cryptoxanthins has been researched along with Neoplasms* in 4 studies
3 review(s) available for cryptoxanthins and Neoplasms
Article | Year |
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Mechanistic understanding of β-cryptoxanthin and lycopene in cancer prevention in animal models.
To better understand the potential function of carotenoids in the chemoprevention of cancers, mechanistic understanding of carotenoid action on genetic and epigenetic signaling pathways is critically needed for human studies. The use of appropriate animal models is the most justifiable approach to resolve mechanistic issues regarding protective effects of carotenoids at specific organs and tissue sites. While the initial impetus for studying the benefits of carotenoids in cancer prevention was their antioxidant capacity and pro-vitamin A activity, significant advances have been made in the understanding of the action of carotenoids with regards to other mechanisms. This review will focus on two common carotenoids, provitamin A carotenoid β-cryptoxanthin and non-provitamin A carotenoid lycopene, as promising chemopreventive agents or chemotherapeutic compounds against cancer development and progression. We reviewed animal studies demonstrating that β-cryptoxanthin and lycopene effectively prevent the development or progression of various cancers and the potential mechanisms involved. We highlight recent research that the biological functions of β-cryptoxanthin and lycopene are mediated, partially via their oxidative metabolites, through their effects on key molecular targeting events, such as NF-κB signaling pathway, RAR/PPARs signaling, SIRT1 signaling pathway, and p53 tumor suppressor pathways. The molecular targets by β-cryptoxanthin and lycopene, offer new opportunities to further our understanding of common and distinct mechanisms that involve carotenoids in cancer prevention. This article is part of a Special Issue entitled Carotenoids recent advances in cell and molecular biology edited by Johannes von Lintig and Loredana Quadro. Topics: Animals; Antioxidants; Beta-Cryptoxanthin; Disease Models, Animal; Gene Expression Regulation, Neoplastic; Humans; Lycopene; Neoplasms; NF-kappa B; Sirtuin 1; Tumor Suppressor Protein p53 | 2020 |
Absorption, metabolism, and functions of β-cryptoxanthin.
β-Cryptoxanthin, a carotenoid found in fruits and vegetables such as tangerines, red peppers, and pumpkin, has several functions important for human health. Most evidence from observational, in vitro, animal model, and human studies suggests that β-cryptoxanthin has relatively high bioavailability from its common food sources, to the extent that some β-cryptoxanthin-rich foods might be equivalent to β-carotene-rich foods as sources of retinol. β-Cryptoxanthin is an antioxidant in vitro and appears to be associated with decreased risk of some cancers and degenerative diseases. In addition, many in vitro, animal model, and human studies suggest that β-cryptoxanthin-rich foods may have an anabolic effect on bone and, thus, may help delay osteoporosis. Topics: Animals; Antioxidants; Biological Availability; Bone and Bones; Carotenoids; Cryptoxanthins; Diet; Humans; Intestinal Absorption; Neoplasms; Vitamin A | 2016 |
[Potency of carotenoids found in vegetables and fruits].
Topics: Administration, Ophthalmic; Antioxidants; beta Carotene; Carotenoids; Cryptoxanthins; Eye Diseases; Female; Fruit; Humans; Lutein; Lycopene; Male; Neoplasms; Osteoporosis; Vegetables; Xanthophylls; Zeaxanthins | 2013 |
1 other study(ies) available for cryptoxanthins and Neoplasms
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Plasma carotenoid levels in Dutch men and women, and the relation with vegetable and fruit consumption.
Fruit and vegetable intake is inversely associated with cancer risk in many epidemiological studies. Accurate assessment of consumption of these foods is difficult, and biomarkers of intake would overcome several drawbacks of currently used dietary assessment methods. Therefore, we investigated the relation between plasma carotenoids and usual vegetable and fruit intake.. Plasma carotenoid concentrations were measured and vegetable, fruit and juice consumption was assessed by a food frequency questionnaire (FFQ) in a random sample of 591 Dutch men and women aged 20-59 y from the MORGEN-project, one of the contributions to the European Prospective Investigation into Cancer and Nutrition (EPIC)-study.. In this sample of the general Dutch population, in both genders, relative to the other carotenoids, plasma beta-cryptoxanthin was the best indicator for fruit intake, and for the sum of vegetable, fruit and juice intake, while lutein concentrations best reflected intake of vegetables, although quartiles of intake were not consistently separated. Since levels of lycopene were not associated with any of the main food groups examined, associations with total carotenoids improved when excluding lycopene, and monotonously increasing plasma levels were seen for intakes of vegetables, of fruits, and of the sum of vegetables, fruits and juices. Several vegetable types and orange/grapefruit juice were associated with plasma levels of one of the carotenoids.. Plasma carotenoids were only crude indicators of vegetable and fruit intake as assessed by a FFQ; beta-cryptoxanthin for fruit intake and lutein for vegetable intake. None of the plasma carotenoids could distinguish all four quartiles of vegetables, fruit and/or juice intake. Topics: Adult; beta Carotene; Beverages; Biomarkers; Carotenoids; Cryptoxanthins; Diet; Female; Fruit; Humans; Lutein; Lycopene; Male; Middle Aged; Neoplasms; Netherlands; Prospective Studies; Surveys and Questionnaires; Vegetables; Xanthophylls | 2004 |