cuprizone has been researched along with Allergic Encephalomyelitis in 69 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (1.45) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (10.14) | 29.6817 |
| 2010's | 39 (56.52) | 24.3611 |
| 2020's | 22 (31.88) | 2.80 |
| Authors | Studies |
|---|---|
| Bose, S; Böser, P; Cui, YF; Fung, E; Huang, L; Klein, C; Kutskova, YA; Memmott, J; Miller, R; Mueller, BK; Popp, A; Tarcsa, E; Veldman, GM | 1 |
| Luo, F; Luo, Y; Zhang, Z | 1 |
| Chang, L; Hashimoto, K; Ma, L; Qu, Y; Shan, J; Tan, Y; Wan, X; Wang, X; Yang, Y | 1 |
| Almolda, B; Castellano, B; Enrich-Bengoa, J; González, B; Manich, G; Perálvarez-Marín, A; Sanchez-Molina, P; Saura, J; Solà, C; Valente, T | 1 |
| Han, X; Huang, F; Jin, H; Liang, J; Shi, H; Tao, Y; Wu, H; Wu, X; Xu, N; Yang, L; Yuan, J; Zhang, X | 1 |
| Chen, Y; Du, X; Guo, Y; Li, M; Li, Q; Li, Y; Liu, L; Liu, Q; Ran, Q; Sun, L; Yang, L; Yang, Q; Zhu, X | 1 |
| Becher, B; Bechmann, I; Buch, T; Culmsee, C; Dolga, A; Gold, M; Huber, M; Ingold-Heppner, B; Kalaitzaki, V; Katsoulas, A; Krueger, M; Locatelli, G; Marques-Ferreira, F; Milchevskaya, V; Prazeres da Costa, O; Prinz, M; Sankowski, R; Tresch, A; Waisman, A; Walthert, S | 1 |
| Sun, J; Wang, D; Wang, J; Wang, Y; Wu, S; Zhang, H | 1 |
| Barnett, SC; Goodyear, CS; Kipp, M; Lindsay, SL; McCanney, GA; Scheld, M; Smith, RS; Turnbull, JE; Yates, EA; Zhan, J | 1 |
| Beiter, RM; Chappell, MS; Dupree, JL; Farber, E; Fernández-Castañeda, A; Gaultier, A; Johanson, DM; Liskey, D; Onengut-Gumuscu, S; Overall, CC; Rosen, DA; Seki, SM | 1 |
| Bando, Y; Geisler, JG | 1 |
| Bäuerle, T; González Alvarado, MN; Hoffmann, A; Kuhbandner, K; Linker, RA; Seyler, L; Winkler, J | 1 |
| Berger, L; González-Alvarado, MN; Haase, S; Kuhbandner, K; Lee, DH; Linker, RA; London, B; Rötger, C | 1 |
| Chen, WJ; Ciric, B; Curtis, MT; Li, X; Rostami, A; Zhang, GX; Zhang, Y | 1 |
| Calzado, MA; Feliú, A; García-Martin, A; Garrido-Rodríguez, M; Guaza, C; Mestre, L; Muñoz, E; Navarrete, C | 1 |
| Almuslehi, MSM; Coorssen, JR; Mahns, DA; Sen, MK; Shortland, PJ | 1 |
| Buonvicino, D; Chiarugi, A; Ranieri, G | 1 |
| Alberro, A; Castillo-Triviño, T; Egimendia, A; Iparraguirre, L; Moles, L; Muñoz-Culla, M; Osorio-Querejeta, I; Otaegui, D; Ramos-Cabrer, P; Sepúlveda, L; Suárez, J | 1 |
| Baumlin, N; Farine, H; Marrie, J; Martinic, MM; Mentzel, U; Pouzol, L; Sassi, A; Tunis, M; Vezzali, E | 1 |
| Chan, JR; Chen, Y; Kunjamma, RB; Popko, B; Weiner, M | 1 |
| Ahmad, I; Barsnes, H; Berven, FS; Bø, L; Guldbrandsen, A; Kroksveen, AC; Lereim, RR; Myhr, KM; Oveland, E; Wergeland, S | 1 |
| Cheng, X; Cruz, J; Ma, J; Peng, X; Ye, N; Zhang, A | 1 |
| Bassani, C; Bedogni, F; Colombo, E; Comi, G; Di Dario, M; Dina, G; Farina, C; Fermo, I; Fredrickx, E; Martinelli, V; Newcombe, J; Quattrini, A; Taveggia, C; Triolo, D | 1 |
| Biton, I; Chappell-Maor, L; David, E; Eilam-Altstadter, R; Engel, A; Gross, M; Grozovski, J; Jung, S; Kim, JS; Levy-Efrati, L; Rotkopf, R; Shemer, A; Wolf, Y | 1 |
| Becker, B; Beyer, C; Hustadt, F; Kipp, M; Leopold, P; Michel, A; Nyamoya, S; Schmitz, C | 1 |
| Clements, RJ; Freeman, EJ; Huang, H; McDonough, J; Popescu, DC; Shriver, L; Singhal, NK | 1 |
| Baharvand, H; Deng, W; Javan, M; Mokhtarzadeh Khanghahi, A; Satarian, L | 1 |
| Arnoux, I; Barger, Z; Bittner, S; Ellwardt, E; Jubal, ER; Kuhlmann, T; Luchtman, D; Lutz, B; Mandal, S; Mittmann, T; Novkovic, T; Pramanik, G; Ruiz de Azua, I; Schmalz, M; Stroh, A; Vogelaar, CF; Vogt, J; Zipp, F | 1 |
| Nissen, JC; Pretory, A; Thompson, KK; Tsirka, SE | 1 |
| Gu, Y; Huang, J; Huang, R; Jin, M; Li, Q; Wan, B; Xu, X; Zhang, Y | 1 |
| Bartenstein, P; Beyer, C; Brendel, M; Daerr, M; Deussing, M; Focke, C; Hoornaert, C; Kipp, M; Nack, A; Nedelcu, J; Nyamoya, S; Ponsaerts, P; Rominger, A; Schmitz, C | 1 |
