cuprizone has been researched along with Clinically Isolated CNS Demyelinating Syndrome in 560 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (1.25) | 18.7374 |
| 1990's | 5 (0.89) | 18.2507 |
| 2000's | 80 (14.29) | 29.6817 |
| 2010's | 313 (55.89) | 24.3611 |
| 2020's | 155 (27.68) | 2.80 |
| Authors | Studies |
|---|---|
| Gan, G; He, Y; Hu, Y; Liu, X; Yang, J; Yao, Y; Zhang, A; Zhang, C; Zhu, X | 1 |
| Dong, X; Kang, X; Li, T; Li, X; Wang, X; Zhang, Z; Zhao, C; Zhao, Z; Zheng, R | 1 |
| Bao-Guo, X; Lei, Z; Meng-Ru, Z; Ming-Yang, Y; Ruo-Xuan, S; Tong, T; Ying-Bo, Y | 1 |
| Dekiwadia, C; Pagnin, M; Petratos, S; Richardson, SJ | 1 |
| An, J; Chai, Z; Chen, YY; Ding, ZB; Han, QX; He, Y; Ma, CG; Song, LJ; Wang, Q; Xiao, BG; Yin, JJ; Yu, JZ | 1 |
| Lafaille, JJ; Salzer, JL; Samanta, J; Silva, HM | 1 |
| Arasteh, J; Ebrahimi, MT; Kazemi, F; Sadeghirashed, S; Taheri, S | 1 |
| Anyaegbu, C; Bartlett, CA; Fitzgerald, M; Hellewell, SC; Lins, B; McGonigle, T; Papini, M; Toomey, LM; Warnock, A; Wright, AJ | 1 |
| Alexander, T; Li, X; Liao, BY; Song, SJ; Wang, LB; Wang, ZH; Wu, WC; Wu, XY; Xiao, D; Xiao, Y; Zhang, Y; Zhao, ZH | 1 |
| Correale, JD; de Olmos, S; Di Pietro, AA; Igaz, LM; Marcora, MS; Marder, M; Pasquini, JM; Pasquini, LA; Silva Pinto, P; Vence, M; Wies Mancini, VSB | 1 |
| Grund, EM; Howe, CL; Standiford, MM | 1 |
| Chen, Y; Liu, Q; Sheng, J; Tang, X; Zhao, Y; Zhu, S | 1 |
| Barati, S; Kashani, IR; Tahmasebi, F | 1 |
| Hahn, KR; Hwang, IK; Jung, HY; Kim, DW; Kim, W; Kwon, HJ; Yoon, YS | 2 |
| Gao, R; Gao, YH; Guo, YX; He, J; Li, X; Wang, LB; Xiao, Y; Zhang, Y; Zhao, ZH | 1 |
| Albrecht, S; Budde, T; Cerina, M; Chaudhary, R; Chetkovich, DM; Datunashvili, M; Han, Y; Kuhlmann, T; Lüttjohann, A; Meuth, SG; Narayanan, V; Pape, HC; Ruck, T; Zobeiri, M | 1 |
| Dunn, JF; Hashem, M; Rho, JM; Shafqat, Q; Wu, Y | 1 |
| Coorssen, JR; Mahns, DA; Sen, MK; Shortland, PJ | 2 |
| Anada, K; Honda, T; Murayama, T; Nakamura, H; Tanaka, A; Yasue, M | 1 |
| Jeffries, MA; Mather, ML; Wood, TL | 1 |
| Castillo-Rodriguez, MLA; Gingele, S; Gudi, V; Möllenkamp, T; Schröder, LJ; Skripuletz, T; Stangel, M | 1 |
| Chen, WJ; Chuang, MH; Huang, HC; Lai, CY; Lai, PL; Lee, YC; Lin, H; Lu, J; Ng, CH; Schuyler, SC; Wang, V; Wu, CH; Yang, CH | 1 |
| Assinck, P; Caprariello, AV; Plemel, JR; Sizov, A; Zirngibl, M | 1 |
| Cardona, AE; Cardona, SM; Church, KA; Garcia, SA; Kokovay, E; Lin, CA; Lira, SA; Macklin, W; Mendiola, AS; Ransohoff, RM; Vanegas, D | 1 |
| Begum, Z; Gurusamy, K; Raghunath, G; Sivanesan, S; Subramanian, V; Vijayaraghavan, R | 1 |
| Crocker, SJ; Hardy, CC; Ramasamy, R; Smith, PP | 1 |
| Almeida, L; Ambrósio, AF; Castelo-Branco, M; Dinis, J; Henriques, S; Madeira, MH; Martins, J; Palavra, F; Pereira, FC; Petrella, L; Reis, F; Santiago, R; Sereno, J; Viana, SD | 1 |
| Bitar, Y; Frintrop, L; Joost, S; Kaddatz, H; Kipp, M; Staffeld, A; Wittekindt, M | 1 |
| Bauch, J; Faissner, A | 1 |
| Gosselin, D; Lee, J; Ragoussis, J; Richard, S; Rivest, S; Villarreal, OD; Wang, YC | 1 |
| George, GN; Nienaber, KH; Pickering, IJ; Pushie, MJ; Summers, KL | 1 |
| Isonishi, A; Kawabe, Y; Nakahara, K; Tanaka, T; Tatsumi, K; Wanaka, A | 1 |
| Khadivi, F; Mohammadi, A; Mojaverrostami, S; Zarini, D | 1 |
| El-Naga, RN; Michel, HE; Naeem, AG | 1 |
| Akkermann, R; Azim, K; de Amorim, VCM; Göttle, P; Gruchot, J; Han, S; Küry, P; Lewen, I; Reiche, L; Schira-Heinen, J; Silva Oliveira Junior, M | 1 |
| Bakhtiari, N; Hojati, V; Honarvar, F; Javan, M; Zare, L | 1 |
| Bohlen, CJ; Friedman, BA; Hanson, JE; Kaminker, JS; Kotova, N; Laufer, BI; Lee, SH; Newton, DF; Otero-García, M; Pandey, S; Rezzonico, MG; Shen, K; Shen, YA; Vito, ST; Wang, Y; Yuen, TJ | 1 |
| Haruta, C; Iwasa, K; Maruyama, K; Matsumoto, M; Shimizu, K; Takeda, N; Yamamoto, S; Yamashina, K; Yoshikawa, K | 1 |
| Esfandiary, E; Ghanadian, M; Ghasemi, N; Moradi, V; Rashidi, B | 1 |
| Amirizadeh, S; Hashemi, M; Kashani, IR; Majidpoor, J; Mojaverrostami, S; Mortezaee, K; Omidi, A; Pasbakhsh, P; Shabani, M; Zarini, D | 1 |
| Chen, M; Han, M; Zhang, Y; Zhu, Y | 1 |
| Kashani, IR; Kazemzadeh, S; Madadi, S; Pasbakhsh, P; Shiri, E; Tahmasebi, F; Zibara, K | 1 |
| Benito-Cuesta, I; Feng, Y; Harris, RA; Sarlus, H; Sun, JX; Wang, DJ; Wang, J; Wang, YM; Wang, YQ; Wu, S; Zhang, MZ; Zhao, XQ; Zhong, QY; Zhu, KY; Zou, ZF | 1 |
| Giesler, P; Kipp, M; Lubrich, C | 1 |
| Bonzheim, I; Fallier-Becker, P; Pfeiffer, F | 1 |
| Alnobani, A; Asmann, YW; Bu, G; Doss, SV; Ikezu, TC; Jeevaratnam, S; Liu, CC; Martens, YA; Rosenberg, C; Shue, F; Wang, M; Wang, N; Wren, M; Zhang, B | 1 |
| Byrne, AJ; Franco, PG; Molinari, YA; Pérez, MJ; Silvestroff, L | 1 |
| Alsop, DC; Buron, J; Cayre, M; Duhamel, G; Durbec, P; Girard, OM; Hertanu, A; Le Priellec, J; Le Troter, A; Prevost, VH; Ranjeva, JP; Soustelle, L; Varma, G | 1 |
| Chang, L; Eguchi, A; Hashimoto, K; Ma, L; Mori, C; Qu, Y; Shan, J; Wan, X; Wang, X; Yang, J; Yang, Y | 1 |
| Dégano, IR; Enrich-Bengoa, J; Manich, G; Perálvarez-Marín, A | 1 |
| Albrecht, S; Groll, K; Herold, M; Hucke, S; Klotz, L; Kuhlmann, T; Thomas, C; Wallhorn, L; Yilmaz, EN | 1 |
| Baaklini, CS; Burr, MK; Caprariello, AV; Hammond, BP; Ho, MFS; Kerr, BJ; Lee, KV; Mainali, A; Panda, SP; Plemel, JR; Power, C; Simmen, T; Sizov, A; Williams, S; Zia, S; Zirngibl, M | 1 |
| Kipp, M; Leo, H | 1 |
| Clyde, AE; Festa, LK; Grinspan, JB; Jordan-Sciutto, KL; Long, CC; Roth, LM | 1 |
| Huang, JK; Kouki, T; Ohno, N; Osanai, Y; Yamazaki, R | 1 |
| Beckmann, N; Berth, R; Doelemeyer, A; Feuerbach, D; Frieauff, W; Gasparini, F; Joller, S; Neuhaus, A; Neumann, U; Patino, C; Rudin, S; Schweizer, T; Shimshek, DR; Volkmer, P; Zurbruegg, S | 1 |
| Clawson, ED; Radecki, DZ; Samanta, J | 1 |
| Andhey, PS; Artyomov, MN; Cai, Z; Chen, Y; Colonna, M; Fitzpatrick, JAJ; Gilfillan, S; Guimaraes, RM; Hou, J; Kim, DH; Qiu, T; Strout, G; Sviben, S; Swain, A; Terekhova, M; Ulezko Antonova, A; Van Dyken, SJ; Zhou, Y | 1 |
| Sun, J; Wang, D; Wang, J; Wang, Y; Wu, S; Zhang, H; Zhao, X; Zhu, K | 1 |
| Akin, AT; Akyuz, E; Doğanyiğit, Z; Okan, A; Uçar, S; Yılmaz, S | 1 |
| Damania, A; Kim, J; Lukomska, A; Rheaume, BA; Sajid, MS; Trakhtenberg, EF; Xing, J | 1 |
| Chen, H; Chen, K; Lei, C | 1 |
| Bizen, N; Hashimoto, Y; Hirase, H; Iguchi, M; Kakita, A; Kanai, K; Kanekiyo, K; Kawaguchi, Y; Kitazume, S; Matsuda, N; Muto, Y; Ogawa, H; Sakuda, K; Takahashi, K; Takebayashi, H; Uzuki, M | 1 |
| Ahmed, KA; Ibrahim Fouad, G | 1 |
| Feng, T; Guo, J; Hu, F; Nana, AL; Seeley, WW; Wu, K; Yang, G; Zhang, T | 1 |
| Abdelmonsif, DA; Hassaan, PS; Mohamed, DY; Saleh, SR; Samy, DM; Zaki, EI | 1 |
| Calabresi, PA; Dawson, T; Dawson, VL; Galleguillos, D; Garton, T; Gharagozloo, M; Hussein, O; Jank, L; Kumar, S; Lee, S; Mace, JW; Potluri, S; Siu, C; Smith, MD; Sotirchos, ES; Taylor, M | 1 |
| Borhani-Haghighi, M; Mohamadi, Y | 1 |
| Rowhanirad, S; Taherianfard, M | 1 |
| Baumann, L; Beecken, M; Greiner, T; Heinig, L; Joost, S; Kipp, M; Manzhula, K; Schauerte, S; Vankriekelsvenne, E | 1 |
| Gudi, V; Kalinke, U; Mulenge, F; Pavlou, A; Schröder, LJ; Skripuletz, T; Stangel, M | 1 |
| Abakumov, M; Abakumova, T; Chekhonin, V; Gubskii, I; Gurina, O; Ionova, K; Koshkin, P; Kuzkina, A; Melnikov, P; Nukolova, N; Pozdeeva, D | 1 |
| Haruta, C; Iwasa, K; Maruyama, K; Yamagishi, A; Yamamoto, S; Yoshikawa, K | 1 |
| Kim, KW; Ljunggren-Rose, Å; Matta, P; Sriram, S; Toki, S | 1 |
| Wang, W; Wen, C; Xu, Z | 1 |
| Bao, H; Dai, L; Li, H; Qian, M; Sun, X; Wang, L; Yin, M; Zhao, Y | 1 |
| Bhatt, JM; Dravid, SM; Gakare, SG; Narasimhan, KKS | 1 |
| Kipp, M | 1 |
| Chen, T; Hoshino, Y; Miyake, S; Mizuno, M; Noto, D | 1 |
| Cao, L; Li, QY; Ma, CG; Miao, Q; Sui, RX; Xiao, BG; Xiao, W; Yu, WB | 1 |
| Labunets, IF; Rodnichenko, AE | 1 |
| Beyer, C; Clarner, T; Fragoulis, A; Nellessen, A; Nyamoya, S; Slowik, A; Wruck, C; Zendedel, A | 1 |
| Bando, Y; Geisler, JG | 1 |
| Akulov, A; Anan'ina, T; Glazacheva, V; Khodanovich, M; Pan, E; Pishchelko, A; Svetlik, M; Tyumentseva, Y; Yarnykh, V | 1 |
| Heidari, R; Khodaei, F; Khoshnoud, MJ; Rashedinia, M; Rezaei, M | 1 |
| Almuslehi, MSM; Coorssen, JR; Gyengesi, E; Mahns, DA; Myers, SJ; Sen, MK; Shortland, PJ | 1 |
| An, J; Ding, ZB; Han, QX; He, Y; Ma, CG; Miao, Q; Sui, RX; Wang, Q; Xiao, BG; Yin, JJ | 1 |
| Beyer, C; Chrzanowski, U; Kaye, J; Kipp, M; Nyamoya, S; Schmitz, C; Steinle, J | 1 |
| An, J; He, Y; Ma, CG; Miao, Q; Shi, FD; Sui, RX; Wang, Q; Xiao, BG; Yin, JJ; Yu, JW; Yu, JZ | 1 |
| Barnett, A; Bellinger, TJ; Luo, F; Luo, Y; Schmidt, K; Turcato, F; Zhang, Z | 1 |
| Ács, P; Berente, Z; Bölcskei, K; Komoly, S; Kriszta, G; Nemes, B; Pintér, E; Sándor, Z | 1 |
| Choi, CI; Kim, HN; Kleppe, LS; Langley, MR; Scarisbrick, IA; Simon, WL; Triplet, EM; Yoon, H | 1 |
| Han, SR; Kang, YH; Lee, MS; Lee, SH; Yoo, SM | 1 |
| Agbemenyah, HY; Celarain, N; Havemann-Reinecke, U; Quintana, E; Ramió-Torrentà, L; Tomas-Roig, J | 1 |
| Han, SR; Jeon, H; Kang, YH; Lee, MS; Lee, S; Lee, SH; Min, SS; Park, SJ; Song, DY; Yoo, SM | 1 |
| Almuslehi, MSM; Coorssen, JR; Mahns, DA; Sen, MK; Shortland, PJ | 2 |
| Brink, LE; Cambi, F; Dubaniewicz, MT; Guzman, K; Kozai, TDY; Li, L; Sridhar, S; Stieger, KC; Wellman, SM | 1 |
| Laflamme, N; Pons, V; Préfontaine, P; Rivest, S | 1 |
| He, YQ; Liu, J; Liu, Q; Lv, HW; Ma, QR; Yang, S | 1 |
| Cheli, VT; Paez, PM; Santiago González, DA; Wan, R; Zamora, NN | 1 |
| Boreland, AJ; Hart, RP; Jiang, P; Kwan, K; Li, X; Posyton, A; Xu, R | 1 |
| Behrangi, N; Frank, M; Joost, S; Kipp, M; Mann, T; Zhan, J | 1 |
| Berger, L; González-Alvarado, MN; Haase, S; Kuhbandner, K; Lee, DH; Linker, RA; London, B; Rötger, C | 1 |
| Bi, HZ; Chen, NH; Chu, SF; Dong, YX; He, WB; Tian, YJ; Wang, SS; Zang, YD; Zhang, DM; Zhang, Z | 1 |
| Gingele, S; Gudi, V; Heckers, S; Henkel, F; Hümmert, MW; Moellenkamp, TM; Skripuletz, T; Stangel, M | 1 |
| Ding, J; He, QX; Liu, J; Liu, Q; Lv, HW; Ma, QR; Shao, Y; Zhang, C | 1 |
| Bacmeister, CM; Barr, HJ; Hughes, EG; McClain, CR; Nettles, D; Thornton, MA; Welle, CG | 1 |
| Clements, R; Frankle, L; Freeman, E; McDonough, J; Shelestak, J; Singhal, N; Sternbach, S; Tomor, R | 1 |
| Abdel-Maged, AE; Awad, AS; Azab, SS; Gad, AM; Mohamed, EA; Rashed, LA | 1 |
| Chrzanowski, U; Hochstrasser, T; Kipp, M; Pröbstl, N; Reinbach, C; Schmitz, C; Stadler, MS | 1 |
| Budde, T; Cerina, M; Dik, A; Faber, C; Fleischer, V; Gallus, M; Gonzalez-Escamilla, G; Groppa, S; Hundehege, P; Koirala, N; Krämer, J; Meuth, SG; Muthuraman, M; Narayanan, V; Schiffler, P; Tenberge, JG; Wachsmuth, L | 1 |
| Jin, L; Li, Y; Liu, C; Loers, G; Petridis, AK; Siebert, HC; Wang, Z; Yin, X; Zhang, N; Zhang, R; Zheng, X | 1 |
| Alizadeh, Z; Borhani-Haghighi, M; Kashani, IR; Mehdi, A; Mojaverrostami, S; Nekoonam, S; Pasbakhsh, P; Pirhajati Mahabadi, V; Shiri, E; Zibara, K | 1 |
| Calzado, MA; Feliú, A; García-Martin, A; Garrido-Rodríguez, M; Guaza, C; Mestre, L; Muñoz, E; Navarrete, C | 1 |
| Kashani, IR; Madadi, S; Mojaverrostami, S; Nekoonam, S; Noori, L; Pasbakhsh, P; Salama, M; Shiri, E; Zarini, D; Zibara, K | 1 |
| Aimone, JB; Denli, AM; Gage, FH; Genoud, S; Georges Ghosh, S; Kerman, BE; Kurt Vatandaslar, B; Xu, X; Yeo, GW | 1 |
| Babashah, S; Javan, M; Motavaf, M; Sadeghizadeh, M; Zare, L | 1 |
| Caprariello, AV; Kaushik, DK; Morgan, ML; Stys, PK | 1 |
| Jin, L; Liu, C; Loers, G; Petridis, AK; Siebert, HC; Wang, Z; Zhang, N; Zhang, R; Zheng, X | 1 |
| Iwasa, K; Maruyama, K; Sakemoto, C; Shimizu, K; Yamamoto, S; Yoshikawa, K | 1 |
| Feng, R; Luo, G; Shi, J; Wang, H; Wang, J | 1 |
| Barati, S; Kashani, IR; Madadi, S; Pasbakhsh, P; Tahmasebi, F | 1 |
| Amor, S; Greiner, T; Joost, S; Kipp, M; Rohr, SO; Schmitz, C; Valk, PV | 1 |
| Chen, Y; Dong, F; Fan, H; Jiang, F; Liu, D; Liu, J; Liu, Y; Qu, X; Wu, X; Yao, R | 1 |
| David, S; Haumont, A; Jhelum, P; Lenoël, I; Santos-Nogueira, E; Stys, PK; Teo, W | 1 |
| An, J; Ding, ZB; Han, QX; He, Y; Huang, JJ; Ma, CG; Miao, Q; Sui, RX; Xiao, BG; Yin, JJ | 1 |
| Aliomrani, M; Eftekhari, SM; Gholami, S; Mirian, M | 1 |
| Abouhamzeh, B; Fattahi, N; Khalilian, B; Madadi, S | 1 |
| Amor, S; Chrzanowski, U; Frenz, J; Gingele, S; Greiner, T; Gudi, V; Joost, S; Kaddatz, H; Kipp, M; Müller, M; Müller-Hilke, B; Nedelcu, J; Santrau, E; Schmitz, C; Stangel, M; van der Valk, P; Zhan, J | 1 |
| Carrete, A; Jafarian-Tehrani, M; Meffre, D; Padilla-Ferrer, A; Simon, A | 1 |
| Branchi, I; Cisbani, G; Laflamme, N; Poggini, S; Pons, V; Rivest, S; Tremblay, MÈ | 1 |
| Heo, H; Kim, JK; Kim, KW; Lee, DH; Lee, DW; Woo, CW; Woo, DC | 1 |
| Fan, H; Li, X; Liu, J; Liu, M; Liu, Y; Liu, Z; Qu, X; Wu, X; Yao, R | 1 |
| Buonvicino, D; Chiarugi, A; Ranieri, G | 1 |
| Del Valle, E; García-Álvarez, E; Larráyoz, IM; Martínez-Pinilla, E; Navarro, A; Peláez, R; Rubio-Sardón, N; Tolivia, J | 1 |
| Caprariello, AV; Geurts, JJG; Joseph, JT; Luchicchi, A; Morgan, ML; Schenk, GJ; Stys, PK; Teo, W | 1 |
| Brügger-Verdon, V; Liddelow, S; Marzan, DE; Salzer, JL; Samanta, J; West, BL | 1 |
| Baltan, S; Battapady, HD; Chan, R; Chen, J; Chomyk, AM; Dutta, R; Jawaid, SS; Kidd, GJ; Trapp, BD | 1 |
| Foreman, O; Friedman, BA; Kyauk, RV; Modrusan, Z; Ngu, H; Reichelt, M; Shen, K; Shen, YA; Sheng, M; Yuen, TJ | 1 |
| Abd El Aziz, AE; El Sayed, NS; Sallam, NA; Sayed, RH | 1 |
| Azizzadeh Pormehr, L; Meknatkhah, S; Mousavi, MS; Riazi, GH; Sharif Dashti, P | 1 |
| Heo, H; Kim, JK; Lee, DH; Lee, DW; Woo, DC | 1 |
| Chan, JR; Chen, Y; Kunjamma, RB; Popko, B; Weiner, M | 1 |
| Amani, S; Aryanpour, R; Ghanbari, A; Jame'ei, SB; Kashani, IR; Mahmoudi, R; Namjoo, Z; Pasbakhsh, P; Zibara, K | 1 |
| Dreyfus, CF; Huang, Y; Lercher, LD; McAuliffe, G; Patel, A; Sainato, DM; Saitta, KS | 1 |
| Bai, X; Cheng, Y; Ding, H; Fan, S; Jiang, Y; Li, J; Tian, H; Zhang, Y | 1 |
| Atangulov, G; Borodin, A; Gadzhiibragimova, Z; Kachanov, D; Usov, S | 1 |
| Chai, Z; Chu, GG; Ding, ZB; Guo, MF; Han, QX; Li, XY; Ma, CG; Song, LJ; Wang, Q; Xiao, BG; Yu, JZ | 1 |
| Abd ElWahed, MK; El Sharouny, SH; Elsayed, RM; Shaaban, MH; Tahef, AW | 1 |
| Gan, G; Li, X; Liu, X; Yang, J; Yao, Y; Zhang, A; Zhang, C; Zhu, X | 1 |
| Chen, X; Ding, S; Du, S; Guo, Y; Han, Y; Li, Y; Yan, Z; Zhu, Q | 1 |
| Elmieh, A; Sajedi, D; Shabani, R | 1 |
| Brousse, B; Cayre, M; Daian, F; Durbec, P; Magalon, K; Mercier, O | 1 |
| Chen, NH; Chu, SF; Dong, YX; Du, YS; He, WB; Tian, YJ; Wang, SS; Wang, ZZ; Yan, X; Zhang, Z | 1 |
| Karaszewski, B; Klejbor, I; Klimaszewska-Łata, J; Moryś, J; Rutkowska, A; Shimshek, DR; Szutowicz, A; Velasco-Estevez, M | 1 |
| Danchev, N; Kostadinova, I; Landzhov, B; Marinov, L; Vezenkov, L | 1 |
| Chang, H; Cong, H; Du, L; Liang, M; Wang, Y; Yin, L; Zhang, X | 1 |
| Avloniti, M; Fortosi, A; Kyrargyri, V; Probert, L; Roufagalas, I; Thomaidou, D; Xingi, E | 1 |
| Aliomrani, M; Eftekhari, SM; Safaei, HA | 1 |
| Eliav, U; Navon, G; Nevo, U; Sasson, E; Wilczynski, E | 1 |
| Ghasemi, S; Kashani, IR; Mojaverrostami, S; Nekoonam, S; Pasbakhsh, P; Shabani, M; Zarini, D | 1 |
| Don, AS; Duncan, T; Lee, JY; McEwen, HP; Song, H; Teo, JD | 1 |
| Ahmad, I; Bø, L; Oveland, E; Wergeland, S | 1 |
| Bello, AM; Caprariello, AV; Chakka, SK; Dunn, SE; Kotra, LP; Muthuramu, CM; Sarswat, A; Stys, PK; Wasilewski, E | 1 |
| Chen, WC; Foxley, S; Kleinnijenhuis, M; Miller, KL; Xu, T | 1 |
| Akulov, AE; Glazacheva, VY; Khodanovich, MY; Mustafina, LR; Nemirovich-Danchenko, NM; Romashchenko, AV; Sorokina, IV; Tolstikova, TG; Yarnykh, VL | 1 |
| Bihler, K; Brandenburg, LO; Clarner, T; Esser, S; Kress, E; Nyamoya, S; Pufe, T; Stope, MB; Tauber, SC | 1 |
| Al-Ebraheem, A; Bock, NA; Farquharson, MJ; Oakden, W; Stanisz, GJ | 1 |
| Ai, H; Chang, H; Chen, G; Liu, J; Wang, F; Wu, Y; Yin, L; Zhang, L; Zhang, Y | 1 |
| Bahn, E; Brück, W; Junker, A; Scheidt, U; Schultz, V; Stadelmann, C; van der Meer, F; Wrzos, C | 1 |
| Folts, CJ; Hogestyn, JM; Mayer-Pröschel, M; Noble, MD; Piester, G; Scott-Hewitt, NJ | 1 |
| Caggiano, AO; Colburn, RW; Cui, C; Mullin, AP; Parry, TJ; Pavlopoulos, E; Troy, E; Wang, J; Wang, Y | 1 |
| Anne Becker, K; Chami, M; Fassbender, K; Gulbins, E; Halmer, R; Meier, C; Schnoeder, L; Walter, S | 1 |
| Becker, P; Beisswenger, C; Hainz, N; Meier, C; Rapp, D; Tschernig, T; Wagenpfeil, S; Wonnenberg, B | 1 |
| Duong, D; Giddens, MM; Hall, RA; Li, F; Neil, J; Nguyen, TT; Owino, S; Smith, BM | 1 |
| Gonzalez-Perez, O; Mendez-Victoriano, G; Morales-Luckie, RA; Vega-Riquer, JM | 1 |
| Gotoh, M; Ishikawa, M; Iwasa, K; Maruyama, K; Murakami-Murofushi, K; Yagishita, S; Yamamoto, S; Yamashina, K; Yoshikawa, K | 1 |
| Campbell, IL; Castellano, B; Gonzalez, B; Petković, F | 2 |
| Chen, X; Gu, HS; Li, L; Li, XM; Sun, ZY; Zhang, JW; Zhang, L | 1 |
| Araújo, SES; Campello-Costa, P; Fox, MA; Fuss, B; Gomes, FCA; Jacobs, KM; Mendonça, HR; Wheeler, NA | 1 |
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| Cai, L; Fan, B; Fan, K; Gao, W; Li, N; Ma, J; Yang, X; Zhang, Y | 1 |
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| Li, C; Liu, Z; Mei, F; Shen, HY; Wang, H; Xiao, L | 1 |
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| Badaracco, ME; Pasquini, JM; Rosato Siri, MV | 1 |
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| Armstrong, RC; Hibbits, N; Mierzwa, AJ; Vana, AC; Zhou, YX | 1 |
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| Baekelandt, V; Bogie, J; Hellings, N; Hendriks, JJ; Janssens, K; Lambrichts, I; Maheshwari, A; Slaets, H; Stinissen, P; Struys, T; Van Den Haute, C | 1 |
| Karagogeos, D; Kleopa, KA; Markoullis, K; Zoupi, L | 1 |
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| Albrecht, S; Antel J, J; Brück, W; Cui, QL; Hagemeier, K; Hoffmann, E; Hucke, S; Klassen, E; Klotz, L; Kuhlmann, T; Lürbke, A; Preisner, A | 1 |
| Baumgärtner, W; Bénardais, K; Gudi, V; Hansmann, F; Heijnen, CJ; Hoffmann, A; Janßen, S; Kavelaars, A; Nessler, J; Prajeeth, CK; Salinas Tejedor, L; Skripuletz, T; Stangel, M; van Velthoven, C | 1 |
| De Vocht, N; Guglielmetti, C; Maes, F; Ponsaerts, P; Praet, J; Rangarajan, JR; Van der Linden, A; Verhoye, M; Vreys, R | 1 |
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| Araújo, SM; da Cruz-Höfling, MA; Luna, RL; Nunes, AK; Peixoto, CA; Raposo, C | 1 |
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| Furukawa, Y; Furuta, K; Kawamura, T; Nakajima, M; Nakanishi, M; Okuyama, S; Sugino, M; Tokui, R | 1 |
| Hoyos, HC; Marder, M; Mendez-Huergo, SP; Pasquini, JM; Pasquini, LA; Rabinovich, GA; Rinaldi, M | 1 |
| Buchpiguel, CA; Copray, S; de Paula Faria, D; de Vries, EF; Dierckx, RA; Sijbesma, JW | 1 |
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| Adilijiang, A; Hartle, K; Huang, Q; Kong, J; Li, XM; Tan, Q; Wang, J; Wang, L; Xu, H; Zhang, D; Zhang, H; Zhang, Y; Zhang, Z | 1 |
| Peng, H; Wu, R; Xu, H; Xuan, Y; Yan, G | 1 |
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| Bénardais, K; Gai, L; Gudi, V; Neßler, J; Prajeeth, CK; Singh, V; Skripuletz, T; Stangel, M | 1 |
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| Boucher, C; El-Etr, M; Ghoumari, AM; Kumar, N; Liere, P; Pianos, A; Rame, M; Schumacher, M; Sitruk-Ware, R | 1 |
| Darvishi, M; Ghadiri, T; Ghaemi, A; Gorji, A; Khodagholi, F; Noorbakhsh, F; Sharifzadeh, M; Vakilzadeh, G | 1 |
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| Harada, C; Harada, T; Kimura, A; Matsumoto, Y; Namekata, K; Yoshida, H | 1 |
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| Goings, GE; Miller, SD; Robinson, AP; Rodgers, JM | 1 |
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| Baumgärtner, W; Degen, D; Gold, R; Gropengießer, K; Gudi, V; Hammer, A; Jörg, S; Lee, DH; Linker, RA; Manzel, A; Moharregh-Khiabani, D; Pul, R; Salinas Tejedor, L; Schäfer, N; Singh, V; Skripuletz, T; Stangel, M; Voss, E; Vulinovic, F; Wolf, R | 1 |
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| Akkermann, R; Binder, MD; Butzkueven, H; Cate, HS; Doherty, W; Gresle, MM; Gundlach, AL; Holmes, FE; Jokubaitis, VG; Jonas, A; Kilpatrick, TJ; Marriott, MP; Perreau, VM; Soo, PY; Thiem, S; Wynick, D; Xiao, J | 1 |
| Beyer, C; Clarner, T; Janssen, K; Kipp, M; Rickert, M | 1 |
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| Al-Ebraheem, A; Bock, NA; Farquharson, MJ; Lobo, L; Moldovan, N; Park, R | 1 |
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| Colonna, M; Fontana, E; Gilfillan, S; Poliani, PL; Robinette, ML; Wang, Y; Yamanishi, Y | 1 |
| Bansal, R; Franklin, RJ; Furusho, M; Roulois, AJ | 1 |
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| Baxi, EG; Calabresi, PA; DeBruin, J; Fairchild, AN; Gocke, AR; Grishkan, IV; Kirby, LA; Smith, MD; Strasburger, HJ; Tosi, DM | 1 |
| Beyer, C; Clarner, T; Goldberg, J; Kipp, M | 1 |
| Gingele, S; Gudi, V; Kucman, V; Pul, R; Salinas Tejedor, L; Skripuletz, T; Stangel, M; Sühs, KW | 1 |
| Brück, W; Nessler, S; Pfeifenbring, S; Stadelmann, C; Wegner, C | 1 |
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| Fujikawa, A; Kuboyama, K; Noda, M; Suzuki, R | 1 |
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| Gudi, V; Hildebrandt, H; Koutsoudaki, PN; Moharregh-Khiabani, D; Skripuletz, T; Stangel, M; Trebst, C | 1 |
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| Brück, W; Klinker, F; Krauss, S; Merkler, D; Prinz, M; Raasch, J; Schmidt, H | 1 |
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| Gilmore, W; Matsushima, GK; Taylor, LC; Ting, JP | 1 |
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| Baumgartner, W; Beyer, C; Clarner, T; Dang, J; Gingele, S; Kipp, M; Pott, F | 1 |
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| Gilmore, W; Matsushima, GK; Puranam, K; Taylor, LC; Ting, JP | 1 |
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| Armstrong, RC; Budde, MD; Chen, CI; Cross, AH; McDaniel, DP; Song, SK; Tobin, JE; Trinkaus, K; Xie, M | 1 |
| Blank, A; Gudi, V; Miller, E; Moharregh-Khiabani, D; Pul, R; Skripuletz, T; Stangel, M; Trebst, C | 1 |
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| Blank, A; Gudi, V; Kotsiari, A; Miller, E; Moharregh-Khiabani, D; Skripuletz, T; Stangel, M | 1 |
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| Gudi, V; Hildebrandt, H; Koutsoudaki, PN; Skripuletz, T; Škuljec, J; Stangel, M | 1 |
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| Macklin, WB; Miller, RH; Popescu, DC; Wang, C; Wang, Y; Wu, C; Zhu, J | 1 |
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| Calabresi, PA; Jones, MV; McMahon, MT; Mori, S; Zhang, J | 1 |
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| Amor, S; Beyer, C; Clarner, T; Gingele, S; Kipp, M; Pott, F; van der Valk, P | 1 |
| Frichert, K; Gudi, V; Moharregh-Khiabani, D; Skripuletz, T; Škuljec, J; Stangel, M; Voss, E; Wissel, K; Wolter, S; Yildiz, Ö | 1 |
| Bakker, EN; Baron, W; Bauer, J; Binnekade, R; Bol, JG; Brevé, JJ; Drukarch, B; Van Dam, AM; Van Der Laarse, WJ; Van Strien, ME | 1 |
| Armstrong, RC; Le, TQ; Pannu, R; Zhou, YX | 1 |
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| Gudi, V; Pul, R; Skripuletz, T; Škuljec, J; Stangel, M; Trebst, C; Voss, EV | 1 |
| Gudi, V; Hackstette, D; Skripuletz, T; Stangel, M | 1 |
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| Boretius, S; Ehrenreich, H; Frahm, J; Ghezzi, P; Hagemeyer, N; Ott, C; Simons, M; Sperling, S; Von Streitberg, A; Welpinghus, H | 1 |
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| Awad, H; Berger, K; Beyer, C; Buschmann, JP; Clarner, T; Kipp, M | 1 |
| Bi, X; He, J; Jiang, W; Kong, J; Li, XM; Tan, Q; Wang, J; Wang, L; Xiao, L; Xu, H; Zhang, D; Zhang, H; Zhang, R; Zhang, Y; Zhu, S | 1 |
| Gulen, MF; Kang, Z; Li, X; Liu, L; Ouyang, W; Ransohoff, RM; Spangler, R; Spear, C; Veenstra, M; Wang, C | 1 |
| Cruz-Höfling, MA; Luna, RL; Nunes, AK; Peixoto, CA; Rapôso, C | 1 |
| Brakelmann, L; Brück, W; Hagemeier, K; Hanisch, UK; Hayardeny, L; John, GR; Kramann, N; Kuhlmann, T; Pförtner, R; Pham, T; Piryatinsky, V; Regen, T; Stadelmann, C; van Rossum, D; Wegner, C; Zhang, J | 1 |
| Chen, LP; Guo, L; Li, R; Li, ZF; Liu, J; Ping, M; Song, XJ; Xie, XH | 1 |
| Bernard, F; Chédotal, A; Dumas, L; Fouquet, S; Heitz-Marchaland, C; Lee, X; Mi, S; Moreau-Fauvarque, C; Shao, Z; Zagar, Y | 1 |
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| Bauer, K; Baumgärtner, W; Berger, K; Gudi, V; Hackstette, D; Kipp, M; Pul, R; Skripuletz, T; Stangel, M; Voss, E | 1 |
| Doan, V; Kleindienst, AM; Long, BR; Matsushima, GK; McMahon, EJ; Taylor, LC | 1 |
| Boggs, JM; Hirahara, Y; Kawata, M; Matsuda, KI; Morisaki, S; Saitou, A; Takanami, K; Yamada, H | 1 |
| Crawford, DK; Hannsun, G; Molaie, D; Moore, S; Patel, R; Sasidhar, MV; Tan, K; Tiwari-Woodruff, SK | 1 |
| Cai, QY; Chen, XS; Liu, YL; Su, L; Xu, Y; Yao, ZX; Ye, JN; Zhan, XL; Zhao, SF | 1 |
| Bielecki, B; Boehm, N; Ghandour, MS; Ghoumari, AM; Habert, R; Hussain, R; Kumar, N; Liere, P; Macklin, WB; Mhaouty-Kodja, S; Schumacher, M; Sitruk-Ware, R; Steibel, J; Tronche, F | 1 |
| Armstrong, RC; Borke, RC; Frost, EE; Le, TQ; Vana, AC | 1 |
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| Avellana-Adalid, V; Baron Van Evercooren, A; Bernasconi, L; Boschert, U; Cirillo, R; Feger, G; Graber, P; Kadi, L; Kosco-Vilbois, M; Losberger, C; Papoian, R; Picard-Riera, N; Selvaraju, R | 1 |
| Goldman, JE; Hostettler, JD; Mason, JL; Matsushima, GK; Morell, P; Suzuki, K; Toews, A | 1 |
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| Bacia, A; Soliven, B; Wollmann, R | 1 |
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| Armstrong, RC; Cross, AH; Le, TQ; Lin, SJ; Song, SK; Sun, SW; Yoshino, J | 1 |
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| Boddeke, HW; Copray, JC; Küst, BM; Mantingh-Otter, I | 1 |
| Arnett, HA; Bergstralh, DT; Carson, MJ; Iovanna, JL; McMahon, EJ; Miller, SD; Plant, SR; Thrash, JC; Ting, JP; Vasseur, S; Wang, Y | 1 |
| Armstrong, RC; Cross, AH; Liang, HF; Song, SK; Sun, SW; Trinkaus, K | 1 |
| Adamo, AM; Escobar Cabrera, OE; Franco, PG; Paez, PM; Pasquini, JM; Soto, EF; Wolfson, M | 1 |
| Dupree, JL; Harding, HP; Kemper, A; Lin, W; Popko, B; Ron, D | 1 |
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| Alexander, WS; Binder, MD; Butzkueven, H; Cate, HS; Cooper, H; Croker, B; Emery, B; Kilpatrick, TJ; Marriott, M; Merson, T; Murray, S; Snell, C; Soo, PY; Zhang, JG | 1 |
| Feinstein, DL; Feng, Y; Gould, RM; Lubetzki, C; Mufson, EJ; Polak, P; Sharp, A; Stankoff, B; Tian, D; Wang, Y; Wei, J; Wu, C; Zalc, B | 1 |
| Liebetanz, D; Merkler, D | 1 |
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| Bédard, A; Chernomoretz, A; Tremblay, P; Vallières, L | 1 |
