cucurbitacin-i and Adenocarcinoma

cucurbitacin-i has been researched along with Adenocarcinoma* in 1 studies

Other Studies

1 other study(ies) available for cucurbitacin-i and Adenocarcinoma

ArticleYear
Cucurbitacin I inhibits cell migration and invasion and enhances chemosensitivity in colon cancer.
    Oncology reports, 2015, Volume: 33, Issue:4

    Colorectal cancers are the third most common types of cancers worldwide. Surgical resection is unable to eliminate tumors completely due to metastasis. A demand for new chemotherapeutic tools exists. In the present study, we examined the chemopreventive potential of cucurbitacin I, a natural component extracted from plants of the Cucurbitaceae family, in the colon cancer cell line COLO205. We hypothesized that cucurbitacin I would prevent colon cancer cell migration and invasion, and sensitize colon cancer cells to chemotherapy. Our data demonstrated that exposure of the COLO205 cells to cucurbitacin I significantly decreased cell viability. Furthermore our data demonstrated for the first time that in the COLO205 cells, cucurbitacin I could suppress the cell migration and invasion, and harbor chemosensitization activity against colon cancer. The anticancer activity of cucurbitacin I was accomplished by downregulating p-STAT3 and MMP-9 expression. Collectively, our results suggest that cucurbitacin I may be a potent adjuvant chemotherapeutic agent for colon cancer with anti-migration, anti-invasion and chemosensitizing activities.

    Topics: Adenocarcinoma; Antineoplastic Agents, Phytogenic; Cell Division; Cell Line, Tumor; Cell Movement; Colonic Neoplasms; Depression, Chemical; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Phosphorylation; Protein Processing, Post-Translational; STAT3 Transcription Factor; Triterpenes

2015
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