| Baumgartner, L; de Vries, R; Galeno, G; Good, A; Good, N; Hlavica, M; Hooijmans, CR; Ineichen, BV; Jung, T; Schneider, MP; Schuler, FAF | 1 |
| Gu, H; Guo, YE; He, B; Suo, N; Xie, X | 1 |
| Amor, S; Beyer, C; Bhattarai, S; Chrzanowski, U; Clarner, T; Denecke, B; Fallier-Becker, P; Hochstrasser, T; Horn-Bochtler, A; Kipp, M; Nyamoya, S; Rohr, SO; Scheld, M; Schmitz, C; Schweiger, F | 1 |
| Behrangi, N; Hochstrasser, T; Horn, A; Kipp, M; Schmitz, C; Schweiger, F; Yakimov, V; Zhan, J | 1 |
| Itoh, N; Itoh, Y; Jang, E; Matsukawa, MA; Ren, E; Suen, TT; Tassoni, A; Tse, V; Voskuhl, RR | 1 |
| Connor, B; Kivell, B; La Flamme, AC; McCaughey-Chapman, A; Templeton, N | 1 |
| Eid, F; Gu, C; Jukkola, P; Nickel, M | 1 |
| Karagogeos, D; Kleopa, KA; Markoullis, K; Zoupi, L | 1 |
| Rawji, KS; Yong, VW | 1 |
| Ahmad, I; Deshmukh, VA; Gage, FH; Green, CC; Kerman, B; Kim, HJ; Kondo, T; Lairson, LL; Lawson, BR; Lyssiotis, CA; Padmanabhan, K; Schultz, PG; Swoboda, JG; Tardif, V; Theofilopoulos, AN | 1 |
| Harding, HP; Huang, G; Jamison, S; Li, J; Lin, W; Lin, Y; Ron, D | 1 |
| Attorri, L; Di Benedetto, R; Di Biase, A; Malchiodi, F; Martinelli, A; Salvati, S | 1 |
| Bauer, J; Binder, CJ; Bradl, M; Haider, L; Hametner, S; Lassmann, H; Liblau, RS; Mahad, D; Probert, L; Schuh, C; Smith, KJ; Van Dam, AM; Wimmer, I | 1 |
| Goings, GE; Miller, SD; Robinson, AP; Rodgers, JM | 1 |
| Coorssen, JR; Gopinath, S; Myers, SJ; Partridge, MA | 1 |
| Becher, B; Berrit-Schönthaler, H; Ingold-Heppner, B; Locatelli, G; Pehl, D; Schreiner, B | 1 |
| Abraham, CR; Avila, R; Chen, CD; Medicetty, S; Zeldich, E | 1 |
| Baxi, EG; Glenn, JD; Kirby, LA; Smith, MD; Whartenby, KA | 1 |
| Chopp, M; Elias, SB; Li, Y; Lu, M; Zhang, J; Zhang, Y; Zhang, ZG | 1 |
| Beyer, C; Clarner, T; Dreymüller, D; Fallier-Becker, P; Große-Veldmann, R; Kipp, M; Ohl, K; Rüther, BJ; Scheld, M; Tenbrock, K; Zendedel, A | 1 |
| Baer, M; Benusa, SD; Clark, KC; Davenne, M; DeVries, GH; Dilsizoglu-Senol, A; Dupree, JL; Elford, H; Hartley, RK; Josephson, A; Joslyn, M; Lubetzki, C; Oh, U; Sword, BA; Thummala, S | 1 |
| Becker, B; Beyer, C; Clarner, T; Hochstrasser, T; Kipp, M; Scheld, M; Wagenknecht, N | 1 |
| Beyer, C; Clarner, T; Hochstrasser, T; Höflich, KM; Kipp, M; Nyamoya, S; Schmitz, C | 1 |
| Amor, S; Hochstrasser, T; Kipp, M; Nyamoya, S | 1 |
| Barrette, B; Berghoff, SA; Böhler, C; Dibaj, P; Edgar, JM; Gerndt, N; Hosang, L; Liebetanz, D; Möbius, W; Odoardi, F; Ruhwedel, T; Saher, G; Stassart, R; Stumpf, SK; Winchenbach, J | 1 |
| Bollyky, PL; Han, MH; Kuipers, HF; Palmer, TD; Steinman, L; van Horssen, J; Yoon, J | 1 |
| Grund, LZ; Komegae, EN; Lima, C; Lopes-Ferreira, M; Souza, TA | 1 |
| Chew, LJ; Schmitz, T | 1 |
| Correcha, M; Fordham, SA; Liñares, D; Maña, P; Silva, D; Staykova, MA; Willenborg, DO | 1 |
| Brinkmann, BG; Brück, W; Glaser, R; Guedes, RC; Jürgens, T; Klinker, F; Liebetanz, D; Merkler, D; Paulus, W; Sereda, MW; Stadelmann-Nessler, C | 1 |
| Choi, K; Darnall, L; Hu, T; Lane, TE; Liu, L; Ransohoff, RM | 1 |
| Amor, S; Baumgartner, W; Beyer, C; Clarner, T; Denecke, B; Dreher, W; Gan, L; Gingele, S; Godbout, R; Kipp, M; Pfeifenbring, S; Pott, F; Siffrin, V; van der Valk, P; Zipp, F | 1 |
| Boretius, S; Brück, W; Dallenga, T; Escher, A; Frahm, J; Nessler, S; Stadelmann, C; Tammer, R; Wrzos, C | 1 |
| Araújo, GW; Herrmann, MM; Mandelkow, EM; Merkler, D; Schneider, A; Simons, M; Trajkovic, K; Weissert, R | 1 |
| Arnett, HA; Bergstralh, DT; Carson, MJ; Iovanna, JL; McMahon, EJ; Miller, SD; Plant, SR; Thrash, JC; Ting, JP; Vasseur, S; Wang, Y | 1 |
| Dupree, JL; Harding, HP; Kemper, A; Lin, W; Popko, B; Ron, D | 1 |
| Biswas, S; Emerson, MR; LeVine, SM | 1 |
| Bakker, DA; Ludwin, SK | 1 |
5 review(s) available for cuprizone and Allergic Encephalomyelitis
| Article | Year |
|---|---|
Revisiting the Pathoetiology of Multiple Sclerosis: Has the Tail Been Wagging the Mouse?