| Akita, M; Asou, H; Fukutake, M; Ishige, A; Sakai, R; Seiwa, C; Takeda, S; Tanaka, K; Ueki, T; Watanabe, K; Yagi, T; Yamamoto, M | 1 |
| Colomina, MT; Franco-Pons, N; Torrente, M; Vilella, E | 1 |
| Babcock, AA; Owens, T; Remington, LT; Zehntner, SP | 1 |
| Kusnecov, AW; Urbach-Ross, D | 1 |
| Arnett, HA; Carson, MJ; Fu, YX; Iocca, HA; O'Connor, BP; Plant, SR; Thrash, JC; Ting, JP; Wang, Y | 1 |
| Adachi, E; Hashimoto, N; Inagawa-Ogashiwa, M; Kato, C; Moriya-Sato, A; Song, SY; Umeda, R | 1 |
| Baumgärtner, W; Fokuhl, J; Garde, N; Grothe, C; Haastert, K; Heine, S; Lindner, M; Linsmeier, F; Stangel, M | 1 |
| Binder, M; Cate, HS; Egan, GF; Fang, K; Kemper, D; Kilpatrick, TJ; Marriott, M; Quick, MJ; Wang, HX; Wu, QZ; Yang, Q | 1 |
| Armstrong, RC; Flint, NC; Fruttiger, M; Harwood, NE; Le, TQ; Vana, AC | 1 |
| Gröticke, I; Hoffmann, K; Lindner, M; Löscher, W; Stangel, M | 1 |
| Burkly, LC; Hahm, K; Iocca, HA; Lundsmith, ET; O'Connor, BP; Plant, SR; Runkel, L; Ting, JP; van Deventer, HW; Wang, Y | 1 |
| Binder, MD; Butzkueven, H; Cate, HS; Egan, G; Emery, B; Gordon, IR; Kemper, D; Kilpatrick, TJ; Kolbe, S; Marriott, MP; Murray, S; Wang, H; Wu, Q | 1 |
| Heine, S; Koutsoudaki, PN; Lindner, M; Skripuletz, T; Stangel, M; Trebst, C | 1 |
| Binder, MD; Butzkueven, H; Carmeliet, P; Cate, HS; Cipriani, T; Gresle, MM; Jokubaitis, VG; Kemper, D; Kilpatrick, TJ; Prieto, AL | 1 |
| Carey, EM; Freeman, NM | 1 |
| Blakemore, WF | 1 |
| Akazawa, Y; Imoh, A; Koide, M; Sudou, K; Tashiro, S | 1 |
| Ludwin, SK | 3 |
| Cammer, W; Tansey, FA; Zhang, H | 1 |
| Barrett, CV; Hostettler, JD; Knapp, GW; Mason, JL; Matsushima, GK; Morell, P; Toews, AD | 1 |
| Hiremath, MM; Knapp, GW; Matsushima, GK; Saito, Y; Suzuki, K; Ting, JP | 1 |
| Jones, JJ; Mason, JL; Matsushima, GK; Morell, P; Suzuki, K; Taniike, M | 1 |
| D'Ercole, AJ; Mason, JL; Matsushima, GK; Suzuki, K; Ye, P | 1 |
| D'Ercole, AJ; Gao, X; Gillig, TA; Matsushima, GK; Popko, B; Ye, P | 1 |
| Matsushima, GK; Morell, P | 1 |
| Langaman, C; Mason, JL; Matsushima, GK; Morell, P; Suzuki, K | 1 |
| Chaplin, DD; Mason, JL; Matsushima, GK; Suzuki, K | 1 |
| Arnett, HA; Marino, M; Mason, J; Matsushima, GK; Suzuki, K; Ting, JP | 1 |
| Arnett, HA; Hellendall, RP; Laubach, VE; Matsushima, GK; Sherman, P; Suzuki, K; Ting, JP | 1 |
| Hostettler, J; Jurevics, H; Kleindienst, A; Largent, C; Matsushima, GK; Morell, P; Sammond, DW; Toews, AD | 1 |
| Bondy, CA; Hudson, LD; Komoly, S; Webster, HD | 1 |
| Jeyasingham, MD; Komoly, S; Lantos, PL; Pratt, OE | 1 |
| Bakker, DA; Ludwin, SK | 1 |
22 review(s) available for cuprizone and Clinically Isolated CNS Demyelinating Syndrome
| Article | Year |
|---|---|
The roles of microglia and astrocytes in phagocytosis and myelination: Insights from the cuprizone model of multiple sclerosis.
Topics: Animals; Astrocytes; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mice; Mice, Inbred C57BL; Microglia; Multiple Sclerosis; Myelin Sheath; Phagocytosis | 2022 |
The mechanistic target of rapamycin as a regulator of metabolic function in oligodendroglia during remyelination.
Topics: Animals; Cuprizone; Demyelinating Diseases; Humans; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Oligodendroglia; Remyelination; Sirolimus; TOR Serine-Threonine Kinases | 2022 |
Oligodendrocyte death and myelin loss in the cuprizone model: an updated overview of the intrinsic and extrinsic causes of cuprizone demyelination.
Topics: Animals; Astrocytes; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mice; Mice, Inbred C57BL; Microglia; Myelin Sheath; Oligodendroglia | 2022 |
Disease-associated oligodendrocyte responses across neurodegenerative diseases.
Topics: Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Humans; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Neurodegenerative Diseases; Oligodendroglia | 2022 |
Motor Behavioral Deficits in the Cuprizone Model: Validity of the Rotarod Test Paradigm.
Topics: Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Sheath; Remyelination; Rotarod Performance Test | 2022 |
Remyelination in Multiple Sclerosis: Findings in the Cuprizone Model.
Topics: Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Humans; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Sheath; Remyelination; Reproducibility of Results | 2022 |
Astrocytes: Lessons Learned from the Cuprizone Model.
Topics: Animals; Astrocytes; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Humans; Mice; Mice, Inbred C57BL; Microglia; Multiple Sclerosis; Myelin Sheath; Oligodendroglia | 2023 |
Behavioural phenotypes in the cuprizone model of central nervous system demyelination.
Topics: Animals; Behavior, Animal; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Myelin Sheath; Oligodendroglia | 2019 |
The Cuprizone Model: Dos and Do Nots.
Topics: Animals; Body Weight; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Gene Expression Regulation; Multiple Sclerosis | 2020 |
Revisiting the Pathoetiology of Multiple Sclerosis: Has the Tail Been Wagging the Mouse?
Topics: Animals; Autoimmunity; Central Nervous System; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Disease Progression; Encephalomyelitis, Autoimmune, Experimental; Humans; Mice; Multiple Sclerosis; Oligodendroglia | 2020 |
Five Decades of Cuprizone, an Updated Model to Replicate Demyelinating Diseases.
Topics: Animals; Brain; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Oligodendroglia; Reproducibility of Results | 2019 |
Remyelination promoting therapies in multiple sclerosis animal models: a systematic review and meta-analysis.
Topics: Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Ethidium; Eye Proteins; Lysophosphatidylcholines; Mice; Multiple Sclerosis; Myelin Sheath; Nerve Growth Factors; Oligodendrocyte Precursor Cells; Oligodendroglia; Platelet-Derived Growth Factor; Remyelination; Serpins; Tocopherols | 2019 |
The benefits and detriments of macrophages/microglia in models of multiple sclerosis.
Topics: Animals; Cell Movement; Central Nervous System; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Humans; Immunologic Factors; Lysophosphatidylcholines; Macrophages; Microglia; Multiple Sclerosis; Neurons; Oligodendroglia; T-Lymphocytes | 2013 |
Paving the way for adequate myelination: The contribution of galectin-3, transferrin and iron.
Topics: Animals; Cuprizone; Demyelinating Diseases; Galectin 3; Humans; Iron; Myelin Sheath; Transferrin | 2015 |
Multiple sclerosis animal models: a clinical and histopathological perspective.
Topics: Animals; Axons; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Disease Progression; Encephalomyelitis, Autoimmune, Experimental; Humans; Leukoencephalopathies; Multiple Sclerosis; Neurodegenerative Diseases; Spinal Cord | 2017 |
Cytokines and myelination in the central nervous system.
Topics: Alzheimer Disease; Animals; Brain; Brain Ischemia; Central Nervous System; Cuprizone; Cytokines; Demyelinating Diseases; Encephalomyelitis, Autoimmune, Experimental; Humans; Hyperoxia; Infant, Newborn; Inflammation; Multiple Sclerosis; Myelin Sheath; Schizophrenia; Signal Transduction | 2008 |
Myelin, copper, and the cuprizone model of schizophrenia.
Topics: Animals; Biological Evolution; Copper; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Humans; Mice; Myelin Sheath; Oligodendroglia; Schizophrenia | 2011 |
Brain lipid binding protein (FABP7) as modulator of astrocyte function.
Topics: Animals; Astrocytes; Carrier Proteins; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Fatty Acid-Binding Protein 7; Fatty Acid-Binding Proteins; Humans; Multiple Sclerosis; Myelin Sheath; Nerve Tissue Proteins; Signal Transduction; Tumor Suppressor Proteins | 2011 |
De- and remyelination in the CNS white and grey matter induced by cuprizone: the old, the new, and the unexpected.
Topics: Animals; Central Nervous System; Chelating Agents; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Female; Male; Mice; Mice, Inbred C57BL; Myelin Sheath; Neuroprotective Agents; Neurotoxicity Syndromes; Species Specificity | 2011 |
The response of oligodendrocytes to chemical injury.
Topics: 6-Aminonicotinamide; Animals; Axons; Cuprizone; Demyelinating Diseases; Ethidium; Isoniazid; Mice; Myelin Sheath; Neuroglia; Oligodendroglia; Rats; Triethyltin Compounds | 1984 |
Central nervous system remyelination: studies in chronically damaged tissue.
Topics: Animals; Cell Division; Central Nervous System; Cuprizone; Demyelinating Diseases; Mice; Multiple Sclerosis; Myelin Sheath; Nerve Degeneration; Nerve Regeneration; Oligodendroglia; Phagocytosis; Rats | 1994 |
The neurotoxicant, cuprizone, as a model to study demyelination and remyelination in the central nervous system.
Topics: Animals; Central Nervous System; Chelating Agents; Cuprizone; Demyelinating Diseases; Mice; Mice, Inbred C57BL; Microglia; Models, Animal; Myelin Sheath; Oligodendroglia | 2001 |
538 other study(ies) available for cuprizone and Clinically Isolated CNS Demyelinating Syndrome
| Article | Year |
|---|---|
Valproic acid suppresses cuprizone-induced hippocampal demyelination and anxiety-like behavior by promoting cholesterol biosynthesis.
Topics: Animals; Anxiety; Cholesterol; Cuprizone; Demyelinating Diseases; Hippocampus; Male; Mice; Mice, Inbred C57BL; Monoamine Oxidase Inhibitors; Multiple Sclerosis; Neuroprotective Agents; Psychomotor Performance; Valproic Acid | 2021 |
Untargeted Metabolomic Profiling of Cuprizone-Induced Demyelination in Mouse Corpus Callosum by UPLC-Orbitrap/MS Reveals Potential Metabolic Biomarkers of CNS Demyelination Disorders.
Topics: Animals; Biomarkers; Central Nervous System Diseases; Chromatography, Liquid; Corpus Callosum; Cuprizone; Demyelinating Diseases; Male; Mass Spectrometry; Metabolome; Mice; Mice, Inbred C57BL; Monoamine Oxidase Inhibitors | 2021 |
Antagonizing astrocytic platelet activating factor receptor-neuroinflammation for total flavone of epimedium in response to cuprizone demyelination.
Topics: Administration, Oral; Animals; Astrocytes; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Epimedium; Flavones; Humans; Male; Mice; Myelin Sheath; Neuroinflammatory Diseases; Plant Extracts; Platelet Membrane Glycoproteins; Receptors, G-Protein-Coupled | 2021 |
Enhanced re-myelination in transthyretin null mice following cuprizone mediated demyelination.
Topics: Animals; Corpus Callosum; Cuprizone; Demyelinating Diseases; Female; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Prealbumin; Remyelination | 2022 |
Temporal and spatial evolution of various functional neurons during demyelination induced by cuprizone.
Topics: Animals; Astrocytes; Axons; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Glutamic Acid; Mice; Monoamine Oxidase Inhibitors; Multiple Sclerosis; Myelin Sheath; Neurons | 2021 |
Transcriptomic analysis of loss of Gli1 in neural stem cells responding to demyelination in the mouse brain.
Topics: Animals; Cuprizone; Demyelinating Diseases; Mice; Neural Stem Cells; Oligodendroglia; Transcriptome; Zinc Finger Protein GLI1 | 2021 |
A novel probiotic strain exerts therapeutic effects on mouse model of multiple sclerosis by altering the expression of inflammasome and IDO genes and modulation of T helper cytokine profile.
Topics: Animals; Cuprizone; Cytokines; Demyelinating Diseases; Disease Models, Animal; Inflammasomes; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Probiotics; T-Lymphocytes, Helper-Inducer | 2022 |
Cuprizone feed formulation influences the extent of demyelinating disease pathology.
Topics: Animal Feed; Animals; Astrocytes; Body Weight; Chelating Agents; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; DNA Damage; Gliosis; Inflammation; Male; Mice; Mice, Inbred C57BL; Microglia; Multiple Sclerosis; Oligodendroglia; Reproducibility of Results | 2021 |
Encapsulation of bryostatin-1 by targeted exosomes enhances remyelination and neuroprotection effects in the cuprizone-induced demyelinating animal model of multiple sclerosis.
Topics: Animals; Bryostatins; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Exosomes; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Neural Stem Cells; Neuroprotection; Neuroprotective Agents; Oligodendroglia; Remyelination | 2022 |
Colony-stimulating factor-1 receptor inhibition attenuates microgliosis and myelin loss but exacerbates neurodegeneration in the chronic cuprizone model.
Topics: Animals; Colony-Stimulating Factors; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mice; Mice, Inbred C57BL; Microglia; Multiple Sclerosis; Myelin Sheath | 2022 |
Citrullinated myelin induces microglial TNFα and inhibits endogenous repair in the cuprizone model of demyelination.
Topics: Animals; Cells, Cultured; Chelating Agents; Citrulline; Cuprizone; Cytokines; Demyelinating Diseases; Mice; Mice, Inbred C57BL; Microglia; Microinjections; Motor Cortex; Myelin Basic Protein; Myelin Sheath; Tumor Necrosis Factor-alpha | 2021 |
Clemastine Rescues Chemotherapy-Induced Cognitive Impairment by Improving White Matter Integrity.
Topics: Animals; Chemotherapy-Related Cognitive Impairment; Clemastine; Corpus Callosum; Cuprizone; Demyelinating Diseases; Mice; Mice, Inbred C57BL; Myelin Sheath; Oligodendroglia; White Matter | 2022 |
The effects of mesenchymal stem cells transplantation on A1 neurotoxic reactive astrocyte and demyelination in the cuprizone model.
Topics: Animals; Astrocytes; Biomarkers; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Male; Mesenchymal Stem Cells; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Oligodendroglia | 2022 |
Comparison of the Effects of Cuprizone on Demyelination in the Corpus Callosum and Hippocampal Progenitors in Young Adult and Aged Mice.
Topics: Animals; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Hippocampus; Mice; Mice, Inbred C57BL; Oligodendroglia | 2022 |
A targeted extracellular vesicles loaded with montelukast in the treatment of demyelinating diseases.
Topics: Acetates; Animals; Cell Differentiation; Cell Lineage; Cuprizone; Cyclopropanes; Demyelinating Diseases; Disease Models, Animal; Drug Delivery Systems; Exosomes; Extracellular Vesicles; In Vitro Techniques; Ligands; Male; Mice; Mice, Inbred C57BL; Myelin Basic Protein; Myelin Sheath; Neurons; Oligodendrocyte Precursor Cells; Oligodendroglia; Phagocytosis; Quinolines; Receptor, Platelet-Derived Growth Factor alpha; Regeneration; Stem Cells; Sulfides | 2022 |
Modulation of pacemaker channel function in a model of thalamocortical hyperexcitability by demyelination and cytokines.
Topics: Animals; Cerebral Cortex; Cuprizone; Cytokines; Demyelinating Diseases; Epilepsy, Absence; Humans; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Mice; Mice, Inbred C3H; Neurons; Nucleotides, Cyclic; Seizures; Thalamus | 2022 |
Abnormal oxidative metabolism in the cuprizone mouse model of demyelination: An in vivo NIRS-MRI study.
Topics: Animals; Cell Hypoxia; Cerebral Cortex; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Magnetic Resonance Imaging; Male; Mice; Mice, Inbred C57BL; Mitochondria; Oxidative Stress; Remyelination; Spectroscopy, Near-Infrared; Spin Labels | 2022 |
Ceramide kinase knockout ameliorates multiple sclerosis-like behaviors and demyelination in cuprizone-treated mice.
Topics: Age Factors; Animals; Behavior, Animal; Brain; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Female; Male; Mice, Inbred C57BL; Mice, Knockout; Multiple Sclerosis; Oligodendroglia; Phosphotransferases (Alcohol Group Acceptor); Proteins; Tail | 2022 |
Astroglial and oligodendroglial markers in the cuprizone animal model for de- and remyelination.
Topics: Animals; Astrocytes; Biomarkers; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mice; Mice, Inbred C57BL; Myelin Sheath; Oligodendroglia; Remyelination; Vimentin | 2022 |
Development of a Chemical Cocktail That Rescues Mouse Brain Demyelination in a Cuprizone-Induced Model.
Topics: Animals; Corpus Callosum; Cuprizone; Demyelinating Diseases; Mice; Mice, Inbred C57BL; Oligodendroglia | 2022 |
Defective fractalkine-CX3CR1 signaling aggravates neuroinflammation and affects recovery from cuprizone-induced demyelination.
Topics: Animals; Chemokine CX3CL1; Cuprizone; CX3C Chemokine Receptor 1; Demyelinating Diseases; Disease Models, Animal; Humans; Mice; Mice, Inbred C57BL; Microglia; Myelin Sheath; Neuroinflammatory Diseases; Remyelination | 2022 |
Efficacy of different intensity of aquatic exercise in enhancing remyelination and neuronal plasticity using cuprizone model in male Wistar rats.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Glial Fibrillary Acidic Protein; Male; Methylprednisolone; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Basic Protein; Neuronal Plasticity; Neuroprotective Agents; Rats; Rats, Wistar; Remyelination | 2022 |
Cuprizone-mediated demyelination reversibly degrades voiding behavior in mice while sparing brainstem reflex.
Topics: Animals; Brain Stem; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Humans; Inflammation; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Sheath; Oligodendroglia; Quality of Life; Reflex; Urination | 2022 |
Defining milestones for the study of remyelination using the cuprizone mouse model: How early is early?
Topics: Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Humans; Male; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Sheath; Remyelination | 2022 |
Different Methods for Evaluating Microglial Activation Using Anti-Ionized Calcium-Binding Adaptor Protein-1 Immunohistochemistry in the Cuprizone Model.
Topics: Animals; Astrocytes; Calcium; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Immunohistochemistry; Mice; Mice, Inbred C57BL; Microglia; Multiple Sclerosis | 2022 |
The Extracellular Matrix Proteins Tenascin-C and Tenascin-R Retard Oligodendrocyte Precursor Maturation and Myelin Regeneration in a Cuprizone-Induced Long-Term Demyelination Animal Model.
Topics: Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Extracellular Matrix; Mice; Mice, Inbred C57BL; Mice, Knockout; Myelin Sheath; Oligodendrocyte Precursor Cells; Tenascin | 2022 |
PRMT1 is required for the generation of MHC-associated microglia and remyelination in the central nervous system.
Topics: Animals; Central Nervous System; Cuprizone; Demyelinating Diseases; Mice; Mice, Inbred C57BL; Microglia; Remyelination | 2022 |
Synthesis and structural characterization of copper-cuprizone complexes.
Topics: Animals; Coordination Complexes; Copper; Crystallography, X-Ray; Cuprizone; Demyelinating Diseases; Ligands; Mice; Mice, Inbred C57BL; X-Ray Absorption Spectroscopy | 2022 |
Characterization of Glial Populations in the Aging and Remyelinating Mouse Corpus Callosum.
Topics: Animals; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mice; Mice, Inbred C57BL; Myelin Sheath; Oligodendroglia | 2022 |
Combination effects of mesenchymal stem cells transplantation and anodal transcranial direct current stimulation on a cuprizone-induced mouse model of multiple sclerosis.
Topics: Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mesenchymal Stem Cells; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Transcranial Direct Current Stimulation | 2022 |
Nebivolol elicits a neuroprotective effect in the cuprizone model of multiple sclerosis in mice: emphasis on M1/M2 polarization and inhibition of NLRP3 inflammasome activation.
Topics: Animals; Cell Polarity; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Inflammasomes; Macrophages; Mice; Mice, Inbred C57BL; Microglia; Multiple Sclerosis; Nebivolol; Neuroprotective Agents; NLR Family, Pyrin Domain-Containing 3 Protein | 2022 |
Myelin repair is fostered by the corticosteroid medrysone specifically acting on astroglial subpopulations.
Topics: Adrenal Cortex Hormones; Animals; Astrocytes; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mice; Mice, Inbred C57BL; Myelin Sheath; Oligodendroglia; Pregnenediones | 2022 |
Ursolic Acid Enhances Myelin Repair in Adult Mice Brains and Stimulates Exhausted Oligodendrocyte Progenitors to Remyelinate.
Topics: Animals; Anti-Inflammatory Agents; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Glial Fibrillary Acidic Protein; Gliosis; Inflammation; Interleukin-10; Mice; Mice, Inbred C57BL; Myelin Sheath; Oligodendrocyte Precursor Cells; Oligodendroglia; Tumor Necrosis Factor-alpha; Ursolic Acid | 2022 |
Suppressive Effect of Fruiting Bodies of Medicinal Mushrooms on Demyelination and Motor Dysfunction in a Cuprizone-Induced Multiple Sclerosis Mouse Model.
Topics: Agaricales; Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Fruiting Bodies, Fungal; Mice; Mice, Inbred C57BL; Multiple Sclerosis | 2022 |
The effect of Zingiber Officinale Extract on Preventing Demyelination of Corpus Callosum in a Rat Model of Multiple Sclerosis
Topics: Animals; Anti-Inflammatory Agents; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Fingolimod Hydrochloride; Male; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Sheath; Rats; Rats, Wistar; Zingiber officinale | 2022 |
Glial Response to Intranasal Mesenchymal Stem Cells in Intermittent Cuprizone Model of Demyelination.
Topics: Animals; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Interleukin-10; Mesenchymal Stem Cells; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Sheath; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha | 2022 |
Stemazole Promotes Oligodendrocyte Precursor Cell Survival In Vitro and Remyelination In Vivo.
Topics: Animals; Cell Differentiation; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Hydrazines; Mice; Mice, Inbred C57BL; Myelin Sheath; Oligodendrocyte Precursor Cells; Oligodendroglia; Oxadiazoles; Remyelination | 2022 |
Combination Therapy of Mesenchymal Stem Cell Transplantation and Astrocyte Ablation Improve Remyelination in a Cuprizone-Induced Demyelination Mouse Model.
Topics: Animals; Astrocytes; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mesenchymal Stem Cell Transplantation; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Sheath; Remyelination; RNA, Messenger | 2022 |
Activation of TRPV1 receptor facilitates myelin repair following demyelination via the regulation of microglial function.
Topics: Animals; Capsaicin; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Humans; Mice; Mice, Inbred C57BL; Microglia; Multiple Sclerosis; Myelin Sheath; TRPV Cation Channels | 2023 |
Cuprizone feeding induces swollen astrocyte endfeet.
Topics: Animals; Astrocytes; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mice; Mice, Inbred C57BL | 2022 |
Opposing effects of apoE2 and apoE4 on microglial activation and lipid metabolism in response to demyelination.
Topics: Animals; Apolipoprotein E2; Apolipoprotein E3; Apolipoprotein E4; Apolipoproteins E; Cuprizone; Demyelinating Diseases; Lipid Metabolism; Mice; Microglia | 2022 |
The Effects of Cuprizone on Murine Subventricular Zone-Derived Neural Stem Cells and Progenitor Cells Grown as Neurospheres.
Topics: Animals; Cell Differentiation; Cuprizone; Demyelinating Diseases; Lateral Ventricles; Mice; Mice, Inbred C57BL; Neural Stem Cells; Oligodendroglia | 2023 |
Inhomogeneous Magnetization Transfer (ihMT) imaging in the acute cuprizone mouse model of demyelination/remyelination.
Topics: Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Magnetic Resonance Imaging; Mice; Mice, Inbred C57BL; Myelin Sheath; Remyelination | 2023 |
Key role of the gut-microbiota-brain axis via the subdiaphragmatic vagus nerve in demyelination of the cuprizone-treated mouse brain.
Topics: Animals; Brain; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mice; Mice, Inbred C57BL; Microbiota; Microglia; Multiple Sclerosis; Vagus Nerve | 2023 |
Deciphering the Genetic Crosstalk between Microglia and Oligodendrocyte Precursor Cells during Demyelination and Remyelination Using Transcriptomic Data.
Topics: Animals; Cell Differentiation; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Humans; Mice; Mice, Inbred C57BL; Microglia; Multiple Sclerosis; Myelin Sheath; Oligodendrocyte Precursor Cells; Oligodendroglia; Remyelination | 2022 |
Influx of T cells into corpus callosum increases axonal injury, but does not change the course of remyelination in toxic demyelination.
Topics: Animals; Axons; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Sheath; Oligodendroglia; Remyelination; T-Lymphocytes | 2023 |
Single-cell microglial transcriptomics during demyelination defines a microglial state required for lytic carcass clearance.
Topics: Acridine Orange; Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mice; Mice, Inbred C57BL; Microglia; Transcriptome | 2022 |
Antiretroviral treatment reveals a novel role for lysosomes in oligodendrocyte maturation.
Topics: Animals; Cell Differentiation; Cuprizone; Demyelinating Diseases; Lysosomes; Mice; Mice, Inbred C57BL; Myelin Sheath; Oligodendroglia; Rats | 2023 |
Pharmacological treatment promoting remyelination enhances motor function after internal capsule demyelination in mice.
Topics: Animals; Clemastine; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Internal Capsule; Lysophosphatidylcholines; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Sheath; Oligodendroglia; Remyelination | 2023 |
Genetic models of cleavage-reduced and soluble TREM2 reveal distinct effects on myelination and microglia function in the cuprizone model.
Topics: Animals; Cuprizone; Cytokines; Demyelinating Diseases; Disease Models, Animal; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia; Models, Genetic; Myelin Sheath; Neuroinflammatory Diseases; Receptors, Immunologic | 2023 |
Cu,Zn-Superoxide Dismutase has Minimal Effects Against Cuprizone-Induced Demyelination, Microglial Activation, and Neurogenesis Defects in the C57BL/6 Mouse Hippocampus.
Topics: Animals; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Doublecortin Domain Proteins; Hippocampus; Ki-67 Antigen; Mice; Mice, Inbred C57BL; Microglia; Neurogenesis; Superoxide Dismutase-1; Zinc | 2023 |
Immunofluorescence assay for demyelination, remyelination, and proliferation in an acute cuprizone mouse model.
Topics: Animals; Cell Proliferation; Cuprizone; Demyelinating Diseases; Fluorescent Antibody Technique; Mice; Remyelination | 2023 |
Transcriptomic atlas and interaction networks of brain cells in mouse CNS demyelination and remyelination.
