cucurbitacin-d and Melanoma

cucurbitacin-d has been researched along with Melanoma* in 1 studies

Other Studies

1 other study(ies) available for cucurbitacin-d and Melanoma

Article	Year
Cucurbitacins from Trichosanthes kirilowii as the inhibitory components on tyrosinase activity and melanin synthesis of B16/F10 melanoma cells. Planta medica, 2002, Volume: 68, Issue:9 Cucurbitacins 1 and 2 were isolated from the root of Trichosanthes kirilowii by tyrosinase inhibitory activity-guided fractionation. Spectroscopic analysis revealed that compounds 1 and 2 were cucurbitacin D and 23,24-dihydro-cucurbitacin D, respectively. Compounds 1 and 2 effectively inhibited the activity of tyrosinase (IC(50) = 0.18 microM and 6.7 microM, respectively), and the synthesis of melanin (IC(50) = 0.16 microM and 7.5 microM, respectively) in B16/F10 melanoma cells. Topics: Animals; Antineoplastic Agents, Phytogenic; Inhibitory Concentration 50; Melanins; Melanoma; Mice; Molecular Structure; Monophenol Monooxygenase; Plant Extracts; Plant Roots; Trichosanthes; Triterpenes; Tumor Cells, Cultured	2002

Article

Year

Cucurbitacins from Trichosanthes kirilowii as the inhibitory components on tyrosinase activity and melanin synthesis of B16/F10 melanoma cells.

Planta medica, 2002, Volume: 68, Issue:9

Cucurbitacins 1 and 2 were isolated from the root of Trichosanthes kirilowii by tyrosinase inhibitory activity-guided fractionation. Spectroscopic analysis revealed that compounds 1 and 2 were cucurbitacin D and 23,24-dihydro-cucurbitacin D, respectively. Compounds 1 and 2 effectively inhibited the activity of tyrosinase (IC(50) = 0.18 microM and 6.7 microM, respectively), and the synthesis of melanin (IC(50) = 0.16 microM and 7.5 microM, respectively) in B16/F10 melanoma cells.

Topics: Animals; Antineoplastic Agents, Phytogenic; Inhibitory Concentration 50; Melanins; Melanoma; Mice; Molecular Structure; Monophenol Monooxygenase; Plant Extracts; Plant Roots; Trichosanthes; Triterpenes; Tumor Cells, Cultured

2002