Topics: Animals; Autoimmunity; Central Nervous System; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Disease Progression; Encephalomyelitis, Autoimmune, Experimental; Humans; Mice; Multiple Sclerosis; Oligodendroglia | 2020 |
Remyelination promoting therapies in multiple sclerosis animal models: a systematic review and meta-analysis.
Topics: Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Ethidium; Eye Proteins; Lysophosphatidylcholines; Mice; Multiple Sclerosis; Myelin Sheath; Nerve Growth Factors; Oligodendrocyte Precursor Cells; Oligodendroglia; Platelet-Derived Growth Factor; Remyelination; Serpins; Tocopherols | 2019 |
The benefits and detriments of macrophages/microglia in models of multiple sclerosis.
Topics: Animals; Cell Movement; Central Nervous System; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Humans; Immunologic Factors; Lysophosphatidylcholines; Macrophages; Microglia; Multiple Sclerosis; Neurons; Oligodendroglia; T-Lymphocytes | 2013 |
Multiple sclerosis animal models: a clinical and histopathological perspective.
Topics: Animals; Axons; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Disease Progression; Encephalomyelitis, Autoimmune, Experimental; Humans; Leukoencephalopathies; Multiple Sclerosis; Neurodegenerative Diseases; Spinal Cord | 2017 |
Cytokines and myelination in the central nervous system.
Topics: Alzheimer Disease; Animals; Brain; Brain Ischemia; Central Nervous System; Cuprizone; Cytokines; Demyelinating Diseases; Encephalomyelitis, Autoimmune, Experimental; Humans; Hyperoxia; Infant, Newborn; Inflammation; Multiple Sclerosis; Myelin Sheath; Schizophrenia; Signal Transduction | 2008 |
64 other study(ies) available for cuprizone and Allergic Encephalomyelitis
| Article | Year |
|---|---|
Elezanumab, a clinical stage human monoclonal antibody that selectively targets repulsive guidance molecule A to promote neuroregeneration and neuroprotection in neuronal injury and demyelination models.
Topics: Animals; Cuprizone; Encephalomyelitis, Autoimmune, Experimental; GPI-Linked Proteins; Mice; Monoamine Oxidase Inhibitors; Nerve Regeneration; Nerve Tissue Proteins; Neuroprotection; Optic Nerve; Optic Nerve Injuries; Optic Neuritis; Recovery of Function; Retina; Surface Plasmon Resonance | 2021 |
Differential Role of p53 in Oligodendrocyte Survival in Response to Various Stresses: Experimental Autoimmune Encephalomyelitis, Cuprizone Intoxication or White Matter Stroke.
Topics: Animals; Chelating Agents; Cuprizone; Encephalomyelitis, Autoimmune, Experimental; Female; Leukoencephalopathies; Male; Memory Disorders; Mice; Mice, Inbred C57BL; Mice, Knockout; Oligodendroglia; Stroke; Tumor Suppressor Protein p53 | 2021 |
(R)-ketamine ameliorates demyelination and facilitates remyelination in cuprizone-treated mice: A role of gut-microbiota-brain axis.
Topics: Animals; Brain; Cuprizone; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Humans; Ketamine; Mice; Mice, Inbred C57BL; Microbiota; Microglia; Myelin Sheath; Oligodendroglia; Remyelination; RNA, Ribosomal, 16S | 2022 |
TRPV2: A Key Player in Myelination Disorders of the Central Nervous System.
Topics: Animals; Calcium Channels; Central Nervous System; Cuprizone; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Humans; Inflammation; Mice; Mice, Inbred C57BL; Myelin Sheath; Oligodendroglia; Remyelination; TRPV Cation Channels | 2022 |
Total astragalosides promote oligodendrocyte precursor cell differentiation and enhance remyelination in cuprizone-induced mice through suppression of Wnt/β-catenin signaling pathway.