Topics: Animals; Brain; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mice; Mice, Inbred C57BL; Microglia; Myelin Sheath; Oligodendroglia; Remyelination; Transcriptome | 2023 |
Microglial aryl hydrocarbon receptor enhances phagocytic function via SYK and promotes remyelination in the cuprizone mouse model of demyelination.
Topics: Animals; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mice; Mice, Inbred C57BL; Microglia; Myelin Sheath; Receptors, Aryl Hydrocarbon; Remyelination | 2023 |
Immunoreactivity of Kir3.1, muscarinic receptors 2 and 3 on the brainstem, vagus nerve and heart tissue under experimental demyelination.
Topics: Animals; Brain Stem; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Female; Male; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Sheath; Rats; Rats, Wistar; Receptors, Muscarinic; Vagus Nerve | 2023 |
Post-injury born oligodendrocytes incorporate into the glial scar and contribute to the inhibition of axon regeneration.
Topics: Axons; Cuprizone; Demyelinating Diseases; Gliosis; Humans; Nerve Regeneration; Oligodendroglia; Retinal Ganglion Cells | 2023 |
Effects of Bone Marrow Mesenchymal Stem Cells on Myelin Repair and Emotional Changes of a Cuprizone-Induced Demyelination Model.
Topics: Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Male; Mesenchymal Stem Cells; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Sheath | 2023 |
Brain-specific glycosylation of protein tyrosine phosphatase receptor type Z (PTPRZ) marks a demyelination-associated astrocyte subtype.
Topics: Animals; Astrocytes; Brain; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Glycosylation; Mice; Mice, Inbred C57BL; Polysaccharides; Protein Tyrosine Phosphatases | 2023 |
Remyelinating activities of Carvedilol or alpha lipoic acid in the Cuprizone-Induced rat model of demyelination.
Topics: Animals; Carvedilol; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Neurodegenerative Diseases; Rats; Thioctic Acid | 2023 |
Progranulin deficiency results in sex-dependent alterations in microglia in response to demyelination.
Topics: Animals; Cuprizone; Demyelinating Diseases; Female; Frontotemporal Dementia; Frontotemporal Lobar Degeneration; Intercellular Signaling Peptides and Proteins; Lysosomes; Male; Mice; Microglia; Progranulins | 2023 |
Neurobehavioral, biochemical and histological assessment of the effects of resveratrol on cuprizone-induced demyelination in mice: role of autophagy modulation.
Topics: Animals; Autophagy; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mice; Mice, Inbred C57BL; Myelin Sheath; Resveratrol | 2023 |
The Effects of NLY01, a Novel Glucagon-Like Peptide-1 Receptor Agonist, on Cuprizone-Induced Demyelination and Remyelination: Challenges and Future Perspectives.
Topics: Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Glucagon-Like Peptide-1 Receptor; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Sheath; Remyelination | 2023 |
TGN020 application against aquaporin 4 improved multiple sclerosis by inhibiting astrocytes, microglia, and NLRP3 inflammasome in a cuprizone mouse model.
Topics: Animals; Aquaporin 4; Astrocytes; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Inflammasomes; Male; Mice; Mice, Inbred C57BL; Microglia; Multiple Sclerosis; NLR Family, Pyrin Domain-Containing 3 Protein | 2023 |
The neuroprotective effects of Chalcones from Ashitaba on cuprizone-induced demyelination via modulation of brain-derived neurotrophic factor and tumor necrosis factor α.
Topics: Animals; Brain-Derived Neurotrophic Factor; Chalcones; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Neuroprotective Agents; Tumor Necrosis Factor-alpha | 2023 |
The Cuprizone Mouse Model: A Comparative Study of Cuprizone Formulations from Different Manufacturers.
Topics: Animals; Body Weight; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Gliosis; Male; Mice; Mice, Inbred C57BL; Myelin Sheath | 2023 |
Dynamics of reactive astrocytes fosters tissue regeneration after cuprizone-induced demyelination.
Topics: Animals; Astrocytes; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mice; Mice, Inbred C57BL; Myelin Sheath; Neuroglia; Oligodendroglia | 2023 |
Localized Increased Permeability of Blood-Brain Barrier for Antibody Conjugates in the Cuprizone Model of Demyelination.
Topics: Animals; Antibodies; Blood-Brain Barrier; Coloring Agents; Cuprizone; Demyelinating Diseases; Diffusion Tensor Imaging; Evans Blue; Gadolinium; Immunoconjugates; Mice | 2023 |
Microglial depletion exacerbates axonal damage and motor dysfunction in mice with cuprizone-induced demyelination.
Topics: Animals; Axons; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mice; Mice, Inbred C57BL; Microglia; Multiple Sclerosis | 2023 |
Inhibition of SUMOylation promotes remyelination and reduces IL-17 mediated autoimmune inflammation: Novel approach toward treatment of inflammatory CNS demyelinating disease.
Topics: Animals; Cell Differentiation; Central Nervous System Diseases; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Humans; Inflammation; Interleukin-17; Mice; Mice, Inbred C57BL; Myelin Sheath; Oligodendroglia; Remyelination; Sumoylation; Transcription Factors | 2023 |
Role of MAPK and PI3K-Akt signaling pathways in cuprizone-induced demyelination and cognitive impairment in mice.
Topics: Animals; Cognitive Dysfunction; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mice; Mice, Inbred C57BL; Myelin Sheath; Oligodendroglia; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction | 2024 |
FKBP5 activates mitophagy by ablating PPAR-γ to shape a benign remyelination environment.
Topics: Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mice; Mice, Inbred C57BL; Mitophagy; Multiple Sclerosis; Myelin Sheath; Neurodegenerative Diseases; PPAR gamma; Remyelination | 2023 |
Glutamate delta-1 receptor regulates oligodendrocyte progenitor cell differentiation and myelination in normal and demyelinating conditions.
Topics: Animals; Cell Differentiation; Corpus Callosum; Cuprizone; Demyelinating Diseases; Glutamic Acid; Mice; Mice, Inbred C57BL; Mice, Knockout; Myelin Sheath; Oligodendrocyte Precursor Cells; Oligodendroglia; Receptors, Glutamate | 2023 |
Butyrate suppresses demyelination and enhances remyelination.
Topics: Animals; Anti-Bacterial Agents; Butyrates; Cell Differentiation; Cuprizone; Demyelinating Diseases; Gastrointestinal Microbiome; Male; Mice; Mice, Inbred C57BL; Myelin Sheath; Oligodendroglia; Organ Culture Techniques; Remyelination | 2019 |
Ginkgolide K supports remyelination via induction of astrocytic IGF/PI3K/Nrf2 axis.
Topics: Animals; Astrocytes; Behavior, Animal; Brain; Cells, Cultured; Cuprizone; Cytokines; Demyelinating Diseases; Ginkgolides; Lactones; Male; Mice, Inbred C57BL; Myelin Sheath; NF-E2-Related Factor 2; Phosphatidylinositol 3-Kinases; Somatomedins | 2019 |
[Melatonin effects in young and aged mice with toxic cuprizone-induced model of demyelination.]
Topics: Animals; Antioxidants; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Melatonin; Mice; Mice, Inbred C57BL; Neurons | 2019 |
Nrf2 deficiency increases oligodendrocyte loss, demyelination, neuroinflammation and axonal damage in an MS animal model.
Topics: Animals; Axons; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Inflammation; Mice; Mice, Knockout; Multiple Sclerosis; NF-E2-Related Factor 2; Oligodendroglia; Oxidative Stress | 2020 |
Disease modifying mitochondrial uncouplers, MP101, and a slow release ProDrug, MP201, in models of Multiple Sclerosis.
Topics: 2,4-Dinitrophenol; Animals; Axons; Brain-Derived Neurotrophic Factor; Cuprizone; Cytokines; Delayed-Action Preparations; Demyelinating Diseases; Encephalitis; Encephalomyelitis, Autoimmune, Experimental; Female; Immunization; Mice; Mice, Inbred C57BL; Mitochondria; Multiple Sclerosis; Nerve Growth Factors; Paralysis; Prodrugs; Uncoupling Agents | 2019 |
Quantitative Imaging of White and Gray Matter Remyelination in the Cuprizone Demyelination Model Using the Macromolecular Proton Fraction.
Topics: Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Gray Matter; Magnetic Resonance Imaging; Male; Mesothelin; Mice; Myelin Basic Protein; Oligodendrocyte Precursor Cells; Oligodendroglia; Remyelination; White Matter | 2019 |
Ellagic acid improves muscle dysfunction in cuprizone-induced demyelinated mice via mitochondrial Sirt3 regulation.
Topics: Animals; Behavior, Animal; Chelating Agents; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Ellagic Acid; Male; Mice; Mice, Inbred C57BL; Mitochondria, Muscle; Muscular Diseases; Oxidative Stress; Sirtuin 3 | 2019 |
Suppression of the Peripheral Immune System Limits the Central Immune Response Following Cuprizone-Feeding: Relevance to Modelling Multiple Sclerosis.
Topics: Adaptive Immunity; Animals; Brain; Computational Biology; Cuprizone; Cytokines; Demyelinating Diseases; Disease Models, Animal; Gliosis; Immune System; Male; Mice; Mice, Inbred C57BL; Microglia; Mitochondria; Multiple Sclerosis; Oligodendroglia | 2019 |
Ethyl pyruvate enhances spontaneous remyelination by targeting microglia phagocytosis.
Topics: Animals; Behavior, Animal; Cell Line; Cell Movement; Cell Survival; Cuprizone; Cytokines; Demyelinating Diseases; Disease Models, Animal; Male; Mice, Inbred C57BL; Microglia; Multiple Sclerosis; Phagocytosis; Pyruvates; Remyelination | 2019 |
Laquinimod Supports Remyelination in Non-Supportive Environments.
Topics: Animals; Brain; Cell Differentiation; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mice; Mice, Inbred C57BL; Microglia; Multiple Sclerosis; Myelin Sheath; Oligodendrocyte Transcription Factor 2; Oligodendroglia; Quinolones; Remyelination | 2019 |
Temporal and Spatial Dynamics of Astroglial Reaction and Immune Response in Cuprizone-Induced Demyelination.
Topics: Animals; Astrocytes; Blood-Brain Barrier; Brain; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Male; Mice, Inbred C57BL; Myelin Sheath; T-Lymphocytes | 2020 |
Cuprizone-induced demyelination under physiological and post-stroke condition leads to decreased neurogenesis response in adult mouse brain.
Topics: Animals; Behavior, Animal; Brain Ischemia; Cell Differentiation; Cell Movement; Cell Proliferation; Cell Survival; Chelating Agents; Cuprizone; Demyelinating Diseases; Magnetic Resonance Imaging; Male; Mice; Mice, Inbred C57BL; Neural Stem Cells; Neurogenesis; Stroke; White Matter | 2020 |
Investigation of Cuprizone-Induced Demyelination in mGFAP-Driven Conditional Transient Receptor Potential Ankyrin 1 (TRPA1) Receptor Knockout Mice.
Topics: Animals; Astrocytes; Brain; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Disease Susceptibility; Gene Expression; Glial Fibrillary Acidic Protein; Immunohistochemistry; Magnetic Resonance Imaging; Mice; Mice, Knockout; Microglia; RNA, Messenger; TRPA1 Cation Channel | 2019 |
Blocking the Thrombin Receptor Promotes Repair of Demyelinated Lesions in the Adult Brain.
Topics: Animals; Astrocytes; Axons; Brain-Derived Neurotrophic Factor; Chelating Agents; Coculture Techniques; Copper; Corpus Callosum; Cuprizone; Demyelinating Diseases; Gene Expression Profiling; Lysophosphatidylcholines; Male; Mice; Mice, Knockout; Myelin Sheath; Nerve Regeneration; Neural Stem Cells; Oligodendroglia; Receptor, PAR-1; Rotarod Performance Test; Spinal Cord; White Matter | 2020 |
Diverse Gene Expressions in the Prediction of Cuprizone-Induced Demyelination.
Topics: Animals; Astrocytes; Brain; Cuprizone; Demyelinating Diseases; Gene Expression; Male; Mice, Inbred C57BL; Microglia; Myelin Sheath; Oligodendroglia; Transcriptome | 2020 |
Dose-dependent effect of cannabinoid WIN-55,212-2 on myelin repair following a demyelinating insult.
Topics: Animals; Benzoxazines; Calcium-Binding Proteins; Corpus Callosum; Cuprizone; Demyelinating Diseases; Dose-Response Relationship, Drug; Glial Fibrillary Acidic Protein; Male; Mice; Microfilament Proteins; Morpholines; Myelin Sheath; Naphthalenes; Receptor, Cannabinoid, CB1; Receptor, Platelet-Derived Growth Factor alpha | 2020 |
Differential Expression of miRNAs and Behavioral Change in the Cuprizone-Induced Demyelination Mouse Model.
Topics: Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Exploratory Behavior; Female; Gene Expression Regulation; Gene Regulatory Networks; Male; Mice; Mice, Inbred C57BL; MicroRNAs; Rotarod Performance Test | 2020 |
Behavioural and histological changes in cuprizone-fed mice.
Topics: Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mice; Mice, Inbred C57BL; Oligodendroglia | 2020 |
Cuprizone-induced oligodendrocyte loss and demyelination impairs recording performance of chronically implanted neural interfaces.
Topics: Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mice; Mice, Inbred C57BL; Myelin Sheath; Oligodendroglia | 2020 |
Role of Macrophage Colony-Stimulating Factor Receptor on the Proliferation and Survival of Microglia Following Systemic Nerve and Cuprizone-Induced Injuries.
Topics: Animals; Brain; Cell Proliferation; Cell Survival; Chimera; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Hypoglossal Nerve Injuries; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor | 2020 |
NEP1-40 alleviates behavioral phenotypes and promote oligodendrocyte progenitor cell differentiation in the hippocampus of cuprizone-induced demyelination mouse model.
Topics: Animals; Cell Differentiation; Chelating Agents; Cuprizone; Demyelinating Diseases; Hippocampus; Male; Mice; Mice, Inbred C57BL; Myelin Proteins; Oligodendrocyte Precursor Cells; Peptide Fragments; Phenotype; Stereotaxic Techniques | 2020 |
Deletion of Voltage-Gated Calcium Channels in Astrocytes during Demyelination Reduces Brain Inflammation and Promotes Myelin Regeneration in Mice.
Topics: Animals; Astrocytes; Brain; Calcium Channel Blockers; Calcium Channels; Cuprizone; Demyelinating Diseases; Female; Inflammation; Male; Mice; Mice, Knockout; Myelin Sheath; Nimodipine; Remyelination | 2020 |
Human iPSC-derived mature microglia retain their identity and functionally integrate in the chimeric mouse brain.
Topics: Animals; Brain; Cell Differentiation; Cell Line; Chimera; Cuprizone; Demyelinating Diseases; Female; Humans; Imaging, Three-Dimensional; Induced Pluripotent Stem Cells; Mice; Microglia; RNA-Seq; Single-Cell Analysis; Transcriptome | 2020 |
Functional role of endogenous Kv1.4 in experimental demyelination.
Topics: Animals; Cell Proliferation; Chelating Agents; Cuprizone; Demyelinating Diseases; Encephalomyelitis, Autoimmune, Experimental; Kv1.4 Potassium Channel; Mice; Mice, Inbred C57BL; Mice, Knockout; Oligodendroglia; Remyelination; Th1 Cells | 2020 |
CZ-7, a new derivative of Claulansine F, promotes remyelination induced by cuprizone by enhancing myelin debris clearance.
Topics: Animals; Carbazoles; Chelating Agents; Cuprizone; Demyelinating Diseases; Male; Mice; Mice, Inbred C57BL; Microglia; Myelin Proteins; Remyelination | 2020 |
Delayed Demyelination and Impaired Remyelination in Aged Mice in the Cuprizone Model.
Topics: Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Male; Mice; Monoamine Oxidase Inhibitors; Multiple Sclerosis; Remyelination | 2020 |
Effect of Sox10 on remyelination of the hippocampus in cuprizone-induced demyelinated mice.
Topics: Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Hippocampus; Male; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Myelin Sheath; Oligodendroglia; Remyelination; SOXE Transcription Factors | 2020 |
Motor learning promotes remyelination via new and surviving oligodendrocytes.
Topics: Animals; Cell Differentiation; Cuprizone; Demyelinating Diseases; Learning; Mice; Mice, Inbred C57BL; Monoamine Oxidase Inhibitors; Motor Activity; Motor Cortex; Oligodendrocyte Precursor Cells; Oligodendroglia; Recovery of Function; Remyelination | 2020 |
Increased blood-brain barrier hyperpermeability coincides with mast cell activation early under cuprizone administration.
Topics: Animals; Blood-Brain Barrier; Capillary Permeability; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mast Cells; Mice; Mice, Inbred C57BL; Tight Junction Proteins | 2020 |
Repurposing of Secukinumab as Neuroprotective in Cuprizone-Induced Multiple Sclerosis Experimental Model via Inhibition of Oxidative, Inflammatory, and Neurodegenerative Signaling.
Topics: Animals; Anti-Inflammatory Agents; Antibodies, Monoclonal, Humanized; Cuprizone; Demyelinating Diseases; Inflammation; Male; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Sheath; Neurodegenerative Diseases; Neuroprotective Agents; Oligodendroglia; Oxidative Stress; Remyelination | 2020 |
CD44 expression in the cuprizone model.
Topics: Animals; Brain; Chelating Agents; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Hyaluronan Receptors; Mice; Mice, Inbred C57BL; Multiple Sclerosis; White Matter | 2020 |
Myelination- and immune-mediated MR-based brain network correlates.
Topics: Animals; Brain; Chelating Agents; Cuprizone; Demyelinating Diseases; Diffusion Tensor Imaging; Female; Mice; Mice, Inbred C57BL; Myelin Sheath; Nerve Net; Remyelination | 2020 |
Amelioration of clinical course and demyelination in the cuprizone mouse model in relation to ketogenic diet.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Astrocytes; Body Weight; Brain; Chemokine CXCL10; Cuprizone; Cytokines; Demyelinating Diseases; Diet, Ketogenic; Disease Models, Animal; Down-Regulation; Glial Fibrillary Acidic Protein; Histone Deacetylases; Inflammasomes; Male; Mice; Mice, Inbred C57BL; Microglia; Myelin Basic Protein; NLR Family, Pyrin Domain-Containing 3 Protein; Signal Transduction; Weight Loss | 2020 |
Mesenchymal Stem Cells Ameliorate Cuprizone-Induced Demyelination by Targeting Oxidative Stress and Mitochondrial Dysfunction.
Topics: Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Humans; Male; Mesenchymal Stem Cells; Mice, Inbred C57BL; Mitochondria; Multiple Sclerosis; Myelin Sheath; Oligodendroglia; Oxidative Stress; Remyelination | 2021 |
Effects of EHP-101 on inflammation and remyelination in murine models of Multiple sclerosis.
Topics: Animals; Cannabinoid Receptor Agonists; Cannabinoids; Chelating Agents; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Inflammation; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Remyelination; Spinal Cord | 2020 |
Calorie restriction promotes remyelination in a Cuprizone-Induced demyelination mouse model of multiple sclerosis.
Topics: Animals; Astrocytes; Brain; Caloric Restriction; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mice; Microglia; Motor Skills; Multiple Sclerosis; Myelin Sheath; Remyelination | 2020 |
Motoneuron expression profiling identifies an association between an axonal splice variant of HDGF-related protein 3 and peripheral myelination.
Topics: Animals; Axons; Cell Nucleus; Coculture Techniques; Cuprizone; Demyelinating Diseases; Gene Expression Profiling; Intracellular Signaling Peptides and Proteins; Male; Mice; Motor Neurons; Myelin Sheath; Neuroglia; Protein Isoforms; Rats | 2020 |
Dendrosomal nanocurcumin promotes remyelination through induction of oligodendrogenesis in experimental demyelination animal model.
Topics: Acute Disease; Animals; Astrocytes; Cell Differentiation; Cell Lineage; Cell Proliferation; Cell Survival; Cells, Cultured; Chronic Disease; Cuprizone; Curcumin; Demyelinating Diseases; Disease Models, Animal; Embryo, Mammalian; Male; Mice, Inbred C57BL; Nanoparticles; Neural Stem Cells; Neurogenesis; Oligodendroglia; Remyelination | 2020 |
Autofluorescence spectroscopy as a proxy for chronic white matter pathology.
Topics: Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Humans; Mice; Mice, Inbred C57BL; Myelin Sheath; Spectrum Analysis; White Matter | 2021 |
Cuprizone-Induced Demyelination in Mouse Hippocampus Is Alleviated by Ketogenic Diet.
Topics: Animals; Astrocytes; Cuprizone; Demyelinating Diseases; Diet, Ketogenic; Disease Models, Animal; Glutathione; Hippocampus; Humans; Male; Malondialdehyde; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Oligodendroglia; PPAR gamma; Sirtuin 1 | 2020 |
Ursolic acid treatment suppresses cuprizone-induced demyelination and motor dysfunction via upregulation of IGF-1.
Topics: Administration, Oral; Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Gene Expression; Insulin-Like Growth Factor I; Mice; Motor Activity; Multiple Sclerosis; Triterpenes; Up-Regulation; Ursolic Acid | 2020 |
Dcf1 deficiency induces hypomyelination by activating Wnt signaling.
Topics: Animals; Corpus Callosum; Cuprizone; Demyelinating Diseases; Down-Regulation; Electroporation; Hippocampus; Male; Membrane Proteins; Mice; Mice, Knockout; Myelin Proteins; Myelin Sheath; Nerve Tissue Proteins; Postural Balance; Psychomotor Performance; Wnt Signaling Pathway | 2021 |
The effect of microglial ablation and mesenchymal stem cell transplantation on a cuprizone-induced demyelination model.
Topics: Aminopyridines; Animals; Behavior, Animal; Biomarkers; Calcium-Binding Proteins; Chemokine CX3CL1; Corpus Callosum; Cuprizone; CX3C Chemokine Receptor 1; Demyelinating Diseases; Disease Models, Animal; Glial Fibrillary Acidic Protein; Injections, Intraventricular; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mice, Inbred C57BL; Microfilament Proteins; Microglia; Myelin Sheath; Pyrroles | 2021 |
Aquaporin-4 Expression during Toxic and Autoimmune Demyelination.
Topics: Animals; Aquaporin 4; Autoimmune Diseases; Brain; Brain Injuries; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Gene Expression Regulation; Humans; Inflammation; Mice; Multiple Sclerosis; Myelin Sheath; Neuromyelitis Optica | 2020 |
Conditional Deletion of Foxg1 Alleviates Demyelination and Facilitates Remyelination via the Wnt Signaling Pathway in Cuprizone-Induced Demyelinated Mice.
Topics: Animals; Cell Differentiation; Cuprizone; Demyelinating Diseases; Forkhead Transcription Factors; Glycogen Synthase Kinase 3; Mice; Mice, Inbred C57BL; Myelin Sheath; Nerve Tissue Proteins; Oligodendroglia; Remyelination; Wnt Signaling Pathway | 2021 |
Ferroptosis Mediates Cuprizone-Induced Loss of Oligodendrocytes and Demyelination.
Topics: Animals; Chelating Agents; Corpus Callosum; Cuprizone; Cyclohexylamines; Demyelinating Diseases; Ferritins; Ferroptosis; Free Radicals; Glutathione; Homeostasis; Iron; Lipid Peroxidation; Male; Mice; Mice, Inbred C57BL; Oligodendroglia; Oxidative Stress; Phenylenediamines; Remyelination | 2020 |
Ethyl Pyruvate-Derived Transdifferentiation of Astrocytes to Oligodendrogenesis in Cuprizone-Induced Demyelinating Model.
Topics: Animals; Astrocytes; Cell Transdifferentiation; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Oligodendroglia; Phagocytosis; Pyruvates; Receptors, Interleukin-1 | 2021 |
Apamin administration impact on miR-219 and miR-155-3p expression in cuprizone induced multiple sclerosis model.
Topics: Animals; Apamin; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Gene Expression Regulation; Male; Mice, Inbred C57BL; MicroRNAs; Multiple Sclerosis; Myelin Sheath | 2020 |
Coenzyme Q10 enhances remyelination and regulate inflammation effects of cuprizone in corpus callosum of chronic model of multiple sclerosis.
Topics: Animals; Behavior, Animal; Biomarkers; Chronic Disease; Corpus Callosum; Cuprizone; Cytokines; Demyelinating Diseases; Disease Models, Animal; Inflammation; Inflammation Mediators; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Sheath; Oxidative Stress; Remyelination; Ubiquinone | 2021 |
Cuprizone-induced demyelination triggers a CD8-pronounced T cell recruitment.
Topics: Animals; CD8-Positive T-Lymphocytes; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mice; Mice, Inbred C57BL; Oligodendroglia | 2021 |
Effect of Etazolate upon Cuprizone-induced Demyelination In Vivo: Behavioral and Myelin Gene Analysis.
Topics: Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Etazolate; Mice; Mice, Inbred C57BL; Myelin Sheath; Oligodendroglia; Phosphodiesterase Inhibitors; Remyelination | 2021 |
The Intellicage system provides a reproducible and standardized method to assess behavioral changes in cuprizone-induced demyelination mouse model.
Topics: Animals; Behavior, Animal; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Housing, Animal; Mice; Monoamine Oxidase Inhibitors; Neuropsychological Tests; Neurotoxicity Syndromes | 2021 |
Temporal Changes in In Vivo Glutamate Signal during Demyelination and Remyelination in the Corpus Callosum: A Glutamate-Weighted Chemical Exchange Saturation Transfer Imaging Study.
Topics: Administration, Oral; Animals; Axons; Brain; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Glutamic Acid; Immunohistochemistry; Magnetic Resonance Imaging; Male; Microscopy, Electron, Transmission; Myelin Sheath; Rats; Rats, Sprague-Dawley; Remyelination | 2020 |
Trpv4 regulates Nlrp3 inflammasome via SIRT1/PGC-1α pathway in a cuprizone-induced mouse model of demyelination.
Topics: Animals; Chelating Agents; Cognition Disorders; Corpus Callosum; Cuprizone; Demyelinating Diseases; Gene Knockdown Techniques; Inflammasomes; Male; Mice; Mice, Inbred C57BL; Mitochondria; Neuroglia; NLR Family, Pyrin Domain-Containing 3 Protein; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Reactive Oxygen Species; RNA, Small Interfering; Sirtuin 1; TRPV Cation Channels | 2021 |
Cuprizone-Dependent De/Remyelination Responses and Functional Correlates in Mouse Strains Adopted to Model Relapsing, Chronic and Progressive Experimental Autoimmune Encephalomyelitis.
Topics: Animals; Chelating Agents; Chronic Disease; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Disease Progression; Encephalomyelitis, Autoimmune, Experimental; Female; Mice; Mice, Inbred C57BL; Mice, Inbred NOD; Myelin Sheath; Remyelination | 2021 |
Neuroprotective Effect of Apolipoprotein D in Cuprizone-Induced Cell Line Models: A Potential Therapeutic Approach for Multiple Sclerosis and Demyelinating Diseases.
Topics: Animals; Apolipoproteins D; Cell Line; Cell Survival; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Humans; Mice; Multiple Sclerosis; Neuroprotective Agents; Oligodendroglia; Reactive Oxygen Species | 2021 |
Nile Red fluorescence spectroscopy reports early physicochemical changes in myelin with high sensitivity.
Topics: Aged; Animals; Case-Control Studies; Cell Line; Cuprizone; Demyelinating Diseases; Fluorescent Dyes; Gray Matter; Humans; Lipids; Male; Mice, Inbred C57BL; Middle Aged; Multiple Sclerosis; Myelin Sheath; Oligodendroglia; Oxazines; Spectrometry, Fluorescence; White Matter | 2021 |
Activated microglia drive demyelination via CSF1R signaling.
Topics: Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Macrophages; Mice; Microglia; Receptors, Colony-Stimulating Factor; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; Signal Transduction | 2021 |
Neuronal hibernation following hippocampal demyelination.
Topics: Animals; Astrocytes; Cognitive Dysfunction; Cuprizone; Demyelinating Diseases; Dendritic Spines; Disease Models, Animal; Hippocampus; Long-Term Potentiation; Magnetic Resonance Imaging; Male; Mice; Mice, Inbred C57BL; Microscopy, Electron; Multiple Sclerosis; Neurons; Post-Synaptic Density; Sequence Analysis, RNA | 2021 |
Multiple sclerosis risk gene Mertk is required for microglial activation and subsequent remyelination.
Topics: Animals; c-Mer Tyrosine Kinase; Cell Differentiation; Cell Movement; Cuprizone; Cyclin-Dependent Kinase Inhibitor p21; Demyelinating Diseases; Disease Models, Animal; Interferon-gamma; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia; Multiple Sclerosis; Myelin Sheath; Oligodendroglia; Phagocytosis; Remyelination | 2021 |
Neuroprotective Effects of Telmisartan and Nifedipine Against Cuprizone-Induced Demyelination and Behavioral Dysfunction in Mice: Roles of NF-κB and Nrf2.
Topics: Animals; Cuprizone; Demyelinating Diseases; Hand Strength; Locomotion; Male; Mice; Mice, Inbred C57BL; Neuroprotective Agents; NF-E2-Related Factor 2; NF-kappa B; Nifedipine; Telmisartan | 2021 |
The brain 3β-HSD up-regulation in response to deteriorating effects of background emotional stress: an animal model of multiple sclerosis.
Topics: 3-Hydroxysteroid Dehydrogenases; Animals; Anxiety; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Electroshock; Female; Maze Learning; Multiple Sclerosis; Neuroprotection; Psychological Distress; Psychomotor Performance; Rats; Rats, Wistar; RNA, Messenger; Up-Regulation | 2021 |
Amide Proton Transfer-weighted 7-T MRI Contrast of Myelination after Cuprizone Administration.
Topics: Amides; Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Magnetic Resonance Imaging; Male; Protons; Rats; Rats, Wistar; White Matter | 2021 |
Prolonging the integrated stress response enhances CNS remyelination in an inflammatory environment.
Topics: Animals; Axons; Central Nervous System; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Inflammation; Interferon-gamma; Male; Mice; Oligodendroglia; Remyelination | 2021 |
17β-Estradiol Reduces Demyelination in Cuprizone-fed Mice by Promoting M2 Microglia Polarity and Regulating NLRP3 Inflammasome.
Topics: Animals; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Estradiol; Inflammasomes; Mice; Mice, Inbred C57BL; Microglia; NLR Family, Pyrin Domain-Containing 3 Protein | 2021 |
CHPG enhances BDNF and myelination in cuprizone-treated mice through astrocytic metabotropic glutamate receptor 5.
Topics: Animals; Astrocytes; Brain-Derived Neurotrophic Factor; Cuprizone; Demyelinating Diseases; Mice; Receptor, Metabotropic Glutamate 5 | 2021 |
18β-Glycyrrhetinic acid alleviates demyelination by modulating the microglial M1/M2 phenotype in a mouse model of cuprizone-induced demyelination.
Topics: Animals; Cuprizone; Demyelinating Diseases; Glycyrrhetinic Acid; Locomotion; Male; Mice; Mice, Inbred C57BL; Microglia; Myelin Sheath; Phenotype | 2021 |
THYROID STATUS: IS IT POSSIBLE TO RESTORE MYELIN?
Topics: Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mice; Mice, Inbred C57BL; Myelin Sheath; Oligodendroglia; Rats; Thyroid Gland | 2021 |
Fasudil enhances the phagocytosis of myelin debris and the expression of neurotrophic factors in cuprizone-induced demyelinating mice.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Brain-Derived Neurotrophic Factor; Cell Differentiation; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Glial Cell Line-Derived Neurotrophic Factor; Humans; Male; Mice; Microglia; Myelin Sheath; Oligodendroglia; Phagocytosis; Remyelination | 2021 |
N-acetylcysteine protects against cuprizone-induced demyelination: histological and immunohistochemical study.
Topics: Acetylcysteine; Animals; Corpus Callosum; Cuprizone; Demyelinating Diseases; Myelin Sheath; Rats | 2022 |
ADAM10 suppresses demyelination and reduces seizure susceptibility in cuprizone-induced demyelination model.
Topics: ADAM10 Protein; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Membrane Proteins; Mice; Mice, Inbred C57BL; Seizures | 2021 |
Demyelination and remyelination detected in an alternative cuprizone mouse model of multiple sclerosis with 7.0 T multiparameter magnetic resonance imaging.
Topics: Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Magnetic Resonance Imaging; Male; Mice; Multiple Sclerosis; Myelin Sheath; Remyelination | 2021 |
Changes in leptin, serotonin, and cortisol after eight weeks of aerobic exercise with probiotic intake in a cuprizone-induced demyelination mouse model of multiple sclerosis.
Topics: Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Female; Hydrocortisone; Inflammation; Leptin; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Physical Conditioning, Animal; Probiotics; Serotonin | 2021 |
Endogenous neural stem cells modulate microglia and protect against demyelination.
Topics: Animals; Cell Differentiation; Corpus Callosum; Cuprizone; Demyelinating Diseases; Inflammation; Lateral Ventricles; Ligands; Mice, Transgenic; Microglia; Neural Stem Cells; Neuroprotection; Receptors, Cell Surface | 2021 |
Rg1 exerts protective effect in CPZ-induced demyelination mouse model via inhibiting CXCL10-mediated glial response.
Topics: Animals; Chemokine CXCL10; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Dose-Response Relationship, Drug; Ginsenosides; Hypokinesia; Inflammation Mediators; Male; Mice; Mice, Inbred C57BL; Microglia; NF-kappa B; Panax; Phagocytosis; RNA, Small Interfering | 2022 |
EBI2 is expressed in glial cells in multiple sclerosis lesions, and its knock-out modulates remyelination in the cuprizone model.
