animal; Female; Growth Substances; Interferon gamma Receptor; Interferon-gamma; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia; Oligodendroglia; Receptors, Interferon; Time Factors | 2006 |
Endogenous cell repair of chronic demyelination.
Topics: Animals; Chelating Agents; Corpus Callosum; Cuprizone; Disease Models, Animal; Fibroblast Growth Factor 2; Humans; In Situ Hybridization; Mice; Mice, Inbred C57BL; Mice, Knockout; Multiple Sclerosis; Myelin Sheath; Oligodendroglia; Regeneration; Stem Cells | 2006 |
Effects of commissural de- and remyelination on motor skill behaviour in the cuprizone mouse model of multiple sclerosis.
Topics: Analysis of Variance; Animals; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Female; Immunohistochemistry; Mice; Mice, Inbred C57BL; Monoamine Oxidase Inhibitors; Motor Skills; Multiple Sclerosis; Time Factors | 2006 |
Implications of protease M/neurosin in myelination during experimental demyelination and remyelination.
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Cells, Cultured; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Glutathione S-Transferase pi; Immunohistochemistry; Interferon-gamma; Kallikreins; Mice; Mice, Inbred BALB C; Monoamine Oxidase Inhibitors; Myelin Basic Protein; Myelin Sheath; Oligodendroglia; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Time Factors; Tumor Necrosis Factor-alpha | 2006 |
Identification of genes preferentially expressed by microglia and upregulated during cuprizone-induced inflammation.
Topics: Animals; Biomarkers; Brain; Chelating Agents; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Gene Expression; In Situ Hybridization; Male; Mice; Mice, Inbred C57BL; Microglia; Neuritis; Oligonucleotide Array Sequence Analysis; RNA, Messenger; Spleen; Up-Regulation | 2007 |
Restoration of FcRgamma/Fyn signaling repairs central nervous system demyelination.
Topics: Aging; Animals; Anti-Inflammatory Agents; Central Nervous System; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Drugs, Chinese Herbal; Female; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Monoamine Oxidase Inhibitors; Multiple Sclerosis; Myelin Basic Protein; Myelin Sheath; Nerve Regeneration; Neuroprotective Agents; Neurotoxins; Proto-Oncogene Proteins c-fyn; Receptors, IgG; Recovery of Function; Signal Transduction | 2007 |
Behavioral deficits in the cuprizone-induced murine model of demyelination/remyelination.
Topics: Animals; Behavior, Animal; Brain; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Myelin Basic Protein | 2007 |
Effects of acute and repeated exposure to lipopolysaccharide on cytokine and corticosterone production during remyelination.
Topics: Acute Disease; Animals; Body Weight; CD11b Antigen; Chelating Agents; Chronic Disease; Corpus Callosum; Corticosterone; Cuprizone; Cytokines; Demyelinating Diseases; Disease Models, Animal; Leukocyte Common Antigens; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Microglia; Myelin Basic Protein; Myelin Sheath; Nerve Regeneration; Spleen | 2007 |
Astrocyte-specific expression of a soluble form of the murine complement control protein Crry confers demyelination protection in the cuprizone model.
Topics: Animals; Apoptosis; Astrocytes; Brain; Chelating Agents; Complement System Proteins; Corpus Callosum; Cuprizone; Cytoprotection; Demyelinating Autoimmune Diseases, CNS; Disease Models, Animal; Glial Fibrillary Acidic Protein; Gliosis; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nerve Regeneration; Oligodendroglia; Receptors, Complement; Receptors, Complement 3b; Time Factors | 2007 |
Expression of an acyl-CoA synthetase, lipidosin, in astrocytes of the murine brain and its up-regulation during remyelination following cuprizone-induced demyelination.
Topics: Adrenoleukodystrophy; Animals; Astrocytes; Brain; Chelating Agents; Coenzyme A Ligases; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Fatty Acids; Glial Fibrillary Acidic Protein; Immunohistochemistry; Lipid Metabolism; Mice; Mice, Inbred ICR; Microscopy, Immunoelectron; Myelin Sheath; Nerve Regeneration; Rats; Rats, Wistar; RNA, Messenger; Up-Regulation | 2007 |
Lack of interferon-beta leads to accelerated remyelination in a toxic model of central nervous system demyelination.
Topics: Animals; Astrocytes; Axons; Chelating Agents; Cuprizone; Disease Models, Animal; Gliosis; Interferon-beta; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia; Microscopy, Electron, Transmission; Multiple Sclerosis; Myelin Sheath; Recovery of Function | 2007 |
MRI identification of the rostral-caudal pattern of pathology within the corpus callosum in the cuprizone mouse model.