Topics: Animals; beta Catenin; Cell Differentiation; Cuprizone; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Humans; Mice; Mice, Inbred C57BL; Myelin Sheath; Oligodendrocyte Precursor Cells; Oligodendroglia; Remyelination; Wnt Signaling Pathway | 2022 |
Ginsenoside Rg1 promotes remyelination and functional recovery in demyelinating disease by enhancing oligodendrocyte precursor cells-mediated myelin repair.
Topics: Animals; beta Catenin; Cell Differentiation; Cuprizone; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Ginsenosides; Glycogen Synthase Kinase 3 beta; Mice; Mice, Inbred C57BL; Myelin Sheath; Oligodendrocyte Precursor Cells; Remyelination | 2022 |
IGF1R expression by adult oligodendrocytes is not required in the steady-state but supports neuroinflammation.
Topics: Animals; Cuprizone; Encephalomyelitis, Autoimmune, Experimental; Insulin-Like Growth Factor I; Mice; Mice, Inbred C57BL; Myelin Sheath; Neuroinflammatory Diseases; Oligodendroglia; Receptor, IGF Type 1 | 2023 |
Huperzine-A Improved Animal Behavior in Cuprizone-Induced Mouse Model by Alleviating Demyelination and Neuroinflammation.
Topics: Acetylcholinesterase; Animals; Behavior, Animal; Cuprizone; Cytokines; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Neuroinflammatory Diseases | 2022 |
Low sulfated heparan sulfate mimetic differentially affects repair in immune-mediated and toxin-induced experimental models of demyelination.
Topics: Animals; Central Nervous System Diseases; Corpus Callosum; Cuprizone; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Heparitin Sulfate; Mice; Mice, Inbred C57BL; Myelin Sheath; Oligodendroglia; Sulfates | 2023 |
The active contribution of OPCs to neuroinflammation is mediated by LRP1.
Topics: Animals; Cell Culture Techniques; Cell Differentiation; Cuprizone; Encephalomyelitis, Autoimmune, Experimental; Histocompatibility Antigens Class I; Humans; Low Density Lipoprotein Receptor-Related Protein-1; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Oligodendrocyte Precursor Cells | 2020 |
Disease modifying mitochondrial uncouplers, MP101, and a slow release ProDrug, MP201, in models of Multiple Sclerosis.
Topics: 2,4-Dinitrophenol; Animals; Axons; Brain-Derived Neurotrophic Factor; Cuprizone; Cytokines; Delayed-Action Preparations; Demyelinating Diseases; Encephalitis; Encephalomyelitis, Autoimmune, Experimental; Female; Immunization; Mice; Mice, Inbred C57BL; Mitochondria; Multiple Sclerosis; Nerve Growth Factors; Paralysis; Prodrugs; Uncoupling Agents | 2019 |
alpha-Synuclein: a Modulator During Inflammatory CNS Demyelination.
Topics: alpha-Synuclein; Animals; Cuprizone; Encephalomyelitis, Autoimmune, Experimental; Mice; Mice, Inbred C57BL; Myelin Sheath; Spinal Cord | 2020 |
Functional role of endogenous Kv1.4 in experimental demyelination.
Topics: Animals; Cell Proliferation; Chelating Agents; Cuprizone; Demyelinating Diseases; Encephalomyelitis, Autoimmune, Experimental; Kv1.4 Potassium Channel; Mice; Mice, Inbred C57BL; Mice, Knockout; Oligodendroglia; Remyelination; Th1 Cells | 2020 |
A dual effect of ursolic acid to the treatment of multiple sclerosis through both immunomodulation and direct remyelination.
Topics: Animals; Astrocytes; Cell Differentiation; Corpus Callosum; Cuprizone; Encephalomyelitis, Autoimmune, Experimental; Female; Gene Expression Regulation; Humans; Immunomodulation; Male; Mice; Multiple Sclerosis; Myelin Sheath; Oligodendroglia; PPAR gamma; Remyelination; Triterpenes; Ursolic Acid | 2020 |
Effects of EHP-101 on inflammation and remyelination in murine models of Multiple sclerosis.
Topics: Animals; Cannabinoid Receptor Agonists; Cannabinoids; Chelating Agents; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Inflammation; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Remyelination; Spinal Cord | 2020 |
Cuprizone-Dependent De/Remyelination Responses and Functional Correlates in Mouse Strains Adopted to Model Relapsing, Chronic and Progressive Experimental Autoimmune Encephalomyelitis.
Topics: Animals; Chelating Agents; Chronic Disease; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Disease Progression; Encephalomyelitis, Autoimmune, Experimental; Female; Mice; Mice, Inbred C57BL; Mice, Inbred NOD; Myelin Sheath; Remyelination | 2021 |
Gut Microbiota Changes in Experimental Autoimmune Encephalomyelitis and Cuprizone Mice Models.
Topics: Animals; Cuprizone; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Gastrointestinal Microbiome; Humans; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Neurodegenerative Diseases | 2021 |
ACT-1004-1239, a first-in-class CXCR7 antagonist with both immunomodulatory and promyelinating effects for the treatment of inflammatory demyelinating diseases.
Topics: Animals; Cell Differentiation; Cuprizone; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Immunomodulation; Inflammation; Male; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Sheath; Myelin-Oligodendrocyte Glycoprotein; Oligodendroglia; Receptors, CXCR; Stem Cells | 2021 |
Prolonging the integrated stress response enhances CNS remyelination in an inflammatory environment.