Topics: Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Sheath; Neuroglia; Oligodendroglia; Remyelination; Sclerosis | 2021 |
Neuroprotective effect of newly synthesized 4-aminopyridine derivatives on cuprizone-induced demyelination in mice-a behavioral and immunohistochemical study.
Topics: 4-Aminopyridine; Animals; Behavior, Animal; Cuprizone; Demyelinating Diseases; Immunohistochemistry; Male; Mice; Neuroprotective Agents | 2021 |
Icariin ameliorates the cuprizone-induced acute brain demyelination and modulates the number of oligodendrocytes, microglia and astrocytes in the brain of C57BL/6J mice.
Topics: Animals; Astrocytes; Behavior, Animal; Brain; Brain-Derived Neurotrophic Factor; Cell Count; Chelating Agents; Cuprizone; Demyelinating Diseases; Female; Flavonoids; Mice; Mice, Inbred C57BL; Microglia; Oligodendroglia; Stem Cells | 2021 |
Novel cell-based analysis reveals region-dependent changes in microglial dynamics in grey matter in a cuprizone model of demyelination.
Topics: Animals; CA1 Region, Hippocampal; Cell Enlargement; Cell Proliferation; Cerebral Cortex; Chelating Agents; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Gray Matter; Hippocampus; Imaging, Three-Dimensional; Mice; Mice, Knockout; Microglia; Microscopy, Confocal; Multiple Sclerosis; Optical Imaging; Phagocytosis; Potassium Channels, Tandem Pore Domain; Remyelination | 2021 |
Analysis of platelet-derived growth factor receptor A and oligodendrocyte transcription factor 2 markers following Hydroxychloroquine administration in animal induced multiple sclerosis model.
Topics: Animals; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Hydroxychloroquine; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Sheath; Oligodendrocyte Transcription Factor 2; Oligodendroglia; Receptors, Platelet-Derived Growth Factor | 2021 |
An in vivo implementation of the MEX MRI for myelin fraction of mice brain.
Topics: Animals; Brain; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Magnetic Resonance Imaging; Mice; Mice, Inbred C57BL; Myelin Sheath; Protons; White Matter | 2022 |
Protective Features of Calorie Restriction on Cuprizone-induced Demyelination via Modulating Microglial Phenotype.
Topics: Animals; Blood Glucose; Caloric Restriction; Chelating Agents; Cuprizone; Demyelinating Diseases; Male; Mice; Mice, Inbred C57BL; Microglia; Phenotype | 2021 |
Sphingosine kinase 2 is essential for remyelination following cuprizone intoxication.
Topics: Animals; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mice; Mice, Inbred C57BL; Myelin Sheath; Oligodendroglia; Phosphotransferases (Alcohol Group Acceptor); Remyelination | 2021 |
A higher proportion of ermin-immunopositive oligodendrocytes in areas of remyelination.
Topics: Animals; Brain; Cerebral Cortex; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Female; Gray Matter; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Basic Protein; Myelin Proteins; Myelin Sheath; Oligodendroglia; Remyelination; White Matter | 2021 |
Inhibitors of protein arginine deiminases and their efficacy in animal models of multiple sclerosis.
Topics: Animals; Brain; Catalytic Domain; Cuprizone; Demyelinating Diseases; Encephalitis; Enzyme Inhibitors; Female; Half-Life; Humans; Hydantoins; Hydrolases; Imidazoles; Isoenzymes; Male; Mice, Inbred C57BL; Molecular Docking Simulation; Multiple Sclerosis; Myelitis; Neuroprotective Agents; Spinal Cord; Tetrazoles | 2017 |
The effect of realistic geometries on the susceptibility-weighted MR signal in white matter.
Topics: Algorithms; Animals; Anisotropy; Axons; Biophysics; Computer Simulation; Cuprizone; Demyelinating Diseases; Diffusion Tensor Imaging; Disease Models, Animal; Fourier Analysis; Magnetic Resonance Imaging; Mice; Mice, Inbred C57BL; Myelin Sheath; White Matter | 2018 |
Histological validation of fast macromolecular proton fraction mapping as a quantitative myelin imaging method in the cuprizone demyelination model.
Topics: Animals; Brain; Brain Mapping; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Gray Matter; Humans; Indoles; Macromolecular Substances; Magnetic Resonance Imaging; Mesothelin; Mice, Inbred C57BL; Myelin Sheath; Protons; White Matter | 2017 |
Formyl Peptide Receptor 1-Mediated Glial Cell Activation in a Mouse Model of Cuprizone-Induced Demyelination.
Topics: Animals; Corpus Callosum; Cuprizone; Cytokines; Demyelinating Diseases; Immunity, Innate; Macrophage Activation; Macrophages; Male; Mice; Mice, Inbred C57BL; Neuroglia; Receptors, Formyl Peptide; RNA, Messenger | 2017 |
Early regional cuprizone-induced demyelination in a rat model revealed with MRI.
Topics: Animals; Contrast Media; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Iron; Liver; Magnetic Resonance Imaging; Male; Myelin Sheath; Rats, Wistar; Signal Processing, Computer-Assisted | 2017 |
Increased central dopaminergic activity might be involved in the behavioral abnormality of cuprizone exposure mice.
Topics: Animals; Astrocytes; Behavior, Animal; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Dopamine; Male; Memory, Short-Term; Mice, Inbred C57BL; Microglia; Oligodendroglia; Schizophrenia | 2017 |
Acutely damaged axons are remyelinated in multiple sclerosis and experimental models of demyelination.
Topics: Amyloid beta-Protein Precursor; Animals; Axons; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Female; Glial Fibrillary Acidic Protein; Lysophosphatidylcholines; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Microglia; Monoamine Oxidase Inhibitors; Multiple Sclerosis; Myelin Sheath; Rats; Rats, Inbred Lew; Statistics, Nonparametric; Time Factors | 2017 |
Heterozygote galactocerebrosidase (GALC) mutants have reduced remyelination and impaired myelin debris clearance following demyelinating injury.
Topics: Animals; Cuprizone; Demyelinating Diseases; Galactosylceramidase; Genome-Wide Association Study; Heterozygote; Membrane Glycoproteins; Mice; Microglia; Multiple Sclerosis; Myelin Sheath; Receptors, Immunologic; Remyelination | 2017 |
rHIgM22 enhances remyelination in the brain of the cuprizone mouse model of demyelination.
Topics: Analysis of Variance; Animals; Cell Differentiation; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Immunoglobulin M; Male; Mice; Mice, Inbred C57BL; Monoamine Oxidase Inhibitors; Myelin Basic Protein; Myelin Sheath; Oligodendrocyte Transcription Factor 2; Oligodendroglia; Optic Nerve; Receptor, Platelet-Derived Growth Factor alpha; Remyelination; Time Factors | 2017 |
Acid sphingomyelinase deficiency enhances myelin repair after acute and chronic demyelination.
Topics: Amitriptyline; Amyloid Precursor Protein Secretases; Animals; Astrocytes; Axons; Cell Count; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Enzyme Inhibitors; Gene Expression Regulation; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia; Multiple Sclerosis; Nerve Regeneration; Oligodendroglia; Recovery of Function; Sphingomyelin Phosphodiesterase; Synaptophysin | 2017 |
Probenecid-treatment reduces demyelination induced by cuprizone feeding.
Topics: Animals; Cuprizone; Demyelinating Diseases; Diet; Disease Models, Animal; Leukocytes; Lymphocytes; Mice; Optic Nerve; Probenecid | 2017 |
Mice lacking Gpr37 exhibit decreased expression of the myelin-associated glycoprotein MAG and increased susceptibility to demyelination.
Topics: Animals; Antigens; Cell Line, Transformed; Chromatin Immunoprecipitation; Corpus Callosum; Cuprizone; Demyelinating Diseases; Gene Expression Regulation; Humans; Mice; Mice, Inbred C57BL; Mice, Knockout; Monoamine Oxidase Inhibitors; Myelin-Associated Glycoprotein; Oligodendroglia; Proteoglycans; Receptors, G-Protein-Coupled; RNA, Messenger; Time Factors; Transfection | 2017 |
Protective and therapeutic role of 2-carba-cyclic phosphatidic acid in demyelinating disease.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Cell Differentiation; Cell Line, Transformed; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Female; Gene Expression Regulation; Humans; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Monoamine Oxidase Inhibitors; Myelin Sheath; NLR Family, Pyrin Domain-Containing 3 Protein; p38 Mitogen-Activated Protein Kinases; Phosphatidic Acids; Proto-Oncogene Proteins c-bcl-2 | 2017 |
Reduced cuprizone-induced cerebellar demyelination in mice with astrocyte-targeted production of IL-6 is associated with chronically activated, but less responsive microglia.
Topics: Animals; Astrocytes; Calcium-Binding Proteins; Cerebellum; Cuprizone; Cytokines; Demyelinating Diseases; Disease Models, Animal; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Interleukin-6; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microfilament Proteins; Microglia; Myelin Basic Protein; Time Factors | 2017 |
A novel flavanone derivative ameliorates cuprizone-induced behavioral changes and white matter pathology in the brain of mice.
Topics: Animals; Brain; Chelating Agents; Corpus Callosum; Cuprizone; Demyelinating Diseases; Flavanones; Locomotion; Male; Mice; Mice, Inbred C57BL; Myelin Sheath; Neurogenesis; Oligodendroglia; Random Allocation; White Matter | 2017 |
Inflammatory demyelination alters subcortical visual circuits.
Topics: Animals; Chelating Agents; Corpus Callosum; Cuprizone; Demyelinating Diseases; Geniculate Bodies; Male; Mice; Mice, Inbred C57BL; Visual Pathways | 2017 |
Peripherally derived FGF21 promotes remyelination in the central nervous system.
Topics: Animals; Blood-Brain Barrier; Cell Differentiation; Cell Proliferation; Central Nervous System; Cuprizone; Demyelinating Diseases; Female; Fibroblast Growth Factors; Humans; Kinetics; Klotho Proteins; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Multiple Sclerosis; Myelin Sheath; Nerve Regeneration; Oligodendroglia; Permeability; Regenerative Medicine; Stem Cells | 2017 |
Expression of Unconventional Myosin VI in Oligodendrocytes.
Topics: Animals; Cell Differentiation; Cell Lineage; Central Nervous System; Cuprizone; Demyelinating Diseases; Female; Mice, Inbred C57BL; Myelin Basic Protein; Myelin Sheath; Neurogenesis; Neurons; Oligodendroglia | 2017 |
GD1a Overcomes Inhibition of Myelination by Fibronectin via Activation of Protein Kinase A: Implications for Multiple Sclerosis.
Topics: Animals; Axons; Cells, Cultured; Cuprizone; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Demyelinating Diseases; Enzyme Activation; Fibronectins; Gangliosides; Male; Mice; Multiple Sclerosis; Myelin Sheath; Neural Stem Cells; Oligodendroglia; Rats; Signal Transduction | 2017 |
The flavonoid Baicalein attenuates cuprizone-induced demyelination via suppression of neuroinflammation.
Topics: Animals; Astrocytes; Cuprizone; Cytokines; Demyelinating Diseases; Disease Models, Animal; Flavanones; Flavonoids; Male; Mice; Mice, Inbred C57BL; Microglia; Multiple Sclerosis; Myelin Sheath; Neuroimmunomodulation; Oligodendroglia; Tumor Necrosis Factor-alpha | 2017 |
Targeting demyelination via α-secretases promoting sAPPα release to enhance remyelination in central nervous system.
Topics: Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Axons; Brain; Cells, Cultured; Cerebellum; Corpus Callosum; Cuprizone; Demyelinating Diseases; Etazolate; Lysophosphatidylcholines; Male; Mice, Inbred C57BL; Myelin Sheath; Neuroprotective Agents; Remyelination | 2018 |
Loss of Gas6 and Axl signaling results in extensive axonal damage, motor deficits, prolonged neuroinflammation, and less remyelination following cuprizone exposure.
Topics: Animals; Axl Receptor Tyrosine Kinase; Axons; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Encephalitis; Gene Expression Regulation; Intercellular Signaling Peptides and Proteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Monoamine Oxidase Inhibitors; Movement Disorders; Myelin Sheath; Nerve Tissue Proteins; Proprioception; Proto-Oncogene Proteins; Psychomotor Performance; Receptor Protein-Tyrosine Kinases; Reflex, Righting; Remyelination; Signal Transduction | 2017 |
Yokukansan Reduces Cuprizone-Induced Demyelination in the Corpus Callosum Through Anti-inflammatory Effects on Microglia.
Topics: Animals; Anti-Inflammatory Agents; Astrocytes; Corpus Callosum; Cuprizone; Cytokines; Demyelinating Diseases; Disease Models, Animal; Drugs, Chinese Herbal; Female; Inflammation; Mice, Inbred C57BL; Microglia; Multiple Sclerosis; Oligodendroglia | 2017 |
Lineage tracing reveals dynamic changes in oligodendrocyte precursor cells following cuprizone-induced demyelination.
Topics: Age Factors; Animals; Autophagy-Related Proteins; Bacterial Proteins; Cell Differentiation; Cell Lineage; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Hippocampus; Intracellular Signaling Peptides and Proteins; Luminescent Proteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Monoamine Oxidase Inhibitors; Oligodendrocyte Precursor Cells; Receptor, Platelet-Derived Growth Factor alpha; Remyelination; RNA, Untranslated | 2017 |
Effects of green tea epigallocatechin-3-gallate on the proteolipid protein and oligodendrocyte transcription factor 1 messenger RNA gene expression in a mouse model of multiple sclerosis.
Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Brain; Catechin; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mice, Inbred C57BL; Multiple Sclerosis; Oligodendroglia; RNA, Messenger; Tea | 2017 |
Unconventional Myosin ID is Involved in Remyelination After Cuprizone-Induced Demyelination.
Topics: Animals; Astrocytes; Axons; Cell Differentiation; Corpus Callosum; Cuprizone; Demyelinating Diseases; Mice, Inbred C57BL; Microglia; Myelin Sheath; Oligodendroglia; Remyelination | 2018 |
Quantitative temporal changes in DTI values coupled with histological properties in cuprizone-induced demyelination and remyelination.
Topics: Animals; Astrocytes; Brain; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Male; Mice, Inbred C57BL; Microglia; Myelin Sheath; Oligodendroglia; Remyelination; White Matter | 2018 |
Prednisone alleviates demyelination through regulation of the NLRP3 inflammasome in a C57BL/6 mouse model of cuprizone-induced demyelination.
Topics: Animals; Astrocytes; Corpus Callosum; Cuprizone; Cytokines; Demyelinating Diseases; Disease Models, Animal; Inflammasomes; Male; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Basic Protein; Myelin Sheath; NLR Family, Pyrin Domain-Containing 3 Protein; Oligodendroglia; Prednisone; Signal Transduction | 2018 |
Postnatal Sonic hedgehog (Shh) responsive cells give rise to oligodendrocyte lineage cells during myelination and in adulthood contribute to remyelination.
Topics: Alkaline Phosphatase; Animals; Cell Lineage; Cell Membrane; Cell Proliferation; Chelating Agents; Corpus Callosum; Cuprizone; Demyelinating Diseases; Female; Hedgehog Proteins; Male; Mice; Myelin Sheath; Neural Stem Cells; Oligodendroglia; Zinc Finger Protein GLI1 | 2018 |
Humanin affects object recognition and gliosis in short-term cuprizone-treated mice.
Topics: Animals; Brain; Cuprizone; Demyelinating Diseases; Gliosis; Intracellular Signaling Peptides and Proteins; Male; Maze Learning; Memory, Short-Term; Mice; Microglia; Recognition, Psychology | 2017 |
The function of contactin-2/TAG-1 in oligodendrocytes in health and demyelinating pathology.
Topics: Animals; Axons; Brain; Calcium Channels; Cells, Cultured; Contactin 2; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Gene Expression Regulation; Male; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Neural Conduction; Neural Stem Cells; Oligodendroglia; Tissue Culture Techniques | 2018 |
Functional antagonism of sphingosine-1-phosphate receptor 1 prevents cuprizone-induced demyelination.
Topics: Animals; Apoptosis; Brain; Chimera; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Fingolimod Hydrochloride; Gene Expression; Gliosis; Indans; Inflammation; Male; Mice, Inbred C57BL; Mice, Transgenic; Neuroglia; Neuroprotective Agents; Oxadiazoles; Receptors, Lysosphingolipid; Sphingosine-1-Phosphate Receptors; White Matter | 2018 |
Blood-brain barrier hyperpermeability precedes demyelination in the cuprizone model.
Topics: Animals; Aquaporin 4; Blood-Brain Barrier; Brain; Cells, Cultured; Cuprizone; Cytokines; Demyelinating Diseases; Disease Models, Animal; Endothelial Cells; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Monoamine Oxidase Inhibitors; Occludin; Oligodendrocyte Transcription Factor 2; Platelet Endothelial Cell Adhesion Molecule-1; Rats; Receptors, CXCR3; Time Factors | 2017 |
MMP9 Gene Expression Variation by Ingesting Tart Cherry and P-Coumaric Acid During Remyelination in the Cuprizone Mouse Model.
Topics: Animals; Brain; Coumaric Acids; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Female; Male; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Myelin Sheath; Propionates; Remyelination | 2017 |
Toll-Like Receptor 2-Mediated Glial Cell Activation in a Mouse Model of Cuprizone-Induced Demyelination.
Topics: Animals; Astrocytes; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Hippocampus; Lymphocyte Count; Lymphocytes; Mice, Inbred C57BL; Microglia; Neuroglia; Oligodendroglia; RNA, Messenger; Toll-Like Receptor 2 | 2018 |
Quantitative analysis of lipid debris accumulation caused by cuprizone induced myelin degradation in different CNS areas.
Topics: Aged; Animals; Axons; Brain; Brain Neoplasms; Cuprizone; Demyelinating Diseases; Female; Humans; Lipid Droplets; Lipid Metabolism; Male; Mice, Inbred C57BL; Myelin Sheath; Tissue Culture Techniques | 2018 |
Vitamin C promotes oligodendrocytes generation and remyelination.
Topics: Animals; Antioxidants; Ascorbic Acid; Brain; Cell Differentiation; Coculture Techniques; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Ganglia, Spinal; Mice; Mice, Inbred C57BL; Neurons; Neuroprotective Agents; Oligodendroglia; Remyelination; Time Factors | 2018 |
Differential local tissue permissiveness influences the final fate of GPR17-expressing oligodendrocyte precursors in two distinct models of demyelination.
Topics: Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Female; Green Fluorescent Proteins; Male; Mice, Inbred C57BL; Mice, Transgenic; Myelin-Oligodendrocyte Glycoprotein; Nerve Tissue Proteins; Oligodendrocyte Precursor Cells; Peptide Fragments; Receptors, G-Protein-Coupled; Remyelination; Spinal Cord | 2018 |
Brain region-specific enhancement of remyelination and prevention of demyelination by the CSF1R kinase inhibitor BLZ945.
Topics: Animals; Axons; Benzothiazoles; Brain; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Female; Longitudinal Studies; Magnetic Resonance Imaging; Membrane Glycoproteins; Mice, Inbred C57BL; Mice, Knockout; Microglia; Neuroprotective Agents; Picolinic Acids; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; Receptors, Immunologic; Remyelination; Spinal Cord | 2018 |
AATYK is a Novel Regulator of Oligodendrocyte Differentiation and Myelination.
Topics: Animals; Animals, Newborn; Apoptosis Regulatory Proteins; Cell Differentiation; Cell Proliferation; Cells, Cultured; Cuprizone; Demyelinating Diseases; Embryo, Mammalian; Gene Expression Regulation, Developmental; Ki-67 Antigen; Mice; Mice, Inbred C57BL; Myelin Basic Protein; Myelin Proteolipid Protein; Myelin Sheath; Oligodendroglia; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; RNA, Small Interfering | 2018 |
Phosphatidylcholine 36:1 concentration decreases along with demyelination in the cuprizone animal model and in post-mortem multiple sclerosis brain tissue.
Topics: Adult; Aged; Aged, 80 and over; Animals; Brain; Chelating Agents; Corpus Callosum; Cuprizone; Demyelinating Diseases; Female; Humans; Lipid Metabolism; Male; Mice; Mice, Inbred C57BL; Middle Aged; Multiple Sclerosis; Myelin Sheath; Oleic Acid; Phosphatidylcholines; Postmortem Changes | 2018 |
Experimental Demyelination and Axonal Loss Are Reduced in MicroRNA-146a Deficient Mice.
Topics: Animals; Axons; Cell Differentiation; Chemokine CCL2; Corpus Callosum; Cuprizone; Demyelinating Diseases; Female; Gene Expression Profiling; Humans; Mice; Mice, Inbred C57BL; Mice, Knockout; MicroRNAs; Models, Animal; Oligodendroglia; Receptors, Tumor Necrosis Factor | 2018 |
Microglial MHC class II is dispensable for experimental autoimmune encephalomyelitis and cuprizone-induced demyelination.
Topics: Animals; Antigen Presentation; Cell Proliferation; Central Nervous System; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Histocompatibility Antigens Class II; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia; Multiple Sclerosis | 2018 |
Biochemically altered myelin triggers autoimmune demyelination.
Topics: Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Encephalitis; Hashimoto Disease; Humans; Hydrolases; Inflammation; Male; Mice; Mice, Inbred C57BL; Monoamine Oxidase Inhibitors; Multiple Sclerosis; Myelin Sheath | 2018 |
Behavioural alterations and morphological changes are attenuated by the lack of TRPA1 receptors in the cuprizone-induced demyelination model in mice.
Topics: Animals; Behavior, Animal; Brain; Chelating Agents; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; TRPA1 Cation Channel | 2018 |
Conditional depletion of GSK3b protects oligodendrocytes from apoptosis and lessens demyelination in the acute cuprizone model.
Topics: Animals; Apoptosis; Astrocytes; Caspases; Cell Nucleus; Cell Proliferation; Cell Survival; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Female; Glycogen Synthase Kinase 3 beta; Male; Mice, Inbred C57BL; Mice, Transgenic; Microglia; Myelin Sheath; Oligodendroglia | 2018 |
The antibody rHIgM22 facilitates hippocampal remyelination and ameliorates memory deficits in the cuprizone mouse model of demyelination.
Topics: Animals; Antibodies; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Hippocampus; Male; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Sheath; Oligodendroglia; Remyelination | 2018 |
Neuroprotective effect of linagliptin against cuprizone-induced demyelination and behavioural dysfunction in mice: A pivotal role of AMPK/SIRT1 and JAK2/STAT3/NF-κB signalling pathway modulation.
Topics: AMP-Activated Protein Kinases; Animals; Behavior, Animal; Brain; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Janus Kinase 2; Linagliptin; Male; Mice, Inbred C57BL; Motor Activity; Myelin Sheath; Neuroprotective Agents; NF-kappa B; Oxidative Stress; Remyelination; Signal Transduction; Sirtuin 1; STAT3 Transcription Factor | 2018 |
G-Protein-Coupled Receptor Gpr17 Expression in Two Multiple Sclerosis Remyelination Models.
Topics: Animals; Cerebral Cortex; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Gray Matter; Male; Mice; Multiple Sclerosis; Myelin Sheath; Nerve Tissue Proteins; Receptors, G-Protein-Coupled; Remyelination; White Matter | 2019 |
Sulfasalazine alters microglia phenotype by competing endogenous RNA effect of miR-136-5p and long non-coding RNA HOTAIR in cuprizone-induced demyelination.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Survival; Cells, Cultured; Chelating Agents; Cuprizone; Demyelinating Diseases; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred C57BL; Microglia; MicroRNAs; Phenotype; RNA, Long Noncoding; Sulfasalazine | 2018 |
Effects of vitamin D on axonal damage during de- and remyelination in the cuprizone model.
Topics: Animals; Axons; Chelating Agents; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Female; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Random Allocation; Remyelination; Vitamin D | 2018 |
Targeting TrkB with a Brain-Derived Neurotrophic Factor Mimetic Promotes Myelin Repair in the Brain.
Topics: Animals; Brain; Brain-Derived Neurotrophic Factor; Cell Division; Corpus Callosum; Cuprizone; Demyelinating Diseases; Female; Infusion Pumps, Implantable; Infusions, Intraventricular; Male; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Molecular Targeted Therapy; Myelin Basic Protein; Myelin Sheath; Neural Stem Cells; Oligodendroglia; Peptides, Cyclic; Phosphorylation; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Remyelination; Specific Pathogen-Free Organisms | 2018 |
Expression Profiles of Metallothionein I/II and Megalin in Cuprizone Model of De- and Remyelination.
Topics: Animals; Brain; Cerebral Cortex; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Female; Gene Expression Profiling; Gene Expression Regulation; Low Density Lipoprotein Receptor-Related Protein-2; Metallothionein; Mice, Inbred C57BL; Neural Stem Cells; Neuroglia; Neurons; Remyelination | 2018 |
Impairment of frequency-specific responses associated with altered electrical activity patterns in auditory thalamus following focal and general demyelination.
Topics: Acoustic Stimulation; Action Potentials; Animals; Auditory Cortex; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Female; Functional Laterality; Geniculate Bodies; Gliosis; Gray Matter; Lysophosphatidylcholines; Mice; Mice, Inbred C57BL; Monoamine Oxidase Inhibitors; Myelin Proteolipid Protein; Neurons; Psychoacoustics; Thalamus | 2018 |
Adenosine Promotes the Recovery of Mice from the Cuprizone-Induced Behavioral and Morphological Changes while Effecting on Microglia and Inflammatory Cytokines in the Brain.
Topics: Adenosine; Animals; Behavior, Animal; Brain Chemistry; Cerebral Cortex; Chelating Agents; Cuprizone; Cytokines; Demyelinating Diseases; Dose-Response Relationship, Drug; Gliosis; Hippocampus; Male; Mice; Mice, Inbred C57BL; Microglia; Multiple Sclerosis; Oligodendroglia; Psychomotor Performance; Schizophrenia | 2018 |
Orthologous proteins of experimental de- and remyelination are differentially regulated in the CSF proteome of multiple sclerosis subtypes.
Topics: Animals; Axl Receptor Tyrosine Kinase; Axons; Cerebrospinal Fluid Proteins; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Gene Expression Regulation; Humans; Mice; Multiple Sclerosis; Myelin Sheath; Proteome; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; Remyelination; Tissue Inhibitor of Metalloproteinase-1 | 2018 |
Microglia polarization by methylprednizolone acetate accelerates cuprizone induced demyelination.
Topics: Animals; Chemokine CXCL10; Cuprizone; Demyelinating Diseases; Inflammation; Methylprednisolone; Mice; Microglia; Multiple Sclerosis | 2018 |
N-Phenylquinazolin-2-amine Yhhu4952 as a novel promotor for oligodendrocyte differentiation and myelination.
Topics: Animals; Cell Differentiation; Cells, Cultured; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Dose-Response Relationship, Drug; Myelin Basic Protein; Myelin Sheath; Oligodendroglia; Quinazolines; Rats; Remyelination; Signal Transduction; Time Factors | 2018 |
Visualization of the Breakdown of the Axonal Transport Machinery: a Comparative Ultrastructural and Immunohistochemical Approach.
Topics: Animals; Axonal Transport; Axons; Biomarkers; Cuprizone; Demyelinating Diseases; Humans; Immunohistochemistry; Mice, Inbred C57BL; Mice, Transgenic; Mitochondrial Proteins; Multiple Sclerosis; Myelin Sheath; Nerve Tissue Proteins; Neuroglia; Spheroids, Cellular | 2019 |
Protective and therapeutic role of Bilobalide in cuprizone-induced demyelination.
Topics: Animals; Autoantibodies; Behavior, Animal; Corpus Callosum; Cuprizone; Cyclopentanes; Cytokines; Demyelinating Diseases; Disease Models, Animal; Furans; Ginkgolides; Humans; Immunity, Humoral; Inflammation; Inflammation Mediators; Male; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin-Oligodendrocyte Glycoprotein; Neuroprotective Agents; Oligodendroglia | 2019 |
Microglial modulation through colony-stimulating factor-1 receptor inhibition attenuates demyelination.
Topics: Amyloid beta-Peptides; Animals; Benzothiazoles; Brain; Bromodeoxyuridine; Cuprizone; Cytokines; Demyelinating Diseases; Disease Models, Animal; Male; Mice; Mice, Inbred C57BL; Microglia; Microscopy, Electron, Transmission; Myelin Basic Protein; Nerve Tissue Proteins; Nitric Oxide Synthase Type II; Picolinic Acids; Receptors, Colony-Stimulating Factor; Time Factors | 2019 |
Defining Changes in the Spatial Distribution and Composition of Brain Lipids in the Shiverer and Cuprizone Mouse Models of Myelin Disease.
Topics: Animals; Ceramides; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Immunohistochemistry; Lipid Metabolism; Male; Mice; Mice, Transgenic; Myelin Sheath; Phosphatidylcholines; Spectrometry, Mass, Electrospray Ionization; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Sulfoglycosphingolipids; White Matter | 2019 |
Amyloid precursor protein and amyloid precursor-like protein 2 have distinct roles in modulating myelination, demyelination, and remyelination of axons.
Topics: Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Axons; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Male; Mice; Mice, Knockout; Myelin Sheath; Oligodendroglia; Optic Nerve; Remyelination | 2019 |
Cuprizone-induced graded oligodendrocyte vulnerability is regulated by the transcription factor DNA damage-inducible transcript 3.
Topics: Animals; Animals, Newborn; Astrocytes; Calcium-Binding Proteins; Cells, Cultured; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Endoplasmic Reticulum Stress; Gene Expression Regulation; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microfilament Proteins; Microscopy, Electron, Scanning; Monoamine Oxidase Inhibitors; Nerve Tissue Proteins; Oligodendroglia; Transcription Factor CHOP | 2019 |
Psychological stress effects on myelin degradation in the cuprizone-induced model of demyelination.
Topics: Animals; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Female; Myelin Sheath; Rats, Wistar; Stress, Psychological | 2019 |
The protective effect of rifampicin on behavioral deficits, biochemical, and neuropathological changes in a cuprizone model of demyelination.
Topics: Animals; Behavior, Animal; Corpus Callosum; Cuprizone; Demyelinating Diseases; Male; Mice; Rifampin | 2019 |
Mitochondrial Impairment in Oligodendroglial Cells Induces Cytokine Expression and Signaling.
Topics: Animals; Cell Line; Cuprizone; Demyelinating Diseases; Interleukin-6; Mice; Mice, Inbred C57BL; Microglia; Mitochondria; Oligodendroglia; Rats; Signal Transduction; Sodium Azide | 2019 |
Arecoline attenuates memory impairment and demyelination in a cuprizone-induced mouse model of schizophrenia.
Topics: Animals; Arecoline; Chelating Agents; Cholinergic Agonists; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Maze Learning; Memory Disorders; Mice; Mice, Inbred C57BL; Schizophrenia | 2019 |
Repurposing of omeprazole for oligodendrocyte differentiation and remyelination.
Topics: Animals; Axons; Cell Differentiation; Cuprizone; Demyelinating Diseases; Drug Repositioning; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Myelin Sheath; Neurogenesis; Oligodendroglia; Omeprazole; p38 Mitogen-Activated Protein Kinases; Primary Cell Culture; Rats; Remyelination | 2019 |
Evaluation strategy to determine reliable demyelination in the cuprizone model.
Topics: Animals; Brain; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Male; Mice, Inbred C57BL; Myelin Basic Protein; Myelin Sheath; Oligodendroglia | 2019 |
The K
Topics: Anesthetics, Local; Animals; Animals, Newborn; Bupivacaine; Cell Differentiation; Cell Movement; Cells, Cultured; Cuprizone; Demyelinating Diseases; Gene Expression Regulation; Humans; Mice; Mice, Inbred C57BL; Mice, Transgenic; Monoamine Oxidase Inhibitors; Myelin Proteins; Nerve Tissue Proteins; Oligodendrocyte Precursor Cells; Oligodendroglia; Potassium Channels, Tandem Pore Domain; Receptor, Platelet-Derived Growth Factor alpha; Transcription Factors | 2019 |
Effect of the CSF1R inhibitor PLX3397 on remyelination of corpus callosum in a cuprizone-induced demyelination mouse model.
Topics: Aminopyridines; Animals; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Gene Expression Regulation; Indoles; Macrophage Colony-Stimulating Factor; Male; Mice, Inbred C57BL; Microglia; Microscopy, Electron, Transmission; Multiple Sclerosis; Myelin Sheath; Pyrroles; Real-Time Polymerase Chain Reaction; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; Rotarod Performance Test | 2019 |
In vivo conversion of astrocytes to oligodendrocyte lineage cells in adult mice demyelinated brains by Sox2.
Topics: Animals; Astrocytes; Brain; Cell Differentiation; Cell Lineage; Cells, Cultured; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Genetic Vectors; Lentivirus; Male; Mice, Inbred C57BL; Neural Stem Cells; Oligodendroglia; Regeneration; SOXB1 Transcription Factors | 2019 |
Astrocyte ablation induced by La-aminoadipate (L-AAA) potentiates remyelination in a cuprizone demyelinating mouse model.
Topics: Animals; Astrocytes; Brain; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Male; Mice, Inbred C57BL; Microglia; Oligodendroglia; Remyelination | 2019 |
Hydroxyfasudil alleviates demyelination through the inhibition of MOG antibody and microglia activation in cuprizone mouse model.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Behavior, Animal; Brain; CD4-Positive T-Lymphocytes; Cuprizone; Cytokines; Demyelinating Diseases; Disease Models, Animal; Macrophages; Male; Mice, Inbred C57BL; Motor Activity; Spleen | 2019 |
The PTN-PTPRZ signal activates the AFAP1L2-dependent PI3K-AKT pathway for oligodendrocyte differentiation: Targeted inactivation of PTPRZ activity in mice.
