cucumarioside-a2-2 has been researched along with Leukemia* in 1 studies
1 other study(ies) available for cucumarioside-a2-2 and Leukemia
| Article | Year |
|---|---|
Differential effects of triterpene glycosides, frondoside A and cucumarioside A2-2 isolated from sea cucumbers on caspase activation and apoptosis of human leukemia cells.
Frondoside A is a pentaoside having an acetyl moiety at the aglycon ring and xylose as a third monosaccharide residue. Cucumarioside A(2)-2 is a pentaoside having glucose as a third monosaccahride unit. We compared the effects of frondoside A and A(2)-2 for cell death-inducing capability with close attention paid to structure-activity relationships. Both frondoside A and A(2)-2 strongly induced apoptosis of leukemic cells. Frondoside A-induced apoptosis was more potent and rapid than A(2)-2-induced apoptosis. A(2)-2-induced but not frondoside A-induced apoptosis was caspase-dependent. This suggests that holothurians may induce apoptosis of leukemic cells caspase-dependently or -independently, depending on the holothurian structure. Topics: Animals; Annexin A5; Apoptosis; Caspases; Cell Survival; Dose-Response Relationship, Drug; Enzyme Activation; Fluorescein-5-isothiocyanate; Fluorescent Dyes; Glycosides; HL-60 Cells; Humans; Lethal Dose 50; Leukemia; Molecular Structure; Saponins; Sea Cucumbers; Time Factors; Triterpenes | 2009 |