cryptophycin and Carcinoma

cryptophycin has been researched along with Carcinoma* in 1 studies

Other Studies

1 other study(ies) available for cryptophycin and Carcinoma

Article	Year
Synthesis and biological evaluation of novel cryptophycin analogs with modification in the beta-alanine region. Bioorganic & medicinal chemistry letters, 1999, Jan-04, Volume: 9, Issue:1 Structure modification of the beta-alanine region (fragment C) of the potent antimitotic agent cryptophycin was investigated. This includes: (1) introduction of substituents at the previously unsubstituted C7 position of the macrolide ring and (2) replacement of the (2R)-3-amino-2-methyl-propanoic acid (beta-alanine) with various (1)-amino acids to give the corresponding 15-membered unnatural cryptophycin analogs. Topics: Amino Acid Substitution; Animals; Antineoplastic Agents; beta-Alanine; Carcinoma; Colonic Neoplasms; Depsipeptides; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Mice; Models, Molecular; Pancreatic Neoplasms; Peptides, Cyclic; Protein Conformation; Structure-Activity Relationship; Tumor Cells, Cultured	1999

Article

Year

Synthesis and biological evaluation of novel cryptophycin analogs with modification in the beta-alanine region.

Bioorganic & medicinal chemistry letters, 1999, Jan-04, Volume: 9, Issue:1

Structure modification of the beta-alanine region (fragment C) of the potent antimitotic agent cryptophycin was investigated. This includes: (1) introduction of substituents at the previously unsubstituted C7 position of the macrolide ring and (2) replacement of the (2R)-3-amino-2-methyl-propanoic acid (beta-alanine) with various (1)-amino acids to give the corresponding 15-membered unnatural cryptophycin analogs.

Topics: Amino Acid Substitution; Animals; Antineoplastic Agents; beta-Alanine; Carcinoma; Colonic Neoplasms; Depsipeptides; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Mice; Models, Molecular; Pancreatic Neoplasms; Peptides, Cyclic; Protein Conformation; Structure-Activity Relationship; Tumor Cells, Cultured

1999