Topics: Animals; Axons; Central Nervous System; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Inflammation; Interferon-gamma; Male; Mice; Oligodendroglia; Remyelination | 2021 |
Cuprizone and EAE mouse frontal cortex proteomics revealed proteins altered in multiple sclerosis.
Topics: Adult; Aged; Aged, 80 and over; Animals; Biomarkers; Complement C1q; Cuprizone; Cysteine Endopeptidases; Encephalomyelitis, Autoimmune, Experimental; Female; Frontal Lobe; Gene Expression Regulation; Hemopexin; Humans; Immunohistochemistry; Male; Mice; Middle Aged; Multiple Sclerosis; Proteomics; Young Adult | 2021 |
Remyelination is enhanced by Astragalus polysaccharides through inducing the differentiation of oligodendrocytes from neural stem cells in cuprizone model of demyelination.
Topics: Animals; Astragalus Plant; Cell Differentiation; Chelating Agents; Cuprizone; Encephalomyelitis, Autoimmune, Experimental; Male; Mice; Mice, Inbred C57BL; Neural Stem Cells; Oligodendroglia; Polysaccharides; Remyelination | 2021 |
Dysregulated copper transport in multiple sclerosis may cause demyelination via astrocytes.
Topics: Animals; Astrocytes; Biological Transport; Chronic Disease; Cicatrix; Copper; Cuprizone; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Humans; Inflammation; Ligands; Membrane Transport Proteins; Mice, Knockout; Multiple Sclerosis; Myelin Sheath; Nerve Growth Factors; Receptor, trkB; Up-Regulation; White Matter | 2021 |
Microglial MHC class II is dispensable for experimental autoimmune encephalomyelitis and cuprizone-induced demyelination.
Topics: Animals; Antigen Presentation; Cell Proliferation; Central Nervous System; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Histocompatibility Antigens Class II; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia; Multiple Sclerosis | 2018 |
G-Protein-Coupled Receptor Gpr17 Expression in Two Multiple Sclerosis Remyelination Models.
Topics: Animals; Cerebral Cortex; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Gray Matter; Male; Mice; Multiple Sclerosis; Myelin Sheath; Nerve Tissue Proteins; Receptors, G-Protein-Coupled; Remyelination; White Matter | 2019 |
Vitamin K enhances the production of brain sulfatides during remyelination.
Topics: Animals; Brain; Cuprizone; Encephalomyelitis, Autoimmune, Experimental; Galactosylceramides; Male; Mice, Inbred C57BL; Multiple Sclerosis; Neuroprotective Agents; Remyelination; Sulfoglycosphingolipids; Swine; Vitamin D; Vitamin K | 2018 |
In vivo conversion of astrocytes into oligodendrocyte lineage cells with transcription factor Sox10; Promise for myelin repair in multiple sclerosis.
Topics: Animals; Astrocytes; Cell Lineage; Cells, Cultured; Cuprizone; Encephalomyelitis, Autoimmune, Experimental; Green Fluorescent Proteins; HEK293 Cells; Humans; Male; Mice, Inbred C57BL; Multiple Sclerosis; Oligodendroglia; SOXE Transcription Factors | 2018 |
Maladaptive cortical hyperactivity upon recovery from experimental autoimmune encephalomyelitis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbazoles; Cells, Cultured; Cerebral Cortex; Cuprizone; Disease Models, Animal; Egtazic Acid; Encephalomyelitis, Autoimmune, Experimental; Excitatory Amino Acid Antagonists; Female; Freund's Adjuvant; Hyperkinesis; Membrane Potentials; Mice; Mice, Transgenic; Microglia; Myelin Proteolipid Protein; Peptide Fragments; Proto-Oncogene Proteins c-fos; Quinoxalines; Recovery of Function; Sodium Channel Blockers; Tetrodotoxin | 2018 |
Tuftsin Combines With Remyelinating Therapy and Improves Outcomes in Models of CNS Demyelinating Disease.
Topics: Animals; Benztropine; Cuprizone; Disease Models, Animal; Drug Therapy, Combination; Encephalomyelitis, Autoimmune, Experimental; Mice; Multiple Sclerosis; Myelin Sheath; Tuftsin | 2018 |
Leonurine suppresses neuroinflammation through promoting oligodendrocyte maturation.
Topics: Animals; Cell Differentiation; Central Nervous System; Cuprizone; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Gallic Acid; Humans; Inflammation; Jumonji Domain-Containing Histone Demethylases; Mice; Microglia; Multiple Sclerosis; Myelin Sheath; Neurogenesis; Oligodendroglia; Remyelination | 2019 |
Expression of Translocator Protein and [18F]-GE180 Ligand Uptake in Multiple Sclerosis Animal Models.
Topics: Animals; Astrocytes; Axons; Biomarkers; Carbazoles; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Inflammation; Ligands; Mice, Inbred C57BL; Mitochondria; Monocytes; Multiple Sclerosis; Neuroglia; Receptors, GABA; RNA, Messenger | 2019 |
Inhibition of MAPK/ERK pathway promotes oligodendrocytes generation and recovery of demyelinating diseases.
Topics: Animals; Cells, Cultured; Cerebral Cortex; Coculture Techniques; Cuprizone; Demyelinating Diseases; Encephalomyelitis, Autoimmune, Experimental; Enzyme Inhibitors; Female; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Oligodendroglia; Recovery of Function; Remyelination | 2019 |
Oligodendrocyte degeneration and concomitant microglia activation directs peripheral immune cells into the forebrain.