Topics: Adaptor Proteins, Signal Transducing; Animals; Carrier Proteins; Cell Differentiation; Cuprizone; Cytokines; Demyelinating Diseases; Disease Models, Animal; HEK293 Cells; Humans; Immunoprecipitation; In Situ Nick-End Labeling; Luminescent Proteins; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microfilament Proteins; Myelin Proteins; Oligodendroglia; Proto-Oncogene Proteins c-akt; Receptor-Like Protein Tyrosine Phosphatases, Class 5; Red Fluorescent Protein; RNA, Small Interfering; Signal Detection, Psychological; Signal Transduction; Transfection; X-Ray Microtomography | 2019 |
Expression of Translocator Protein and [18F]-GE180 Ligand Uptake in Multiple Sclerosis Animal Models.
Topics: Animals; Astrocytes; Axons; Biomarkers; Carbazoles; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Inflammation; Ligands; Mice, Inbred C57BL; Mitochondria; Monocytes; Multiple Sclerosis; Neuroglia; Receptors, GABA; RNA, Messenger | 2019 |
Acute and chronic demyelinated CNS lesions exhibit opposite elastic properties.
Topics: Acute Disease; Animals; Biomechanical Phenomena; Central Nervous System Diseases; Chronic Disease; Corpus Callosum; Cuprizone; Demyelinating Diseases; Elasticity; Extracellular Matrix; Female; Humans; Mice; Middle Aged; Models, Biological; Multiple Sclerosis | 2019 |
Long lasting behavioural effects on cuprizone fed mice after neurotoxicant withdrawal.
Topics: Animals; Behavior, Animal; Brain; Central Nervous System; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Grooming; Male; Mice; Mice, Inbred C57BL; Motor Skills; Myelin Sheath; Oligodendroglia | 2019 |
Functional Effects of Cuprizone-Induced Demyelination in the Presence of the mTOR-Inhibitor Rapamycin.
Topics: Animals; Axons; Cell Differentiation; Corpus Callosum; Cuprizone; Demyelinating Diseases; Male; Mice, Inbred C57BL; Myelin Sheath; Oligodendroglia; Sirolimus; TOR Serine-Threonine Kinases | 2019 |
Transferrin Enhances Microglial Phagocytic Capacity.
Topics: Animals; Animals, Newborn; Astrocytes; Cell Proliferation; Cell Survival; Cells, Cultured; Cuprizone; Demyelinating Diseases; Humans; Microglia; Oligodendroglia; Phagocytosis; Rats, Wistar; Receptors, Transferrin; Transferrin | 2019 |
Glial fibrillary acidic protein expression alters astrocytic chemokine release and protects mice from cuprizone-induced demyelination.
Topics: Adolescent; Animals; Animals, Newborn; Astrocytes; Cells, Cultured; Chelating Agents; Chemokines; Cuprizone; Demyelinating Diseases; Female; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Humans; Mice; Mice, Transgenic | 2019 |
Therapeutic effect of oligomeric proanthocyanidin in cuprizone-induced demyelination.
Topics: Animals; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mice; Oligodendroglia; Proanthocyanidins; Treatment Outcome | 2019 |
Inhibition of MAPK/ERK pathway promotes oligodendrocytes generation and recovery of demyelinating diseases.
Topics: Animals; Cells, Cultured; Cerebral Cortex; Coculture Techniques; Cuprizone; Demyelinating Diseases; Encephalomyelitis, Autoimmune, Experimental; Enzyme Inhibitors; Female; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Oligodendroglia; Recovery of Function; Remyelination | 2019 |
Toxin-Based Models to Investigate Demyelination and Remyelination.
Topics: Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Ethidium; Lysophosphatidylcholines; Mice; Mice, Inbred C57BL; Rats; Remyelination | 2019 |
Plant polyprenols reduce demyelination and recover impaired oligodendrogenesis and neurogenesis in the cuprizone murine model of multiple sclerosis.
Topics: Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Hippocampus; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Neurogenesis; Phosphotransferases (Alcohol Group Acceptor); Plants | 2019 |
Donepezil, a drug for Alzheimer's disease, promotes oligodendrocyte generation and remyelination.
Topics: Animals; Cell Differentiation; Corpus Callosum; Cuprizone; Demyelinating Diseases; Donepezil; Drug Repositioning; Female; Ganglia, Spinal; Mice, Inbred C57BL; Oligodendrocyte Precursor Cells; Oligodendroglia; Remyelination | 2019 |
Animal Weight Is an Important Variable for Reliable Cuprizone-Induced Demyelination.
Topics: Animals; Body Weight; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Female; Male; Mice; Mice, Inbred C57BL; Reproducibility of Results | 2019 |
Impaired Remyelination in a Mouse Model of Huntington Disease.
Topics: Animals; Axons; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Humans; Huntington Disease; Male; Mice, Transgenic; Neuroglia; Remyelination | 2019 |
Pathological changes in mice with long term cuprizone administration.
Topics: Animals; Brain; Chelating Agents; Cuprizone; Demyelinating Diseases; Drug Administration Schedule; Female; Mice; Mice, Inbred C57BL; Time Factors | 2019 |
Mesenchymal stem cell mediated effects on microglial phenotype in cuprizone-induced demyelination model.
Topics: Animals; Chemokine CX3CL1; Corpus Callosum; Cuprizone; CX3C Chemokine Receptor 1; Demyelinating Diseases; Disease Models, Animal; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mice, Inbred C57BL; Microglia; Phenotype; Remyelination; Signal Transduction | 2019 |
Probing demyelination and remyelination of the cuprizone mouse model using multimodality MRI.
Topics: Animals; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Imaging, Three-Dimensional; Mice; Multiparametric Magnetic Resonance Imaging; Prospective Studies; Remyelination; Sensitivity and Specificity; White Matter | 2019 |
Oligoprotective effect of metformin through the AMPK-dependent on restoration of mitochondrial hemostasis in the cuprizone-induced multiple sclerosis model.
Topics: AMP-Activated Protein Kinase Kinases; Animals; Axons; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Hemostasis; Humans; Metformin; Mice; Mitochondria; Multiple Sclerosis; Oligodendroglia; Oxidative Stress; Protein Kinases; Signal Transduction | 2019 |
Effect of mesenchymal stem cells on glial cells population in cuprizone induced demyelination model.
Topics: Animals; Chemokine CX3CL1; Cuprizone; Cytokines; Demyelinating Diseases; Male; Mesenchymal Stem Cells; Mice; Neuroglia; Transforming Growth Factor beta | 2019 |
Clozapine administration enhanced functional recovery after cuprizone demyelination.
Topics: Animals; Astrocytes; Central Nervous System; Clozapine; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Sheath | 2019 |
Structural adaption of axons during de- and remyelination in the Cuprizone mouse model.
Topics: Animals; Axons; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mice; Mice, Inbred C57BL; Mice, Transgenic; Multiple Sclerosis; Myelin Sheath; NAV1.6 Voltage-Gated Sodium Channel; Neurons; Oligodendroglia; Ranvier's Nodes; Remyelination; Sodium Channels | 2019 |
Neural Stem Cells of the Subventricular Zone Contribute to Neuroprotection of the Corpus Callosum after Cuprizone-Induced Demyelination.
Topics: Animals; Cell Movement; Corpus Callosum; Cuprizone; Demyelinating Diseases; Female; Lateral Ventricles; Mice; Mice, Inbred C57BL; Myelin Sheath; Neural Stem Cells; Oligodendroglia | 2019 |
Multiple functional therapeutic effects of DL-3-n-butylphthalide in the cuprizone model of demyelination.
Topics: Animals; Astrocytes; Axons; Benzofurans; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Gene Expression Regulation; Male; Mice; Mice, Inbred C57BL; Microglia; Multiple Sclerosis; Myelin Sheath; Neuroprotective Agents; NF-kappa B; Oligodendroglia; Signal Transduction | 2019 |
The effects of a combination of ion channel inhibitors on pathology in a model of demyelinating disease.
Topics: Animals; Calcium; Cations, Divalent; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Drug Therapy, Combination; Ion Channels; Male; Mice, Inbred C57BL; Neuroglia; Neuroprotective Agents; Oxidative Stress; Random Allocation | 2019 |
Correlations of quantitative MRI metrics with myelin basic protein (MBP) staining in a murine model of demyelination.
Topics: Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Fluorescence; Magnetic Resonance Imaging; Mice, Inbred C57BL; Myelin Basic Protein | 2019 |
Diffusion tensor imaging identifies aspects of therapeutic estrogen receptor β ligand-induced remyelination in a mouse model of multiple sclerosis.
Topics: Animals; Corpus Callosum; Cuprizone; Demyelinating Diseases; Diffusion Tensor Imaging; Disease Models, Animal; Estrogen Receptor beta; Female; Indazoles; Magnetic Resonance Imaging; Male; Mice; Multiple Sclerosis; Neuroprotective Agents; Remyelination | 2019 |
The Spatial and Temporal Characters of Demyelination and Remyelination in the Cuprizone Animal Model.
Topics: Animals; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Hippocampus; Mice; Mice, Inbred C57BL; Microglia; Monoamine Oxidase Inhibitors; Myelin Sheath; Remyelination; Spatio-Temporal Analysis | 2019 |
Cordycepin (3'-deoxyadenosine) promotes remyelination via suppression of neuroinflammation in a cuprizone-induced mouse model of demyelination.
Topics: Animals; Anti-Inflammatory Agents; Astrocytes; Corpus Callosum; Cuprizone; Cytokines; Demyelinating Diseases; Deoxyadenosines; Disease Models, Animal; Hippocampus; Male; Mice; Mice, Inbred C57BL; Neuroglia; Neuroprotective Agents; Remyelination | 2019 |
Cuprizone-induced demyelination in mice: age-related vulnerability and exploratory behavior deficit.
Topics: Age Factors; Analysis of Variance; Animals; Antigens, CD; Cell Adhesion Molecules; Chelating Agents; Cohort Studies; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Exploratory Behavior; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Mental Disorders; Mice; Mice, Inbred C57BL; Myelin Basic Protein; Oligodendroglia | 2013 |
Hippocampal demyelination and memory dysfunction are associated with increased levels of the neuronal microRNA miR-124 and reduced AMPA receptors.
Topics: Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Gene Expression Regulation; Hippocampus; Humans; Immunosuppressive Agents; Memory Disorders; Mice; MicroRNAs; Monoamine Oxidase Inhibitors; Multiple Sclerosis; Neurons; Postmortem Changes; Receptors, AMPA; RNA, Messenger; Sirolimus | 2013 |
Glatiramer promotes oligodendroglial cell maturation in a cuprizone-induced demyelination model.
Topics: Animals; Cells, Cultured; Cuprizone; Demyelinating Diseases; Glatiramer Acetate; Microscopy, Electron; Oligodendroglia; Peptides; Rats; Rats, Wistar | 2013 |
Minocycline reduces remyelination by suppressing ciliary neurotrophic factor expression after cuprizone-induced demyelination.
Topics: Animals; Anti-Bacterial Agents; Blotting, Western; Cells, Cultured; Ciliary Neurotrophic Factor; Corpus Callosum; Cuprizone; Demyelinating Diseases; Female; Immunohistochemistry; Mice; Mice, Inbred C57BL; Microglia; Minocycline; Monoamine Oxidase Inhibitors; Myelin Basic Protein; Myelin Sheath; Oligodendroglia; Real-Time Polymerase Chain Reaction | 2013 |
Investigation of sequential growth factor delivery during cuprizone challenge in mice aimed to enhance oligodendrogliogenesis and myelin repair.
Topics: Animals; Astrocytes; Bone Morphogenetic Protein 4; Carrier Proteins; Cell Differentiation; Corpus Callosum; Cuprizone; Demyelinating Diseases; Drug Evaluation, Preclinical; Drug Therapy, Combination; Insulin-Like Growth Factor I; Mice; Mice, Inbred C57BL; Myelin Sheath; Neural Stem Cells; Oligodendroglia | 2013 |
Stage-specific deletion of Olig2 conveys opposing functions on differentiation and maturation of oligodendrocytes.
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Animals, Newborn; Arabidopsis Proteins; Autophagy-Related Proteins; Basic Helix-Loop-Helix Transcription Factors; Bromodeoxyuridine; Cell Differentiation; Cuprizone; Demyelinating Diseases; Gene Expression Regulation, Developmental; Green Fluorescent Proteins; In Situ Nick-End Labeling; Intracellular Signaling Peptides and Proteins; Intramolecular Transferases; Male; Mice; Mice, Transgenic; Microscopy, Electron, Transmission; Monoamine Oxidase Inhibitors; Myelin Basic Protein; Myelin Proteolipid Protein; Nerve Tissue Proteins; Oligodendrocyte Transcription Factor 2; Oligodendroglia; ran GTP-Binding Protein; Transfection | 2013 |
FGF2 and FGFR1 signaling regulate functional recovery following cuprizone demyelination.
Topics: Animals; Behavior, Animal; Cuprizone; Demyelinating Diseases; Fibroblast Growth Factor 2; Interpersonal Relations; Mice; Mice, Transgenic; Nerve Fibers, Myelinated; Psychomotor Performance; Receptor, Fibroblast Growth Factor, Type 1; Recovery of Function; Signal Transduction | 2013 |
Regional regulation of glutamate signaling during cuprizone-induced demyelination in the brain.
Topics: Amino Acid Transport System X-AG; Animals; Blotting, Western; Brain; Cells, Cultured; Chelating Agents; Corpus Callosum; Cuprizone; Demyelinating Diseases; Fluorescent Antibody Technique; Glutamic Acid; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Protein Array Analysis; Real-Time Polymerase Chain Reaction; Receptors, Glutamate; Signal Transduction | 2013 |
Loss of branched O-mannosyl glycans in astrocytes accelerates remyelination.
Topics: Age Factors; Animals; Astrocytes; Brain; CD11b Antigen; Cells, Cultured; Clathrin Heavy Chains; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Embryo, Mammalian; Mice; Mice, Inbred C57BL; Mice, Transgenic; N-Acetylglucosaminyltransferases; Nerve Tissue Proteins; Neurons; Oligodendroglia; Polysaccharides; Receptor-Like Protein Tyrosine Phosphatases, Class 3 | 2013 |
Local overexpression of interleukin-11 in the central nervous system limits demyelination and enhances remyelination.
Topics: Animals; Cell Proliferation; Central Nervous System; Cuprizone; Demyelinating Diseases; Humans; Immunohistochemistry; Interleukin-11; Male; Mice; Mice, Inbred C57BL; Microglia; Microscopy, Electron, Transmission; Myelin Sheath | 2013 |
Alterations of juxtaparanodal domains in two rodent models of CNS demyelination.
Topics: Animals; Central Nervous System; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Male; Mice, Inbred C57BL; Nerve Fibers, Myelinated; Protein Structure, Tertiary | 2013 |
Distribution of oligodendrocyte loss and mitochondrial toxicity in the cuprizone-induced experimental demyelination model.
Topics: Animals; Cell Death; Chelating Agents; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Male; Mice; Mice, Inbred C57BL; Mitochondria; Oligodendroglia; Spinal Cord; Superoxide Dismutase | 2013 |
SOX17 is expressed in regenerating oligodendrocytes in experimental models of demyelination and in multiple sclerosis.
Topics: Aged; Animals; Antigens; Autophagy-Related Proteins; Basic Helix-Loop-Helix Transcription Factors; Brain; Bromodeoxyuridine; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Female; Humans; Intracellular Signaling Peptides and Proteins; Leukocyte Common Antigens; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Middle Aged; Monoamine Oxidase Inhibitors; Multiple Sclerosis; Myelin Basic Protein; Nerve Tissue Proteins; Oligodendrocyte Transcription Factor 2; Oligodendroglia; Proteoglycans; SOXF Transcription Factors; Time Factors; Up-Regulation | 2013 |
Puma, but not noxa is essential for oligodendroglial cell death.
Topics: Adult; Aged; Analysis of Variance; Animals; Animals, Newborn; Apoptosis Regulatory Proteins; Brain; Cell Death; Cells, Cultured; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Female; Flow Cytometry; Gene Expression Profiling; Gene Expression Regulation; Humans; In Situ Nick-End Labeling; Interferon-gamma; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Middle Aged; Multiple Sclerosis; Oligodendroglia; Peptide Fragments; Proto-Oncogene Proteins c-bcl-2; Tumor Suppressor Proteins | 2013 |
Effects of murine and human bone marrow-derived mesenchymal stem cells on cuprizone induced demyelination.
Topics: Animals; Bone Marrow Cells; Cell Count; Cell Tracking; Chemokines; Corpus Callosum; Cuprizone; Cytoprotection; Demyelinating Diseases; Feeding Behavior; Hepatocyte Growth Factor; Humans; Immunohistochemistry; Integrin alpha4; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mice; Mice, Inbred C57BL; Oligodendroglia; Organic Chemicals; RNA, Messenger | 2013 |
Multimodal imaging of subventricular zone neural stem/progenitor cells in the cuprizone mouse model reveals increased neurogenic potential for the olfactory bulb pathway, but no contribution to remyelination of the corpus callosum.
Topics: Animals; Cell Movement; Cell Tracking; Cerebral Ventricles; Corpus Callosum; Cuprizone; Demyelinating Diseases; Diffusion Magnetic Resonance Imaging; Female; Mice; Mice, Inbred C57BL; Microscopy, Fluorescence; Multimodal Imaging; Nerve Fibers, Myelinated; Neural Pathways; Neural Stem Cells; Neurogenesis; Olfactory Bulb | 2014 |
Quantitative MRI and ultrastructural examination of the cuprizone mouse model of demyelination.
Topics: Animals; Axons; Corpus Callosum; Cuprizone; Demyelinating Diseases; Diet; Disease Models, Animal; Female; Magnetic Resonance Imaging; Mice; Mice, Inbred C57BL; Myelin Sheath; Perfusion; Signal Processing, Computer-Assisted; Statistics, Nonparametric | 2013 |
Sildenafil (Viagra) protective effects on neuroinflammation: the role of iNOS/NO system in an inflammatory demyelination model.
Topics: Animals; Cuprizone; Cyclic GMP; Demyelinating Diseases; Glutathione S-Transferase pi; Inflammation; Mice; Mice, Knockout; Microscopy, Electron, Transmission; Microscopy, Fluorescence; Myelin Sheath; Neurons; Nitric Oxide; Nitric Oxide Synthase Type II; Phosphodiesterase 5 Inhibitors; Piperazines; Purines; Sildenafil Citrate; Sulfones | 2013 |
Mesenchymal stromal-cell transplants induce oligodendrocyte progenitor migration and remyelination in a chronic demyelination model.
Topics: Animals; Axons; Cell Differentiation; Cell Movement; Chronic Disease; Cuprizone; Demyelinating Diseases; Dentate Gyrus; Disease Models, Animal; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mice; Models, Biological; Myelin Sheath; Nerve Fibers; Nerve Growth Factors; Neural Conduction; Neurogenesis; Oligodendroglia; Stem Cell Niche | 2013 |
Enhanced accumulation of Kir4.1 protein, but not mRNA, in a murine model of cuprizone-induced demyelination.
Topics: Animals; Aquaporin 4; Autoantibodies; Brain; Cuprizone; Demyelinating Diseases; Female; Glial Fibrillary Acidic Protein; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Neuromyelitis Optica; Potassium Channels, Inwardly Rectifying; RNA, Messenger; Spinal Cord | 2013 |
Galectin-3 controls the response of microglial cells to limit cuprizone-induced demyelination.
Topics: Animals; Astrocytes; Corpus Callosum; Cuprizone; Demyelinating Diseases; Galectin 3; Locomotion; Male; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia; Nerve Fibers, Myelinated; Oligodendroglia; Phagocytosis | 2014 |
PET imaging of demyelination and remyelination in the cuprizone mouse model for multiple sclerosis: a comparison between [11C]CIC and [11C]MeDAS.
Topics: Animals; Carbon Radioisotopes; Chelating Agents; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Male; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Positron-Emission Tomography; Radiopharmaceuticals | 2014 |
Geissoschizine methyl ether, an alkaloid from the Uncaria hook, improves remyelination after cuprizone-induced demyelination in medial prefrontal cortex of adult mice.
Topics: Animals; Cuprizone; Demyelinating Diseases; Indole Alkaloids; Indoles; Mice; Myelin Basic Protein; Prefrontal Cortex; Regeneration | 2014 |
PERK activation preserves the viability and function of remyelinating oligodendrocytes in immune-mediated demyelinating diseases.
Topics: Animals; Axons; Cell Death; Cell Survival; Cuprizone; Cytoprotection; Demyelinating Diseases; eIF-2 Kinase; Encephalomyelitis, Autoimmune, Experimental; Enzyme Activation; Inflammation; Interferon-gamma; Mice; Mice, Inbred C57BL; Myelin Sheath; Oligodendroglia; Signal Transduction; Tacrolimus; Tremor | 2014 |
Deep gray matter demyelination detected by magnetization transfer ratio in the cuprizone model.
Topics: Animals; Brain; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Female; Magnetic Resonance Imaging; Mice; Mice, Inbred C57BL; Time Factors | 2013 |
Disruption of myelin leads to ectopic expression of K(V)1.1 channels with abnormal conductivity of optic nerve axons in a cuprizone-induced model of demyelination.
Topics: Action Potentials; Animals; Axons; Brain; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Immunoenzyme Techniques; Kv1.1 Potassium Channel; Kv1.2 Potassium Channel; Mice; Mice, Inbred C57BL; Monoamine Oxidase Inhibitors; Myelin Sheath; Optic Nerve | 2014 |
Olanzapine ameliorates neuropathological changes and increases IGF-1 expression in frontal cortex of C57BL/6 mice exposed to cuprizone.
Topics: Animals; Antipsychotic Agents; Astrocytes; Benzodiazepines; Cuprizone; Demyelinating Diseases; Female; Frontal Lobe; Insulin-Like Growth Factor I; Mice; Mice, Inbred C57BL; Microglia; Myelin Sheath; Olanzapine; Oligodendroglia; Schizophrenia; Stem Cells | 2014 |
Concurrent changes in ¹H MRS metabolites and antioxidant enzymes in the brain of C57BL/6 mouse short-termly exposed to cuprizone: possible implications for schizophrenia.
Topics: Animals; Antioxidants; Brain; Chelating Agents; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Hydrogen Peroxide; Male; Mice, Inbred C57BL; Oligodendroglia; Schizophrenia | 2014 |
Effect of high-dose 1.25 dihydroxyvitamin D3 on remyelination in the cuprizone model.
Topics: Animals; Brain; Calcitriol; Cuprizone; Demyelinating Diseases; Dietary Supplements; Dose-Response Relationship, Drug; Female; Gliosis; Mice; Mice, Inbred C57BL; Myelin Proteins; Myelin Sheath; Nogo Proteins; T-Lymphocytes | 2014 |
Gender influence on schizophrenia-relevant abnormalities in a cuprizone demyelination model.
Topics: Animals; Astrocytes; Brain; Cuprizone; Demyelinating Diseases; Diet; Disease Models, Animal; Dopamine; Female; Male; Microglia; Motor Activity; Rats, Wistar; Recognition, Psychology; Schizophrenia; Serotonin; Sex Characteristics; Social Behavior; Tyrosine 3-Monooxygenase | 2014 |
Histological correlation of diffusional kurtosis and white matter modeling metrics in cuprizone-induced corpus callosum demyelination.
Topics: Animals; Corpus Callosum; Cuprizone; Demyelinating Diseases; Diffusion; Diffusion Tensor Imaging; Male; Mice, Inbred C57BL; Statistics, Nonparametric; White Matter | 2014 |
Long-term impact of neonatal inflammation on demyelination and remyelination in the central nervous system.
Topics: Animals; Animals, Newborn; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Female; Inflammation; Lipopolysaccharides; Male; Mice, Inbred C57BL; Microglia; Myelin Sheath; Oligodendroglia; Pregnancy; Random Allocation; RNA, Messenger | 2014 |
Astrocyte-derived BDNF supports myelin protein synthesis after cuprizone-induced demyelination.
Topics: Animals; Astrocytes; Brain-Derived Neurotrophic Factor; Cuprizone; Demyelinating Diseases; Dioxolanes; Disease Models, Animal; Estrogen Antagonists; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Humans; Mice; Mice, Inbred C57BL; Mice, Transgenic; Myelin Proteins; Purines; Receptors, Metabotropic Glutamate; RNA, Untranslated; Signal Transduction; Tamoxifen | 2014 |
CXCR3 modulates glial accumulation and activation in cuprizone-induced demyelination of the central nervous system.
Topics: Analysis of Variance; Animals; Antigens, CD; Body Weight; Cuprizone; Cytokines; Demyelinating Diseases; Flow Cytometry; Gene Expression Regulation; Mice; Mice, Inbred C57BL; Mice, Transgenic; Monoamine Oxidase Inhibitors; Neuroglia; Receptors, CXCR3; RNA, Messenger | 2014 |
Cyclic phosphatidic acid treatment suppress cuprizone-induced demyelination and motor dysfunction in mice.
Topics: Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Heterocyclic Compounds, 1-Ring; Male; Mice; Mice, Inbred C57BL; Motor Activity; Motor Skills Disorders; Phosphatidic Acids; Treatment Outcome | 2014 |
Progesterone and nestorone promote myelin regeneration in chronic demyelinating lesions of corpus callosum and cerebral cortex.
Topics: Animals; Cerebral Cortex; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Female; Mice, Inbred C57BL; Mice, Knockout; Multiple Sclerosis; Myelin Basic Protein; Myelin Proteolipid Protein; Myelin Sheath; Oligodendroglia; Progesterone; Stem Cells | 2015 |
Protective Effect of a cAMP Analogue on Behavioral Deficits and Neuropathological Changes in Cuprizone Model of Demyelination.
Topics: Animals; Apoptosis; Behavior, Animal; Biomarkers; Bucladesine; Cuprizone; Cyclic AMP; Demyelinating Diseases; Disease Models, Animal; Dose-Response Relationship, Drug; Heme Oxygenase-1; Injections, Intraperitoneal; Interleukin-6; Male; Mice, Inbred C57BL; Movement; Myelin Sheath; Neurons; Neuroprotective Agents; NF-kappa B; Nociception | 2015 |
A pivotal role of nonmuscle myosin II during microglial activation.
Topics: Animals; Animals, Newborn; Brain; Cell Movement; Cells, Cultured; Chemokine CCL2; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Dose-Response Relationship, Drug; Heterocyclic Compounds, 4 or More Rings; Male; Mice, Inbred C57BL; Microglia; Monoamine Oxidase Inhibitors; Myosin Heavy Chains; Nonmuscle Myosin Type IIB; Phagocytosis; Rats; Rats, Sprague-Dawley | 2014 |
Dock3 protects myelin in the cuprizone model for demyelination.
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Carrier Proteins; Cells, Cultured; Chelating Agents; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Electroretinography; Extracellular Signal-Regulated MAP Kinases; Guanine Nucleotide Exchange Factors; Mice; Mice, Inbred C57BL; Mice, Transgenic; Myelin Basic Protein; Nerve Tissue Proteins; Oligodendroglia; Optic Nerve; Retina; Signal Transduction | 2014 |
The sphingosine 1-phosphate receptor agonist FTY720 is neuroprotective after cuprizone-induced CNS demyelination.
Topics: Amyloid beta-Protein Precursor; Animals; Corpus Callosum; Cuprizone; Demyelinating Diseases; Fingolimod Hydrochloride; Gene Expression Regulation; Liver; Male; Membrane Proteins; Mice, Inbred C57BL; Neuroprotective Agents; Phosphatidate Phosphatase; Phosphoric Monoester Hydrolases; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Receptors, Lysosphingolipid; Sphingosine | 2015 |
Prostaglandin F2α FP receptor inhibitor reduces demyelination and motor dysfunction in a cuprizone-induced multiple sclerosis mouse model.
Topics: Animals; Corpus Callosum; Cuprizone; Demyelinating Diseases; Dinoprost; Disease Models, Animal; Humans; Mice; Motor Activity; Multiple Sclerosis; Myelin Sheath; Oligodendroglia; Prostaglandin H2; Receptors, Prostaglandin; Tumor Necrosis Factor-alpha | 2014 |
Characterization of oligodendroglial populations in mouse demyelinating disease using flow cytometry: clues for MS pathogenesis.
Topics: Animals; Antibodies; Antigens; Cells, Cultured; Cuprizone; Demyelinating Diseases; Encephalomyelitis, Autoimmune, Experimental; Female; Flow Cytometry; Humans; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Oligodendroglia; Stem Cells | 2014 |
A new model of cuprizone-mediated demyelination/remyelination.
Topics: Analysis of Variance; Animals; Basic Helix-Loop-Helix Transcription Factors; Body Weight; Brain; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Immunosuppressive Agents; Ki-67 Antigen; Male; Mice; Mice, Inbred C57BL; Monoamine Oxidase Inhibitors; Myelin Sheath; Myelin-Oligodendrocyte Glycoprotein; Nerve Tissue Proteins; Oligodendrocyte Transcription Factor 2; Oligodendroglia; Receptor, Platelet-Derived Growth Factor alpha; Sirolimus | 2014 |
Pivotal role of choline metabolites in remyelination.
Topics: Animals; Cell Proliferation; Chelating Agents; Choline; Cuprizone; Cytidine Diphosphate Choline; Demyelinating Diseases; Mice; Mice, Inbred C57BL; Myelin Sheath; Neural Stem Cells; Neuroglia; Nootropic Agents; Oligodendroglia; Rats; Rats, Sprague-Dawley; T-Lymphocytes | 2015 |
Thyroid hormone alleviates demyelination induced by cuprizone through its role in remyelination during the remission period.
Topics: Animals; Astrocytes; Axons; Cell Differentiation; Cell Lineage; Cell Proliferation; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Humans; Male; Mice; Mice, Inbred C57BL; Microglia; Multiple Sclerosis, Relapsing-Remitting; Myelin Sheath; Oligodendroglia; Thyroid Hormones | 2015 |
Proteomics of a conundrum: Thoughts on addressing the aetiology versus progression of multiple sclerosis.
Topics: Animals; Cuprizone; Demyelinating Diseases; Encephalomyelitis, Autoimmune, Experimental; Humans; Multiple Sclerosis; Proteomics | 2015 |
TREM2 regulates microglial cell activation in response to demyelination in vivo.
Topics: Animals; Brain; Cell Proliferation; Chelating Agents; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Immunohistochemistry; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia; Microscopy, Immunoelectron; Oligonucleotide Array Sequence Analysis; Real-Time Polymerase Chain Reaction; Receptors, Immunologic | 2015 |
Galanin is an autocrine myelin and oligodendrocyte trophic signal induced by leukemia inhibitory factor.
Topics: Animals; Astrocytes; Brain; Cell Survival; Cells, Cultured; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Galanin; Gene Expression; Leukemia Inhibitory Factor; MAP Kinase Signaling System; Mice, Inbred C57BL; Mice, Knockout; Myelin Sheath; Neural Stem Cells; Oligodendroglia; Optic Nerve; Rats, Sprague-Dawley; RNA, Messenger | 2015 |
Absence of CCL2 and CCL3 Ameliorates Central Nervous System Grey Matter But Not White Matter Demyelination in the Presence of an Intact Blood-Brain Barrier.
Topics: Animals; Astrocytes; Blood-Brain Barrier; Brain; Cells, Cultured; Chemokine CCL2; Chemokine CCL3; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Female; Gliosis; Gray Matter; Macrophages, Peritoneal; Mice; Mice, Inbred C57BL; Mice, Knockout; Viscera; White Matter | 2016 |
CXCL10 triggers early microglial activation in the cuprizone model.
Topics: Animals; Astrocytes; Cell Movement; Chemokine CXCL10; Chemokines; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Gene Expression; Gene Expression Profiling; Immunohistochemistry; Lactate Dehydrogenases; Mice; Mice, Knockout; Microglia; Oligodendroglia; Phagocytosis; Rats | 2015 |
Altered transition metal homeostasis in the cuprizone model of demyelination.
Topics: Animals; Brain; Chelating Agents; Copper; Cuprizone; Demyelinating Diseases; Homeostasis; Iron; Liver; Male; Manganese; Mice, Inbred C57BL; Neurons; Neurotoxicity Syndromes; Time Factors; Zinc | 2015 |
Deletion of Jun proteins in adult oligodendrocytes does not perturb cell survival, or myelin maintenance in vivo.
Topics: Animals; Brain; Cell Survival; Cuprizone; Demyelinating Diseases; Encephalomyelitis, Autoimmune, Experimental; Female; Mice; Mice, Knockout; Motor Activity; Oligodendroglia; Phenotype; Proto-Oncogene Proteins c-jun; Transcription Factors | 2015 |
Cuprizone-induced demyelination and demyelination-associated inflammation result in different proton magnetic resonance metabolite spectra.
Topics: Animals; Aspartic Acid; Brain Chemistry; Choline; Creatine; Cuprizone; Demyelinating Diseases; Dipeptides; Disease Models, Animal; Female; Gliosis; Magnetic Resonance Imaging; Male; Mice; Mice, Inbred C57BL; Neuroimaging; Oligodendroglia; Phosphocreatine; Proton Magnetic Resonance Spectroscopy | 2015 |
TREM2 sustains microglial expansion during aging and response to demyelination.
Topics: Aging; Animals; Axons; Brain; Cell Count; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Gene Expression Profiling; Genes, Reporter; Humans; Lipodystrophy; Membrane Glycoproteins; Mice; Mice, Knockout; Microglia; Myelin Sheath; Nerve Tissue Proteins; Osteochondrodysplasias; Phagocytosis; Receptors, Immunologic; Regeneration; Subacute Sclerosing Panencephalitis; Transcription, Genetic | 2015 |
Fibroblast growth factor signaling in oligodendrocyte-lineage cells facilitates recovery of chronically demyelinated lesions but is redundant in acute lesions.