Topics: Animals; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Immunohistochemistry; Magnetic Resonance Imaging; Mice; Mice, Inbred C57BL; Monoamine Oxidase Inhibitors; Multiple Sclerosis | 2008 |
Epileptic seizures and hippocampal damage after cuprizone-induced demyelination in C57BL/6 mice.
Topics: Animals; Behavior, Animal; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Electroencephalography; Epilepsy; Gene Expression Regulation; Hippocampus; Male; Mice; Mice, Inbred C57BL; Myelin Proteolipid Protein; Myelin Sheath; Nerve Tissue Proteins; Neurons | 2008 |
Leukemia inhibitory factor signaling modulates both central nervous system demyelination and myelin repair.
Topics: Analysis of Variance; Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Female; Glial Fibrillary Acidic Protein; Indoles; Leukemia Inhibitory Factor; Magnetic Resonance Imaging; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Knockout; Myelin Proteins; Myelin Sheath; Oligodendroglia; Severity of Illness Index; Signal Transduction; Wound Healing | 2008 |
Cortical demyelination is prominent in the murine cuprizone model and is strain-dependent.
Topics: Animals; Astrocytes; Cerebral Cortex; Corpus Callosum; Cuprizone; Disease Models, Animal; Glial Fibrillary Acidic Protein; Immunohistochemistry; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Microglia; Myelin Sheath; Time Factors | 2008 |
Gas6 deficiency increases oligodendrocyte loss and microglial activation in response to cuprizone-induced demyelination.
Topics: Animals; Axl Receptor Tyrosine Kinase; c-Mer Tyrosine Kinase; Cell Death; Cell Survival; Cells, Cultured; Chelating Agents; Coculture Techniques; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Gliosis; Intercellular Signaling Peptides and Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia; Nerve Fibers, Myelinated; Neurotoxins; Oligodendroglia; Oncogene Proteins; Proto-Oncogene Proteins; Rats; Rats, Sprague-Dawley; Receptor Protein-Tyrosine Kinases | 2008 |
Rapid upregulation of the Pi isoform of glutathione-S-transferase in mouse brains after withdrawal of the neurotoxicant, cuprizone.
Topics: Animals; Astrocytes; Cuprizone; Demyelinating Diseases; Diet; Disease Models, Animal; Glutathione S-Transferase pi; Glutathione Transferase; Isoenzymes; Male; Mice; Microglia; Neurotoxins; Substance Withdrawal Syndrome; Time Factors; Up-Regulation; Weaning | 1997 |
Interferon-gamma protects against cuprizone-induced demyelination.
Topics: Animals; Astrocytes; Chelating Agents; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Gene Expression; Gliosis; Insulin-Like Growth Factor I; Interferon-gamma; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microglia; Myelin Proteins | 2000 |
Episodic demyelination and subsequent remyelination within the murine central nervous system: changes in axonal calibre.
Topics: Amidines; Animals; Axons; Cell Size; Central Nervous System; Chronic Disease; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Fluorescent Dyes; Mice; Mice, Inbred C57BL; Microscopy, Electron; Nerve Fibers, Myelinated; Recurrence; Remission, Spontaneous | 2001 |
TNF alpha promotes proliferation of oligodendrocyte progenitors and remyelination.
Topics: Animals; Antigens, CD; Apoptosis; B-Lymphocytes; Brain Chemistry; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Humans; Immunohistochemistry; In Situ Nick-End Labeling; Macrophages; Male; Mice; Mice, Knockout; Microglia; Monoamine Oxidase Inhibitors; Myelin Sheath; Oligodendroglia; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type I; Receptors, Tumor Necrosis Factor, Type II; Stem Cells; Tumor Necrosis Factor-alpha; Up-Regulation | 2001 |
Alterations in metabolism and gene expression in brain regions during cuprizone-induced demyelination and remyelination.
Topics: Animals; Biomarkers; Brain; Brain Stem; Cerebellum; Cerebrosides; Chelating Agents; Cholesterol; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Disease Progression; Galactosyltransferases; Gene Expression Profiling; Gene Expression Regulation; Mice; Mice, Inbred C3H; Myelin Basic Protein; Myelin Sheath; N-Acylsphingosine Galactosyltransferase; Oligonucleotide Array Sequence Analysis; RNA, Messenger | 2002 |