Topics: Animals; Cuprizone; Encephalomyelitis, Autoimmune, Experimental; Female; Immunity, Cellular; Male; Mice; Mice, Inbred C57BL; Microglia; Multiple Sclerosis; Myelin-Oligodendrocyte Glycoprotein; Oligodendroglia; Peptide Fragments; Prosencephalon | 2019 |
Continuous cuprizone intoxication allows active experimental autoimmune encephalomyelitis induction in C57BL/6 mice.
Topics: Administration, Oral; Animals; Apoptosis; Cuprizone; Encephalomyelitis, Autoimmune, Experimental; Female; Mice; Mice, Inbred C57BL; Myelin-Oligodendrocyte Glycoprotein; Oligodendroglia; Peptide Fragments | 2019 |
Gene expression in oligodendrocytes during remyelination reveals cholesterol homeostasis as a therapeutic target in multiple sclerosis.
Topics: Animals; Case-Control Studies; Cholesterol; Cuprizone; Encephalomyelitis, Autoimmune, Experimental; Estrogen Receptor beta; Female; Gene Expression; Homeostasis; Humans; Mice, Inbred C57BL; Middle Aged; Multiple Sclerosis; Oligodendroglia; Remyelination; Sequence Analysis, RNA | 2019 |
Clozapine administration enhanced functional recovery after cuprizone demyelination.
Topics: Animals; Astrocytes; Central Nervous System; Clozapine; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Sheath | 2019 |
Copper chelation and autoimmunity differentially impact myelin in the hippocampal-prefrontal circuit.
Topics: Animals; Autoimmunity; Chelating Agents; Copper; Cuprizone; Encephalomyelitis, Autoimmune, Experimental; Female; Hippocampus; Male; Mice; Myelin Sheath; Nerve Net; Prefrontal Cortex | 2019 |
Alterations of juxtaparanodal domains in two rodent models of CNS demyelination.
Topics: Animals; Central Nervous System; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Male; Mice, Inbred C57BL; Nerve Fibers, Myelinated; Protein Structure, Tertiary | 2013 |
A regenerative approach to the treatment of multiple sclerosis.
Topics: Animals; Antiparkinson Agents; Benztropine; Cell Differentiation; Coculture Techniques; Cuprizone; Encephalomyelitis, Autoimmune, Experimental; Female; Fingolimod Hydrochloride; Immune System; Mice; Mice, Inbred C57BL; Models, Biological; Multiple Sclerosis; Myelin Proteolipid Protein; Myelin Sheath; Oligodendroglia; Optic Nerve; Propylene Glycols; Rats; Receptor, Muscarinic M1; Receptor, Muscarinic M3; Recurrence; Regeneration; Sphingosine; Stem Cells | 2013 |
PERK activation preserves the viability and function of remyelinating oligodendrocytes in immune-mediated demyelinating diseases.
Topics: Animals; Axons; Cell Death; Cell Survival; Cuprizone; Cytoprotection; Demyelinating Diseases; eIF-2 Kinase; Encephalomyelitis, Autoimmune, Experimental; Enzyme Activation; Inflammation; Interferon-gamma; Mice; Mice, Inbred C57BL; Myelin Sheath; Oligodendroglia; Signal Transduction; Tacrolimus; Tremor | 2014 |
Eicosapentaenoic acid pre-treatment reduces biochemical changes induced in total brain and myelin of weanling Wistar rats by cuprizone feeding.
Topics: Animals; Brain; Cells, Cultured; Cerebrosides; Cuprizone; Drug Evaluation, Preclinical; Eicosapentaenoic Acid; Encephalomyelitis, Autoimmune, Experimental; Erythrocytes; Fatty Acids; Inflammation Mediators; Myelin Sheath; Neuroprotective Agents; Oligodendroglia; Rats; Rats, Wistar; Weaning | 2014 |
Oxidative tissue injury in multiple sclerosis is only partly reflected in experimental disease models.
Topics: Aging; Animals; CD4 Antigens; CD8 Antigens; Coronavirus Infections; Cuprizone; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Gene Expression; Iron; Lipopolysaccharides; Macrophages; Mice, Inbred C57BL; Microglia; Multiple Sclerosis; Myelin-Oligodendrocyte Glycoprotein; Oxidative Stress; Peptide Fragments; Rats; Rats, Inbred Lew; Respiratory Burst; T-Lymphocytes | 2014 |
Characterization of oligodendroglial populations in mouse demyelinating disease using flow cytometry: clues for MS pathogenesis.
Topics: Animals; Antibodies; Antigens; Cells, Cultured; Cuprizone; Demyelinating Diseases; Encephalomyelitis, Autoimmune, Experimental; Female; Flow Cytometry; Humans; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Oligodendroglia; Stem Cells | 2014 |
Proteomics of a conundrum: Thoughts on addressing the aetiology versus progression of multiple sclerosis.
Topics: Animals; Cuprizone; Demyelinating Diseases; Encephalomyelitis, Autoimmune, Experimental; Humans; Multiple Sclerosis; Proteomics | 2015 |
Deletion of Jun proteins in adult oligodendrocytes does not perturb cell survival, or myelin maintenance in vivo.
Topics: Animals; Brain; Cell Survival; Cuprizone; Demyelinating Diseases; Encephalomyelitis, Autoimmune, Experimental; Female; Mice; Mice, Knockout; Motor Activity; Oligodendroglia; Phenotype; Proto-Oncogene Proteins c-jun; Transcription Factors | 2015 |
The Anti-Aging Protein Klotho Enhances Remyelination Following Cuprizone-Induced Demyelination.
