cucurbitacin-c has been researched along with Liver-Neoplasms* in 1 studies
1 other study(ies) available for cucurbitacin-c and Liver-Neoplasms
Article | Year |
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Cucurbitacin B induces apoptosis and S phase cell cycle arrest in BEL-7402 human hepatocellular carcinoma cells and is effective via oral administration.
Cucurbitacin B is an anti-cancer drug candidate and its efficacy has been demonstrated in hepatocellular carcinoma (HCC). To explore its mechanism against HCC, BEL-7402 cells were treated with cucurbitacin B in vitro. Treatment with cucurbitacin B induced S phase arrest and apoptosis. The growth inhibition effect was associated with cyclin D1 and cdc-2 down regulations. Western blotting analysis of cell signaling molecules indicated that cucurbitacin B inhibited c-Raf activation without affecting STAT3 phosphorylation. Moreover, in vivo study demonstrated that cucurbitacin B is effective against BEL-7402 xenograft when administrated orally. Topics: Administration, Oral; Animals; Antineoplastic Agents; Apoptosis; Blotting, Western; Carcinoma, Hepatocellular; Cell Cycle; Cell Division; Cell Line, Tumor; Flow Cytometry; Humans; Liver Neoplasms; Mice; Mice, Nude; Proto-Oncogene Proteins c-raf; S Phase; STAT3 Transcription Factor; Transplantation, Heterologous; Triterpenes | 2010 |