Topics: 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase; Animals; Animals, Newborn; Basic Helix-Loop-Helix Transcription Factors; Cell Differentiation; Cell Lineage; Cells, Cultured; Chelating Agents; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Fibroblast Growth Factors; Lysophosphatidylcholines; Mice; Mice, Inbred C57BL; Mice, Transgenic; Oligodendroglia; Receptor, Fibroblast Growth Factor, Type 1; Receptor, Fibroblast Growth Factor, Type 2; Recovery of Function; Signal Transduction; Spinal Cord | 2015 |
Oncostatin M protects against demyelination by inducing a protective microglial phenotype.
Topics: Animals; Calcium-Binding Proteins; Central Nervous System; Chelating Agents; Cuprizone; Cytokines; Demyelinating Diseases; Disease Models, Animal; Glial Fibrillary Acidic Protein; Growth Inhibitors; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microfilament Proteins; Microglia; Oncostatin M; Oncostatin M Receptor beta Subunit; Phenotype; Time Factors; Transduction, Genetic; Up-Regulation | 2015 |
Non-steroidal anti-inflammatory drug indometacin enhances endogenous remyelination.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Differentiation; Cell Line, Tumor; Cells, Cultured; Cerebellum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Indomethacin; Male; Mice, Inbred C57BL; Mice, Transgenic; Myelin Sheath; Neural Stem Cells; Neuroprotective Agents; Oligodendroglia; Tissue Culture Techniques; Wnt Signaling Pathway | 2015 |
Myelin loss and axonal ion channel adaptations associated with gray matter neuronal hyperexcitability.
Topics: Animals; Axons; Cuprizone; Demyelinating Diseases; Gray Matter; Ion Channels; Male; Mice; Mice, Inbred C57BL; Myelin Sheath; Nerve Fibers, Myelinated; Neurons | 2015 |
Cuprizone Model as a Tool for Preclinical Studies of the Efficacy of Multiple Sclerosis Diagnosis and Therapy.
Topics: Animals; Brain; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Female; Glial Fibrillary Acidic Protein; Magnetic Resonance Imaging; Male; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Sheath; Nerve Tissue Proteins; Radiography | 2015 |
Transfer of myelin-reactive th17 cells impairs endogenous remyelination in the central nervous system of cuprizone-fed mice.
Topics: Adoptive Transfer; Animals; Cell Polarity; Cells, Cultured; Central Nervous System; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Freund's Adjuvant; Interleukin-17; Leukocyte Common Antigens; Mice; Mice, Inbred C57BL; Mice, Transgenic; Monoamine Oxidase Inhibitors; Monocytes; Myelin Proteins; Myelin Sheath; Myelin-Oligodendrocyte Glycoprotein; Neutrophil Infiltration; Peptide Fragments; Regeneration; Th17 Cells; Time Factors | 2015 |
Anatomical Distribution of Cuprizone-Induced Lesions in C57BL6 Mice.
Topics: Animals; Axons; Corpus Callosum; Cuprizone; Demyelinating Diseases; Gray Matter; Mice; Mice, Inbred C57BL; Monoamine Oxidase Inhibitors; Myelin Sheath; White Matter | 2015 |
Oligodendroglial markers in the cuprizone model of CNS de- and remyelination.
Topics: Adenomatous Polyposis Coli Protein; Animals; Basic Helix-Loop-Helix Transcription Factors; Biomarkers; Brain; Chelating Agents; Cuprizone; Demyelinating Diseases; Glial Fibrillary Acidic Protein; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Myelin Proteins; Myelin Sheath; Nerve Tissue Proteins; Nogo Proteins; Oligodendrocyte Transcription Factor 2; Oligodendroglia | 2015 |
Remyelination After Cuprizone-Induced Demyelination Is Accelerated in Juvenile Mice.
Topics: Aging; Animals; Brain; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Immunohistochemistry; Mice; Mice, Inbred C57BL; Microscopy, Electron, Transmission; Monoamine Oxidase Inhibitors; Nerve Regeneration; Oligodendroglia | 2015 |
Microglial Hv1 proton channel promotes cuprizone-induced demyelination through oxidative damage.
Topics: Animals; Chelating Agents; Cuprizone; Demyelinating Diseases; Ion Channels; Macrophage Activation; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia; Multiple Sclerosis; Myelin Basic Protein; NADPH Oxidases; Neural Stem Cells; Oxidative Stress; Postural Balance; Reactive Oxygen Species | 2015 |
Fingolimod does not enhance cerebellar remyelination in the cuprizone model.
Topics: Animals; Cerebellum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Female; Fingolimod Hydrochloride; Immunosuppressive Agents; Mice; Mice, Inbred C57BL; Propylene Glycols; Sphingosine | 2015 |
Administration of leukemia inhibitory factor increases Opalin and myelin oligodendrocyte glycoprotein expression in the cerebral cortex in a cuprizone-induced model of demyelination.
Topics: Animals; Blotting, Western; Cerebral Cortex; Chelating Agents; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Leukemia Inhibitory Factor; Mice; Mice, Inbred BALB C; Multiple Sclerosis; Myelin Proteins; Myelin-Oligodendrocyte Glycoprotein | 2015 |
Quetiapine Ameliorates Schizophrenia-Like Behaviors and Protects Myelin Integrity in Cuprizone Intoxicated Mice: The Involvement of Notch Signaling Pathway.
Topics: Animals; Cuprizone; Demyelinating Diseases; Injections, Intraventricular; Male; Mice; Mice, Inbred C57BL; Myelin Sheath; Neuroprotective Agents; Peptides; Quetiapine Fumarate; Receptors, Notch; Schizophrenia; Signal Transduction | 2015 |
Clemastine rescues behavioral changes and enhances remyelination in the cuprizone mouse model of demyelination.
Topics: Animals; Behavior, Animal; Brain; Cell Differentiation; Clemastine; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Exploratory Behavior; Male; Mice; Mice, Inbred C57BL; Motor Activity; Myelin Basic Protein; Myelin Sheath; Oligodendroglia; Schizophrenia | 2015 |
The Effect of Melatonin on Behavioral, Molecular, and Histopathological Changes in Cuprizone Model of Demyelination.
Topics: Animals; Antioxidants; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Dose-Response Relationship, Drug; Inflammation Mediators; Injections, Intraperitoneal; Male; Melatonin; Mice; Mice, Inbred C57BL; Pain Measurement; Random Allocation | 2016 |
Inactivation of Protein Tyrosine Phosphatase Receptor Type Z by Pleiotrophin Promotes Remyelination through Activation of Differentiation of Oligodendrocyte Precursor Cells.
Topics: Amyloid beta-Protein Precursor; Animals; Antigens; Carrier Proteins; Cell Differentiation; Cells, Cultured; Corpus Callosum; Cuprizone; Cytokines; Demyelinating Diseases; Disease Models, Animal; Gene Expression Regulation; Mice; Mice, Inbred C57BL; Mice, Transgenic; Myelin Basic Protein; Nerve Tissue Proteins; Oligodendroglia; Proteoglycans; Receptor-Like Protein Tyrosine Phosphatases, Class 5; Stem Cells; Tumor Suppressor Protein p53 | 2015 |
The cuprizone-induced changes in (1)H-MRS metabolites and oxidative parameters in C57BL/6 mouse brain: Effects of quetiapine.
Topics: Animals; Antipsychotic Agents; Brain; Chelating Agents; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Hydrogen Peroxide; Male; Mice, Inbred C57BL; Neurons; Oligodendroglia; Quetiapine Fumarate | 2015 |
Developmental expression and function analysis of protein tyrosine phosphatase receptor type D in oligodendrocyte myelination.
Topics: Animals; Blotting, Western; Brain; Cell Differentiation; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Evoked Potentials, Motor; Immunohistochemistry; In Situ Hybridization; Mice, Transgenic; Motor Activity; Mutation; Oligodendroglia; Receptor-Like Protein Tyrosine Phosphatases, Class 2; Spinal Cord; Transcranial Magnetic Stimulation | 2015 |
Lesion Expansion in Experimental Demyelination Animal Models and Multiple Sclerosis Lesions.
Topics: Aged; Aged, 80 and over; Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Female; Humans; Male; Mice; Mice, Inbred C57BL; Middle Aged; Multiple Sclerosis; Myelin Sheath; White Matter | 2016 |
Involvement of AMPK, IKβα-NFκB and eNOS in the sildenafil anti-inflammatory mechanism in a demyelination model.
Topics: AMP-Activated Protein Kinases; Animals; Anti-Inflammatory Agents; Chelating Agents; Cuprizone; Cytokines; Demyelinating Diseases; Disease Models, Animal; Encephalitis; Enzyme Inhibitors; Glial Fibrillary Acidic Protein; Male; Mice; Mice, Inbred C57BL; NF-kappa B; Nitric Oxide Synthase Type III; Sildenafil Citrate | 2015 |
Disparate Effects of Mesenchymal Stem Cells in Experimental Autoimmune Encephalomyelitis and Cuprizone-Induced Demyelination.
Topics: Animals; CD4-Positive T-Lymphocytes; Cell Death; Cell Proliferation; Corpus Callosum; Cuprizone; Cytokines; Demyelinating Diseases; Encephalomyelitis, Autoimmune, Experimental; Female; Lymphocyte Subsets; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mice, Inbred C57BL; Myelin-Oligodendrocyte Glycoprotein; Oligodendroglia; Peptide Fragments | 2015 |
The antiviral drug ganciclovir does not inhibit microglial proliferation and activation.
Topics: Animals; Animals, Newborn; Antiviral Agents; Brain; Cell Proliferation; Cells, Cultured; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Encephalomyelitis; Ganciclovir; Host-Pathogen Interactions; Humans; Immunohistochemistry; Macrophage Activation; Mice, Inbred C57BL; Microglia; Theilovirus; Vesicular Stomatitis; Vesiculovirus | 2015 |
Phosphodiesterase-5 inhibition promotes remyelination by MCP-1/CCR-2 and MMP-9 regulation in a cuprizone-induced demyelination model.
Topics: Animals; Chemokine CCL2; Cuprizone; Demyelinating Diseases; Matrix Metalloproteinase 9; Mice; Multiple Sclerosis; Myelin Sheath; Phosphodiesterase 5 Inhibitors; Receptors, CCR2; Signal Transduction; Sildenafil Citrate | 2016 |
Diffusion kurtosis imaging probes cortical alterations and white matter pathology following cuprizone induced demyelination and spontaneous remyelination.
Topics: Animals; Cerebral Cortex; Chelating Agents; Cuprizone; Demyelinating Diseases; Diffusion Tensor Imaging; Disease Models, Animal; Female; Mice; Mice, Inbred C57BL; White Matter | 2016 |
Regulatory effect of triiodothyronine on brain myelination and astrogliosis after cuprizone-induced demyelination in mice.
Topics: Animals; Brain; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Gliosis; Male; Mice, Inbred C57BL; Myelin Proteins; Myelin Sheath; Oligodendroglia; Triiodothyronine | 2016 |
The Cannabinoid CB1/CB2 Agonist WIN55212.2 Promotes Oligodendrocyte Differentiation In Vitro and Neuroprotection During the Cuprizone-Induced Central Nervous System Demyelination.
Topics: Animals; Benzoxazines; Cell Differentiation; Cell Line, Transformed; Central Nervous System; Chelating Agents; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Dose-Response Relationship, Drug; Gene Expression Regulation; Male; Mice; Mice, Inbred C57BL; Morpholines; Myelin Basic Protein; Naphthalenes; Neuroprotective Agents; Oligodendroglia; Prepulse Inhibition; Transcriptome | 2016 |
In vivo quantification of demyelination and recovery using compartment-specific diffusion MRI metrics validated by electron microscopy.
Topics: Animals; Brain Mapping; Corpus Callosum; Cuprizone; Demyelinating Diseases; Diffusion; Diffusion Magnetic Resonance Imaging; Diffusion Tensor Imaging; Female; Mice, Inbred C57BL; Microscopy, Electron; Myelin Sheath; Remyelination | 2016 |
Auraptene induces oligodendrocyte lineage precursor cells in a cuprizone-induced animal model of demyelination.
Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Brain; Coumarins; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Drug Evaluation, Preclinical; Gene Expression; Injections, Intraperitoneal; Male; Mice, 129 Strain; Mice, Inbred C57BL; Microglia; Myelin Basic Protein; Nerve Tissue Proteins; Neuroprotective Agents; Oligodendrocyte Transcription Factor 2; Oligodendroglia; Receptor, Platelet-Derived Growth Factor alpha; Stem Cells | 2016 |
The effect of triiodothyronine on maturation and differentiation of oligodendrocyte progenitor cells during remyelination following induced demyelination in male albino rat.
Topics: Animals; Cell Differentiation; Corpus Callosum; Cuprizone; Demyelinating Diseases; Gene Expression Regulation, Developmental; Injections, Subcutaneous; Male; Mice; Microscopy, Electron; Oligodendroglia; Rats; Receptor, Platelet-Derived Growth Factor alpha; Stem Cells; Triiodothyronine | 2016 |
Hes3 expression in the adult mouse brain is regulated during demyelination and remyelination.
Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Cell Culture Techniques; Culture Media, Conditioned; Cuprizone; Demyelinating Diseases; Gene Expression Regulation; Male; Mice; Mice, Inbred C57BL; Motor Cortex; Myelin Basic Protein; Myelin Sheath; Nerve Tissue Proteins; Repressor Proteins; RNA, Messenger | 2016 |
Spatio-Temporal Patterns of Demyelination and Remyelination in the Cuprizone Mouse Model.
Topics: Animals; Body Weight; Brain; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Mice, Inbred C57BL; Myelin Sheath; Transcriptome | 2016 |
Toxicity of cuprizone a Cu(2+) chelating agent on isolated mouse brain mitochondria: a justification for demyelination and subsequent behavioral dysfunction.
Topics: Animals; Behavior, Animal; Brain; Chelating Agents; Cuprizone; Demyelinating Diseases; Female; Membrane Potential, Mitochondrial; Mice; Mice, Inbred C57BL; Mitochondria; Mitochondrial Swelling; Neurons; Oxidative Stress; Reactive Oxygen Species; Rotarod Performance Test | 2016 |
Myelin injury induces axonal transport impairment but not AD-like pathology in the hippocampus of cuprizone-fed mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antibodies, Monoclonal; Axonal Transport; Axons; Cognition; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Fluorescent Antibody Technique; Hippocampus; Humans; Kinesins; Male; Maze Learning; Membrane Proteins; Mice; Mice, Inbred C57BL; Microtubule-Associated Proteins; Myelin Basic Protein; Myelin Sheath; Nerve Tissue Proteins; Neurofilament Proteins; Phosphorylation; tau Proteins | 2016 |
Intraventricular injections of mesenchymal stem cells activate endogenous functional remyelination in a chronic demyelinating murine model.
Topics: Animals; Bone Marrow Cells; Cell Differentiation; Cell- and Tissue-Based Therapy; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Gene Expression; Humans; Injections, Intraventricular; Intercellular Signaling Peptides and Proteins; Lateral Ventricles; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mice; Myelin Sheath; Neural Stem Cells; Oligodendroglia; Paracrine Communication; Signal Transduction | 2016 |
Thalamocortical-auditory network alterations following cuprizone-induced demyelination.
Topics: Action Potentials; Animals; Auditory Cortex; Auditory Pathways; Biophysics; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Electric Stimulation; In Vitro Techniques; Mice; Mice, Inbred C57BL; Monoamine Oxidase Inhibitors; Myelin Proteolipid Protein; Neurons; Patch-Clamp Techniques; Synaptic Potentials; Thalamus; Time Factors | 2016 |
A mouse model for testing remyelinating therapies.
Topics: Animals; Axons; Brain; Calcium-Binding Proteins; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Glial Fibrillary Acidic Protein; Gliosis; Immunosuppressive Agents; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Microfilament Proteins; Monoamine Oxidase Inhibitors; Myelin Proteolipid Protein; Regeneration; Sirolimus; Time Factors; Triiodothyronine; White Matter | 2016 |
Cytokine regulation by modulation of the NMDA receptor on astrocytes.
Topics: Animals; Astrocytes; Bone Morphogenetic Protein 4; Brain; Cells, Cultured; Cuprizone; Cytokines; Demyelinating Diseases; Encephalitis; Hippocampus; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Receptors, N-Methyl-D-Aspartate; RNA, Messenger | 2016 |
Astrocyte-targeted production of interleukin-6 reduces astroglial and microglial activation in the cuprizone demyelination model: Implications for myelin clearance and oligodendrocyte maturation.
Topics: Amyloid beta-Protein Precursor; Animals; Astrocytes; Calcium-Binding Proteins; Caspase 3; Cuprizone; Cytokines; Demyelinating Diseases; Disease Models, Animal; Green Fluorescent Proteins; Interleukin-6; Male; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microfilament Proteins; Microglia; Monoamine Oxidase Inhibitors; Myelin Basic Protein; Myelin Sheath; Nerve Tissue Proteins; Receptors, Immunologic | 2016 |
Cuprizone demyelination induces a unique inflammatory response in the subventricular zone.
Topics: Animals; Animals, Newborn; Calcium-Binding Proteins; Cell Proliferation; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Female; Galectin 3; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Inflammation; Lateral Ventricles; Male; Mice; Mice, Transgenic; Microfilament Proteins; Monoamine Oxidase Inhibitors; Olfactory Bulb; Oligodendroglia | 2016 |
TRPA1 deficiency is protective in cuprizone-induced demyelination-A new target against oligodendrocyte apoptosis.
Topics: Adenomatous Polyposis Coli; Animals; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; Body Weight; Brain; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Fibroblast Growth Factor 2; Gene Expression Regulation; Gliosis; Mice; Mice, Knockout; Monoamine Oxidase Inhibitors; Myelin Basic Protein; Nerve Tissue Proteins; Oligodendroglia; Signal Transduction; TRPA1 Cation Channel | 2016 |
The quality of cortical network function recovery depends on localization and degree of axonal demyelination.
Topics: Adaptive Immunity; Animals; Behavior, Animal; Cerebral Cortex; Cuprizone; Demyelinating Diseases; Electrodes, Implanted; Gray Matter; Lysophosphatidylcholines; Mice; Mice, Inbred C57BL; Myelin Sheath; Nerve Net; Recovery of Function; Sensation; White Matter | 2017 |
Cyclin-dependent kinase inhibitor flavopiridol promotes remyelination in a cuprizone induced demyelination model.
Topics: Animals; Astrocytes; Cell Cycle; Cell Cycle Proteins; Cell Proliferation; Cuprizone; Cyclin-Dependent Kinases; Demyelinating Diseases; Disease Models, Animal; Flavonoids; Gene Expression Regulation; Male; Memory Disorders; Memory, Short-Term; Mice, Inbred C57BL; Microglia; Myelin Sheath; Oligodendroglia; Piperidines; Protein Kinase Inhibitors; Stem Cells; Up-Regulation | 2016 |
Acute axonal damage in three different murine models of multiple sclerosis: A comparative approach.
Topics: Amyloid beta-Protein Precursor; Animals; Axons; Brain; Corpus Callosum; Cuprizone; Demyelinating Diseases; Encephalomyelitis, Autoimmune, Experimental; Immunohistochemistry; Inflammation; Mice; Mice, Inbred C57BL; Microglia; Models, Animal; Multiple Sclerosis; Myelin Sheath; Nerve Degeneration; Spinal Cord | 2016 |
Activation of the astrocytic Nrf2/ARE system ameliorates the formation of demyelinating lesions in a multiple sclerosis animal model.
Topics: Animals; Astrocytes; Brain; Chemokine CXCL10; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Glutamate-Cysteine Ligase; Heme Oxygenase-1; Kelch-Like ECH-Associated Protein 1; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Monoamine Oxidase Inhibitors; Multiple Sclerosis; NF-E2-Related Factor 2; Oxidative Stress; Thioredoxin Reductase 1 | 2016 |
Interleukin-13 immune gene therapy prevents CNS inflammation and demyelination via alternative activation of microglia and macrophages.
Topics: Animals; Antigens, Differentiation; Bone Marrow Transplantation; Cuprizone; Cytokines; Demyelinating Diseases; Disease Models, Animal; Encephalitis; Genetic Therapy; Green Fluorescent Proteins; Interleukin-13; Macrophages; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microglia; Monoamine Oxidase Inhibitors; Myelin Proteins; Nerve Tissue Proteins; Transduction, Genetic | 2016 |
Myricetin alleviates cuprizone-induced behavioral dysfunction and demyelination in mice by Nrf2 pathway.
Topics: Animals; Behavior, Animal; Cuprizone; Demyelinating Diseases; Flavonoids; Gene Expression Regulation; Locomotion; Male; Memory; Mice; Molecular Structure; Neurons; NF-E2-Related Factor 2; Oxidative Stress | 2016 |
Recovery from Toxic-Induced Demyelination Does Not Require the NG2 Proteoglycan.
Topics: Animals; Antigens; Brain; Cell Differentiation; Cell Movement; Cell Proliferation; Cells, Cultured; Cuprizone; Demyelinating Diseases; Gene Expression; Immunohistochemistry; Mice, Knockout; Mice, Transgenic; Microscopy, Electron; Oligodendroglia; Proteoglycans; Receptor, Platelet-Derived Growth Factor alpha; Reverse Transcriptase Polymerase Chain Reaction; Stem Cells | 2016 |
Administration of vitamin D3 induces CNPase and myelin oligodendrocyte glycoprotein expression in the cerebral cortex of the murine model of cuprizone-induced demyelination.
Topics: Animals; Cerebral Cortex; Cholecalciferol; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mice; Mice, Inbred BALB C; Myelin Basic Protein; Myelin-Oligodendrocyte Glycoprotein; Oligodendroglia | 2016 |
The connectomics of brain demyelination: Functional and structural patterns in the cuprizone mouse model.
Topics: Animals; Brain; Connectome; Cuprizone; Demyelinating Diseases; Diffusion Tensor Imaging; Disease Models, Animal; Female; Magnetic Resonance Imaging; Mice, Inbred C57BL; Neural Pathways | 2017 |
Oligodendrocyte Progenitor Cells Directly Utilize Lactate for Promoting Cell Cycling and Differentiation.
Topics: Animals; Arabinose; Cell Cycle; Cell Death; Cell Differentiation; Cell Survival; Cells, Cultured; Corpus Callosum; Cuprizone; Demyelinating Diseases; Female; Glucose; Imino Furanoses; Lactic Acid; Male; Mice, Inbred C57BL; Models, Biological; Monocarboxylic Acid Transporters; Myelin Sheath; Oligodendroglia; Stem Cells; Sugar Alcohols | 2017 |
miR-219 attenuates demyelination in cuprizone-induced demyelinated mice by regulating monocarboxylate transporter 1.
Topics: Animals; Cell Differentiation; Cell Proliferation; Cells, Cultured; Corpus Callosum; Coumaric Acids; Cuprizone; Demyelinating Diseases; Mice, Inbred C57BL; MicroRNAs; Monocarboxylic Acid Transporters; Myelin Sheath; Oligodendroglia; Stem Cells; Symporters | 2017 |
Ultrastructural abnormalities and loss of myelinated fibers in the corpus callosum of demyelinated mice induced by cuprizone.
Topics: Animals; Chelating Agents; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Exploratory Behavior; Male; Maze Learning; Mice; Mice, Inbred C57BL; Microscopy, Electron, Transmission; Myelin Basic Protein; Nerve Fibers, Myelinated; Rotarod Performance Test | 2017 |
IL-17A Promotes Granulocyte Infiltration, Myelin Loss, Microglia Activation, and Behavioral Deficits During Cuprizone-Induced Demyelination.
Topics: Animals; Anxiety; Astrocytes; Behavior, Animal; Cell Proliferation; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Granulocytes; Interleukin-17; Mice; Mice, Transgenic; Microglia; Myelin Sheath | 2018 |
The effect of omega-3 fatty acids on central nervous system remyelination in fat-1 mice.
Topics: Animals; Brain; Cadherins; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Docosahexaenoic Acids; Eicosapentaenoic Acid; Fatty Acids, Omega-3; Fatty Acids, Omega-6; Female; Mice, Inbred C57BL; Mice, Transgenic; Nerve Regeneration | 2017 |
Investigation of Cuprizone Inactivation by Temperature.
Topics: Adenomatous Polyposis Coli Protein; Agglutinins; Animals; Cell Differentiation; Cerebral Cortex; Corpus Callosum; Cuprizone; Demyelinating Diseases; Glial Fibrillary Acidic Protein; Hot Temperature; Mice; Myelin Basic Protein; Oligodendroglia; Primary Cell Culture; Rats | 2017 |
The Effect of Stereotactic Injections on Demyelination and Remyelination: a Study in the Cuprizone Model.
Topics: Animals; Blood-Brain Barrier; Cerebral Cortex; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Gliosis; Gray Matter; Injections, Intraventricular; Lymphocytes; Male; Mice; Mice, Inbred C57BL; Monoamine Oxidase Inhibitors; Myelin Sheath; Stereotaxic Techniques | 2017 |
Transplanted miR-219-overexpressing oligodendrocyte precursor cells promoted remyelination and improved functional recovery in a chronic demyelinated model.
Topics: Animals; Axons; Cell Differentiation; Cell Lineage; Cell Proliferation; Cell Survival; Chronic Disease; Coculture Techniques; Cognition Disorders; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mice; MicroRNAs; Oligodendrocyte Precursor Cells; Pluripotent Stem Cells; Recovery of Function; Remyelination | 2017 |
Chronic demyelination-induced seizures.
Topics: Animals; Aquaporin 4; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Electroencephalography; Gliosis; Hippocampus; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microglia; Multiple Sclerosis; Neurons; Seizures | 2017 |
Cuprizone Intoxication Induces Cell Intrinsic Alterations in Oligodendrocyte Metabolism Independent of Copper Chelation.
Topics: Amino Acids; Animals; Brain; Brain Chemistry; Cell Line; Chelating Agents; Copper; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Energy Metabolism; Male; Metabolome; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Oligodendroglia; Pyridoxal Phosphate | 2017 |
Phosphorylation of αB-crystallin supports reactive astrogliosis in demyelination.
Topics: alpha-Crystallin B Chain; Animals; Astrocytes; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Humans; Male; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Nerve Tissue Proteins; Oligodendroglia; Phosphorylation | 2017 |
MiR-146a promotes remyelination in a cuprizone model of demyelinating injury.
Topics: Animals; Corpus Callosum; Cuprizone; Demyelinating Diseases; Mice; Mice, Inbred C57BL; MicroRNAs; Neurogenesis; Oligodendroglia | 2017 |
Cuprizone-Containing Pellets Are Less Potent to Induce Consistent Demyelination in the Corpus Callosum of C57BL/6 Mice.
Topics: Administration, Oral; Animals; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Drug Implants; Male; Mice; Mice, Inbred C57BL | 2017 |
Inhibition of p53 transcriptional activity: a potential target for future development of therapeutic strategies for primary demyelination.
Topics: Animals; Benzothiazoles; Cells, Cultured; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Enzyme Inhibitors; Lateral Ventricles; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia; Oligodendroglia; Oligonucleotide Array Sequence Analysis; Toluene; Transcription, Genetic; Tumor Suppressor Protein p53 | 2008 |
Thyroid hormones promote differentiation of oligodendrocyte progenitor cells and improve remyelination after cuprizone-induced demyelination.
Topics: Animals; Animals, Newborn; Antigens; Blood Coagulation Factors; Cell Differentiation; Cuprizone; Demyelinating Diseases; Gangliosides; Glial Fibrillary Acidic Protein; Hedgehog Proteins; Myelin Basic Protein; O Antigens; Oligodendroglia; Proteoglycans; Rats; Rats, Wistar; Receptor-Interacting Protein Serine-Threonine Kinases; Receptors, Cell Surface; Stem Cells; Thyroid Hormones; Time Factors; Triiodothyronine | 2008 |
Activation of inflammatory response by a combination of growth factors in cuprizone-induced demyelinated brain leads to myelin repair.
Topics: Animals; Base Sequence; Brain Diseases; Cuprizone; Cytokines; Demyelinating Diseases; DNA Primers; Female; Growth Substances; Immunohistochemistry; Inflammation; Inflammation Mediators; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred C57BL; Microscopy, Electron; Myelin Sheath; Reverse Transcriptase Polymerase Chain Reaction | 2008 |
Monitoring demyelination and remyelination by magnetization transfer imaging in the mouse brain at 9.4 T.
Topics: Animals; Brain; Cuprizone; Demyelinating Diseases; Glial Fibrillary Acidic Protein; Magnetic Resonance Imaging; Magnetics; Mice; Mice, Inbred C57BL; Myelin Basic Protein; Myelin Sheath; Nerve Tissue Proteins | 2008 |
MHC class II exacerbates demyelination in vivo independently of T cells.
Topics: Animals; Chelating Agents; Cuprizone; Cytoplasm; Demyelinating Diseases; Histocompatibility Antigens Class II; Homeodomain Proteins; Interleukin-1beta; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Microglia; Protein Structure, Tertiary; Reactive Oxygen Species; T-Lymphocytes; Tumor Necrosis Factor-alpha | 2008 |
Quetiapine alleviates the cuprizone-induced white matter pathology in the brain of C57BL/6 mouse.
Topics: Animals; Antipsychotic Agents; Astrocytes; Blotting, Western; Brain; Brain Diseases; Chelating Agents; Cuprizone; Demyelinating Diseases; Dibenzothiazepines; Disease Models, Animal; Mice; Mice, Inbred C57BL; Microglia; Oligodendroglia; Quetiapine Fumarate | 2008 |
Differential changes in axonal conduction following CNS demyelination in two mouse models.
Topics: Animals; Axons; Central Nervous System; Chelating Agents; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Electric Stimulation; Mice; Mice, Inbred BALB C; Mice, Knockout; Mice, Neurologic Mutants; Motor Cortex; Myelin Basic Protein; Nerve Fibers, Myelinated; Neural Conduction; Neural Pathways; Reaction Time; Wallerian Degeneration | 2008 |
Effects of dietary intervention on MRI activity, de- and remyelination in the cuprizone model for demyelination.
Topics: Animals; Antigens, Differentiation; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Fatty Acids, Unsaturated; Female; Glial Fibrillary Acidic Protein; Indoles; Injections, Intravenous; Magnetic Resonance Imaging; Mice; Mice, Inbred C57BL; Myelin Proteolipid Protein; Recovery of Function; Statistics, Nonparametric | 2009 |
SJL mice exposed to cuprizone intoxication reveal strain and gender pattern differences in demyelination.
Topics: Animals; Astrocytes; Brain; Cell Count; Chelating Agents; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Female; Immunohistochemistry; Male; Mice; Microglia; Multiple Sclerosis; Oligodendroglia; Sex Characteristics; Stem Cells | 2009 |
Cuprizone treatment induces demyelination and astrocytosis in the mouse hippocampus.
Topics: Aging; Animals; Astrocytes; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Gliosis; Hippocampus; Immunohistochemistry; Indoles; Male; Mice; Mice, Inbred C57BL; Microglia; Microscopy, Electron; Multiple Sclerosis; Myelin Sheath; Oligodendroglia; Reverse Transcriptase Polymerase Chain Reaction | 2009 |
17beta-estradiol and progesterone prevent cuprizone provoked demyelination of corpus callosum in male mice.
Topics: Analysis of Variance; Animals; Corpus Callosum; Cuprizone; Cytoskeleton; Demyelinating Diseases; Disease Models, Animal; Drug Administration Schedule; Estradiol; Estrogens; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Insulin-Like Growth Factor I; Magnetic Resonance Imaging; Male; Mice; Mice, Inbred C57BL; Myelin Proteins; Progesterone; Receptor, Platelet-Derived Growth Factor alpha | 2009 |
A salmon based diet protects mice from behavioural changes in the cuprizone model for demyelination.
Topics: Animals; Behavior, Animal; Brain; Cod Liver Oil; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Fatty Acids, Omega-3; Female; Immunohistochemistry; Mice; Mice, Inbred C57BL; Random Allocation; Salmon; Seafood; Soybean Oil | 2009 |
Demyelination of the hippocampus is prominent in the cuprizone model.
Topics: Animals; Astrocytes; Biomarkers; Chelating Agents; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Gliosis; Hippocampus; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Microglia; Nerve Fibers, Myelinated; Nerve Tissue Proteins; Neurotoxins; Wallerian Degeneration | 2009 |
Recovery from chronic demyelination by thyroid hormone therapy: myelinogenesis induction and assessment by diffusion tensor magnetic resonance imaging.
Topics: Animals; Brain Mapping; Carbonic Anhydrase II; Chronic Disease; Cuprizone; Demyelinating Diseases; Diffusion Magnetic Resonance Imaging; Disease Models, Animal; Female; Hedgehog Proteins; Leukocyte Common Antigens; Mice; Mice, Inbred C57BL; Microscopy, Electron, Transmission; Myelin Sheath; Nerve Tissue Proteins; Neural Cell Adhesion Molecule L1; Proliferating Cell Nuclear Antigen; Recovery of Function; Sialic Acids; Thyroid Hormones; Time Factors; Triiodothyronine | 2008 |
Type I interferon receptor signalling is induced during demyelination while its function for myelin damage and repair is redundant.
Topics: Animals; Central Nervous System; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Female; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Motor Skills; Myelin Sheath; Receptor, Interferon alpha-beta; Signal Transduction; Specific Pathogen-Free Organisms | 2009 |
Age-dependent epigenetic control of differentiation inhibitors is critical for remyelination efficiency.