Topics: Animals; Corpus Callosum; Cuprizone; Encephalomyelitis, Autoimmune, Experimental; Glucuronidase; Glutathione S-Transferase pi; Klotho Proteins; Mice; Mice, Inbred C57BL; Monoamine Oxidase Inhibitors; Myelin Sheath; Oligodendroglia; Receptor, Platelet-Derived Growth Factor alpha | 2015 |
Disparate Effects of Mesenchymal Stem Cells in Experimental Autoimmune Encephalomyelitis and Cuprizone-Induced Demyelination.
Topics: Animals; CD4-Positive T-Lymphocytes; Cell Death; Cell Proliferation; Corpus Callosum; Cuprizone; Cytokines; Demyelinating Diseases; Encephalomyelitis, Autoimmune, Experimental; Female; Lymphocyte Subsets; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mice, Inbred C57BL; Myelin-Oligodendrocyte Glycoprotein; Oligodendroglia; Peptide Fragments | 2015 |
Thymosin beta4 promotes oligodendrogenesis in the demyelinating central nervous system.
Topics: Animals; Cell Differentiation; Cell Proliferation; Cells, Cultured; Chelating Agents; Cuprizone; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Enzyme Inhibitors; ErbB Receptors; Female; Mice; Mice, Inbred C57BL; Myelin Basic Protein; Myelin Proteolipid Protein; Oligodendroglia; Peptide Fragments; Proteoglycans; Quinazolines; Stem Cells; Thymosin; Time Factors; Tyrphostins | 2016 |
Neurodegeneration Triggers Peripheral Immune Cell Recruitment into the Forebrain.
Topics: Adoptive Transfer; Animals; Calcium-Binding Proteins; CD3 Complex; Chelating Agents; Cuprizone; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Freund's Adjuvant; Lymph Nodes; Lymphocytes; Mice; Mice, Inbred C57BL; Microfilament Proteins; Monocytes; Myelin-Oligodendrocyte Glycoprotein; Neurodegenerative Diseases; Peptide Fragments; Pertussis Toxin; Prosencephalon | 2016 |
Compromised axon initial segment integrity in EAE is preceded by microglial reactivity and contact.
Topics: Animals; Animals, Genetically Modified; Autoimmune Diseases of the Nervous System; Axon Initial Segment; Axons; CD11b Antigen; Cell Death; Cells, Cultured; Cuprizone; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Gene Expression Regulation; Hydroxamic Acids; Macrophage Colony-Stimulating Factor; Mice; Mice, Inbred C57BL; Microglia; Monoamine Oxidase Inhibitors; Nitric Oxide Synthase Type II; Thy-1 Antigens; Tumor Necrosis Factor-alpha | 2016 |
Thalamus Degeneration and Inflammation in Two Distinct Multiple Sclerosis Animal Models.
Topics: Animals; Cuprizone; Encephalomyelitis, Autoimmune, Experimental; Inflammation; Mice; Mice, Inbred C57BL; Spinal Cord; Thalamus | 2016 |
Acute axonal damage in three different murine models of multiple sclerosis: A comparative approach.
Topics: Amyloid beta-Protein Precursor; Animals; Axons; Brain; Corpus Callosum; Cuprizone; Demyelinating Diseases; Encephalomyelitis, Autoimmune, Experimental; Immunohistochemistry; Inflammation; Mice; Mice, Inbred C57BL; Microglia; Models, Animal; Multiple Sclerosis; Myelin Sheath; Nerve Degeneration; Spinal Cord | 2016 |
Dietary cholesterol promotes repair of demyelinated lesions in the adult brain.
Topics: Animals; Axons; Biomarkers; Brain; Cell Differentiation; Cell Proliferation; Cells, Cultured; Cholesterol; Cholesterol, Dietary; Cuprizone; Dietary Supplements; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Humans; Male; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Proteins; Oligodendroglia; Primary Cell Culture; Stem Cells | 2017 |
Phosphorylation of αB-crystallin supports reactive astrogliosis in demyelination.
Topics: alpha-Crystallin B Chain; Animals; Astrocytes; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Humans; Male; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Nerve Tissue Proteins; Oligodendroglia; Phosphorylation | 2017 |
Multiple functional therapeutic effects of TnP: A small stable synthetic peptide derived from fish venom in a mouse model of multiple sclerosis.
Topics: Amino Acid Sequence; Animals; Antigens, Differentiation; Brazil; Cuprizone; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Fish Venoms; Gene Expression Regulation; Immunologic Factors; Interferon-gamma; Interleukin-10; Interleukin-17; Macrophages; Matrix Metalloproteinase 9; Mice; Multiple Sclerosis; Peptides; Perciformes; Spinal Cord; T-Lymphocytes, Regulatory; Th1 Cells; Th17 Cells | 2017 |
Demyelination caused by the copper chelator cuprizone halts T cell mediated autoimmune neuroinflammation.
Topics: Animals; Antibody Specificity; Antigens; Chelating Agents; Cuprizone; Cytokines; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Glycoproteins; Immune Tolerance; Lymphocyte Activation; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myelin Proteins; Myelin Sheath; Myelin-Oligodendrocyte Glycoprotein; Peptide Fragments; T-Lymphocytes | 2009 |
Propagation of spreading depression inversely correlates with cortical myelin content.
