cucurbit(8)uril and Neoplasms

In spite of the rapid emergence of numerous nanoparticles (NPs) for biomedical applications, it is often challenging to precisely control, or effectively tame, the bioactivity/toxicity of NPs, thereby exhibiting limited applications in biomedical areas. Herein, we report the construction of hyaluronic acid (HA)-laminated, otherwise toxic methylviologen (MV), NPs

Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents; Bridged-Ring Compounds; Cell Line, Tumor; Escherichia coli; Female; Fluorides; Gadolinium; Hyaluronic Acid; Imidazoles; Infrared Rays; Mice, Inbred C57BL; Microbial Sensitivity Tests; Nanoparticles; Neoplasms; Paraquat; Polyesters; Staphylococcal Infections; Staphylococcus aureus; Thulium; Ytterbium; Zebrafish

Nanosystems responsive to tumor-specific enzymes are considered as a highly attractive approach to intracellular drug release for targeted cancer therapy. Mesoporous silica nanoparticles are capped with tryptophan-mediated cucurbit[8]uril complex with Fe

Topics: Animals; Bridged-Ring Compounds; Cell Survival; Doxorubicin; Drug Carriers; Drug Liberation; Ferrosoferric Oxide; Hep G2 Cells; Humans; Imidazoles; Indoleamine-Pyrrole 2,3,-Dioxygenase; Mice; Mice, Nude; Nanoparticles; Neoplasms; Porosity; Silicon Dioxide; Tissue Distribution; Transplantation, Heterologous; Tryptophan

An amphiphilic supramolecular brush copolymer CB[8]⊃(PEG-Np·PTPE) was constructed on the basis of a novel host-guest molecular recognition model formed by cucurbit[8]uril (CB[8]), 4,4'-bipyridinium derivative, and PEGylated naphthol (PEG-Np). In aqueous solution, the resultant supramolecular brush copolymer self-assembled into supramolecular nanoparticles (SNPs), by which the anticancer drug doxorubicin (DOX) was encapsulated in the hydrophobic core, establishing an artful Förster resonance energy transfer system with dual fluorescence quenched. With the help of intracellular reducing agents and low pH environment, the SNPs disassembled and the loaded drug molecules were released, realizing in situ visualization of the drug release via the location and magnitude of the energy transfer-dependent fluorescence variation. The cytotoxicity evaluation indicated DOX-loaded SNPs effectively inhibited cell proliferation against HeLa cells. Animal experiments demonstrated that these DOX-loaded SNPs highly accumulated in tumor tissues through the enhanced permeability and retention effect and also had a long blood circulation time. These multifunctional supramolecular nanoparticles possessing self-imaging and controllable drug release ability exhibited great potential in cancer therapy.

Topics: Animals; Bridged-Ring Compounds; Doxorubicin; HeLa Cells; Humans; Hydrogen-Ion Concentration; Imidazoles; Nanomedicine; Neoplasms

Activatable photosensitizers (aPSs) have emerged as promising photodynamic therapy (PDT) agents for simultaneous imaging and selective ablation of cancer. However, traditional synthetic aPSs are limited by complex design and tedious synthesis. Here, aPS regulated by cucurbit[8]uril (CB[8]) for targeted cancer imaging and PDT is reported. This system is based on the host-guest interaction between biotinylated toluidine blue (TB-B) and CB[8] to form 2TB-B@CB[8]. Moreover, a facile strategy to turn off/on the fluorescence and photodynamic activity of TB-B is developed through the reversible assembly/disassembly of 2TB-B@CB[8]. This established system can achieve selective accumulation in tumor, light-up cancer imaging, and enhanced anticancer behavior. Therefore, this work provides a novel and promising strategy for the aPS build via simple and facile regulation of supramolecular chemistry.

Topics: Bridged-Ring Compounds; Fluorescence; Imidazoles; Neoplasms; Photochemotherapy; Photosensitizing Agents

A novel noncovalent strategy to construct chemically synthesized vaccines has been designed to trigger a robust immune response and to dramatically improve the efficiency of vaccine preparation. Glycosylated MUC1 tripartite vaccines were constructed through host-guest interactions with cucurbit[8]uril. These vaccines elicited high levels of IgG antibodies that were recognized by transformed cells and induced the secretion of cytokines. The antisera also mediated complement-dependent cytotoxicity. This noncovalent strategy with good suitability, scalability, and feasibility can be applied as a universal strategy for the construction of chemically synthesized vaccines.

Topics: Animals; Bridged-Ring Compounds; Cancer Vaccines; Cell Line, Tumor; Female; Glycosylation; Humans; Imidazoles; Mice, Inbred BALB C; Mucin-1; Neoplasms; Vaccines, Synthetic