Topics: Aging; Animals; Animals, Newborn; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Cell Differentiation; Cells, Cultured; Cerebral Cortex; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Enzyme Inhibitors; Epigenesis, Genetic; Glial Fibrillary Acidic Protein; Histone Deacetylases; Mice; Mice, Inbred C57BL; Microglia; Microscopy, Electron, Transmission; Myelin Proteins; Neurosecretory Systems; Rats; Regeneration; Stem Cells; Time Factors; Transcription Factors; Transcription, Genetic; Valproic Acid | 2008 |
Cuprizone treatment induces distinct demyelination, astrocytosis, and microglia cell invasion or proliferation in the mouse cerebellum.
Topics: Animals; Cell Proliferation; Cerebellum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Glial Fibrillary Acidic Protein; Gliosis; Male; Mice; Mice, Inbred C57BL; Microscopy, Electron, Transmission; Monoamine Oxidase Inhibitors; Myelin Proteolipid Protein; RNA, Messenger; Time Factors | 2009 |
Partial inhibition of proteasome activity enhances remyelination after cuprizone-induced demyelination.
Topics: Acetylcysteine; Animals; Corpus Callosum; Cuprizone; Cysteine Proteinase Inhibitors; Demyelinating Diseases; Disease Models, Animal; Gliosis; Male; Mice; Myelin Sheath; Nerve Fibers, Myelinated; Nerve Regeneration; Neurotoxins; NF-kappa B; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Treatment Outcome | 2009 |
Region-specific susceptibilities to cuprizone-induced lesions in the mouse forebrain: Implications for the pathophysiology of schizophrenia.
Topics: Animal Feed; Animals; Behavior, Animal; Body Weight; Chelating Agents; Copper; Cuprizone; Demyelinating Diseases; Male; Mice; Mice, Inbred C57BL; Myelin Sheath; Nerve Fibers, Myelinated; Neuropil; Oligodendroglia; Prosencephalon; Schizophrenia | 2009 |
Behavioral and neurobiological changes in C57BL/6 mice exposed to cuprizone.
Topics: Analysis of Variance; Animals; Behavior, Animal; Brain; Brain Chemistry; Chromatography, High Pressure Liquid; Cuprizone; Demyelinating Diseases; Dopamine beta-Hydroxylase; Electrochemistry; Exploratory Behavior; Interpersonal Relations; Male; Maze Learning; Mice; Mice, Inbred C57BL; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Myelin Basic Protein; Neural Inhibition; Time Factors | 2009 |
Statin therapy inhibits remyelination in the central nervous system.
Topics: Animals; Anticholesteremic Agents; Basic Helix-Loop-Helix Transcription Factors; Blotting, Western; Cell Differentiation; Cell Proliferation; Chelating Agents; Cuprizone; Demyelinating Diseases; Flow Cytometry; Fluorescent Antibody Technique; Homeobox Protein Nkx-2.2; Homeodomain Proteins; Immunoenzyme Techniques; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myelin Sheath; Nerve Regeneration; Nerve Tissue Proteins; Oligodendrocyte Transcription Factor 2; Oligodendroglia; Phenotype; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Simvastatin; Stem Cells; Transcription Factors; Zebrafish Proteins | 2009 |
Chronic toxic demyelination in the central nervous system leads to axonal damage despite remyelination.
Topics: Animals; Axons; Central Nervous System; Cuprizone; Demyelinating Diseases; Immunohistochemistry; Macrophages; Mice; Mice, Inbred C57BL; Microglia; Monoamine Oxidase Inhibitors; Myelin Proteins; Nerve Fibers, Myelinated; Oligodendroglia | 2009 |
Cerebellar cortical demyelination in the murine cuprizone model.
Topics: Animals; Astrocytes; Cerebellar Cortex; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Gliosis; Male; Mice; Mice, Inbred C57BL; Microglia; Myelin Sheath; Nerve Fibers, Myelinated; Oligodendroglia; Time Factors | 2010 |
Demyelination in the juvenile period, but not in adulthood, leads to long-lasting cognitive impairment and deficient social interaction in mice.
Topics: Age Factors; Animals; Animals, Newborn; Cognition Disorders; Cuprizone; Demyelinating Diseases; Female; Interpersonal Relations; Maze Learning; Mice; Mice, Inbred C57BL; Time Factors | 2009 |
Regional differences between grey and white matter in cuprizone induced demyelination.
Topics: Animals; Astrocytes; Brain; Cerebral Cortex; Chelating Agents; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Disease Progression; Gliosis; Male; Mice; Mice, Inbred C57BL; Microglia; Multiple Sclerosis; Nerve Fibers, Myelinated; Nerve Regeneration; Neurotoxins; Oligodendroglia; Stem Cells; Time Factors | 2009 |
Cuprizone induces similar demyelination in male and female C57BL/6 mice and results in disruption of the estrous cycle.
Topics: Animals; Cell Death; Chelating Agents; Corpus Callosum; Cuprizone; Demyelinating Diseases; Estrogen Receptor alpha; Estrogen Receptor beta; Estrous Cycle; Female; Genitalia; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia; Nerve Regeneration; Oligodendroglia; Organ Size; Sex Characteristics | 2010 |
Propagation of spreading depression inversely correlates with cortical myelin content.
Topics: Animals; Astrocytes; Cerebral Cortex; Cortical Spreading Depression; Cuprizone; Demyelinating Diseases; Electroencephalography; Encephalomyelitis, Autoimmune, Experimental; Female; Functional Laterality; Glial Fibrillary Acidic Protein; Gliosis; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Transgenic; Multiple Sclerosis; Myelin Basic Protein; Myelin Sheath; Neuregulin-1; Rats; Rats, Inbred Lew | 2009 |
Cuprizone effect on myelination, astrogliosis and microglia attraction in the mouse basal ganglia.
Topics: Age Factors; Analysis of Variance; Animals; Basal Ganglia; Cell Count; Cell Proliferation; Cuprizone; Demyelinating Diseases; Female; Gliosis; Immunohistochemistry; Male; Mice; Microglia; Myelin Proteins; Myelin Sheath; Nerve Fibers, Myelinated; Oligodendroglia; Reverse Transcriptase Polymerase Chain Reaction | 2009 |
In toxic demyelination oligodendroglial cell death occurs early and is FAS independent.
Topics: Animals; Caspase 3; Cell Death; Corpus Callosum; Cuprizone; Cytotoxins; Demyelinating Diseases; Disease Models, Animal; Down-Regulation; fas Receptor; Female; Gene Expression Regulation; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Myelin Proteins; Nerve Fibers, Myelinated; Oligodendroglia; RNA, Messenger; Signal Transduction | 2010 |
HDAC1 nuclear export induced by pathological conditions is essential for the onset of axonal damage.
Topics: Active Transport, Cell Nucleus; Animals; Axons; Brain; Cell Nucleus; Cells, Cultured; Cuprizone; Demyelinating Diseases; Exportin 1 Protein; Glutamic Acid; Histone Deacetylase 1; Humans; Karyopherins; Mice; Mice, Inbred C57BL; Mitochondria; Multiple Sclerosis; Neurons; Rats; Receptors, Cytoplasmic and Nuclear; Time Factors; Tumor Necrosis Factor-alpha | 2010 |
CXCR2-positive neutrophils are essential for cuprizone-induced demyelination: relevance to multiple sclerosis.
Topics: Animals; Chimera; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Monoamine Oxidase Inhibitors; Multiple Sclerosis; Myelin Proteins; Myelin Sheath; Neutrophils; Oligodendroglia; Receptors, Interleukin-8B; RNA, Messenger | 2010 |
Inhibiting poly(ADP-ribose) polymerase: a potential therapy against oligodendrocyte death.
Topics: Active Transport, Cell Nucleus; Animals; Apoptosis; Apoptosis Inducing Factor; Brain; Cell Death; Cell Nucleus; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Male; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Sheath; Oligodendroglia; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Signal Transduction | 2010 |
ADAM12 is expressed by astrocytes during experimental demyelination.
Topics: ADAM Proteins; ADAM12 Protein; Animals; Astrocytes; Cells, Cultured; Cerebral Cortex; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Gene Expression Regulation, Enzymologic; Glial Fibrillary Acidic Protein; Glutamates; Lipopolysaccharides; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Neurofilament Proteins; NF-kappaB-Inducing Kinase; Protein Serine-Threonine Kinases; Signal Transduction; Tumor Necrosis Factor-alpha | 2010 |
Modulation of bone morphogenic protein signalling alters numbers of astrocytes and oligodendroglia in the subventricular zone during cuprizone-induced demyelination.
Topics: Animals; Antimetabolites; Astrocytes; Bone Morphogenetic Protein 4; Bone Morphogenetic Protein Receptors; Bone Morphogenetic Proteins; Brain; Bromodeoxyuridine; Carrier Proteins; Cell Count; Cell Differentiation; Cell Lineage; Cell Proliferation; Cerebral Ventricles; Cuprizone; Demyelinating Diseases; Injections, Intraventricular; Mice; Mice, Inbred C57BL; Microdissection; Monoamine Oxidase Inhibitors; Oligodendroglia; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction | 2010 |
17beta-estradiol protects male mice from cuprizone-induced demyelination and oligodendrocyte loss.
Topics: Animals; Antigens; Cell Count; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Drug Interactions; Estradiol; Estrogens; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Glutathione Transferase; Indoles; Insulin-Like Growth Factor I; Macrophages; Male; Mice; Mice, Inbred C57BL; Microglia; Monoamine Oxidase Inhibitors; Oligodendroglia; Periodic Acid; Plant Lectins; Proteoglycans; Stem Cells; Tumor Necrosis Factor-alpha | 2010 |
Proteomic analysis of demyelinated and remyelinating brain tissue following dietary cuprizone administration.
Topics: Administration, Oral; Animals; Behavior, Animal; Brain; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Food, Formulated; Male; Mice; Mice, Inbred C57BL; Monoamine Oxidase Inhibitors; Nerve Fibers, Myelinated; Nerve Regeneration; Neurotoxins; Proteomics; Recovery of Function | 2010 |
Cuprizone-induced demyelination in CNP::GFP transgenic mice.
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Astrocytes; Brain; Cell Count; Cell Proliferation; Cuprizone; Demyelinating Diseases; Glial Fibrillary Acidic Protein; Gliosis; Green Fluorescent Proteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microglia; Myelin Basic Protein; Neurons; Oligodendroglia; Promoter Regions, Genetic | 2010 |
Rostrocaudal analysis of corpus callosum demyelination and axon damage across disease stages refines diffusion tensor imaging correlations with pathological features.
Topics: Animals; CD11b Antigen; Corpus Callosum; Cuprizone; Demyelinating Diseases; Diffuse Axonal Injury; Diffusion Magnetic Resonance Imaging; Disease Models, Animal; Disease Progression; Glial Fibrillary Acidic Protein; Indoles; Luminescent Proteins; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microglia; Microscopy, Electron, Transmission; Myelin Proteins; Myelin-Associated Glycoprotein; Myelin-Oligodendrocyte Glycoprotein; Neurofilament Proteins; Statistics as Topic; Time Factors | 2010 |
Beneficial effects of minocycline on cuprizone induced cortical demyelination.
Topics: Animals; Anti-Bacterial Agents; Behavior, Animal; Cerebral Cortex; Chelating Agents; Corpus Callosum; Cuprizone; Demyelinating Diseases; Male; Mice; Mice, Inbred C57BL; Minocycline; Motor Activity; Nerve Fibers, Myelinated; Oligodendroglia | 2010 |
Dynamic expression of Cx47 in mouse brain development and in the cuprizone model of myelin plasticity.
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Animals, Newborn; Brain; Connexins; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Embryo, Mammalian; Enzyme-Linked Immunosorbent Assay; Female; Gene Expression Regulation, Developmental; Gliosis; HeLa Cells; Humans; Immunoprecipitation; Mice; Mice, Inbred C57BL; Myelin Basic Protein; Myelin Sheath; Neuronal Plasticity; Oligodendroglia; Transfection | 2010 |
Myelin repair is accelerated by inactivating CXCR2 on nonhematopoietic cells.
Topics: Animals; Animals, Newborn; Antibodies; Bone Marrow; Cell Differentiation; Central Nervous System Stimulants; Cerebellum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Flow Cytometry; Freund's Adjuvant; Glycoproteins; In Vitro Techniques; Leukocyte Common Antigens; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Mice, Knockout; Microscopy, Electron, Transmission; Myelin Basic Protein; Myelin Proteolipid Protein; Myelin Sheath; Myelin-Oligodendrocyte Glycoprotein; Nerve Regeneration; Neurologic Examination; Oligodendroglia; Peptide Fragments; Picrotoxin; Proliferating Cell Nuclear Antigen; Receptors, Interleukin-8B; Recovery of Function; Severity of Illness Index; Stem Cells; Time Factors | 2010 |
Effects of fumaric acids on cuprizone induced central nervous system de- and remyelination in the mouse.
Topics: Animals; Apoptosis; Cells, Cultured; Central Nervous System; Cuprizone; Demyelinating Diseases; Dimethyl Fumarate; Fumarates; Immunohistochemistry; Leukocytes, Mononuclear; Male; Maleates; Mice; Mice, Inbred C57BL; Rats; Rats, Sprague-Dawley | 2010 |
Influence of methylprednisolone on magnetic resonance and histological measures during cuprizone-induced demyelination.
Topics: Animals; Brain; Cuprizone; Demyelinating Diseases; Female; Glucocorticoids; Magnetic Resonance Imaging; Methylprednisolone; Mice; Mice, Inbred C57BL; Myelin Sheath; Nerve Fibers, Myelinated | 2010 |
Remyelination after cuprizone induced demyelination is accelerated in mice deficient in the polysialic acid synthesizing enzyme St8siaIV.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Antigens; Antigens, Differentiation; Cell Count; Cell Differentiation; Cerebral Cortex; Corpus Callosum; Cuprizone; Demyelinating Diseases; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Monoamine Oxidase Inhibitors; Myelin Basic Protein; Myelin Proteins; Myelin Proteolipid Protein; Myelin-Associated Glycoprotein; Myelin-Oligodendrocyte Glycoprotein; Neural Cell Adhesion Molecules; Neuroglia; Neurons; Nogo Proteins; Proteoglycans; Regeneration; Sialic Acids; Sialyltransferases | 2010 |
Neurobiological effects of sphingosine 1-phosphate receptor modulation in the cuprizone model.
Topics: Animals; Axons; Blotting, Western; Corpus Callosum; Cuprizone; Demyelinating Diseases; Fingolimod Hydrochloride; Immunohistochemistry; Immunosuppressive Agents; Interleukin-1beta; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microscopy, Electron; Myelin Sheath; Oligodendroglia; Propylene Glycols; Receptors, Lysosphingolipid; Reverse Transcriptase Polymerase Chain Reaction; Sphingosine | 2011 |
Intravenous administration of human embryonic stem cell-derived neural precursor cells attenuates cuprizone-induced central nervous system (CNS) demyelination.
Topics: Animals; Astrocytes; Cell Differentiation; Corpus Callosum; Cuprizone; Demyelinating Diseases; Humans; Mice; Myelin Sheath; Neural Stem Cells; Oligodendroglia | 2011 |
IkappaB kinase 2 determines oligodendrocyte loss by non-cell-autonomous activation of NF-kappaB in the central nervous system.
Topics: Animals; Astrocytes; Blotting, Western; Central Nervous System; Cuprizone; Demyelinating Diseases; I-kappa B Kinase; Mice; Microglia; Myelin Sheath; Nerve Regeneration; NF-kappa B; Oligodendroglia; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction | 2011 |
Longitudinal near-infrared imaging of myelination.
Topics: Analysis of Variance; Animals; Benzothiazoles; Carbocyanines; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Longitudinal Studies; Mice; Mice, Inbred C57BL; Mice, Neurologic Mutants; Mice, Transgenic; Myelin Basic Protein; Myelin Proteolipid Protein; Myelin Sheath; Permeability; Protein Binding; Proto-Oncogene Proteins c-akt; Spectroscopy, Near-Infrared; Time Factors | 2011 |
Reduced axonopathy and enhanced remyelination after chronic demyelination in fibroblast growth factor 2 (Fgf2)-null mice: differential detection with diffusion tensor imaging.
Topics: Animals; Axons; Chelating Agents; Chronic Disease; Cuprizone; Demyelinating Diseases; Diet; Diffusion Tensor Imaging; Fibroblast Growth Factor 2; Mice; Mice, Inbred C57BL; Mice, Knockout; Myelin Sheath; Regeneration | 2011 |
Lack of cuprizone-induced demyelination in the murine spinal cord despite oligodendroglial alterations substantiates the concept of site-specific susceptibilities of the central nervous system.
Topics: Animals; Brain; Cuprizone; Demyelinating Diseases; Mice; Oligodendroglia; Organ Specificity; Spinal Cord | 2011 |
Gas6 increases myelination by oligodendrocytes and its deficiency delays recovery following cuprizone-induced demyelination.
Topics: Animals; Axons; Biomarkers; Cell Lineage; Coculture Techniques; Cuprizone; Demyelinating Diseases; Ganglia, Spinal; Intercellular Signaling Peptides and Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia; Myelin Sheath; Oligodendroglia; Rats; Recovery of Function; Time Factors | 2011 |
Remyelination is altered by bone morphogenic protein signaling in demyelinated lesions.
Topics: Animals; Antimetabolites; Astrocytes; Bone Morphogenetic Protein 4; Bone Morphogenetic Proteins; Bromodeoxyuridine; Carrier Proteins; Cell Count; Chelating Agents; Corpus Callosum; Cuprizone; Demyelinating Diseases; Female; Mice; Mice, Inbred C57BL; Microscopy, Electron; Myelin Sheath; Neuroglia; Oligodendroglia; Signal Transduction; Stem Cells | 2011 |
Corticosteroids impair remyelination in the corpus callosum of cuprizone-treated mice.
Topics: Adrenal Cortex Hormones; Animals; Animals, Newborn; Cells, Cultured; Chelating Agents; Corpus Callosum; Cuprizone; Demyelinating Diseases; Dexamethasone; Drug Evaluation, Preclinical; Male; Methylprednisolone; Mice; Mice, Inbred C57BL; Myelin Sheath; Nerve Regeneration; Oligodendroglia; Rats | 2011 |
The hippocampal fimbria of cuprizone-treated animals as a structure for studying neuroprotection in multiple sclerosis.
Topics: Animals; Chelating Agents; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Hippocampus; Humans; Male; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Nerve Fibers, Myelinated; Neuroprotective Agents; Young Adult | 2011 |
Time-dependent changes in the brain arachidonic acid cascade during cuprizone-induced demyelination and remyelination.
Topics: Animals; Arachidonic Acids; Astrocytes; Cerebral Cortex; Cuprizone; Cyclooxygenase 1; Cyclooxygenase 2; Demyelinating Diseases; Gene Expression Regulation, Enzymologic; Group V Phospholipases A2; Macrophages; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Microglia; Multiple Sclerosis; Myelin Sheath; Nerve Tissue Proteins; Neurons; Phospholipases A2, Cytosolic; RNA, Messenger; Time Factors | 2011 |
Inhibition of 5-lipoxygenase activity in mice during cuprizone-induced demyelination attenuates neuroinflammation, motor dysfunction and axonal damage.
Topics: Animals; Arachidonate 5-Lipoxygenase; Ataxia; Biomarkers; Cerebral Cortex; Corpus Callosum; Cuprizone; Demyelinating Diseases; Gene Expression Regulation, Enzymologic; Indoles; Interleukin-6; Lipoxygenase Inhibitors; Male; Mice; Mice, Inbred C57BL; Microglia; Multiple Sclerosis; Nerve Tissue Proteins; Neuritis; Neurons; RNA, Messenger | 2011 |
BLBP-expression in astrocytes during experimental demyelination and in human multiple sclerosis lesions.
Topics: Adult; Aged; Animals; Astrocytes; Blotting, Western; Carrier Proteins; Cell Count; Cell Line, Tumor; Cuprizone; Demyelinating Diseases; Encephalomyelitis, Autoimmune, Experimental; Fatty Acid-Binding Protein 7; Fatty Acid-Binding Proteins; Female; Fibroblast Growth Factor 2; Fluorescent Antibody Technique, Indirect; Glial Fibrillary Acidic Protein; Humans; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Middle Aged; Multiple Sclerosis; Nerve Tissue Proteins; Oligonucleotide Array Sequence Analysis; Osteopontin; Platelet-Derived Growth Factor; Real-Time Polymerase Chain Reaction; RNA, Messenger; Transfection; Tumor Suppressor Proteins | 2011 |
Lipopolysaccharide delays demyelination and promotes oligodendrocyte precursor proliferation in the central nervous system.
Topics: Animals; Axons; Cell Count; Cell Proliferation; Central Nervous System; Chelating Agents; Cuprizone; Demyelinating Diseases; Flow Cytometry; Immunohistochemistry; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Microglia; Myelin Sheath; Neural Stem Cells; Oligodendroglia; Phagocytosis; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction | 2011 |
In vivo and ex vivo diffusion tensor imaging of cuprizone-induced demyelination in the mouse corpus callosum.
Topics: Animals; Brain Chemistry; Corpus Callosum; Cuprizone; Demyelinating Diseases; Diffusion Tensor Imaging; Image Processing, Computer-Assisted; Immunohistochemistry; Mice; Mice, Inbred C57BL | 2012 |
The cyclooxygenase-2 pathway via the PGE₂ EP2 receptor contributes to oligodendrocytes apoptosis in cuprizone-induced demyelination.
Topics: Animals; Apoptosis; Caspase 3; Cattle; Celecoxib; Chelating Agents; Cuprizone; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Demyelinating Diseases; Dinoprostone; Fluorescent Antibody Technique; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myelin Sheath; Oligodendroglia; Postural Balance; Pyrazoles; Real-Time Polymerase Chain Reaction; Receptors, Prostaglandin E, EP2 Subtype; Signal Transduction; Sulfonamides; Xanthones | 2012 |
Sphingosine 1-phosphate receptor modulator fingolimod (FTY720) does not promote remyelination in vivo.
Topics: Animals; Chelating Agents; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Mice; Mice, Inbred C57BL; Myelin Sheath; Nerve Regeneration; Propylene Glycols; Rats; Rats, Sprague-Dawley; Receptors, Lysosphingolipid; Sphingosine | 2011 |
Spatial and temporal profiles of growth factor expression during CNS demyelination reveal the dynamics of repair priming.
Topics: Animals; Astrocytes; Central Nervous System; Cerebral Cortex; Corpus Callosum; Cuprizone; Demyelinating Diseases; Gene Expression Profiling; Gene Expression Regulation; Intercellular Signaling Peptides and Proteins; Intermediate Filament Proteins; Male; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins; Nestin; RNA, Messenger; Time Factors; Wound Healing | 2011 |
Tissue transglutaminase activity is involved in the differentiation of oligodendrocyte precursor cells into myelin-forming oligodendrocytes during CNS remyelination.
Topics: Animals; Blotting, Western; Cell Differentiation; Cell Survival; Cuprizone; Demyelinating Diseases; Electron Transport Complex II; Electron Transport Complex IV; GTP-Binding Proteins; Immunohistochemistry; In Situ Hybridization; Mice; Mice, Inbred C57BL; Mice, Knockout; Microscopy, Fluorescence; Mitochondria, Heart; Monoamine Oxidase Inhibitors; Myelin Sheath; Neural Stem Cells; Oligodendroglia; Postural Balance; Protein Glutamine gamma Glutamyltransferase 2; Proteolipids; Real-Time Polymerase Chain Reaction; rho GTP-Binding Proteins; rhoA GTP-Binding Protein; RNA, Messenger; Transglutaminases | 2011 |
Fibroblast growth factor 1 (FGFR1) modulation regulates repair capacity of oligodendrocyte progenitor cells following chronic demyelination.
Topics: Animals; Axons; Cell Count; Cell Differentiation; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Fibroblast Growth Factor 1; Mice; Mice, Transgenic; Myelin Sheath; Oligodendroglia; Receptor, Fibroblast Growth Factor, Type 1; Signal Transduction; Stem Cells | 2012 |
Matrix metalloproteinases and their tissue inhibitors in cuprizone-induced demyelination and remyelination of brain white and gray matter.
Topics: Animals; Antigens, CD; Brain; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Male; Matrix Metalloproteinases; Mice; Mice, Inbred C57BL; Microdissection; Microglia; Monoamine Oxidase Inhibitors; RNA, Messenger; Statistics, Nonparametric; Tissue Inhibitor of Metalloproteinases | 2011 |
Assessment of lesion pathology in a new animal model of MS by multiparametric MRI and DTI.
Topics: Animals; Axons; Blood-Brain Barrier; Brain; Cuprizone; Demyelinating Diseases; Diffusion Tensor Imaging; Discriminant Analysis; Encephalomyelitis, Autoimmune, Experimental; Female; Gliosis; Image Processing, Computer-Assisted; Inflammation; Magnetic Resonance Imaging; Mice; Mice, Inbred C57BL; Monoamine Oxidase Inhibitors; Multiple Sclerosis; Pertussis Toxin | 2012 |
Characterisation of microglia during de- and remyelination: can they create a repair promoting environment?
Topics: Animals; Cuprizone; Cytokines; Demyelinating Diseases; Male; Mice; Microglia; Myelin Sheath; Phagocytosis; Up-Regulation; Wound Healing | 2012 |
Demyelination and remyelination in anatomically distinct regions of the corpus callosum following cuprizone intoxication.
Topics: Animals; Axons; Brain; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Glial Fibrillary Acidic Protein; Gliosis; Male; Mice; Mice, Inbred C57BL; Microglia; Myelin Sheath; Nerve Tissue Proteins; Oligodendroglia; Weight Loss | 2012 |
Dietary vitamin D3 supplements reduce demyelination in the cuprizone model.
Topics: Animals; Cholecalciferol; Cuprizone; Demyelinating Diseases; Dietary Supplements; Dose-Response Relationship, Drug; Female; Macrophages; Mice; Mice, Inbred C57BL; Microglia; Myelin Sheath; T-Lymphocytes | 2011 |
BACE1 in central nervous system myelination revisited.
Topics: Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Axons; Corpus Callosum; Cuprizone; Demyelinating Diseases; Mice; Mice, Knockout; Myelin Sheath; Nerve Fibers, Myelinated; Neuregulin-1 | 2012 |
XIAP protects oligodendrocytes against cell death in vitro but has no functional role in toxic demyelination.
Topics: Animals; Animals, Genetically Modified; Cell Line; Chelating Agents; Cuprizone; Cytoprotection; Demyelinating Diseases; Disease Models, Animal; Down-Regulation; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Fibers, Myelinated; Neural Pathways; Oligodendroglia; Primary Cell Culture; Rats; Up-Regulation; X-Linked Inhibitor of Apoptosis Protein | 2012 |
Magnetic resonance imaging and histological evidence for the blockade of cuprizone-induced demyelination in C57BL/6 mice.
Topics: Animals; Antipsychotic Agents; Chelating Agents; Cuprizone; Data Interpretation, Statistical; Demyelinating Diseases; Dibenzothiazepines; Diffusion Tensor Imaging; Image Processing, Computer-Assisted; Immunohistochemistry; Magnetic Resonance Imaging; Mice; Mice, Inbred C57BL; Phenotype; Quetiapine Fumarate | 2012 |
Adult CNP::EGFP transgenic mouse shows pronounced hypomyelination and an increased vulnerability to cuprizone-induced demyelination.
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Aldehydes; Animals; Brain; CD11b Antigen; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Ectodysplasins; Exploratory Behavior; Gene Expression Regulation; Green Fluorescent Proteins; Interleukin-1beta; Male; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microscopy, Electron, Transmission; Mitochondria; Monoamine Oxidase Inhibitors; Motor Activity; Myelin Proteins; Nerve Tissue Proteins; Oligodendroglia; Psychomotor Performance; Reactive Oxygen Species; Stem Cells; Time Factors; Tumor Necrosis Factor-alpha | 2012 |
Quantification of increased cellularity during inflammatory demyelination.
Topics: Animals; Corpus Callosum; Cuprizone; Demyelinating Diseases; Diffusion Tensor Imaging; Inflammation; Magnetic Resonance Imaging; Male; Mice; Myelin Sheath; Nerve Fibers, Myelinated; Trigeminal Nerve | 2011 |
Expression of retinoid X receptor β is induced in astrocytes during corpus callosum demyelination.
Topics: Animals; Astrocytes; Corpus Callosum; Cuprizone; Demyelinating Diseases; Gene Expression Regulation; Male; Mice; Mice, Inbred C57BL; Retinoid X Receptor beta; Up-Regulation | 2012 |
Olesoxime accelerates myelination and promotes repair in models of demyelination.
Topics: Animals; Cholestenones; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Magnetic Resonance Imaging; Mice; Mice, Inbred C57BL; Monoamine Oxidase Inhibitors; Multiple Sclerosis; Myelin Sheath; Oligodendroglia; Rats; Rats, Sprague-Dawley | 2012 |
Late motor decline after accomplished remyelination: impact for progressive multiple sclerosis.
Topics: Aging; Animals; Axons; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Humans; Mice; Mice, Inbred C57BL; Monoamine Oxidase Inhibitors; Motor Skills; Multiple Sclerosis, Chronic Progressive; Myelin Sheath; Time Factors | 2012 |
Erythropoietin attenuates neurological and histological consequences of toxic demyelination in mice.
Topics: Amyloid beta-Protein Precursor; Animals; Axons; Cerebral Ventricles; Corpus Callosum; Cuprizone; Demyelinating Diseases; Erythropoietin; Inflammation; Male; Mice; Mice, Inbred C57BL; Microglia; Neuroprotective Agents; Postural Balance; Psychomotor Performance | 2012 |
Cuprizone-induced demyelination in the rat cerebral cortex and thyroid hormone effects on cortical remyelination.
Topics: Administration, Intranasal; Animals; Axons; Cerebral Cortex; Cuprizone; Demyelinating Diseases; Myelin Basic Protein; Myelin Sheath; Nerve Fibers, Myelinated; Oligodendroglia; Rats; Rats, Wistar; Thyroid Hormones | 2012 |
Golli myelin basic proteins stimulate oligodendrocyte progenitor cell proliferation and differentiation in remyelinating adult mouse brain.
Topics: Animals; Astrocytes; Calcium; Cell Differentiation; Cell Proliferation; Corpus Callosum; Cuprizone; Demyelinating Diseases; Macrophages; Mice; Mice, Knockout; Microglia; Myelin Basic Protein; Myelin Sheath; Neural Stem Cells; Oligodendroglia | 2012 |
Demyelination reduces brain parenchymal stiffness quantified in vivo by magnetic resonance elastography.
Topics: Animals; Axons; Brain; Chelating Agents; Copper; Cuprizone; Demyelinating Diseases; Elasticity Imaging Techniques; Female; Mice; Mice, Inbred C57BL | 2012 |
Inflammatory response and chemokine expression in the white matter corpus callosum and gray matter cortex region during cuprizone-induced demyelination.
Topics: Animals; Cerebral Cortex; Chemokine CCL2; Chemokine CCL3; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Encephalitis; Gene Expression Regulation; Male; Mice; Mice, Inbred C57BL; Microglia; Monoamine Oxidase Inhibitors; Multiple Sclerosis; Oligodendroglia | 2012 |
Quetiapine enhances oligodendrocyte regeneration and myelin repair after cuprizone-induced demyelination.
Topics: Animals; Antipsychotic Agents; Chelating Agents; Cuprizone; Demyelinating Diseases; Dibenzothiazepines; Disease Models, Animal; Memory, Short-Term; Mice; Mice, Inbred C57BL; Motor Activity; Myelin Sheath; Oligodendroglia; Quetiapine Fumarate; Regeneration; Schizophrenia | 2012 |
IL-17-induced Act1-mediated signaling is critical for cuprizone-induced demyelination.
Topics: Animals; Astrocytes; CD3 Complex; Chelating Agents; Connexin 43; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Female; Gene Knockdown Techniques; Interleukin-17; Mice; Mice, Inbred C57BL; Microglia; Multiple Sclerosis; Oligodendroglia; Peptide Fragments; Receptors, Interleukin-17; Signal Transduction; T-Lymphocytes | 2012 |
Sildenafil (Viagra®) down regulates cytokines and prevents demyelination in a cuprizone-induced MS mouse model.
Topics: Animals; Cerebellum; Cuprizone; Cyclooxygenase 2; Cytokines; Demyelinating Diseases; Disease Models, Animal; Down-Regulation; Fluorescent Antibody Technique; Glial Fibrillary Acidic Protein; Immunoblotting; Male; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Piperazines; Purines; Sildenafil Citrate; Sulfones | 2012 |
Reduced astrocytic NF-κB activation by laquinimod protects from cuprizone-induced demyelination.
Topics: Animals; Astrocytes; Axons; Cuprizone; Demyelinating Diseases; Male; Mice; Myelin Sheath; NF-kappa B; Oligodendroglia; Quinolones | 2012 |
Regulation of Olig2 during astroglial differentiation in the subventricular zone of a cuprizone-induced demyelination mouse model.
Topics: Adult Stem Cells; Amidines; Animals; Animals, Newborn; Astrocytes; Basic Helix-Loop-Helix Transcription Factors; Bone Morphogenetic Protein 2; Bone Morphogenetic Protein 4; Bromodeoxyuridine; Cell Differentiation; Cells, Cultured; Cerebral Ventricles; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Gangliosides; Gene Expression Regulation; Inhibitor of Differentiation Protein 2; Inhibitor of Differentiation Proteins; Mice; Monoamine Oxidase Inhibitors; Nerve Tissue Proteins; Oligodendrocyte Transcription Factor 2; Rats, Sprague-Dawley | 2012 |
Role of transmembrane semaphorin Sema6A in oligodendrocyte differentiation and myelination.