Topics: Animals; Astrocytes; Cerebral Cortex; Cortical Spreading Depression; Cuprizone; Demyelinating Diseases; Electroencephalography; Encephalomyelitis, Autoimmune, Experimental; Female; Functional Laterality; Glial Fibrillary Acidic Protein; Gliosis; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Transgenic; Multiple Sclerosis; Myelin Basic Protein; Myelin Sheath; Neuregulin-1; Rats; Rats, Inbred Lew | 2009 |
Myelin repair is accelerated by inactivating CXCR2 on nonhematopoietic cells.
Topics: Animals; Animals, Newborn; Antibodies; Bone Marrow; Cell Differentiation; Central Nervous System Stimulants; Cerebellum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Flow Cytometry; Freund's Adjuvant; Glycoproteins; In Vitro Techniques; Leukocyte Common Antigens; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Mice, Knockout; Microscopy, Electron, Transmission; Myelin Basic Protein; Myelin Proteolipid Protein; Myelin Sheath; Myelin-Oligodendrocyte Glycoprotein; Nerve Regeneration; Neurologic Examination; Oligodendroglia; Peptide Fragments; Picrotoxin; Proliferating Cell Nuclear Antigen; Receptors, Interleukin-8B; Recovery of Function; Severity of Illness Index; Stem Cells; Time Factors | 2010 |
BLBP-expression in astrocytes during experimental demyelination and in human multiple sclerosis lesions.
Topics: Adult; Aged; Animals; Astrocytes; Blotting, Western; Carrier Proteins; Cell Count; Cell Line, Tumor; Cuprizone; Demyelinating Diseases; Encephalomyelitis, Autoimmune, Experimental; Fatty Acid-Binding Protein 7; Fatty Acid-Binding Proteins; Female; Fibroblast Growth Factor 2; Fluorescent Antibody Technique, Indirect; Glial Fibrillary Acidic Protein; Humans; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Middle Aged; Multiple Sclerosis; Nerve Tissue Proteins; Oligonucleotide Array Sequence Analysis; Osteopontin; Platelet-Derived Growth Factor; Real-Time Polymerase Chain Reaction; RNA, Messenger; Transfection; Tumor Suppressor Proteins | 2011 |
Assessment of lesion pathology in a new animal model of MS by multiparametric MRI and DTI.
Topics: Animals; Axons; Blood-Brain Barrier; Brain; Cuprizone; Demyelinating Diseases; Diffusion Tensor Imaging; Discriminant Analysis; Encephalomyelitis, Autoimmune, Experimental; Female; Gliosis; Image Processing, Computer-Assisted; Inflammation; Magnetic Resonance Imaging; Mice; Mice, Inbred C57BL; Monoamine Oxidase Inhibitors; Multiple Sclerosis; Pertussis Toxin | 2012 |
Hyperphosphorylation and aggregation of tau in experimental autoimmune encephalomyelitis.
Topics: Animals; Blotting, Western; Brain; Cells, Cultured; Cuprizone; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinases; Encephalomyelitis, Autoimmune, Experimental; Glucocorticoids; Immunohistochemistry; Mice; Mice, Inbred C57BL; Microtubules; Models, Genetic; Neurodegenerative Diseases; Oligodendroglia; Phosphoprotein Phosphatases; Phosphorylation; Prednisolone; Protein Structure, Tertiary; Rats; tau Proteins; Time Factors; Up-Regulation | 2004 |
Upregulation of the stress-associated gene p8 in mouse models of demyelination and in multiple sclerosis tissues.
Topics: Animals; Apoptosis; Cell Death; Chelating Agents; Corpus Callosum; Cuprizone; Demyelinating Diseases; Encephalomyelitis, Autoimmune, Experimental; Immunohistochemistry; In Situ Hybridization; Macrophages; Mice; Mice, Inbred C57BL; Mice, Knockout; Multiple Sclerosis; Reverse Transcriptase Polymerase Chain Reaction; RNA; Stress, Psychological; Up-Regulation | 2006 |
Interferon-gamma inhibits central nervous system remyelination through a process modulated by endoplasmic reticulum stress.
Topics: Animals; Cuprizone; Demyelinating Diseases; eIF-2 Kinase; Encephalomyelitis, Autoimmune, Experimental; Endoplasmic Reticulum; Female; Interferon-gamma; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Multiple Sclerosis; Myelin Sheath; Nerve Regeneration; Oligodendroglia; Reverse Transcriptase Polymerase Chain Reaction; Stress, Physiological | 2006 |
Cuprizone and piperonyl butoxide, proposed inhibitors of T-cell function, attenuate experimental allergic encephalomyelitis in SJL mice.
Topics: Animals; CD4-CD8 Ratio; Chelating Agents; Chronic Disease; Cuprizone; Encephalomyelitis, Autoimmune, Experimental; Female; Graft vs Host Disease; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Multiple Sclerosis; Pesticide Synergists; Piperonyl Butoxide; Survival Rate; T-Lymphocytes | 2001 |
Blood-brain barrier permeability during Cuprizone-induced demyelination. Implications for the pathogenesis of immune-mediated demyelinating diseases.
Topics: Animals; Blood-Brain Barrier; Cuprizone; Cyclohexanes; Demyelinating Diseases; Encephalomyelitis, Autoimmune, Experimental; Immunoenzyme Techniques; Male; Mesencephalon; Mice | 1987 |