Topics: Age Factors; Animals; Animals, Newborn; Antigens, Differentiation; Basic Helix-Loop-Helix Transcription Factors; Brain; Bromodeoxyuridine; Cell Differentiation; Cells, Cultured; Coculture Techniques; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Embryo, Mammalian; Female; Ganglia, Spinal; Gene Expression Regulation, Developmental; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Monoamine Oxidase Inhibitors; Mutation; Myelin Basic Protein; Myelin Proteolipid Protein; Myelin Sheath; Nerve Tissue Proteins; Neurons; Oligodendrocyte Transcription Factor 2; Oligodendroglia; Pregnancy; Ranvier's Nodes; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Cell Surface; RNA, Messenger; Semaphorins; Stem Cells; Time Factors; Transcription Factors | 2012 |
The cuprizone model: regional heterogeneity of pathology.
Topics: Animals; Cerebral Cortex; Complement System Proteins; Corpus Callosum; Cuprizone; Demyelinating Diseases; Female; Gliosis; Hypoxia-Inducible Factor 1, alpha Subunit; Lymphocytes; Macrophages; Mice; Mice, Inbred C57BL; Microglia; Mitochondria; Multiple Sclerosis; Myelin Sheath; Oligodendroglia | 2012 |
Rolipram promotes remyelination possibly via MEK-ERK signal pathway in cuprizone-induced demyelination mouse.
Topics: Animals; Blotting, Western; Brain; Cell Differentiation; Cuprizone; Demyelinating Diseases; Lysophosphatidylcholines; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Monoamine Oxidase Inhibitors; Oligodendroglia; Organ Culture Techniques; Phosphodiesterase 4 Inhibitors; Rats; Rats, Sprague-Dawley; Rolipram; Stem Cells | 2012 |
Pathogenesis of multiple sclerosis: what can we learn from the cuprizone model.
Topics: Animals; Apoptosis; Cuprizone; Demyelinating Diseases; Gene Expression Regulation; Humans; Immunohistochemistry; Immunologic Techniques; Mice; Mice, Inbred C57BL; Models, Biological; Multiple Sclerosis; Myelin Basic Protein; Oligodendroglia | 2012 |
Interferon regulatory factor 8/interferon consensus sequence binding protein is a critical transcription factor for the physiological phenotype of microglia.
Topics: Animals; Animals, Newborn; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Brain; Calcium-Binding Proteins; CD11b Antigen; Cell Proliferation; Cells, Cultured; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Flow Cytometry; Gene Expression Regulation; Interferon Regulatory Factors; Mice; Mice, Inbred C57BL; Mice, Knockout; Microfilament Proteins; Microglia; Monoamine Oxidase Inhibitors; Myelin Sheath; Phagocytosis; Phenotype; Phenylurea Compounds; Spinal Cord | 2012 |
Astrogliosis during acute and chronic cuprizone demyelination and implications for remyelination.
Topics: Animals; Cell Proliferation; Chondroitin Sulfate Proteoglycans; Cicatrix; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Gliosis; Male; Mice; Mice, Inbred C57BL; Monoamine Oxidase Inhibitors; Myelin Basic Protein; Statistics as Topic; Time Factors | 2012 |
Selective ultrastructural vulnerability in the cuprizone-induced experimental demyelination.
Topics: Animals; Apoptosis; Astrocytes; Cerebellum; Chelating Agents; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Humans; Macrophages; Mice; Mice, Inbred C57BL; Microscopy, Electron; Multiple Sclerosis; Myelin Sheath; Oligodendroglia | 2012 |
Targeted deletion of the antisilencer/enhancer (ASE) element from intron 1 of the myelin proteolipid protein gene (Plp1) in mouse reveals that the element is dispensable for Plp1 expression in brain during development and remyelination.
Topics: Age Factors; Animals; Animals, Newborn; Brain; Cell Line, Transformed; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Enhancer Elements, Genetic; Female; Gene Expression Regulation, Developmental; Introns; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Monoamine Oxidase Inhibitors; Myelin Proteolipid Protein; Oligodendroglia; Sequence Deletion; Transfection | 2013 |
Astrocytes regulate myelin clearance through recruitment of microglia during cuprizone-induced demyelination.
Topics: Animals; Astrocytes; Axons; Brain; Corpus Callosum; Cuprizone; Demyelinating Diseases; Glial Fibrillary Acidic Protein; Gliosis; Male; Mice; Mice, Transgenic; Microglia; Myelin Sheath; Nerve Fibers, Myelinated; Nerve Regeneration; Nerve Tissue Proteins | 2013 |
Abbreviated exposure to cuprizone is sufficient to induce demyelination and oligodendrocyte loss.
Topics: Animals; Cell Count; Cell Death; Cuprizone; Demyelinating Diseases; Male; Mice; Mice, Inbred C57BL; Oligodendroglia; Time Factors | 2013 |
G protein-coupled receptor 30 contributes to improved remyelination after cuprizone-induced demyelination.
Topics: Animals; Corpus Callosum; Cuprizone; Demyelinating Diseases; Male; Myelin Sheath; Oligodendroglia; Rats; Rats, Wistar; Receptors, Estrogen; Receptors, G-Protein-Coupled; Selective Estrogen Receptor Modulators; Spinal Cord | 2013 |
Attenuation of corpus callosum axon myelination and remyelination in the absence of circulating sex hormones.
Topics: Action Potentials; Animals; Animals, Newborn; Castration; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Estradiol; Female; Glial Fibrillary Acidic Protein; Gonadal Steroid Hormones; Green Fluorescent Proteins; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Monoamine Oxidase Inhibitors; Myelin Proteolipid Protein; Myelin Sheath; Reaction Time; Sex Characteristics | 2013 |
Progesterone alleviates neural behavioral deficits and demyelination with reduced degeneration of oligodendroglial cells in cuprizone-induced mice.
Topics: Animals; Apoptosis; Behavior, Animal; Body Weight; Caspase 3; Cuprizone; Demyelinating Diseases; Immunohistochemistry; In Situ Nick-End Labeling; Male; Mice; Mice, Inbred C57BL; Microscopy, Electron, Transmission; Oligodendroglia; Progesterone; Rotarod Performance Test | 2013 |
The neural androgen receptor: a therapeutic target for myelin repair in chronic demyelination.
Topics: Androgens; Animals; Brain; Cuprizone; Demyelinating Diseases; Female; Male; Mice; Mice, Knockout; Myelin Sheath; Nerve Fibers, Myelinated; Oligodendroglia; Receptors, Androgen; Testosterone | 2013 |
Absence of fibroblast growth factor 2 promotes oligodendroglial repopulation of demyelinated white matter.
Topics: Animals; Antibodies; Cell Count; Cell Differentiation; Cell Division; Cell Lineage; Cells, Cultured; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Female; Fibroblast Growth Factor 2; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Murine hepatitis virus; Myelin Sheath; Nerve Regeneration; Oligodendroglia; Stem Cells | 2002 |
Quantifying the early stages of remyelination following cuprizone-induced demyelination.
Topics: Animals; Axons; Chelating Agents; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Hippocampus; Mice; Mice, Inbred C57BL; Mice, Knockout; Microscopy, Electron; Myelin Sheath; Prosencephalon; Regression Analysis; Sex Characteristics; Time Factors | 2003 |
Functional genomic analysis of remyelination reveals importance of inflammation in oligodendrocyte regeneration.
Topics: Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Gene Expression; Gene Expression Profiling; Gene Expression Regulation; Histocompatibility Antigens Class I; Histocompatibility Antigens Class II; Inflammation; Mice; Mice, Inbred C57BL; Mice, Knockout; Myelin Sheath; Oligodendroglia; Oligonucleotide Array Sequence Analysis; Regeneration; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Necrosis Factor-alpha | 2003 |
Platelet-derived growth factor regulates oligodendrocyte progenitor numbers in adult CNS and their response following CNS demyelination.
Topics: Animals; Central Nervous System; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Glial Fibrillary Acidic Protein; Lysophosphatidylcholines; Mice; Mice, Transgenic; Nerve Regeneration; Oligodendroglia; Platelet-Derived Growth Factor; Promoter Regions, Genetic; Stem Cells; Up-Regulation | 2004 |
Peripheral benzodiazepine receptor imaging in CNS demyelination: functional implications of anatomical and cellular localization.
Topics: Animals; Astrocytes; Autoradiography; Biomarkers; Cerebral Cortex; Cuprizone; Demyelinating Diseases; Glial Fibrillary Acidic Protein; Immunoenzyme Techniques; Isoquinolines; Macrophage-1 Antigen; Male; Mice; Mice, Inbred C57BL; Microglia; Neuroglia; Receptors, GABA-A | 2004 |
Osteopontin is upregulated during in vivo demyelination and remyelination and enhances myelin formation in vitro.
Topics: Animals; Astrocytes; Brain; Cell Division; Cells, Cultured; Coculture Techniques; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Female; Gene Expression Regulation, Developmental; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia; Myelin Proteins; Myelin Sheath; Nerve Regeneration; Oligodendroglia; Osteopontin; Rats; Recombinant Fusion Proteins; Sialoglycoproteins; Stem Cells; Up-Regulation | 2004 |
Oligodendrocytes and progenitors become progressively depleted within chronically demyelinated lesions.
Topics: Animals; Antigens; Apoptosis; Axons; Cell Death; Cell Differentiation; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Progression; Glutathione Transferase; Immunohistochemistry; Lectins; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microglia; Myelin Sheath; Oligodendroglia; Protein Isoforms; Proteoglycans; Recombinant Fusion Proteins; RNA; Stem Cells; Time Factors | 2004 |
Expression of the low-affinity neurotrophin receptor, p75(NTR), is upregulated by oligodendroglial progenitors adjacent to the subventricular zone in response to demyelination.
Topics: Adult; Aged; Aged, 80 and over; Animals; Brain; Brain Chemistry; Carrier Proteins; Cell Death; Chelating Agents; Cuprizone; Demyelinating Diseases; Female; Humans; Image Processing, Computer-Assisted; Immunohistochemistry; In Situ Nick-End Labeling; Male; Mice; Mice, Inbred C57BL; Middle Aged; Multiple Sclerosis; Nerve Tissue Proteins; Oligodendroglia; Phenotype; Receptors, Growth Factor; Receptors, Nerve Growth Factor; Stem Cells; Tissue Fixation; Up-Regulation | 2004 |
K+ channel blockade impairs remyelination in the cuprizone model.
Topics: 4-Aminopyridine; Animals; Astrocytes; Chelating Agents; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Gliosis; Male; Mice; Mice, Inbred C57BL; Microscopy, Electron, Transmission; Myelin Basic Protein; Myelin Sheath; Nerve Regeneration; Neuroglia; Oligodendroglia; Potassium Channel Blockers; Potassium Channels; Stem Cells | 2004 |
Astroglial-derived lymphotoxin-alpha exacerbates inflammation and demyelination, but not remyelination.
Topics: Animals; Astrocytes; Cell Count; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Encephalitis; Gliosis; Glutathione S-Transferase pi; Glutathione Transferase; Inflammation Mediators; Isoenzymes; Lymphotoxin-alpha; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia; Nerve Regeneration; Oligodendroglia; Signal Transduction; Time Factors; Tumor Necrosis Factor-alpha | 2005 |
Remyelination assessment by MRI texture analysis in a cuprizone mouse model.
Topics: Animals; Brain; Cuprizone; Demyelinating Diseases; Female; Magnetic Resonance Imaging; Male; Mice; Mice, Inbred C57BL; Myelin Sheath | 2004 |
bHLH transcription factor Olig1 is required to repair demyelinated lesions in the CNS.
Topics: Animals; Animals, Newborn; Basic Helix-Loop-Helix Transcription Factors; Brain; Cell Nucleus; Cuprizone; Cytoplasm; Demyelinating Diseases; DNA-Binding Proteins; Ethidium; Humans; Lysophosphatidylcholines; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Sheath; Nerve Tissue Proteins; Oligodendrocyte Transcription Factor 2; Oligodendroglia; Rats; Rats, Sprague-Dawley; Spinal Cord; Stem Cells; Transcription Factors | 2004 |
Demyelination increases radial diffusivity in corpus callosum of mouse brain.
Topics: Algorithms; Amidines; Amyloid beta-Peptides; Animals; Axons; Brain; Brain Chemistry; Chelating Agents; Corpus Callosum; Cuprizone; Demyelinating Diseases; Diffusion Magnetic Resonance Imaging; Histocytochemistry; Image Interpretation, Computer-Assisted; Male; Mice; Mice, Inbred C57BL; Myelin Sheath; Periodic Acid-Schiff Reaction; Tissue Fixation | 2005 |
Experimental demyelination caused by primary oligodendrocyte dystrophy. Regional distribution of the lesions in the nervous system of mice [corrected].
Topics: Animals; Brain; Chelating Agents; Cuprizone; Demyelinating Diseases; Humans; Immunohistochemistry; In Situ Hybridization; Male; Mice; Multiple Sclerosis; Oligodendroglia; Optic Nerve; Sciatic Nerve; Spinal Cord; Time Factors | 2005 |
Multicontrast MRI of remyelination in the central nervous system.
Topics: Animals; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Image Enhancement; Magnetic Resonance Imaging; Male; Mice; Mice, Inbred C57BL; Nerve Fibers, Myelinated; Nerve Regeneration | 2005 |
p75NTR independent oligodendrocyte death in cuprizone-induced demyelination in C57BL/6 mice.
Topics: Animals; Apoptosis; Corpus Callosum; Cuprizone; Demyelinating Diseases; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Monoamine Oxidase Inhibitors; Nerve Regeneration; Oligodendroglia; Receptor, Nerve Growth Factor; T-Lymphocytes | 2005 |
Upregulation of the stress-associated gene p8 in mouse models of demyelination and in multiple sclerosis tissues.
Topics: Animals; Apoptosis; Cell Death; Chelating Agents; Corpus Callosum; Cuprizone; Demyelinating Diseases; Encephalomyelitis, Autoimmune, Experimental; Immunohistochemistry; In Situ Hybridization; Macrophages; Mice; Mice, Inbred C57BL; Mice, Knockout; Multiple Sclerosis; Reverse Transcriptase Polymerase Chain Reaction; RNA; Stress, Psychological; Up-Regulation | 2006 |
Noninvasive detection of cuprizone induced axonal damage and demyelination in the mouse corpus callosum.
Topics: Animals; Brain Chemistry; Corpus Callosum; Cuprizone; Demyelinating Diseases; Diffuse Axonal Injury; Diffusion Magnetic Resonance Imaging; Linear Models; Mice; Mice, Inbred C57BL; Statistics, Nonparametric | 2006 |
Remyelination after cuprizone-induced demyelination in the rat is stimulated by apotransferrin.
Topics: Analysis of Variance; Animals; Animals, Newborn; Antigens; Apoproteins; Brain; Bromodeoxyuridine; CD11b Antigen; Cell Count; Cuprizone; Cytoskeletal Proteins; Demyelinating Diseases; Drug Interactions; Galactolipids; Glial Fibrillary Acidic Protein; Immunohistochemistry; Indoles; Myelin Basic Protein; Myelin Sheath; Proteoglycans; Rats; Rats, Wistar; Recovery of Function; Regeneration; Time Factors; Transferrin | 2006 |
Interferon-gamma inhibits central nervous system remyelination through a process modulated by endoplasmic reticulum stress.
Topics: Animals; Cuprizone; Demyelinating Diseases; eIF-2 Kinase; Encephalomyelitis, Autoimmune, Experimental; Endoplasmic Reticulum; Female; Interferon-gamma; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Multiple Sclerosis; Myelin Sheath; Nerve Regeneration; Oligodendroglia; Reverse Transcriptase Polymerase Chain Reaction; Stress, Physiological | 2006 |
Imaging the peripheral benzodiazepine receptor response in central nervous system demyelination and remyelination.
Topics: Animals; Corpus Callosum; Cuprizone; Demyelinating Diseases; Isoquinolines; Male; Mice; Mice, Inbred C57BL; Myelin Sheath; Neuroglia; Positron-Emission Tomography; Receptors, GABA-A | 2006 |
Age increases axon loss associated with primary demyelination in cuprizone-induced demyelination in C57BL/6 mice.
Topics: Aging; Animals; Axons; Corpus Callosum; Cuprizone; Demyelinating Diseases; Female; Mice; Mice, Inbred C57BL | 2006 |
Deleterious role of IFNgamma in a toxic model of central nervous system demyelination.
Topics: Animals; Brain; Central Nervous System; Corpus Callosum; Cuprizone; Cytokines; Demyelinating Diseases; Disease Models, Animal; Female; Growth Substances; Interferon gamma Receptor; Interferon-gamma; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia; Oligodendroglia; Receptors, Interferon; Time Factors | 2006 |
Suppressor of cytokine signaling 3 limits protection of leukemia inhibitory factor receptor signaling against central demyelination.
Topics: Animals; Chelating Agents; Ciliary Neurotrophic Factor; Cuprizone; Demyelinating Diseases; Interleukin-6; Leukemia Inhibitory Factor; Leukemia Inhibitory Factor Receptor alpha Subunit; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Myelin Sheath; Oligodendroglia; Receptors, Cytokine; Receptors, OSM-LIF; Signal Transduction; Suppressor of Cytokine Signaling 3 Protein; Suppressor of Cytokine Signaling Proteins; Tissue Distribution | 2006 |
A novel fluorescent probe that is brain permeable and selectively binds to myelin.
Topics: Aniline Compounds; Animals; Blood-Brain Barrier; Brain; Cuprizone; Demyelinating Diseases; Female; Fluorescent Dyes; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Myelin Sheath; Permeability; Stilbenes | 2006 |
Effects of commissural de- and remyelination on motor skill behaviour in the cuprizone mouse model of multiple sclerosis.
Topics: Analysis of Variance; Animals; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Female; Immunohistochemistry; Mice; Mice, Inbred C57BL; Monoamine Oxidase Inhibitors; Motor Skills; Multiple Sclerosis; Time Factors | 2006 |
Implications of protease M/neurosin in myelination during experimental demyelination and remyelination.
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Cells, Cultured; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Glutathione S-Transferase pi; Immunohistochemistry; Interferon-gamma; Kallikreins; Mice; Mice, Inbred BALB C; Monoamine Oxidase Inhibitors; Myelin Basic Protein; Myelin Sheath; Oligodendroglia; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Time Factors; Tumor Necrosis Factor-alpha | 2006 |
The neurotoxic effect of cuprizone on oligodendrocytes depends on the presence of pro-inflammatory cytokines secreted by microglia.
Topics: Animals; Cell Survival; Cells, Cultured; Culture Media, Conditioned; Cuprizone; Demyelinating Diseases; Immunohistochemistry; Interferon-gamma; Male; Mice; Microglia; Minocycline; Oligodendroglia; Rats; Tumor Necrosis Factor-alpha | 2007 |
Identification of genes preferentially expressed by microglia and upregulated during cuprizone-induced inflammation.
Topics: Animals; Biomarkers; Brain; Chelating Agents; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Gene Expression; In Situ Hybridization; Male; Mice; Mice, Inbred C57BL; Microglia; Neuritis; Oligonucleotide Array Sequence Analysis; RNA, Messenger; Spleen; Up-Regulation | 2007 |
Restoration of FcRgamma/Fyn signaling repairs central nervous system demyelination.
Topics: Aging; Animals; Anti-Inflammatory Agents; Central Nervous System; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Drugs, Chinese Herbal; Female; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Monoamine Oxidase Inhibitors; Multiple Sclerosis; Myelin Basic Protein; Myelin Sheath; Nerve Regeneration; Neuroprotective Agents; Neurotoxins; Proto-Oncogene Proteins c-fyn; Receptors, IgG; Recovery of Function; Signal Transduction | 2007 |
Behavioral deficits in the cuprizone-induced murine model of demyelination/remyelination.
Topics: Animals; Behavior, Animal; Brain; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Myelin Basic Protein | 2007 |
Microglial recruitment, activation, and proliferation in response to primary demyelination.
Topics: Animals; Cell Proliferation; Corpus Callosum; Cuprizone; Demyelinating Diseases; Female; Flow Cytometry; Immunohistochemistry; Macrophages; Mice; Mice, Inbred C57BL; Microglia; Monoamine Oxidase Inhibitors; T-Lymphocytes | 2007 |
Effects of acute and repeated exposure to lipopolysaccharide on cytokine and corticosterone production during remyelination.
Topics: Acute Disease; Animals; Body Weight; CD11b Antigen; Chelating Agents; Chronic Disease; Corpus Callosum; Corticosterone; Cuprizone; Cytokines; Demyelinating Diseases; Disease Models, Animal; Leukocyte Common Antigens; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Microglia; Myelin Basic Protein; Myelin Sheath; Nerve Regeneration; Spleen | 2007 |
Lymphotoxin beta receptor (Lt betaR): dual roles in demyelination and remyelination and successful therapeutic intervention using Lt betaR-Ig protein.
Topics: Animals; Apoptosis; Brain; Cell Division; Corpus Callosum; Cuprizone; Demyelinating Diseases; Immunoglobulin G; Lymphotoxin beta Receptor; Macrophages; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia; Myelin Sheath; Oligodendroglia; Recombinant Fusion Proteins; Time Factors; Tumor Necrosis Factor Ligand Superfamily Member 14 | 2007 |
Expression of an acyl-CoA synthetase, lipidosin, in astrocytes of the murine brain and its up-regulation during remyelination following cuprizone-induced demyelination.
Topics: Adrenoleukodystrophy; Animals; Astrocytes; Brain; Chelating Agents; Coenzyme A Ligases; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Fatty Acids; Glial Fibrillary Acidic Protein; Immunohistochemistry; Lipid Metabolism; Mice; Mice, Inbred ICR; Microscopy, Immunoelectron; Myelin Sheath; Nerve Regeneration; Rats; Rats, Wistar; RNA, Messenger; Up-Regulation | 2007 |
Sequential myelin protein expression during remyelination reveals fast and efficient repair after central nervous system demyelination.
Topics: Animals; Corpus Callosum; Cuprizone; Demyelinating Diseases; Immunohistochemistry; Indoles; Male; Mice; Mice, Inbred C57BL; Microscopy, Electron, Transmission; Monoamine Oxidase Inhibitors; Myelin Proteins; Nerve Fibers, Myelinated; Time | 2008 |
MRI identification of the rostral-caudal pattern of pathology within the corpus callosum in the cuprizone mouse model.
Topics: Animals; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Immunohistochemistry; Magnetic Resonance Imaging; Mice; Mice, Inbred C57BL; Monoamine Oxidase Inhibitors; Multiple Sclerosis | 2008 |
Platelet-derived growth factor promotes repair of chronically demyelinated white matter.
Topics: Animals; Apoptosis; Cell Proliferation; Corpus Callosum; Cuprizone; Demyelinating Diseases; Humans; Image Processing, Computer-Assisted; Immunohistochemistry; In Situ Hybridization; In Situ Nick-End Labeling; Mice; Mice, Transgenic; Monoamine Oxidase Inhibitors; Nerve Regeneration; Oligodendroglia; Platelet-Derived Growth Factor; Stem Cells; Time Factors | 2007 |
Epileptic seizures and hippocampal damage after cuprizone-induced demyelination in C57BL/6 mice.
Topics: Animals; Behavior, Animal; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Electroencephalography; Epilepsy; Gene Expression Regulation; Hippocampus; Male; Mice; Mice, Inbred C57BL; Myelin Proteolipid Protein; Myelin Sheath; Nerve Tissue Proteins; Neurons | 2008 |
TNF superfamily member TWEAK exacerbates inflammation and demyelination in the cuprizone-induced model.
Topics: Animals; Astrocytes; Chelating Agents; Copper; Cuprizone; Cytokine TWEAK; Demyelinating Diseases; Double-Blind Method; Encephalitis; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia; Myelin Sheath; Oligodendroglia; Receptors, Tumor Necrosis Factor; RNA, Messenger; Tumor Necrosis Factors; TWEAK Receptor | 2008 |
Leukemia inhibitory factor signaling modulates both central nervous system demyelination and myelin repair.
Topics: Analysis of Variance; Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Female; Glial Fibrillary Acidic Protein; Indoles; Leukemia Inhibitory Factor; Magnetic Resonance Imaging; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Knockout; Myelin Proteins; Myelin Sheath; Oligodendroglia; Severity of Illness Index; Signal Transduction; Wound Healing | 2008 |
The chemokine receptor CXCR2 is differentially regulated on glial cells in vivo but is not required for successful remyelination after cuprizone-induced demyelination.
Topics: Animals; Cuprizone; Demyelinating Diseases; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Mutant Strains; Myelin Sheath; Neuroglia; Receptors, Interleukin-8B; Stem Cells | 2008 |
Gas6 deficiency increases oligodendrocyte loss and microglial activation in response to cuprizone-induced demyelination.
Topics: Animals; Axl Receptor Tyrosine Kinase; c-Mer Tyrosine Kinase; Cell Death; Cell Survival; Cells, Cultured; Chelating Agents; Coculture Techniques; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Gliosis; Intercellular Signaling Peptides and Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia; Nerve Fibers, Myelinated; Neurotoxins; Oligodendroglia; Oncogene Proteins; Proto-Oncogene Proteins; Rats; Rats, Sprague-Dawley; Receptor Protein-Tyrosine Kinases | 2008 |
Remyelination protects axons from demyelination-associated axon degeneration.
Topics: Animals; Axons; Corpus Callosum; Cuprizone; Demyelinating Diseases; Diffusion Magnetic Resonance Imaging; Female; Green Fluorescent Proteins; Immunohistochemistry; Mice; Mice, Inbred C57BL; Mice, Transgenic; Models, Animal; Multiple Sclerosis; Myelin Sheath; Nerve Degeneration; Nerve Regeneration; Stem Cell Transplantation; X-Rays | 2008 |
Biochemical changes in Cuprizone-induced spongiform encephalopathy. I. Changes in the activities of 2',3'-cyclic nucleotide 3'-phosphohydrolase, oligodendroglial ceramide galactosyl transferase, and the hydrolysis of the alkenyl group of alkenyl, acyl-gly
Topics: 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase; 2',3'-Cyclic-Nucleotide Phosphodiesterases; Aging; Animals; Brain; Cuprizone; Cyclohexanes; Demyelinating Diseases; Galactolipids; Galactosyltransferases; Glycolipids; Hydrolases; Male; Mice; N-Acylsphingosine Galactosyltransferase; Oligodendroglia; Phosphoric Diester Hydrolases; Plasmalogens | 1983 |
Phosphatidylethanolamine methyltransferase activity in developing, demyelinating, and diabetic mouse brain.
Topics: Animals; Brain; Cuprizone; Demyelinating Diseases; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Humans; Methyltransferases; Mice; Mice, Inbred C57BL; Phosphatidylethanolamine N-Methyltransferase; Vitamin B 12 | 1983 |
Chronic demyelination inhibits remyelination in the central nervous system. An analysis of contributing factors.
Topics: Aging; Animals; Astrocytes; Axons; Central Nervous System; Cerebellum; Chronic Disease; Cuprizone; Demyelinating Diseases; Male; Mice; Microscopy, Electron; Myelin Sheath; Oligodendroglia | 1980 |
Rapid upregulation of the Pi isoform of glutathione-S-transferase in mouse brains after withdrawal of the neurotoxicant, cuprizone.
Topics: Animals; Astrocytes; Cuprizone; Demyelinating Diseases; Diet; Disease Models, Animal; Glutathione S-Transferase pi; Glutathione Transferase; Isoenzymes; Male; Mice; Microglia; Neurotoxins; Substance Withdrawal Syndrome; Time Factors; Up-Regulation; Weaning | 1997 |
Gene expression in brain during cuprizone-induced demyelination and remyelination.
Topics: Animals; Brain; Corpus Callosum; Cuprizone; Demyelinating Diseases; Diet; Galactosyltransferases; Gene Expression Regulation; Macrophages; Mice; Mice, Inbred C57BL; Microglia; Myelin Basic Protein; Myelin Proteins; Myelin Sheath; Myelin-Associated Glycoprotein; N-Acylsphingosine Galactosyltransferase; Phagocytosis; RNA, Messenger; Transcription, Genetic | 1998 |
Microglial/macrophage accumulation during cuprizone-induced demyelination in C57BL/6 mice.
Topics: Animals; Astrocytes; Body Weight; Brain; Cell Count; Chelating Agents; Copper; Corpus Callosum; Cuprizone; Demyelinating Diseases; Dose-Response Relationship, Drug; Liver; Macrophages; Male; Mice; Mice, Inbred C57BL; Microglia; Myelin Sheath; Time Factors | 1998 |
Mature oligodendrocyte apoptosis precedes IGF-1 production and oligodendrocyte progenitor accumulation and differentiation during demyelination/remyelination.
Topics: Animals; Apoptosis; Cell Count; Cell Differentiation; Corpus Callosum; Cuprizone; Demyelinating Diseases; Immunohistochemistry; Insulin-Like Growth Factor I; Male; Mice; Mice, Inbred C57BL; Myelin Sheath; Oligodendroglia; Stem Cells | 2000 |
Insulin-like growth factor-1 inhibits mature oligodendrocyte apoptosis during primary demyelination.
Topics: Acute Disease; Animals; Apoptosis; Brain Chemistry; Cell Survival; Chelating Agents; Corpus Callosum; Cuprizone; Demyelinating Diseases; Female; Gene Expression; Insulin-Like Growth Factor I; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microglia; Oligodendroglia; Recovery of Function; Stem Cells | 2000 |
Interferon-gamma protects against cuprizone-induced demyelination.
Topics: Animals; Astrocytes; Chelating Agents; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Gene Expression; Gliosis; Insulin-Like Growth Factor I; Interferon-gamma; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microglia; Myelin Proteins | 2000 |
Episodic demyelination and subsequent remyelination within the murine central nervous system: changes in axonal calibre.
Topics: Amidines; Animals; Axons; Cell Size; Central Nervous System; Chronic Disease; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Fluorescent Dyes; Mice; Mice, Inbred C57BL; Microscopy, Electron; Nerve Fibers, Myelinated; Recurrence; Remission, Spontaneous | 2001 |
Interleukin-1beta promotes repair of the CNS.
Topics: Animals; Antigens, Differentiation; Astrocytes; Cell Count; Central Nervous System; Chelating Agents; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Progression; Glutathione S-Transferase pi; Glutathione Transferase; Insulin-Like Growth Factor I; Interleukin-1; Isoenzymes; Macrophages; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia; Myelin Sheath; Oligodendroglia; Regeneration; RNA, Messenger; Stem Cells; Up-Regulation | 2001 |
TNF alpha promotes proliferation of oligodendrocyte progenitors and remyelination.
Topics: Animals; Antigens, CD; Apoptosis; B-Lymphocytes; Brain Chemistry; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Humans; Immunohistochemistry; In Situ Nick-End Labeling; Macrophages; Male; Mice; Mice, Knockout; Microglia; Monoamine Oxidase Inhibitors; Myelin Sheath; Oligodendroglia; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type I; Receptors, Tumor Necrosis Factor, Type II; Stem Cells; Tumor Necrosis Factor-alpha; Up-Regulation | 2001 |
The protective role of nitric oxide in a neurotoxicant-induced demyelinating model.
Topics: Animals; Apoptosis; Cell Movement; Corpus Callosum; Cuprizone; Demyelinating Diseases; Inflammation; Macrophages; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia; Microscopy, Fluorescence; Neuroprotective Agents; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oligodendroglia; Tyrosine | 2002 |
Alterations in metabolism and gene expression in brain regions during cuprizone-induced demyelination and remyelination.
Topics: Animals; Biomarkers; Brain; Brain Stem; Cerebellum; Cerebrosides; Chelating Agents; Cholesterol; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Disease Progression; Galactosyltransferases; Gene Expression Profiling; Gene Expression Regulation; Mice; Mice, Inbred C3H; Myelin Basic Protein; Myelin Sheath; N-Acylsphingosine Galactosyltransferase; Oligonucleotide Array Sequence Analysis; RNA, Messenger | 2002 |
Central nervous system demyelination and remyelination in the mouse: an ultrastructural study of cuprizone toxicity.
Topics: Animals; Axons; Cerebellum; Cuprizone; Cyclohexanes; Demyelinating Diseases; Male; Mice; Myelin Sheath; Time Factors | 1978 |
Insulin-like growth factor I gene expression is induced in astrocytes during experimental demyelination.
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Astrocytes; Cuprizone; Demyelinating Diseases; Gene Expression; Glial Fibrillary Acidic Protein; Immunoenzyme Techniques; Insulin-Like Growth Factor I; Male; Mice; Myelin Basic Protein; Nerve Tissue Proteins; Nucleic Acid Hybridization; Proteolipids; Receptors, Cell Surface; Receptors, Somatomedin; RNA, Messenger | 1992 |
Decrease in oligodendrocyte carbonic anhydrase activity preceding myelin degeneration in cuprizone induced demyelination.
Topics: Animals; Brain; Carbonic Anhydrases; Cuprizone; Demyelinating Diseases; Glial Fibrillary Acidic Protein; Male; Mice; Myelin Basic Protein; Myelin Sheath; Nerve Degeneration; Neuroglia; Oligodendroglia; Time Factors | 1987 |
Blood-brain barrier permeability during Cuprizone-induced demyelination. Implications for the pathogenesis of immune-mediated demyelinating diseases.
Topics: Animals; Blood-Brain Barrier; Cuprizone; Cyclohexanes; Demyelinating Diseases; Encephalomyelitis, Autoimmune, Experimental; Immunoenzyme Techniques; Male; Mesencephalon; Mice | 1987 |